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Rui-Yu Wang, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Leukemia - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1993 SpanTran, Houston, TX, PHD, Basic Sciences
1965 Department of Medicine, Beijing Medical University, China, MD

Postgraduate Training

1/1970-2/1979 Resident, Qinghai District Hospital, Qinghai, China
9/1965-12/1969 Postdoctoral Fellow, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China, Dr. Zuo-gan Zhang

Experience/Service

Academic Appointments

Assistant Professor, Department of Stem Cell Transplantation - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2005-2010
Instructor, Department of Stem Cell Transplantation - Research, Division of Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2001-2005
Research Associate, Department of Stem Cell Transplantation - Research, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 1998-2001
Research Associate, Department of Laboratory Medicine - Research, Division of Pathology/Lab Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 1995-1998
Project Investigator, Department of Laboratory Medicine - Research, Division of Pathology/Lab Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 1993-1995
Associate Professor, Department of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China, 1992-1993
Project Investigator, Department of Laboratory Medicine - Research, Division of Pathology/Lab Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 1991-1992
Associate Professor, Department of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China, 1988-1991
Research Associate, Department of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China, 1987-1988
Visiting Scientist, Department of Cancer Biology, Division of Basic Science Research, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 1985-1987
Research Associate, Department of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China, 1979-1985
Resident Physician, Department of Internal Medicine, Qinghai District Hospital, Qinghai, China, 1970-1979
Research Assistant, Institute of Experimental Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China, 1965-1970

Honors and Awards

1989 Outstanding Teacher, Peking Union College, Chinese Academy of Medical Sciences
1984 World Health Organization (WHO) Fellowship, World Health Organization

Professional Memberships

American Association for Cancer Research
Member, 1999-present
American Society of Hematology
Member, 7/2001-present
Chinese Geriatric Oncology Society
Member, 2007-present
Chinese Society for Anatomy
Member, 1982-present
Chinese Society for Cell Biology
Member, 1987-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Battula VL, Shi Y, Evans KW, Wang RY, Spaeth EL, Jacamo RO, Guerra R, Sahin AA, Marini FC, Hortobagyi G, Mani SA, Andreeff M. Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis. J Clin Invest 122(6):2066-78, 6/2012. e-Pub 5/2012. PMID: 22585577.
2. Chen Y, Jacamo R, Shi YX, Wang RY, Battula VL, Konoplev S, Strunk D, Hofmann NA, Reinisch A, Konopleva M, Andreeff M. Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment. Blood 119(21):4971-80, 5/2012. e-Pub 4/2012. PMCID: PMC3367899.
3. Tabe Y, Jin L, Iwabuchi K, Wang RY, Ichikawa N, Miida T, Cortes J, Andreeff M, Konopleva M. Role of stromal microenvironment in nonpharmacological resistance of CML to imatinib through Lyn/CXCR4 interactions in lipid rafts. Leukemia 26(5):883-892, 5/2012.
4. Mak DH, Wang RY, Schober WD, Konopleva M, Cortes J, Kantarjian H, Andreeff M, Carter BZ. Activation of apoptosis signaling eliminates CD34(+) progenitor cells in blast crisis CML independent of response to tyrosine kinase inhibitors. Leukemia 26(4):788-94, 4/2012. e-Pub 10/2011. PMCID: PMC3598156.
5. Battula VL, Evans KW, Hollier BG, Shi Y, Marini FC, Ayyanan A, Wang RY, Brisken C, Guerra R, Andreeff M, Mani SA. Epithelial-mesenchymal transition-derived cells exhibit multilineage differentiation potential similar to mesenchymal stem cells. Stem Cells Aug;28(8):1435-45., 2010.
6. Ling X, Marini F, Konopleva M, Schober W, Shi Y, Burks JK, Clise-Dwyer K,Wang RY, Zhang W, Yuan X, Lu H, Caldwell L, Andreeff M. Mesenchymal Stem Cells Overexpressing IFN-β Inhibit Breast Cancer Growth and Metastases through Stat3 Signaling in a Syngeneic Tumor Model. Cancer Microenvironment 3:83–95, 2010.
7. Vega F, Davuluri Y, Cho-Vega JH, Singh RR, Ma S, Wang RY, Multani AS, Drakos I, Pham L, Lee YC, Shen L, Ambrus J, Medeiros LJ, Ford RJ. Side Population of a Murine Mantle Cell Lymphoma Model Contains Tumor-Initiating Cells Responsible for Lymphoma Maintenance and Dissemination. J Cell Mol Med. e-Pub 7/2009. PMID: 19656242.
8. Guo W, Wu S, Wang L, Wang RY, Wei X, Liu J, Fang B. Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1). Mol Cancer Ther 8(2):441-8, 2/2009. e-Pub 2/2009. PMCID: PMC2653085.
9. Zeng Z, Shi YX, Samudio IJ, Wang RY, Ling X, Frolova O, Levis M, Rubin JB, Negrin RR, Estey EH, Konoplev S, Andreeff M, Konopleva M. Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. Blood. e-Pub 10/2008. PMID: 18955566.
10. Carter BZ, Mak DH, Shi Y, Schober WD, Wang RY, Konopleva M, Koller E, Dean NM, Andreeff M. Regulation and targeting of Eg5, a mitotic motor protein in blast crisis CML: overcoming imatinib resistance. Cell Cycle 5:2223-9, 10/2006. PMID: 16969080.
11. Okcu MF, Wang RY, Bueso-Ramos C, Schober W, Weidner D, Andrassy R, Blakely M, Russell H, Ozkan A, Kuttesch J, Andreeff M, Chan KW, Ater J. Flow cytometry and fluorescence in situ hybridization to detect residual neuroblastoma cells in bone marrow. Pediatr Blood Cancer 45:787-95, 11/2005. PMID: 15929127.
12. Konopleva M, Tsao T, Estrov Z, Lee RM, Wang RY, Jackson CE, McQueen T, Monaco G, Munsell M, Belmont J, Kantarjian H, Sporn MB, Andreeff M. The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia. Cancer Res 64:7927-35, 11/2004. PMID: 15520199.
13. Konopleva M, Elstner E, McQueen TJ, Tsao T, Sudarikov A, Hu W, Schober WD, Wang RY, Chism D, Kornblau SM, Younes A, Collins SJ, Koeffler HP, Andreeff M. Peroxisome proliferator-activated receptor gamma and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias. Mol Cancer Ther 3:1249-62, 10/2004. PMID: 15486192.
14. Norwood K, Wang RY, Hirschmann-Jax C, Andreeff M, Brenner MK, Goodell MA, Wulf GG. An in vivo propagated human acute myeloid leukemia expressing ABCA3. Leuk Res 28:295-299, 2004.
15. Monaco G, Konopleva M, Munsell M, Leysath C, Wang RY, Jackson CE, Korbling M, Estey E, Belmont J, Andreeff M. Engraftment of AML in NOD/Scid mice is independent of CXCR4 and predicts poor patient survival. Stem Cells 22:188-201, 2004.
16. Carter BZ, Kornblau SM, Tsao T, Wang RY, Schober WD, Milella M, Sung HG, Reed JC, Andreeff M. Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis. Blood 102:4179-86, 12/2003. PMID: 12920030.
17. Carter BZ, Wang RY, Schober WD, Milella M, Chism D, Andreeff M. Targeting Survivin expression induces cell proliferation defect and subsequent cell death involving mitochondrial pathway in myeloid leukemic cells. Cell Cycle 2:488-93, 9/2003. PMID: 12963850.
18. Bao JJ, Le XF, Wang RY, Yuan J, Wang L, Atkinson EN, LaPushin R, Andreeff M, Fang B, Yu Y, Bast RC, Jr. Reexpression of the tumor suppressor gene ARHI induces apoptosis in ovarian and breast cancer cells through a caspase-independent calpain-dependent pathway. Cancer Res 62:7264-72, 12/2002. PMID: 12499268.
19. Hsu TC, Zhao YJ, Wang RY, Wu YF, Spitz MR, Hong WK. Comparative efficacy as antioxidants between ascorbic acid and epigallocatechin gallate on cells of two human lymphoblastoid lines. Cancer Genet Cytogenet 124:169-71, 1/2001. PMID: 11172912.
20. Wulf GG, Wang RY, Kuehnle I, Weidner D, Marini F, Brenner MK, Andreeff M, Goodell MA. A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia. Blood 98:1166-1173, 2001.
21. Liang JC, Ning Y, Wang RY, Padilla-Nash HM, Schrock E, Soenksen D, Nagarajan L, Ried T. Spectral karyotypic study of the HL-60 cell line: detection of complex rearrangements involving chromosomes 5, 7, and 16 and delineation of critical region of deletion on 5q31.1. Cancer Genet Cytogenet 113:105-9, 9/1999. PMID: 10484974.
22. Hsu TC, Zhao Y, Wang RY, Dickerson R, Liang JC, Wang X, Wu Y. Exaggerated precocious centromere separation in cells of a human breast cancer line treated with a green tea extract. Int J Oncol 12:617-20, 3/1998. PMID: 9472101.
23. Fairman J, Wang RY, Liang H, Zhao L, Saltman D, Liang JC, Nagarajan L. Translocations and deletions of 5q13.1 in myelodysplasia and acute myelogenous leukemia: evidence for a novel critical locus. Blood 88:2259-66, 9/1996. PMID: 8822947.
24. Wang RY, Troncoso P, Palmer JL, El-Naggar AK, Liang JC. Trisomy 7 by dual-color fluorescence in situ hybridization: a potential biological marker for prostate cancer progression. Clin Cancer Res 2:1553-8, 9/1996. PMID: 9816332.
25. Wang RY, Hsu TC, Brock WA, Liang JC. DNA fragility and repair capability are separate genetic phenotypes: studies on in situ nick translation and chromosome breakage. Intl J Oncol 1:51-54, 1995.
26. Wang RY, Yian Y, Wu H, Lio HY, Bao JJ. Suppression of tumorigenicity by fusion of neo-resistant gene transfected normal mouse spleen cells to the human lung cancer cells. Chinese Cancer Res 16:77, 1994.
27. Liang JC, Bailey NM, Gabriel GJ, Kattan MW, Wang RY, Hagemeister FB, Cabanillas FF, Fuller LM. A new chemotherapy regimen for treatment of Hodgkin's disease associated with minimal genotoxicity. Leuk Lymph 9:503-508, 1993.
28. Wang RY, Zhang HY, Wu H, Zhao H, Lio HY, Sun QN, Bao JJ, Xue SP. Analysis of the cytoskeleton in cultured normal and malignant cells with different metastatic abilities. Acta Anatomica Sinica 24:153-156, 1993.
29. Wang RY, Hsu TC, Liang JC. In situ nick translation, an alternative to cytogenetics in analyzing mutagen effects on human cells. Intl J Oncol 2:873-876, 1993.
30. Suen ML, Wang RY, Guan BJ, Song ZL, Lio ZY, Zhang YQ, Zeng ZP, Lio HY, Dong M. Effect of ANF and ACTH on aldosterone secretion in culture human adrenal tissue. ACTA Academiae Medicinae Sinicae 14:38-41, 1992.
31. Wang RY, Tian RM, Lio ZY, Yang T, Bao JJ. Studies on human cervical carcinoma cell line. II. HGPRT-mutant cell clone CC-801AR2 and its biological characteristics. ACTA Academiae Medicinae Sinicae 14:461-464, 1992.
32. Wang RY, Bao JJ, Fei RR, Wu H, Xue XP. The inhibitory effect of erythroid differentiation factor (EDF) on L929 and KB cells. Acta Anatomic Sinica 23:285-289, 1992.
33. J.J. Bao, D Shen, Q.Sheng and Wang RY. A New and Simple Hybridization Method for Studying Oncogene Expression. Acta Academiae Medicine Sinicae. 13:439-442, 1991.
34. Wang RY, Suen ML, Dong M, Jiang BJ, Song ZL, Wang YH, Zeng ZP, Lio HY, Zang MF. Establishment of human adrenal gland and aldosterone-producing adenoma culture and the effect of alpha-human atrial natriuretic factor on aldosterone secretion in vitro. ACTA Academiae Medicinae Sinicae 13:181-185, 1991.
35. Wang RY, Wang CG, Wang DB, He S. Timelapse microcinematographical analysis of the biological characteristic of macrophage-like MMC-1 cell line. ACTA Academiae Medicinae Sinicae 13:24-28, 1991.
36. Cherry LM, Wang RY. Kinetochore staining in multicentric chromosomes of murine cancer cell lines. Cytobios 53:173-183, 1988.
37. Bao JJ, Wang RY, Wang CG, Le K, He S. Studies on human cervical carcinoma cell line. I. Establishment of cloned human cervical carcinoma cell line and biological characteristics of CC-801. ACTA Academiae Medicinae Sinicae 10:258-261, 1988.
38. Wang RY, Hsu TC, Kendal WS. Repeated tandem translocations in a clone and subclones of B16-F10 murine melanoma. Cancer Genet Cytogenet 29(1):81-9, 11/1987. PMID: 3478132.
39. Hu FN, Wang RY, Hsu TC. Clonal origin of metastasis in B16 murine melanoma: A cytogenetic study. JNCI 78:155-163, 1987.
40. Kendle W, Wang RY, Hsu TC, Frost P. Rate of generation of major karyotypics abnormalities in relationship to the metastatic potential of B16 murine melanoma. Cancer Res 47:3835-3841, 1987.
41. Wang RY, Kendle W, Hsu TC, Frost P. Repeated randem translocation in a clone and subclone of B16-F10 murine melanoma. Cancer Genet Cytogenet 29:81-89, 1987.
42. Kendle W, Wang RY, Hsu TC, Frost P. Spontaneous mutation rates in cloned murine tumors do not correlate metastatic potential whereas the prevalence of karyotypic abnormalities in the parental tumor does. Intl J Cancer 40:408-413, 1987.
43. Wang RY, Hsu TC. Improvement of a procedure for increasing mitotic cells suitable for high-resolution banding. Mammalian Chromosome Newsletter 27:109-114, 1986.

Abstracts

1. Patel A, Wang RY, Hixson P, Li J, Milosavljevic A, Kantarjian HM, Cheung S, Andreeff M. Clinical evaluation of a custom genome wide 44K oligoarray for copy number changes in acute myeloid leukemia. Blood 112:4869, 2008.
2. Andreeff M, McQueen T, Williams C, Gu J, Hopwood VL, Appleberry T, Rich C, Dallaire S, Kornblau S, Wang RY. Clonal abnormalities in MSC derived from AML bone marrows. Blood 112:2428, 2008.
3. Wang RY, Samudio IJ, McQueen T, Schober WD, Ruvolo VR, Kornblau SM, Konopleva M, Andreeff. Apoptosis inducing factor acts as a suvival factor in acute myelogenous leukemia through mitochondrial complex 1. Blood 110(11):537a (#1812), 2007.
4. Andreeff M, Konoplev S, Wang RY, Zeng ZH, McQueen T, Shi Y-X, Medeiros LJ, Estey E, McCarty JM, Elkins S, Champlin R, Calandra G, Bridger G, Konopleva M. Massive of mobilization of AML cells into circulation by disruption of leukemia/stroma cell interactions using CXCR4 antagonist AMD3100: First evedance in patients and potential for abolishing bone marrow microenvironment-mediated resistance. Blood 108(11):568, 2006.
5. Wang RY, Ruvolo VR, McQueen T, Schober WD, Kornblau S, Konopleva M, Andreeff M. Overexpression of apoptosis-inducing factor (AIF) and pro-survival function in AML. Blood 108(suppl):4395, 2006.
6. Wang RY, Fuller GN, McQueen T, Shi YX, Champlin RE, Andreeff M. Distribution and differentiation of donor-derived bone marrow stem cells in various areas of the human brain. Blood 106(11):481a, 2005.
7. Andreeff M, Contractor R, Ruvolo PP, Deng X, Samudio I, Shi YX, McQueen T, Wang RY, Schober W, Ling X, Marini F, Harris D, Estrov Z, McCubrey J, May WS, Konopleva M. Mechanisms of apoptosis induction by BH3 inhibitor ABT-737 in AML. Blood 106(11):74a, 2005.
8. Carter BZ,Mak D, Shi YX, Schober WD, Wang RY, McQueen T, Konopleva M, Koller E, Dean NM, and Andreeff M. Regulation and targeting of eg5 in blast crisis CML: overcoming imatinib resistance. Blood 106(11):806a, 2005.
9. Wang RY, Carter BZ, Tsao T, Schober W, McQueen T, Konopleva M, Andreeff M. Role of apoptotic inducing factor (AIF) in acute myeloid leukemia (AML). Blood 106(11):666a, 2005.
10. Wang RY, Fuller, Champlin RE, Andreeff M. Low frequency of donor-derived neuronal, glia, and endothelial cells in the cerebellum of patients undergoing sex-mismatched bone marrow transplantation. Blood 104:980A, 2004.
11. Wang RY, Fuller GN, Luna MA, De Lima M, Champlin RE, Andreeff M. Infrequent bone-marrow origin of epithelial cells in female recipients of sex-mismatched bone marrow transplants. The First Annual Stem Cell Wetlab/Conference-Challenges in the Era of Stem Cell Plasticity, 2003.
12. Bao JJ, Wang RY, Brey E, Andreeff M, Patrick CW, Atkinson EN, Yu Y, Bast RC. Reexpression of the ARHI gene suppresses motility of ovarian cancer cells. Proc Am Assoc Cancer Res 44:4381, 1003, 2003.
13. Carter BZ, Milella M, Wang RY, Schober WD, Chism D, Andreeff M. Targeting surviving expression induces G2/M block and subsequent cell death involving mitochondrial pathway in myeloid leukemic cells. Proc Am Assoc Cancer Res 11:103, 23, 2003.
14. Wang RY, Fuller GN, Sahin AA, Luna MA, de Lima MJ, Champlin RE, Andreeff M. Transdifferentiation of bone-marrow derived stem cells is infrequent in organs and absent in tumor metastases. Blood 102:1216, 337a,, 2003.
15. Ater J, Okcu MF, Wang RY, Schober W, Weidner D, Andrassy J, Blakely M, Bueso-Ramos C, Andreeff M, Chan KW. Flow cytometry (FCM) and fluorescence in situ hybridization (FISH) to detect residual neuroblastoma (NB) cells in bone marrow (BM). Proc Am Soc Clin Oncol 21:1598, p. 400a, 2002.
16. Konopleva M, Hu W, Lapillonne H, McQueen T, Monaco P, Sudarikov A, Wang RY, Belmont J, Sporn M, Andreeff M. PPAR-gamma ligation by a triterpenoid CDDO as a novel therapy for leukemias. 7th Congress of the European Haematology Association (EHA), 2002.
17. Konopleva M, Lapillonne H, Lee R, Wang RY, Tsao T, McQueen T, Andreeff M:. PPARgamma ligand CDDO induces apoptosis in leukemias via multiple apoptosis pathways. Blood 100:2209, 562a, 2002.
18. Konopleva M, Tsao T, Lapillonne HF, Sudarikov A, McQueen T, Hu WX, Monaco G, Wang RY, Belmont J, Sporn MB, Andreeff M. PPARgamma nuclear receptor as a novel molecular target in leukemia therapy. Am Assoc Cancer Res (AACR), 2002.
19. Konopleva M, McQueen T, Tsao T, Monaco G, Wang RY, Belmont J, Sporn M, Andreeff M. PPARg nuclear receptor as a novel therapeutic target in leukemia. AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications, Miami Beach, FL, 10/2001.
20. Weidner DA, Wang RY, Zhao S, Kuenle I, Kantarjian H, Brenner MK, Goodell MA, Andreeff M. Abscence of Ph+ cells in CD34- lin- "SP" bone marrow progenitor cells from patients with chronic myeloid leukemia (CML). Ann Hematol 80:S37, 2001.
21. Wang RY, Fuller GN, Luna MA, De Lima M, Champlin RE, Andreeff M. Bone marrow origin of epithelial cells of multiple organs in human sex-mismatched bone marrow transplant recipients. Blood 98:3291, 791a, 2001.
22. Wulf GG, Wang RY, Andreeff M, Brenner MK, Goodell MA. Leukemia stem cells with efficient drug efflux in acute myeloid leukemia. Ann Hematol 80:S8, 2001.
23. Marini F, Zoltick P, Zompetta C, Wang RY, Wilson JM, Andreeff M. Novel CML therapy using mesenchymal stem cells (MSC) to deliver localized regulated interferon-a 2B (IFN-alpha). Proc Am Assoc Can Res 42:2447, p. 455, 2001.
24. Konopleva M, McQueen T, Tsao T, Monaco G, Lapillonne H, Wang RY, Younes A, Belmont J, Sporn MB, Andreeff M. PPARgamma ligands are potent inducers of apoptosis in leukemias and lymphomas. Blood 98:501, 119a, 2001.
25. Wang RY, Weidner D, McQueen T, Andreeff M. Quantitative determination of Bcl-2 in FACS-sorted normal and AML progenitor cells by laser scanning cytometry (LSC): Comparison with flow cytometry and Western blot analysis. Ann Hematol 80:S32, 2001.
26. Wang RY, Hayes K, Andreeff M. Unexpected t(18;21)(q21;q22) with translocation of the AML1 gene to chromosome 18q21 in HL60 cells transduced with bcl-2. Blood 98:4297, 156b, 2001.
27. Engel H, Wang RY, Weidner R, Kleine HD, Jiang S, Andreeff M. The CD34+/CD38- but not the CD34+/HLA-DR- progenitor cell compartment harbours highly proliferative leukemic cells in acute myeloid leukemia and myelodysplastic syndromes in complete remission. Gemeinsame Jahrestagung der Deutschen und Oesterreichischen Gesellschaften fuer Haematologie und Onkologie, 10/2000.
28. Andreeff M, Weidner DA, Wang RY, Zhao S, Kuenle I, Kantarjian H, Brenner MK, Goodell MA. Absence of detectable Ph+ cells in CD34- lin- "SP" bone marrow progenitor cells from patients with chronic myeloid leukemia (CML). 8th Ann Intl Symp Recent Advances in Hematopoietic Stem Cell Transplantation, Heidelberg, Germany, 5/2000.
29. Andreeff M, Wulf G, Weidner DA, Wang RY, Zhao S, Kuenle I, Marini F, Estey E, Kantarjian H, Brenner MK, Goodell MA. CD34- lin- "SP" progenitor cells in acute and chronic myeloid leukemias. Acta Haematologica 103:15, p. 4, 2000.
30. Marini F, Zompetta C, Wang RY, Studeny M, Zoltick P, Wilson J, Andreeff M. Mesenchymal stem cells (MSC) from patients with chronic myelogenous leukemia (CML) patients can be transduced with common gene transfer vectors at high efficiency, and are genotypically normal. Blood 96:3201, p. 740a, 2000.
31. Wang RY, Weidner D, McQueen T. Quantitative determination of Bcl-2 in FACS-sorted single cells by laser scanning cytometry (LSC): Comparison with flow cytometric and Western blot analysis. Blood 96:3098, p.717a,, 2000.

Book Chapters

1. Wulf GG, Wang RY, Brenner MK, Andreeff M, Goodell MA. Leukemia stem cells with efficient drug efflux in acute myeloid leukemia. In: Acute Leukemias. IX. Ed(s) Hiddemann W, Buchner T, Ritter J, Unterhalt M, Haferlach T. Springer: Heidelberg, German, 128-135, 2003.
2. Wang RY, Weidner D, Schrober W, McQueen T, Jackson CE, Andreeff M. Quantitative determination of Bcl-2 expression in AML cell lines and in normal and leukemic progenitor cell compartments by laser scanning cytometry: Comparison with flow cytometry and Western blot. In: Acute Leukemias. IX. Ed(s) Hiddemann W, Buchner T, Ritter J, Unterhalt M, Haferlach T. Springer: Heidelberg, Germany, 239-251, 2003.
3. Weidner DA, Wang RY, Zhao S, Kuehnle I, Kantarjian H, Brenner MK, Goodell MA, Andreeff M. Reduced level of Philadelphia chromosome positive (Ph+) cells in lineage negative side population bone marrow progenitor cells from patients with chronic myeloid leukemia (CML). In: Acute Leukemias IX. IX. Ed(s) Hiddemann W, Buchner T, Ritter J, Unterhalt M, Haferlach T. Springer: Heidelberg, Germany, 140-149, 2003.

Manuals, Teaching Aids, Other Teaching Publications

1. Wang RY. Tissue culture. Peking Union Medical College Press, 1989.

Grant & Contract Support

Title: The Therapy of AML Core B1: Fluorescence-Activated Cell Sorting (FACS/Molecular Cytogenetics (FISH)/Confocal Microscopy
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Andreeff PI / Core Leader
Duration: 9/20/2007 - 8/31/2012
 
Title: The role of apoptotic inducing factor (AIF) in acute myeloid leukemia
Funding Source: Ladies Leukemia League Grant.
Role: Principal Investigator
Duration: 2005 - 2006
 
Title: Can blood-derived stem cells contribute to neuronal and vascular-endothelial cells in the brain?
Funding Source: The University of Texas M. D. Anderson Cancer Center
Role: Principal Investigator
Duration: 2004 - 2005

Last updated: 9/6/2013