Skip to Content

Shao-Cong Sun, Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
7455 Fannin Street
Unit Number: 902
Houston, TX 77054
Room Number: SCR4.2019

Education & Training

Degree-Granting Education

1992 Stockholm University, Stockholm, Sweden, PHD, Microbiology
1989 Stockholm University, Stockholm, Sweden, MS, Microbiology
1982 Hebei University, Baoding City, China, BS, Microbiology and Biochemistry

Postgraduate Training

1992-1994 Postdoctoral Research Fellowship, The Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA, Dr. Warner Greene

Experience/Service

Administrative Appointments/Responsibilities

Associate Director, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 3/2013-present
Co-director, Center for Inflammation and Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX, 2/2012-present

Endowed Positions

Moshe Talpaz Endowed Chair in Immunology, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, 8/2013-present
M.R. Evelyn Hudson Foundation Endowed Profesorship in Diagnostic Radiology, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, 5/2011-7/2013

Institutional Committee Activities

Member, Promotion and Tenure Committee, 2012-present
Member, CPRIT Scholar Program, 2011-present
Member, Program Income Advisory Committee for the Research Animal Support Facility-Houston, 2011-present
Member, Immunology Chair Search Committee, 2011
Member, Committee of Genetically Engineered Mouse Facility, 2010-present
Senator, Faculty Senate, 2009-2012
Member, Institutional Research Grant, Study Section Review Committee, 2009-2012
Member, Faculty Advisory Committee for South Campus Animal Facility, 2008-present

Honors and Awards

2013-present Endowed Chair, The University of Texas MD Anderson Cancer Center
2012 Best Boss Award, The University of Texas MD Anderson Cancer Center
2010-2013 Endowed Professorship, The University of Texas MD Anderson Cancer Center
2006 Distinguished Professor Award, Penn State University
1998 Hinkle Society Outstanding Junior Investigator Award, Penn State University
1996-1998 Junior Scholar Award, American Society of Hematology
1994-1996 Scholar Award, American Foundation for AIDS Research

Selected Publications

Peer-Reviewed Original Research Articles

1. Ren T, Takahashi Y, Liu X, Loughran TP, Sun SC, Wang HG, Cheng H. HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains. Oncogene. In Press. PMID: 24362528.
2. Jin J, Hu H, Li HS, Yu J, Xiao Y, Brittain GC, Zou Q, Cheng X, Mallette FA, Watowich SS, Sun SC. Noncanonical NF-κB Pathway Controls the Production of Type I Interferons in Antiviral Innate Immunity. Immunity 40(3):342-54, 3/2014. PMID: 24656046.
3. Yang Y, Liu M, Li D, Ran J, Gao J, Suo S, Sun SC, Zhou J. CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation. Proc Natl Acad Sci U S A 111(6):2158-63, 2/2014. e-Pub 1/2014. PMCID: PMC3926035.
4. Chang JH, Hu H, Jin J, Puebla-Osorio N, Xiao Y, Gilbert BE, Brink R, Ullrich SE, Sun SC. TRAF3 regulates the effector function of regulatory T cells and humoral immune responses. J Exp Med 211(1):137-51, 1/2014. e-Pub 12/2013. PMCID: PMC3892978.
5. Blonska M, Joo D, Nurieva RI, Zhao X, Chiao P, Sun SC, Dong C, Lin X. Activation of the transcription factor c-Maf in T cells is dependent on the CARMA1-IKKβ signaling cascade. Sci Signal 6(306):ra110, 12/2013. e-Pub 12/2013. PMID: 24345681.
6. Xiao Y, Jin J, Chang M, Chang JH, Hu H, Zhou X, Brittain GC, Stansberg C, Torkildsen Ø, Wang X, Brink R, Cheng X, Sun SC. Peli 1 promotes microglia-mediated CNS inflammation by regulating TRAF3 degradation. Nat Med 19(5):595-602, 5/2013. e-Pub 4/2013. PMID: 23603814.
7. Zhong B, Liu X, Wang X, Liu X, Li H, Darnay BG, Lin X, Sun SC, Dong C. Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3. Sci Signal 6(275):ra35, 5/2013. e-Pub 5/2013. PMID: 23674823.
8. Hu H, Brittain GC, Chang JH, Puebla-Osorio N, Jin J, Zal A, Xiao Y, Cheng X, Chang M, Fu YX, Zal T, Zhu C, Sun SC. OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3. Nature 494(7437):371-4, 2/2013. e-Pub 1/2013. PMCID: PMC3578967.
9. Zhou XF, Yu J, Chang M, Zhang M, Zhou D, Cammas F, Sun SC. TRIM28 mediates chromatin modifications at the TCRα enhancer and regulates the development of T and natural killer T cells. Proc Natl Acad Sci U S A 109(49):20083-8, 12/2012. e-Pub 11/2012. PMCID: PMC3523851.
10. Jin J, Xiao Y, Chang JH, Yu J, Hu H, Starr R, Brittain GC, Chang M, Cheng X, Sun SC. The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling. Nat Immunol 13(11):1101-9, 11/2012. e-Pub 9/2012. PMCID: PMC3477307.
11. Ren T, Dong W, Takahashi Y, Xiang D, Yuan Y, Liu X, Loughran TP, Sun SC, Wang HG, Cheng H. HTLV-2 Tax immortalizes human CD4+ memory T lymphocytes by oncogenic activation and dysregulation of autophagy. J Biol Chem 287(41):34683-93, 10/2012. e-Pub 8/2012. PMCID: PMC3464572.
12. Bao M, Hanabuchi S, Facchinetti V, Du Q, Bover L, Plumas J, Chaperot L, Cao W, Qin J, Sun SC, Liu YJ. CD2AP/SHIP1 Complex Positively Regulates Plasmacytoid Dendritic Cell Receptor Signaling by Inhibiting the E3 Ubiquitin Ligase Cbl. J Immunol 189(2):786-92, 7/2012. e-Pub 6/2012. PMCID: PMC3665352.
13. Chang JH, Xiao Y, Hu H, Jin J, Yu J, Zhou X, Wu X, Johnson HM, Akira S, Pasparakis M, Cheng X, Sun SC. Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells. Nat Immunol 13(5):481-90, 5/2012. e-Pub 4/2012. PMCID: PMC3361639.
14. Zhang M, Lee AJ, Wu X, Sun SC. Regulation of antiviral innate immunity by deubiquitinase CYLD. Cell Mol Immunol 8(6):502-4, 11/2011. e-Pub 9/2011. PMCID: PMC3210422.
15. Chang M, Jin W, Chang JH, Xiao Y, Brittain GC, Yu J, Zhou X, Wang YH, Cheng X, Li P, Rabinovich BA, Hwu P, Sun SC. The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat Immunol 12(10):1002-9, http://dx.doi.org/10.1038/ni.2090, 10/2011. e-Pub 8/2011. PMCID: PMC3178748.
16. Chiou SH, Shahi P, Wagner RT, Hu H, Lapteva N, Seethammagari M, Sun SC, Levitt JM, Spencer DM. The E3 ligase c-Cbl regulates dendritic cell activation. EMBO Rep 12(9):971-9, 9/2011. e-Pub 9/2011. PMCID: PMC3166462.
17. Hu H, Wu X, Jin W, Chang M, Cheng X, Sun SC. Noncanonical NF-{kappa}B regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development. Proc Natl Acad Sci U S A 108(31):12827-32, 8/2011. e-Pub 7/2011. PMCID: PMC3150902.
18. Wu X, Zhang M,Sun SC. Mutual regulation between deubiquitinase CYLD and retroviral oncoprotein Tax. Cell Biosci 1(1):27, 2011. e-Pub 8/2011. PMCID: PMC3170579.
19. Cheng CS, Feldman KE, Lee J, Verma S, Huang DB, Huynh K, Chang M, Ponomarenko JV, Sun SC, Benedict CA, Ghosh G, Hoffmann A. The specificity of innate immune responses is enforced by repression of interferon response elements by NF-kappaB p50. Sci Signal 4(161):ra11, 2011. e-Pub 2/2011. PMCID: PMC3096068.
20. Espinosa L, Cathelin S, D'Altri T, Trimarchi T, Statnikov A, Guiu J, Rodilla V, Inglés-Esteve J, Nomdedeu J, Bellosillo B, Besses C, Abdel-Wahab O, Kucine N, Sun SC, Song G, Mullighan CC, Levine RL, Rajewsky K, Aifantis I, Bigas A. The Notch/Hes1 pathway sustains NF-kappaB activation through CYLD repression in T cell leukemia. Cancer Cell 18(3):268-81, 9/2010. PMCID: PMC2963042.
21. Peng B, Ling J, Lee AJ, Wang Z, Chang Z, Jin W, Kang Y, Zhang R, Shim D, Wang H, Fleming JB, Zheng H, Sun SC, Chiao PJ. Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter. Proc Natl Acad Sci U S A 107(34):15193-8, 8/2010. e-Pub 8/2010. PMCID: PMC2930541.
22. Lee AJ, Wu X, Cheng H, Zhou X, Cheng X, Sun SC. CARMA1 regulation of regulatory T cell development involves modulation of interleukin-2 receptor signaling. J Biol Chem 285(21):15696-703, 5/2010. e-Pub 3/2010. PMCID: PMC2871435.
23. Lee AJ, Zhou X, Chang M, Hunzeker J, Bonneau RH, Zhou D, Sun SC. Regulation of natural killer T-cell development by deubiquitinase CYLD. EMBO J 29(9):1600-12, 5/2010. e-Pub 3/2010. PMCID: PMC2876956.
24. Nurieva RI, Zheng S, Jin W, Chung Y, Zhang Y, Martinez GJ, Reynolds JM, Wang SL, Lin X, Sun SC, Lozano G, Dong C. The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity 32(5):670-80, 5/2010. e-Pub 5/2010. PMCID: PMC2915546.
25. Tang H, Park S, Sun SC, Trumbly R, Ren G, Tsung E, Yeung KC. RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex. FEBS Lett 584(4):662-8, 2/2010. e-Pub 12/2009. NIHMSID: NIHMS179740.
26. Arima K, Watanabe N, Hanabuchi S, Chang M, Sun SC, Liu YJ. Distinct signal codes generate dendritic cell functional plasticity. Sci Signal 3(105):ra4, 2010. PMCID: PMC3325779.
27. Wu X, Yamamoto M, Akira S, Sun SC. Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13. Proc Natl Acad Sci U S A 106. e-Pub 11/2009. PMCID: PMC2791607.
28. Chang M, Jin W, Sun SC. Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat Immunol 10(10):1089-95, 10/2009. e-Pub 9/2009. PMCID: PMC2748822.
29. Fontenot D, He H, Hanabuchi S, Nehete PN, Zhang M, Chang M, Nehete B, Wang YH, Wang YH, Ma ZM, Lee HC, Ziegler SF, Courtney AN, Miller CJ, Sun SC, Liu YJ, Sastry KJ. TSLP production by epithelial cells exposed to immunodeficiency virus triggers DC-mediated mucosal infection of CD4+ T cells. Proc Natl Acad Sci U S A 106(39):16776-81, 9/2009. e-Pub 9/2009. PMCID: PMC2757857.
30. Jin W, Zhou XF, Yu J, Cheng X, Sun SC. Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK. Blood 113(26):6603-10, 6/2009. e-Pub 5/2009. PMCID: PMC2710918.
31. Zhang M, Jin W, Zhou X, Yu J, Lee AJ, Sun SC. Deregulation of Tpl2 and NF-kappaB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium. Cell Signal 21(4):559-566, 4/2009. PMCID: PMC2688402.
32. Chang M, Lee AJ, Fitzpatrick L, Zhang M, Sun SC. NF-kappa B1 p105 regulates T cell homeostasis and prevents chronic inflammation. J Immunol 182(5):3131-8, 3/2009. PMCID: PMC2739978.
33. Zhang M, Wu X, Lee AJ, Jin W, Chang M, Wright A, Imaizumi T, Sun SC. Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD. J Biol Chem 283(27):18621-6, 7/2008. PMCID: PMC2441564.
34. Jin W, Chang M, Paul EM, Babu G, Lee AJ, Reiley W, Wright A, Zhang M, You J, Sun SC. Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice. J Clin Invest 118(5):1858-66, 5/2008. PMCID: PMC2276399.
35. Wright A, Reiley WW, Chang M, Jin W, Lee AJ, Zhang M, Sun SC. Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD. Dev Cell 13(5):705-16, 11/2007. PMCID: PMC33989.
36. Reiley WW, Jin W, Lee AJ, Wright A, Wu X, Tewalt EF, Leonard TO, Norbury CC, Fitzpatrick L, Zhang M, Sun SC. Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses. J Exp Med 204(6):1475-85, 6/2007. PMCID: PMC2118606.
37. Jin W, Reiley WR, Lee AJ, Wright A, Wu X, Zhang M, Sun SC. Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cells. J Biol Chem 282(21):8269-74, 5/2007. PMID: 17392286.
38. Wu X, Sun SC. Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK. EMBO Rep 8(5):510-5, 5/2007. PMCID: PMC1866198.
39. Harhaj NS, Sun SC, Harhaj EW. Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase. J Biol Chem 282(6):4185-92, 2/2007. PMID: 17145747.
40. Liang C, Zhang M, Sun SC. beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870. Cell Signal 18(8):1309-17, 8/2006. PMID: 16303288.
41. Babu G, Waterfield M, Chang M, Wu X, Sun SC. Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells. J Biol Chem 281(20):14041-7, 5/2006. PMID: 16565081.
42. Reiley WW, Zhang M, Jin W, Losiewicz M, Donohue KB, Norbury CC, Sun SC. Regulation of T cell development by the deubiquitinating enzyme CYLD. Nat Immunol 7(4):411-7, 4/2006. PMID: 16501569.
43. Zhang W, Hirschler-Laszkiewicz I, Tong Q, Conrad K,Sun SC, Penn L, Barber DL, Stahl R, Carey DJ, Cheung JY, Miller BA. TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage. Am J Physiol Cell Physiol 290(4):C1146-59, 4/2006. PMID: 16306129.
44. Babu GR, Jin W, Norman L, Waterfield M, Chang M, Wu X, Zhang M, Sun SC. Phosphorylation of NF-kappaB1/p105 by oncoprotein kinase Tpl2: implications for a novel mechanism of Tpl2 regulation. Biochim Biophys Acta 1763(2):174-81, 2/2006. PMID: 16448710.
45. Reiley W, Zhang M, Wu X, Granger E, Sun SC. Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation. Mol Cell Biol 25(10):3886-95, 5/2005. PMID: 15870263.
46. Morrison MD, Reiley W, Zhang M, Sun SC. An atypical tumor necrosis factor (TNF) receptor-associated factor-binding motif of B cell-activating factor belonging to the TNF family (BAFF) receptor mediates induction of the noncanonical NF-kappaB signaling pathway. J Biol Chem 280(11):10018-24, 3/2005. PMID: 15644327.
47. Harhaj EW, Harhaj NS, Grant C, Mostoller K, Alefantis T, Sun SC, Wigdahl B. Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway. Virology 333(1):145-58, 3/2005. PMID: 15708600.
48. Reiley W, Zhang M, Sun SC. Negative regulation of JNK signaling by the tumor suppressor CYLD. J Biol Chem 279(53):55161-7, 12/2004. PMID: 15496400.
49. Waterfield M, Jin W, Reiley W, Zhang M, Sun SC. IkappaB kinase is an essential component of the Tpl2 signaling pathway. Mol Cell Biol 24(13):6040-8, 7/2004. PMID: 15199157.
50. Xiao G, Fong A, Sun SC. Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation. J Biol Chem 279(29):30099-105, 7/2004. PMID: 15140882.
51. Liao G, Zhang M, Harhaj EW, Sun SC. Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation. J Biol Chem 279(25):26243-50, 6/2004. PMID: 15084608.
52. Liao G, Sun SC. Regulation of NF-kappaB2/p100 processing by its nuclear shuttling. Oncogene 22(31):4848-74, 7/2003. PMID: 12894228.
53. Cvijic ME, Xiao G, Sun SC. Study of T-cell signaling by somatic cell mutagenesis and complementation cloning. J Immunol Methods 278(1-2):293-304, 7/2003. PMID: 12957416.
54. Waterfield MR, Zhang M, Norman LP, Sun SC. NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase. Mol Cell 11(3):685-94, 3/2003. PMID: 12667451.
55. Fong A, Zhang M, Neely J, Sun SC. S9, a 19 S proteasome subunit interacting with ubiquitinated NF-kappaB2/p100. J Biol Chem 277(43):40697-702, 10/2002. PMID: 12185077.
56. Fong A, Sun SC. Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100. J Biol Chem 277(25):22111-4, 6/2002. PMID: 11994270.
57. Xiao G, Cvijic ME, Fong A, Harhaj EW, Uhlik MT, Waterfield M, Sun SC. Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha. EMBO J 20(23):6805-15, 12/2001. PMCID: PMC125766.
58. Rivera-Walsh I, Waterfield M, Xiao G, Fong A, Sun SC. NF-kappaB signaling pathway governs TRAIL gene expression and human T-cell leukemia virus-I Tax-induced T-cell death. J Biol Chem 276(44):40385-8, 11/2001. PMID: 11553609.
59. Senftleben U, Cao Y, Xiao G, Greten FR, Krähn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 293(5534):1495-9, 8/2001. PMID: 11520989.
60. Xiao G, Harhaj EW, Sun SC. NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell 7(2):401-9, 2/2001. PMID: 11239468.
61. Xiao G, Harhaj EW, Sun SC. Domain-specific interaction with the I kappa B kinase (IKK)regulatory subunit IKK gamma is an essential step in tax-mediated activation of IKK. J Biol Chem 275(44):34060-7, 11/2000. PMID: 10906125.
62. Xiao G, Sun SC. Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein. Oncogene 19(45):5198-203, 10/2000. PMID: 11064457.
63. Rivera-Walsh I, Cvijic ME, Xiao G, Sun SC. The NF-kappa B signaling pathway is not required for Fas ligand gene induction but mediates protection from activation-induced cell death. J Biol Chem 275(33):25222-30, 8/2000. PMID: 10837465.
64. Xiao G, Sun SC. Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain. J Biol Chem 275(28):21081-5, 7/2000. PMID: 10887201.
65. Harhaj EW, Good L, Xiao G, Uhlik M, Cvijic ME, Rivera-Walsh I, Sun SC. Somatic mutagenesis studies of NF-kappa B signaling in human T cells: evidence for an essential role of IKK gamma in NF-kappa B activation by T-cell costimulatory signals and HTLV-I Tax protein. Oncogene 19(11):1448-56, 3/2000. PMID: 10723136.
66. Harhaj EW, Sun SC. Regulation of RelA subcellular localization by a putative nuclear export signal and p50. Mol Cell Biol 19(10):7088-95, 10/1999. PMID: 10490645.
67. Harhaj EW, Sun SC. IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein. J Biol Chem 274(33):22911-4, 8/1999. PMID: 10438454.
68. Lamberti A, Romano MF, Agosti V, Garbi C, Sun SC, Bond HM, Bonelli P, Turco MC, Venuta S. Regulation of cell survival in CD95-induced T cell apoptosis: role of NF-kappa B/Rel transcription factors. Apoptosis 4(3):179-86, 6/1999. PMID: 14634280.
69. Sun SC, Maggirwar SB, Harhaj EW, Uhlik M. Binding of c-Rel to STAT5 target sequences in HTLV-I-transformed T cells. Oncogene 18(7):1401-9, 2/1999. PMID: 10050877.
70. Harhaj EW, Good L, Xiao G, Sun SC. Gene expression profiles in HTLV-I-immortalized T cells: deregulated expression of genes involved in apoptosis regulation. Oncogene 18(6):1341-9, 2/1999. PMID: 10022816.
71. Harhaj EW, Sun SC. IkappaB kinases serve as a target of CD28 signaling. J Biol Chem 273(39):25185-90, 9/1998. PMID: 9737979.
72. Zhang MY, Harhaj EW, Bell L, Sun SC, Miller BA. Bcl-3 expression and nuclear translocation are induced by granulocyte-macrophage colony-stimulating factor and erythropoietin in proliferating human erythroid precursors. Blood 92(4):1225-34, 8/1998. PMID: 9694711.
73. Rivera I, Harhaj EW, Sun SC. Involvement of NF-AT in type I human T-cell leukemia virus Tax-mediated Fas ligand promoter transactivation. J Biol Chem 273(35):22382-7, 8/1998. PMID: 9712859.
74. Uhlik M, Good L, Xiao G, Harhaj EW, Zandi E, Karin M, Sun SC. NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation. J Biol Chem 273(33):21132-6, 8/1998. PMID: 9694868.
75. Zhang MY, Sun SC, Bell L, Miller BA. NF-kappaB transcription factors are involved in normal erythropoiesis. Blood 91(11):4136-44, 6/1998. PMID: 9596659.
76. Chen F, Lu Y, Kuhn DC, Maki M, Shi X, Sun SC, Demers LM. Calpain contributes to silica-induced I kappa B-alpha degradation and nuclear factor-kappa B activation. Arch Biochem Biophys 342(2):383-8, 6/1997. PMID: 9186501.
77. Chen F, Sun SC, Kuhn DC, Gaydos LJ, Shi X, Lu Y, Demers LM. Involvement of NF-kappaB in silica-induced cyclooxygenase II gene expression in rat alveolar macrophages. Am J Physiol 272(4 Pt 1):L779-86, 4/1997. PMID: 9142954.
78. Chen F, Sun SC, Kuhn DC, Lu Y, Gaydos LJ, Shi X, Demers LM. Tetrandrine inhibits signal-induced NF-kappa B activation in rat alveolar macrophages. Biochem Biophys Res Commun 231(1):99-102, 2/1997. PMID: 9070227.
79. Harhaj EW, Sun SC. The serine/threonine phosphatase inhibitor calyculin A induces rapid degradation of IkappaBbeta. Requirement of both the N- and C-terminal sequences. J Biol Chem 272(9):5409-12, 2/1997. PMID: 9038140.
80. Good L, Maggirwar SB, Harhaj EW, Sun SC. Constitutive dephosphorylation and activation of a member of the nuclear factor of activated T cells, NF-AT1, in Tax-expressing and type I human T-cell leukemia virus-infected human T cells. J Biol Chem 272(3):1425-8, 1/1997. PMID: 8999806.
81. Maggirwar SB, Harhaj E, Sun SC. Differential regulation of the interleukin-2 CD28 responsive element by NF-ATp and various NF-kB/Rel transcription factors. Mol Cell Biol 17:2605-2614, 1997. PMCID: PMC232110.
82. Turco MC, Roman MF, Bisogni R, Lamberti A, Ferrone S, Sun SC, Greene WC, Venuta S. Stimulation of lymphocyte NF-kB/Rel nublear activity by anti-HLA class I monoclonal antibodies. Tissue Antigens 50:1-7, 1997.
83. Harhaj EW, Maggirwar SB, Good L, Sun SC. CD28 mediates a potent costimulatory signal for rapid degradation of IkappaBbeta which is associated with accelerated activation of various NF-kappaB/Rel heterodimers. Mol Cell Biol 16(12):6736-43, 12/1996. PMCID: PMC231676.
84. Mandal M, Maggirwar SB, Sharma N, Kaufmann SH, Sun SC, Kumar R. Bcl-2 prevents CD95 (Fas/APO-1)-induced degradation of lamin B and poly(ADP-ribose) polymerase and restores the NF-kappaB signaling pathway. J Biol Chem 271(48):30354-9, 11/1996. PMID: 8939996.
85. Good L, Maggirwar SB, Sun SC. Activation of the IL-2 gene promoter by HTLV-I tax involves induction of NF-AT complexes bound to the CD28-responsive element. EMBO J 15(14):3744-50, 7/1996. PMCID: PMC452042.
86. Harhaj EW, Maggirwar SB, Sun SC. Inhibition of p105 processing by NF-kappaB proteins in transiently transfected cells. Oncogene 12(11):2385-92, 6/1996. PMID: 8649779.
87. Good LF, Maggirwar SB, Kealiher A, Uhlik M, Sun SC. Multiple structural domains within I kappa B alpha are required for its inducible degradation by both cytokines and phosphatase inhibitors. Biochem Biophys Res Commun 223(1):123-8, 6/1996. PMID: 8660357.
88. Good L, Sun SC. Persistent activation of NF-kappa B/Rel by human T-cell leukemia virus type 1 tax involves degradation of I kappa B beta. J Virol 70(5):2730-5, 5/1996. PMCID: PMC190129.
89. Sun SC, Elwood J, Greene WC. Both amino- and carboxyl-terminal sequences within I kappa B alpha regulate its inducible degradation. Mol Cell Biol 16(3):1058-65, 3/1996. PMCID: PMC231088.
90. Harhaj E, Blaney J, Millhouse S, Sun SC. Differential effects of I kappa B molecules on Tat-mediated transactivation of HIV-1 LTR. Virology 216(1):284-7, 2/1996. PMID: 8615004.
91. Maggirwar SB, Harhaj E, Sun SC. Activation of NF-kappa B/Rel by Tax involves degradation of I kappa B alpha and is blocked by a proteasome inhibitor. Oncogene 11(5):993-8, 9/1995. PMID: 7675460.
92. Chen F, Kuhn DC, Sun SC, Gaydos LJ, Demers LM. Dependence and reversal of nitric oxide production on NF-kappa B in silica and lipopolysaccharide-induced macrophages. Biochem Biophys Res Commun 214(3):839-46, 9/1995. PMID: 7575553.
93. Chen F, Sun SC, Kuh DC, Gaydos LJ, Demers LM. Essential role of NF-kappa B activation in silica-induced inflammatory mediator production in macrophages. Biochem Biophys Res Commun 214(3):985-92, 9/1995. PMID: 7575573.
94. Sun SC, Maggirwar SB, Harhaj E. Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites. J Biol Chem 270(31):18347-51, 8/1995. PMID: 7629157.
95. Lindstrom I, Sun SC, Faye I.. Structure and expression of Hemolin, an insect member of the immunoglobulin gene superfamily. Eur J Biochem 230(3):920-925, 1995. PMID: 7601154.
96. Sun SC, Faye I.. Transcription of immune genes in the giant silkmoth Hyalophora cecropia, is augmented by H2O2 and diminished by thiol reagents. Eur J Biochem 231(1):93-98, 1995. PMID: 7628488.
97. Sun SC, Elwood J, Béraud C, Greene WC. Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene. Mol Cell Biol 14(11):7377-84, 11/1994. PMCID: PMC359272.
98. Sun SC, Ganchi PA, Béraud C, Ballard DW, Greene WC. Autoregulation of the NF-kappa B transactivator RelA (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs. Proc Natl Acad Sci U S A 91(4):1346-50, 2/1994. PMCID: PMC43155.
99. Béraud C, Sun SC, Ganchi P, Ballard DW, Greene WC. Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product: implications for viral latency. Mol Cell Biol 14(2):1374-82, 2/1994. PMCID: PMC358492.
100. Ganchi PA, Sun SC, Greene WC, Ballard DW. A novel NF-kappa B complex containing p65 homodimers: implications for transcriptional control at the level of subunit dimerization. Mol Cell Biol 13(12):7826-35, 12/1993. PMCID: PMC364854.
101. Engström Y, Kadalayil L,Sun SC, Samakovlis C, Hultmark D, Faye I. kappa B-like motifs regulate the induction of immune genes in Drosophila. J Mol Biol 232(2):327-33, 7/1993. PMID: 8345514.
102. Sun SC, Ganchi PA, Ballard DW, Greene WC. NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science 259(5103):1912-5, 3/1993. PMID: 8096091.
103. Doerre S, Sista P, Sun SC, Ballard DW, Greene WC. The c-rel protooncogene product represses NF-kappa B p65-mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus. Proc Natl Acad Sci U S A 90(3):1023-7, 2/1993. PMCID: PMC45803.
104. Schmidt O, Lindstrom-Dinnetz I, Faye I, Sun SC. Specific immune recognition of insect hemolin. Dev Comp Immunol 17(3):195-200, May-Jun, 1993. PMID: 8325433.
105. Greene WC, Sun SC, Ganchi PA, Doerre S, Ballard DW. The NF-kB/IkB connection: a novel strategy for transcriptional control. Molecular Basis of Immune Responses:73-87, 1993.
106. Ganchi PA, Sun SC, Greene WC, Ballard DW. I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding. Mol Biol Cell 3(12):1339-52, 12/1992. PMCID: PMC275704.
107. Sun SC, Faye I. Affinity purification and characterization of CIF, an insect immunoresponsive factor with NF-kappa B-like properties. Comp Biochem Physiol B 103(1):225-33, 9/1992. PMID: 1451434.
108. Sun SC, Faye I. Cecropia immunoresponsive factor, an insect immunoresponsive factor with DNA-binding properties similar to nuclear-factor kappa B. Eur J Biochem 204(2):885-92, 3/1992. PMID: 1541299.
109. Sun SC, Lindström I, Lee JY, Faye I. Structure and expression of the attacin genes in Hyalophora cecropia. Eur J Biochem 196(1):247-54, 2/1991. PMID: 2001705.
110. Sun SC, Asling B, Faye I.. Organization and expression of the immunoresponsive lysozyme gene in the giant silk moth, Hyalophora cecropia. J Biol Chem 266(10):6644-6649, 1991. PMID: 2007608.
111. Sun SC, Lindström I, Boman HG, Faye I, Schmidt O. Hemolin: an insect-immune protein belonging to the immunoglobulin superfamily. Science 250(4988):1729-32, 12/1990. PMID: 2270488.
112. Anderson K, Sun SC Bowman HG, Seiner H. Purification of the prophenoloxidase from Hyalophora cecropia and four proteins involved in its activation. Insect. Biochem 19:629-639, 1989.

Invited Articles

1. Sun SC, Chang JH, Jin J. Regulation of nuclear factor-κB in autoimmunity. Trends Immunol 34(6):282-9, 6/2013. e-Pub 2/2013. PMCID: PMC3664242.
2. Cheng H, Ren T, Sun SC. New insight into the oncogenic mechanism of the retroviral oncoprotein Tax. Protein Cell 3(8):581-9, 8/2012. e-Pub 7/2012. PMCID: PMC3553852.
3. Jin W, Chang M, Sun SC. Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance. Cell Mol Immunol 9(2):113-22, 3/2012. e-Pub 2/2012. PMID: 22307041.
4. Sun SC. The noncanonical NF-κB pathway. Immunol Rev 246(1):125-40, 3/2012. PMCID: PMC3313452.
5. Sun SC. Non-canonical NF-kappaB signaling pathway. Cell Res 21(1):71-85, 1/2011. e-Pub 12/2010. PMCID: PMC3193406.
6. Sun SC, Cesarman E. NF-kappaB as a Target for Oncogenic Viruses. Curr Top Microbiol Immunol 349:197-244, 2011. e-Pub 9/2010. PMCID: PMC3855473.
7. Sun SC. Controlling the fate of NIK: a central stage in noncanonical NF-kappaB signaling. Sci Signal 3(123):pe18, 2010. e-Pub 5/2010. PMID: 20501935.
8. Sun SC. CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes. Cell Death Differ 17(1):25-34, 4/2009. e-Pub 4/2009. PMID: 19373246.
9. Sun SC, Ley SC. New insights into NF-kappaB regulation and function. Trends Immunol 29(10):469-78, 10/2008. e-Pub 9/2008. PMID: 18775672.
10. Sun SC. Deubiquitylation and regulation of the immune response. Nat Rev Immunol 8(7):501-11, 7/2008. PMID: 18535581.
11. Sun SC, Yamaoka S. Activation of NF-kappaB by HTLV-I and implications for cell transformation. Oncogene 24(39):5952-64, 9/2005. PMID: 16155602.
12. Sun SC, Xiao G. Deregulation of NF-kappaB and its upstream kinases in cancer. Cancer Metastasis Rev 22(4):405-22, 12/2003. PMID: 12884915.
13. Sun SC, Harhaj EW, Xiao G, Good L. Activation of I-kappaB kinase by the HTLV type 1 Tax protein: mechanistic insights into the adaptor function of IKKgamma. AIDS Res Hum Retroviruses 16(16):591-6, 11/2000. PMID: 11080796.
14. Sun SC, Ballard DW. Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases. Oncogene 18(49):6948-58, 11/1999. PMID: 10602469.

Editorials

1. Sun SC. Immune receptor signaling: from ubiquitination to NF-κB activation. Cell Mol Immunol 9(2):97-8, 3/2012. e-Pub 1/2012. PMID: 22231553.
2. Sun SC, Liu ZG. A special issue on NF-kappaB signaling and function. Cell Res 21(1):1-2, 1/2011. e-Pub 1/2011. PMID: 21196938.

Book Chapters

1. Sun S-C, Harhaj EW. "Receptors and Adaptors for NF-kB Signaling". In: NF-kB/Rel Transcription Factor Family. Ed(s) H-C Liou. Springer Science: New York, 2006.

Grant & Contract Support

Title: Regulation of T-cell function and autoimmune inflammation by deubiquitinase CYLD
Funding Source: NIH/NIAID
Role: Principal Investigator
Duration: 8/1/2013 - 6/30/2015
 
Title: Signaling functions of Peli family of E3 ubiquitin ligases
Funding Source: NIH/NIAID
Role: Principal Investigator
Duration: 5/15/2013 - 4/30/2018
 
Title: Linking IKKeta activation to anti-autography in viral protein tax-mediated oncogenesis
Funding Source: NIH/NIAID
Role: Co-Investigator
Duration: 12/1/2012 - 11/30/2016
 
Title: Oncogenic activation of noncanonical NF-kB in B-cell lymphomas
Funding Source: The University of Texas MD Anderson Cancer Center
Role: Principal Investigator
Duration: 10/1/2012 - 9/30/2014
 
Title: Regulation of colon inflammation and tumorigenesis by tumor suppressor CYLD
Funding Source: G.S. Hogan Gastrointestinal Research Fund, MD Anderson
Role: Principal Investigator
Duration: 9/1/2011 - 8/31/2013
 
Title: Regulation of T-cell Function and Autoimmune Inflammation by Deubiquitinase CYLD
Funding Source: NIH/NIAID
Role: Principal Investigator
Duration: 4/1/2005 - 6/30/2015
 
Title: The IKK/Tpl2 Axis of TLR Signaling
Funding Source: NIH/NIAID
Role: Principal Investigator
Duration: 3/1/2004 - 11/30/2014
 
Title: Molecular Mechanisms Regulating Noncaonical NF-kB Signaling
Funding Source: NIH/NIGMS
Role: Principal Investigator
Duration: 1/1/2003 - 11/30/2016

Last updated: 3/27/2014