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Said Akli, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Experimental Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1994 PARIS VII University, Paris, France, PHD, Human Genetics
1990 High Studies Practical School, Paris, France, BA, Human Genetics

Honors and Awards

2010-2011 Career Development Award U-01 Salivary Gland, UTMDACC
2010-2011 DOD Breast Cancer Concept Award, Department of Defense
2010 CCTS Pilot Project Award, UTMDACC
2006-2007 Develomental Research Award-SPORE in Bladder Cancer, UTMDACC

Selected Publications

Peer-Reviewed Original Research Articles

1. Mittendorf EA, Liu Y, Tucker SL, McKenzie T, Qiao N, Akli S, Biernacka A, Liu Y, Meijer L, Keyomarsi K, Hunt KK. A novel interaction between HER2/neu and cyclin E in breast cancer. Oncogene 29(27):3896-907, 7/2010. e-Pub 5/2010. PMCID: PMC2900397.
2. Akli S, Bui T, Wingate H, Biernacka A, Moulder S, Tucker SL, Hunt KK, Keyomarsi K. Low-molecular-weight cyclin e can bypass letrozole-induced g1 arrest in human breast cancer cells and tumors. Clin Cancer Res 16(4):1179-90, 2/2010. e-Pub 2/2010. PMCID: PMC2822889.
3. Akli S, Van Pelt CS, Bui T, Multani AS, Chang S, Johnson D, Tucker S, Keyomarsi K. Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway. Cancer Res 67(15):7212-22, 8/2007. PMID: 17671189.
4. Barton MC, Akli S, Keyomarsi K. Deregulation of cyclin E meets dysfunction in p53: closing the escape hatch on breast cancer. J Cell Physiol 209(3):686-94, 12/2006. PMID: 17001684.
5. Akli S, Keyomarsi K. Low-molecular-weight cyclin E: the missing link between biology and clinical outcome. Breast Cancer Res 6(5):188-91, 9/2004. PMID: 15318923.
6. Akli S, Zheng PJ, Multani AS, Wingate HF, Pathak S, Zhang N, Tucker SL, Chang S, Keyomarsi K. Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p21, p27, and antiestrogens in breast cancer. Cancer Res 64(9):3198-208, 5/2004. PMID: 15126360.
7. Wingate H, Bedrosian I, Akli S, Keyomarsi K. The low molecular weight (LMW) isoforms of cyclin E deregulate the cell cycle of mammary epithelial cells. Cell Cycle 2(5):461-6, 9/2003. PMID: 12963845.
8. Akli S, Keyomarsi K. Cyclin E and its low molecular weight forms in human cancer and as targets for cancer therapy. Cancer Biol Ther 2(4 Suppl 1):S38-47, 7/2003. PMID: 14508079.
9. Akli S, Zhan S, Abdellatif M, Schneider MD. E1A can provoke G1 exit that is refractory to p21 and independent of activating cdk2. Circ Res 85(4):319-28, 8/1999. PMID: 10455060.
10. Guidotti J, Akli S, Castelnau-Ptakhine L, Kahn A, Poenaru L. Retrovirus-mediated enzymatic correction of Tay-Sachs defect in transduced and non-transduced cells. Hum Mol Genet 7(5):831-8, 5/1998. PMID: 9536087.
11. Lisovoski F, Akli S, Peltekian E, Vigne E, Haase G, Perricaudet M, Dreyfus PA, Kahn A, Peschanski M. Phenotypic alteration of astrocytes induced by ciliary neurotrophic factor in the intact adult brain, As revealed by adenovirus-mediated gene transfer. J Neurosci 17(19):7228-36, 10/1997. PMID: 9295369.
12. Haase G, Kennel P, Pettmann B, Vigne E, Akli S, Revah F, Schmalbruch H, Kahn A. Gene therapy of murine motor neuron disease using adenoviral vectors for neurotrophic factors. Nat Med 3(4):429-36, 4/1997. PMID: 9095177.
13. Kahn A, Haase G, Akli S, Guidotti JE. [Gene therapy of neurological diseases]. C R Seances Soc Biol Fil 190(1):9-11, 9/1996. PMID: 8881264.
14. Akli S, Guidotti JE, Vigne E, Perricaudet M, Sandhoff K, Kahn A, Poenaru L. Restoration of hexosaminidase A activity in human Tay-Sachs fibroblasts via adenoviral vector-mediated gene transfer. Gene Ther 3(9):769-74, 9/1996. PMID: 8875224.
15. Cohen-Tannoudji M, Marchand P, Akli S, Sheardown SA, Puech JP, Kress C, Gressens P, Nassogne MC, Beccari T, Muggleton-Harris AL, et al. Disruption of murine Hexa gene leads to enzymatic deficiency and to neuronal lysosomal storage, similar to that observed in Tay-Sachs disease. Mamm Genome 6(12):844-9, 12/1995. PMID: 8747922.
16. Lisovoski F, Cadusseau J, Akli S, Caillaud C, Vigne E, Poenaru L, Stratford-Perricaudet L, Pericaudet M, Kahn A, Peschanski M. In vivo transfer of a marker gene to study motoneuronal development. Neuroreport 5(9):1069-72, 5/1994. PMID: 8080960.
17. Poenaru L, Akli S. Molecular epidemiology of Tay-Sachs disease in Europe. Biomed Pharmacother 48(8-9):341-6, 5/1994. PMID: 7858168.
18. Caillaud C, Akli S, Vigne E, Koulakoff A, Perricaudet M, Poenaru L, Kahn A, Berwald-Netter Y. Adenoviral vector as a gene delivery system into cultured rat neuronal and glial cells. Eur J Neurosci 5(10):1287-91, 10/1993. PMID: 8275231.
19. Peschanski M, Lisovoski F, Akli S, Caillaud C, Wahrman P, Weber-Benarous A, Vigne E, Stratford-Perricaudet L, Perricaudet M, Kahn A. [Gene transfer with a therapeutic purpose in the central nervous system]. Nouv Rev Fr Hematol 35(3):299-300, 6/1993. PMID: 8337147.
20. Akli S, Boue J, Sandhoff K, Kleijer W, Vamos E, Young E, Gatti R, Di Natale P, Motte J, Vanier MT, et al. Collaborative study of the molecular epidemiology of Tay-Sachs disease in Europe. Eur J Hum Genet 1(3):229-38, 6/1993. PMID: 8044648.
21. Akli S, Caillaud C, Vigne E, Stratford-Perricaudet LD, Poenaru L, Perricaudet M, Kahn A, Peschanski MR. Transfer of a foreign gene into the brain using adenovirus vectors. Nat Genet 3(3):224-8, 3/1993. PMID: 8485577.
22. Akli S, Chelly J, Kahn A, Poenaru L. A null allele frequent in non-Jewish Tay-Sachs patients. Hum Genet 90(6):614-20, 2/1993. PMID: 8444467.
23. Akli S, Chomel JC, Lacorte JM, Bachner L, Kahn A, Poenaru L. Ten novel mutations in the HEXA gene in non-Jewish Tay-Sachs patients. Hum Mol Genet 2(1):61-7, 1993. PMID: 8490625.
24. Poenaru L, Akli S, Rocchiccioli F, Eydoux P, Zamet P. Human beta-mannosidosis: a 3-year-old boy with speech impairment and emotional instability. Clin Genet 41(6):331-4, 6/1992. PMID: 1623631.
25. Chelly J, Gilgenkrantz H, Hugnot JP, Hamard G, Lambert M, Recan D, Akli S, Cometto M, Kahn A, Kaplan JC. Illegitimate transcription. Application to the analysis of truncated transcripts of the dystrophin gene in nonmuscle cultured cells from Duchenne and Becker patients. J Clin Invest 88(4):1161-6, 10/1991. PMID: 1918370.
26. Akli S, Chelly J, Lacorte JM, Poenaru L, Kahn A. Seven novel Tay-Sachs mutations detected by chemical mismatch cleavage of PCR-amplified cDNA fragments. Genomics 11(1):124-34, 9/1991. PMID: 1837283.
27. Akli S, Chelly J, Mezard C, Gandy S, Kahn A, Poenaru L. A "G" to "A" mutation at position -1 of a 5' splice site in a late infantile form of Tay-Sachs disease. J Biol Chem 265(13):7324-30, 5/1990. PMID: 2139660.
28. Poenaru L, Mezard C, Akli S, Oury JF, Dumez Y, Boue J. Prenatal diagnosis of mucolipidosis type II on first-trimester amniotic fluid. Prenat Diagn 10(4):231-5, 4/1990. PMID: 1973293.
29. Gandy S, Castelnau L, Akli S, Kahn A, Poenaru L. Msp1 RFLP in the human hexosaminidase beta peptide (Hex B) gene. Nucleic Acids Res 17(16):6761, 8/1989. PMID: 2476722.
30. Poenaru L, Castelnau L, Besancon AM, Nicolesco H, Akli S, Theophil D. First trimester prenatal diagnosis of metachromatic leukodystrophy on chorionic villi by 'immunoprecipitation-electrophoresis'. J Inherit Metab Dis 11(2):123-30, 1988. PMID: 2902245.

Grant & Contract Support

Title: Proteolytic processing of cyclin E in brease cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Khandan Keyomarsi
Duration: 12/1/2010 - 11/30/2015
Title: Identification of the cyclin E-associated kinase driving cyclin E-induced salivary cancer in the absence of CDK2
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 9/15/2010 - 9/14/2011
Title: Identification of new substrates for breast tumor specific LMW cyclin E/CDk2 kinase
Funding Source: DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP)
Role: Principal Investigator
Duration: 9/1/2010 - 8/31/2011

Last updated: 4/28/2014