Skip to Content

'
Ryan E. Watkins, Ph.D.

Present Title & Affiliation

Primary Appointment

Instructor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2004 University of North Carolina at Chapel Hill, Chapel Hill, NC, PHD, Biochemistry with Emphasis in Biophysics
1999 College of Charleston, Charleston, SC, BS, Chemistry
1999 College of Charleston, Charleston, SC, BS, Biochemistry
1999 College of Charleston, Charleston, SC, BS, Biology with Emphasis in Molecular Biology

Selected Publications

Peer-Reviewed Original Research Articles
1. Meuillet EJ, Zuohe S, Lemos R, Ihle N, Kingston J, Watkins R, Moses SA, Zhang S, Du-Cuny L, Herbst R, Jacoby JJ, Zhou LL, Ahad AM, Mash EA, Kirkpatrick DL, Powis G. Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol Cancer Ther 9(3):706-17, 3/2010. e-Pub 3/2/2010. PMCID: PMC2837366.
2. Hassan KA, Xu Z, Watkins RE, Brennan RG, Skurray RA, Brown MH. Optimized production and analysis of the staphylococcal multidrug efflux protein QacA. Protein Expr Purif 64(2):118-124, 4/2009. e-Pub 12/6/2008. PMID: 19073264.
3. Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, LeCluyse E, Tripathy A, McDonnell DP, Redinbo MR. Human PXR forms a tryptophan zipper-mediated homodimer. Biochemistry 45(28):8579-8589, 7/18/2006. PMCID: PMC2515391.
4. Watkins RE, Davis-Searles PR, Lambert MH, Redinbo MR. Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor. J Mol Biol 331(4):815-828, 8/22/2003. PMID: 12909012.
5. Watkins RE, Maglich JM, Moore LB, Wisely GB, Noble SM, Davis-Searles PR, Lambert MH, Kliewer SA, Redinbo MR. 2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin. Biochemistry 42(6):1430-8, 2/18/2003. PMID: 12578355.
6. Watkins RE, Noble SM, Redinbo MR. Structural insights into the promiscuity and function of the human pregnane X receptor. Curr Opin Drug Discov Devel 5(1):150-158, 1/2002. PMID: 11865669.
7. Berrety RP, Hsu D, Kettner L, Mascarenhas A, Redinbo MR, Snoeyink J, Watkins R. Ligand binding to the pregnane X receptor by geometric matching of hydrogen bonding. Currents in Computational Molecular Biology:22-23, 2002.
8. Watkins RE, Wisely GB, Moore LB, Collins JL, Lambert MH, Williams SP, Willson TM, Kliewer SA, Redinbo MR. The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science 292(5525):2329-33, 6/22/2001. e-Pub 6/14/2001. PMID: 11408620.

Last updated: 9/19/2012