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Shinako Takada, Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Biochemistry and Molecular Biology, Division of Basic Science Research, University of Texas M.D. Anderson Cancer Center, Houston, TX

Office Address

The University of Texas M. D. Anderson Cancer Center
6767 Bertner
Unit Number: 1000
Houston, TX 77030
Room Number: S9.8336B
Phone: 713-834-6275
Fax: 713-834-6266
Email: stakada@mdanderson.org

Education & Training

Degree-Granting Education

1990 University of Tokyo, Tokyo, Japan, PHD, Medical Science/ Investigated mechanisms of hepatocarcinogenesis by hepatitis B virus. Studies included identification of activated oncogenes, analysis of the structure of integrated HBV DNA, and expression and functional analysis of the viral X gene
1985 Ochanomizu University, Tokyo, Japan, MS, Biology/ Carried out genetic studies of hybrid dysgenesis caused by a transposable P element in Drosophila
1983 Ochanomizu University, Tokyo, Japan, BS, Biology

Postgraduate Training

4/1995-3/2001 Postdoctoral Fellow, Biochemistry and Molecular Biology, Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, CA, Dr. Robert Tjian
4/1990-3/1991 Postdoctoral Fellow, Japan Society for the Promotion of Science Fellowship, Japanese Foundation for Cancer Research, Department of Gene Research, Cancer Institute, Tokyo, Japan, Dr. Katsuro Koike

Selected Publications

Peer-Reviewed Original Research Articles
1. Anish R, Hossain MB, Jacobson RH, Takada S. Characterization of Transcription from TATA-less Promoters: Identification of a New Core Promoter Element XCPE2 and Analysis of Factor Requirements. PLoS ONE 4:e5103, 4/2009.
2. Hossain MB, Ji P, Anish R, Jacobson RH, and Takada S. Poly(ADP-ribose) polymerase 1 (PARP-1) interacts with nuclear respiratory factor 1 (NRF-1) and plays a role in NRF-1 transcriptional regulation. J. Biol. Chem. 284:8621-8632, 2009.
3. Bhattacharya S, Takada S, Jacobson RH. Structural analysis and dimerization potential of the human TAF5 subunit of TFIID. Proc Natl Acad Sci U S A 104:1189-94, 1/2007. PMID: 17227857.
4. Tokusumi, Y., MaY., SongX., Jacobson, R.H. and Takada, S. A new core promoter element XCPE1 (X core promoter element 1) directs activator-, mediator-, and TATA-binding protein-dependent but TFIID-independent RNA polymerase II transcription from TATA-less promoters. Mol Cell Biol 27:1844-1958, 2007.
5. Wang X, Truckses DM, Takada S, Matsumura T, Tanese N, Jacobson RH. Conserved region I of human coactivator TAF4 binds to a short hydrophobic motif present in transcriptional regulators. Proc Natl Acad Sci U S A. 104:7839-7844, 2007.
6. Isogai, Y., Takada, S., Tjian, R. and Keles S. Novel TRF1/BRF target gene revealed by genome-wide analysis of Drosophila Pol III transcription. The EMBO Journal 26:76-89, 2007.
7. Tokusumi Y, Zhou S, Takada S. Nuclear respiratory factor 1 plays an essential role in transcriptional initiation from the hepatitis B virus x gene promoter. J Virol 78(20):10856-64, 10/2004. PMID: 15452206.
8. Takada S, Lis, JT, Zhou, S, Tjian, R. A TRF1:BRF complex directs Drosophila RNA polymerase III transcription. Cell 101:459-469, 2000.

Invited Articles
1. Koike K, Takada S. Biochemistry and functions of hepatitis B virus X protein. Intervirology 38(1-2):89-99, 1995. PMID: 8666528.
2. Takada S, Tsuchida N, Kobayashi M, Koike K. Disruption of the function of tumor-suppressor gene p53 by the hepatitis B virus X protein and hepatocarcinogenesis. J Cancer Res Clin Oncol 121(9-10):593-601, 1995. PMID: 7559743.

Last updated: 6/29/2009