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Sastry Vedam, M.S., Ph.D., DABR

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Associate Member, Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX

Education & Training

Degree-Granting Education

2003 Virginia Commonwealth University, Richmond, VA, PHD, Biomedical Engineering
2000 Virginia Commonwealth University, Richmond, VA, MS, Biomedical Engineering
1996 Manipal Institute of Technology, Mangalore University, Karnataka, India, BE, Biomedical Engineering

Postgraduate Training

5/2003-10/2005 Post Doctoral Research Associate, Virginia Commonwealth, Richmond, VA, Paul Keall, Ph.D.
3/2001-7/2001 Graduate Intern, Varian Medical Systems, Palo Alto, CA, Hassan Mostafavi, Ph.D.
5/2000-5/2003 Graduate Research Assistant, Virginia Commonwealth University, Richmond, VA, Paul Keall, Ph.D.
8/1997-5/2000 Graduate Teaching Assistant, Virginia Commonwealth University, Richmond, VA, Gerald Miller, Ph.D.

Board Certifications

5/2010 American Board of Radiology

Selected Publications

Peer-Reviewed Original Research Articles

1. Turner LM, Howard JA, Dehghanpour P, Barrett RD, Rebueno N, Palmer M, Vedam S, Klopp A, Komaki R, Welsh JW. Exploring the feasibility of dose escalation positron emission tomography-positive disease with intensity-modulated radiation therapy and the effects on normal tissue structures for thoracic malignancies. Med Dosim. e-Pub 12/6/2010. PMID: 21144734.
2. Tsunashima Y, Vedam S, Dong L, Umezawa M, Balter P, Mohan R. The precision of respiratory-gated delivery of synchrotron-based pulsed beam proton therapy. Phys Med Biol 55(24):7633-7647, 12/21/2010. e-Pub 11/26/2010. PMID: 21113089.
3. Nelson C, Balter P, Morice RC, Bucci K, Dong L, Tucker S, Vedam S, Chang JY, Starkschall G. Evaluation of Tumor Position and PTV Margins Using Image Guidance and Respiratory Gating. Int J Radiat Oncol Biol Phys 76(5):1578-85, 4/2010. e-Pub 2/4/2010. PMID: 20137865.
4. Riegel AC, Chang JY, Vedam SS, Johnson V, Chi PC, Pan T. Cine Computed Tomography Without Respiratory Surrogate in Planning Stereotactic Radiotherapy for Non-Small-Cell Lung Cancer. Int J Radiat Oncol Biol Phys 73(2):433-41, 2/1/2009. e-Pub 7/19/2008. PMID: 18644683.
5. Ezhil M, Vedam S, Balter P, Choi B, Mirkovic D, Starkschall G, Chang JY. Determination of patient-specific internal gross tumor volumes for lung cancer using four-dimensional computed tomography. Radiat Oncol 4:4, 2009. e-Pub 1/27/2009. PMCID: PMC2645420.
6. Ezhil M, Choi B, Starkschall G, Bucci MK, Vedam S, Balter P. Comparison of rigid and adaptive methods of propagating gross tumor volume through respiratory phases of four-dimensional computed tomography image data set. Int J Radiat Oncol Biol Phys 71(1):290-6, 5/2008. PMID: 18406893.
7. Keall PJ, Chang M, Benedict S, Thames H, Vedam SS, Lin PS. Investigating the Temporal Effects of Respiratory-Gated and Intensity-Modulated Radiotherapy Treatment Delivery on In Vitro Survival: An Experimental and Theoretical Study. Int J Radiat Oncol Biol Phys, 5/2008. PMID: 18495369.
8. Tsunashima Y, Vedam S, Dong L, Umezawa M, Sakae T, Bues M, Balter P, Smith A, Mohan R. Efficiency of respiratory-gated delivery of synchrotron-based pulsed proton irradiation. Phys Med Biol 53(7):1947-59, 4/2008. e-Pub 3/2008. PMID: 18364549.
9. Nelson C, Balter P, Morice RC, Choi B, Kudchadker RJ, Bucci K, Chang JY, Dong L, Tucker S, Vedam S, Briere T, Starkschall G. A technique for reducing patient setup uncertainties by aligning and verifying daily positioning of a moving tumor using implanted fiducials. J Appl Clin Med Phys 9(4):2766, 2008. PMID: 19020478.
10. Soofi W, Starkschall G, Britton K, Vedam S. Determination of an optimal organ set to implement deformations to support four-dimensional dose calculations in radiation therapy planning. J Appl Clin Med Phys 9(2):2794, 2008. PMID: 18714284.
11. Vedam S, Archambault L, Starkschall G, Mohan R, Beddar S. Determination of prospective displacement-based gate threshold for respiratory-gated radiation delivery from retrospective phase-based gate threshold selected at 4D CT simulation. Med Phys 34(11)(11):4247-55, 11/2007. PMID: 18072489.
12. Keall PJ, Vedam SS, George R, Williamson JF. Respiratory regularity gated 4D CT acquisition: concepts and proof of principle. Australas Phys Eng Sci Med 30(3):211-20, 9/2007. PMID: 18044305.
13. Keall P, Vedam S, George R, Bartee C, Siebers J, Lerma F, Weiss E, Chung T. The Clinical Implementation of respiratory-gated intensity -modulated radiotherapy. Med Dosim 31(2):152-162, 2006.
14. Keall PJ, Mageras GS, Balter JM, Emery RS, Forster KM, Jiang SB, Kapatoes JM, Low DA, Murphy MJ, Murray BR, Ramsey CR, Van Herk MB, Vedam SS, Wong JW, Yorke E. The management of respiratory motion in radiation oncology report of AAPM Task Group 76. Med Phys 33(10):3874, 2006. PMID: 17089851.
15. George R, Keall PJ, Kini VR, Vedam SS, Ramakrishnan V, Mohan R. Is the diaphragm motion probability density function normally distributed. Med Phys 32(2)(2):396-404, 2005. PMID: 15789585.
16. Keall PJ, Todor AD, Vedam SS, Bartee CL, Siebers JV, Kini VR, Mohan R. On the use of EPID-based implanted marker tracking for 4D radiotherapy. Med Phys 31(12)(12):3492-3499, 2004. PMID: 15651632.
17. Vedam SS, Keall PJ, Docef A, Todor DA, Kini VR, Mohan R. Predicting respiratory motion for four-dimensional radiotherapy. Med Phys 31(8)(8):2274-2283, 2004. PMID: 15377094.
18. Vedam SS, Keall PJ, Kini VR, Mostafavi H, Shukla HP, Mohan R. Acquiring a four-dimensional computed tomography dataset using an external respiratory signal. Phys Med Biol 48(1):45-62, 1/2003. PMID: 12564500.
19. George R, Keall PJ, Kini VR, Vedam SS, Siebers JV, Wu Q, Lauterbach MH, Arthur DW, Mohan R. Quantifying the effect of intrafraction motion during breast IMRT planning and dose delivery. Med Phys 30(4)(4):552-562, 2003. PMID: 12722807.
20. Keall PJ, Kini VR, Vedam SS, Mohan R. Potential radiotherapy improvements with respiratory gating. Australas Phys Eng Sci Med 25(1):1-6, 3/2002. PMID: 12049470.
21. Keall PJ, Kini VR, Vedam SS, Mohan R. Motion adaptive x-ray therapy: a feasibility study. Phys Med Biol 46(1):1-10, 1/2001. PMID: 11197664.


1. Ezhil M, Vedam S, Choi B., Starkschall G, Balter P, Chang J. Determination of Patient-specific Intra-Fractional Respiratory Motion Envelope of Tumors From Maximum Intensity Projections of 4D CT Datasets. Int J Radiat Oncol Biol Phys 69(3)(1,1):S484-S485, 11/2007.
2. C Nelson, Balter P, Choi B, Vedam S, Lindsay P, Kudchadker R, Briere T, Chang J, Morice R, Starkschall G. Improvement in the Daily Alignment of Lung Tumors Using Implanted Fiducials. Medical Physics 34:2328, 2007.
3. Vedam S, Dong L, Zhang J, Chang J, Starkschall G, Cox J, Mohan R, Keall P. Impact of Respiration-Induced Tumor Motion Uncertainties on Adaptive Treatment Delivery Strategies: A Comparison Through Repeat 4D CT Imaging. Int J Radiat Oncol Biol Phys 66 (3) (Supp 1, 1):S614 - S615, 11/2006.
4. Hunjan SS, Balter P, Rosen I, Starkschall G, Prado K, VEdam S. Luo D, Liu H, Mohan R. Correlation Between External Fiducial and Internal Tumor Position During Breath-Hold CT. Intl J Radiat Oncol Biol Phys 33 (Supp 3-1,1):S142-S143, 2006.
5. Wijesooriya K, Bartee C, Siebers J, Vedam SS, Keall P. Determination of Maximum Leaf Velocity and Acceleration of a Dynamic Multi-Leaf Collimator: Implications for 4D Radiotherapy (poster). AAPM Annual Meeting, Pittsburgh, PA, 2005.
6. Chang MG, Lin P, Benedict SH, Thames HD, Vedam S, Keall PJ. Investigating the Effects of Respiratory Gated IMRT Treatment Delivery on Survival. International Journal of Radiation Oncology Biology Physics 63 Supplement 1:S386-S387, 2005.
7. Vedam S. Is the diaphragm motion probaility density function normally distributed?. Med Phys 32:396, 2005.
8. Vedam S, Murphy M, Docef A, George R, Keall P. Long Term Prediction of Respiratory Motion with Artificial Neural Network Based Adaptive Filtering techniques. Med Phys 32:1925, 2005.
9. Guan H, Yan H, Yin F, Kim J, Keall P, Vedam S, Movsas B. Respiratory Gated Radiation Therapy Directly Using Patient's Fluroscopic Images Instead of External Or Internal markers. Med Phys 32:1936, 2005.
10. Vedam S. Respiratory Motion-Conditioned 4D CT: A Method to Determine respiratory Motion Tolerances to Reduce Motion Artifacts During 4D CT Acquisition. International Journal of Radiation Oncology Biology Physics Supplement 1:S204-S205, 2005.
11. George R, Keall P, Vedam S, Chung T, Williamson J. The application of the sinusoidal model to lung cancer patient respiration (poster). AAPM Annual Meeting, 2005.
12. Keall PJ, Wijesooriya K, Vedam S, George R, Todor AD, Murphy M, Siebers J, Williamson J, Mohan R. A four-dimensional controller for DMLC-based tumor tracking. Int J Radiat Oncol Biol Phys:S338-39, 2004.
13. Vedam S, Docef A, Fix M, Murphy M, Keall PJ. Dosimetric effect of respiratory motion prediction error on dynamic multileaf collimator based 4D radiation delivery. American Society for Therapeutic Radiology and Oncology Annual Meeting, Atlanta, GA, 2004.
14. Keall PJ, Joshi S, Tracton G, Kini V, Vedam S, Mohan R. 4-Dimensional radiotherapy planning. Int J Radiat Oncol Biol Phys 57 (Supp 2), S233, American Society for Therapeutic Radiology and Oncology Annual Meeting, Salt Lake City, UT, 2003.
15. Vedam S, Kini VR, Keall PH, Ramakrishnan V, Mostafavi H, Mohan R. Can We predict diaphragm (and tumor) motion based on external anatomy motion? A fluoroscopy study. IGT Image Guided Therapy Workshop, Boston, MA, 2003.
16. George R, Keall P, Kini V, Vedam S, Ramakrishnan R. Does the diaphragm motion follow a normal distribution? Implications for radiation treatment planning for liver and lower lobe lung cancer patients. Med Phys 30(6):1505, 2003.
17. Keall P, George R, Kini V, Vedam S, Mohan R. Life would be easier if things were normal. World Congress on Medical Physics and Biomedical Engineering, 2003.
18. Vedam S, Keall PJ, Kini VR, Mostafavi H, Mohan R. Predicting breathing motion for 4D radiotherapy. World Congress on Medical Physics and Biomedical Engineering, Sydney, Australia, 2003.

Book Chapters

1. Keall P, Vedam S, Murphy M. The Integration of Position-Monitoring and Targeted Radiotherapy Control Systems. In: Integrating New Technologies into the Clinic: Monte Carlo and Image-Guided Radiation Therapy. Medical Physics Publishing, 2006.
2. Vedam SS, Balter J, Keall PJ. Breathing Control In Radiation Therapy. In: Modern Technology in Radiation oncology. 2. Medical Physics Publishing, 2005.
3. George R, Keall PJ, Chung T, Vedam SS, Mohan R. Does breathing training reduce residual motion for respiratory-gated radiotherapy? In: The Use of Computers in Radiation Therapy. Jeong Publishing: Korea, 437-447, 2004.

Grant & Contract Support

Title: Optimizing Proton Radiation Therapy
Funding Source: NIH/NCI
Role: Collaborator
Principal Investigator: Thomas DeLaney
Duration: 9/25/2008 - 7/31/2013

Last updated: 2/12/2013