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Sendurai A. Mani, Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Molecular Pathology, Division of Pathology/Lab Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2000 Indian Institute of Science, Bangalore, India, PHD, Molecular Biology
1993 Madurai Kamaraj University, Madurai, India, MS, Biology
1991 Madurai Kamaraj University, Madurai, India, BS, Biology

Honors and Awards

2008-2013 Fellow, M. D. Anderson Research Trust, The University of TX, M. D. Anderson Cancer Center
2008-2010 V-Scholar, The Jimmy V Foundation for Cancer Research
2001-2004 Postdoctoral Fellowship, Breast Cancer Reserach Program, Department of Defense

Selected Publications

Peer-Reviewed Original Research Articles
1. Lu J, Steeg PS, Price JE, Krishnamurthy S, Mani SA, Reuben J, Cristofanilli M, Dontu G, Bidaut L, Valero V, Hortobagyi GN, Yu D. Breast Cancer Metastasis: Challenges and Opportunities. Cancer Res 69(12), 5/2009. e-Pub 5/2009. PMID: 19470768.
2. Bloushtain-Qimron N, Yao J, Snyder EL, Shipitsin M, Campbell LL, Mani SA, Hu M, Chen H, Ustyansky V, Antosiewicz JE, Argani P, Halushka MK, Thomson JA, Pharoah P, Porgador A, Sukumar S, Parsons R, Richardson AL, Stampfer MR, Gelman RS, Nikolskaya T, Nikolsky Y, Polyak K. Cell type-specific DNA methylation patterns in the human breast. Proc Natl Acad Sci U S A 105(37):14076-81, 9/16/2008. PMID: 18780791.
3. Onder TT, Gupta PB, Mani SA, Yang J, Lander ES, Weinberg RA. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res 68(10):3645-54, 5/15/2008. PMID: 18483246.
4. Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campbell LL, Polyak K, Brisken C, Yang J, Weinberg RA. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133(4):704-15, 5/2008. PMID: 18485877.
5. Liao MJ, Zhang CC, Zhou B, Zimonjic DB, Mani SA, Kaba M, Gifford A, Reinhardt F, Popescu NC, Guo W, Eaton EN, Lodish HF, Weinberg RA. Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity. Cancer Res 67(17):8131-8, 9/1/2007. PMID: 17804725.
6. Mani SA, Yang J, Brooks M, Schwaninger G, Zhou A, Miura N, Kutok JL, Hartwell K, Richardson AL, Weinberg RA. Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A 104(24):10069-74, 6/12/2007. PMID: 17537911.
7. Yang J, Mani SA, Weinberg RA. Exploring a new twist on tumor metastasis. Cancer Res 66(9):4549-52, 5/1/2006. PMID: 16651402.
8. Gupta, P., Mani, S.A., Yang, J., Hartwell, K., Weinberg, R.A.. The evolving portrait of cancer metastasis. Cold Spring Harb Symp Quant Biol 70:291-298, 2005. PMID: 16869765.
9. Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, Savagner P, Gitelman I, Richardson A, Weinberg RA. Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis. Cell 117(7):927–939, 2004. PMID: 15210113.
10. Samudre KR, Mani SA, Vathsala PG, Rangarajan PN, Padmanaban G. Phenobarbitone-mediated translocation of the cytosolic proteins interacting with the 5'-proximal region of rat liver CYP2B1/B2 gene into the nucleus. Biochem Biophys Res Commun 292(2):312-7, 2002. PMID: 11906163.
11. Harish S, Khanam T, Mani S, Rangarajan P. Transcriptional activation by hepatocyte nuclear factor-4 in a cell-free system derived from rat liver nuclei. Nucleic Acids Res 29(5):1047-53, 3/1/2001. PMCID: PMC29722.
12. Mani SA, Harish S, Vathsala PG, Rangarajan PN, Padmanaban G. Receptor-mediated gene delivery approach demonstrates the role of 5'-proximal DNA region in conferring phenobarbitone responsiveness to CYP2B2 gene in rat liver in vivo. Biochem Biophys Res Commun 268(3):734-9, 2/24/2000. PMID: 10679274.
13. Fernandez MA, Mani SA, Rangarajan PN, Seshagiri PB. Sperm-mediated gene transfer into oocytes of the golden hamster: assessment of sperm function. Indian J Exp Biol 37(11):1085-92, 11/1999. PMID: 10783740.
14. Prabhu L, Upadhya P, Ram N, Nirodi CS, Sultana S, Vatsala PG, Mani SA, Rangarajan PN, Surolia A, Padmanaban G. A model for the transcriptional regulation of the CYP2B1/B2 gene in rat liver. Proc Natl Acad Sci U S A 92(21):9628-963, 1995. PMID: 7568186.

Invited Articles
1. Mani SA, Evans KW, Hollier BG, Guo W, and Weinberg RA. Generation of Stem-like Cells via EMT: A New Twist in Cancer Initiation and Progression. Am Assoc Cancer Res Educ Book 2009:173, 4/2009.
2. Hollier, B.G., Evans, K.W. and Mani, S.A.. The Epithelial-to-Mesenchymal Transition and Cancer Stem Cells: A Coalition Against Cancer Therapies. J Mammary Gland Biol Neoplasia 14(1). e-Pub 2/26/2009. PMID: 19242781.

Last updated: 8/7/2009