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Shumei Song, MD, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Gastrointestinal (GI) Medical Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, HOuston, TX
Assistant Professor, Department of Gastroenterology - Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Instructor, Department of Gastroenterology, Hepatology & Nutrition, Division of Internal Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd.
Unit Number: 426
Houston, TX 77030
Room Number: FC10.2050
Phone: 713-834-6144
Fax: 713-745-1163

Education & Training

Degree-Granting Education

1999 Beijing Institute for Cancer Research, The School of Oncology, Beijing University, Beijing, China, PHD, Biochemistry and Molecular Biology
1989 Hubei Medical College, Hubei, China, MS, Microbiology & Immunolgy
1986 Binjou Medical College, Shandong, China, MD

Postgraduate Training

10/2002-2/2004 Postdoctoral Fellow, Department of GI Medicine and Nutrition The University of Texas MD Anderson Cancer Center, Houston, TX, Robert S. Bresalier, MD
1/1999-10/2002 Postdoctoral Fellow, Department of Clinical Cancer Prevention, U.T.M.D. Anderson Cancer Center, Houston, TX, Xiaochun Xu, MD, PhD

Selected Publications

Peer-Reviewed Original Research Articles

1. Song S, Ajani JA. The role of microRNAs in cancers of the upper gastrointestinal tract. Nat Rev Gastroenterol Hepatol 10(2):109-18, 2/2013. e-Pub 11/20/2012. PMID: 23165235.
2. Song S, Ji B, Ramachandran V, Wang H, Hafley M, Logsdon C, Bresalier RS. Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding ras and activating ras signaling. PLoS One 7(8):e42699, 2012. e-Pub 8/10/2012. PMCID: PMC3416861.
3. Song S, Mishra L. Reply to dysfunctional transforming growth factor-β signaling with constitutively active notch signaling in Barrett's esophageal adenocarcinoma. Cancer. e-Pub 9/6/2011. PMID: 21898378.
4. Mendelson J, Song S, Li Y, Maru DM, Mishra B, Davila M, Hofstetter WL, Mishra L. Dysfunctional transforming growth factor-β signaling with constitutively active Notch signaling in Barrett's esophageal adenocarcinoma. Cancer 117(16):3691-702, 8/15/2011. e-Pub 2/8/2011. PMCID: PMC3236645.
5. Song S, Byrd JC, Guha S, Liu KF, Koul D, Bresalier RS. Induction of MUC5AC mucin by conjugated bile acids in the esophagus involves the phosphatidylinositol 3-kinase/protein kinase C/activator protein-1 pathway. Cancer. e-Pub 12/14/2010. PMCID: PMC3116027.
6. Song S, Guan B, Men T, Hoque A, Lotan R, Xu XC. Antitumor effect of retinoic acid receptor-beta2 associated with suppression of cyclooxygenase-2. Cancer Prev Res (Phila Pa) 2(3):274-80, 3/2009. e-Pub 3/3/2009. PMID: 19258542.
7. Song S, Mazurek N, Liu C, Sun Y, Ding QQ, Liu K, Hung MC, Bresalier RS. Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3 beta activity. Cancer Res 69(4):1343-9, 2/15/2009. e-Pub 2/3/2009. PMID: 19190323.
8. Song S, Krishnan K, Liu K, Bresalier RS. Polyphenon E inhibits the growth of human Barrett's and aerodigestive adenocarcinoma cells by suppressing cyclin D1 expression. Clin Cancer Res 15(2):622-31, 1/15/2009. PMCID: PMC2925407.
9. Song S, Guha S, Liu KF, Buttar NS, Bresalier RS. Induction of COX-2 by unconjugated bile acids involves reactive oxygen species-mediated signaling pathway in the esophagus. Gut 56:1512-1521, 2007.
10. Song S, Lippman SM, Zou Y, Ye X, Ajani JA, Xu XC. Induction of cyclooxygenase-2 by benzo[a]pyrene diol epoxide through inhibition of retinoic acid receptor-beta 2 expression. Oncogene 24(56):8268-76, 12/2005. PMID: 16170369.
11. Song S, Byrd JC, Mazurek N, Liu K, Koo JS, Bresalier RS. Galectin-3 modulates MUC2 mucin expression in human colon cancer cells at the level of transcription via AP-1 activation. Gastroenterology 129(5):1581-91, 11/2005. PMID: 16285957.
12. Lei H, An P, Song S, Liu X, He L, Wu J, Meng L, Liu M, Yang J, Shou C. A Novel Peptide Isolated from a Phage Display Library Inhibits Tumor Growth and Metastasis by Blocking the Binding of Vascular Endothelial Growth factor to its Kinase Domain Receptor. J. Bio Chem. 277:43137-43142, 2002.
13. Song S, Xu XC. Effect of benzo[a]pyrene diol epoxide on expression of retinoic acid receptor-beta in immortalized esophageal epithelial cells and esophageal cancer cells. Biochem Biophys Res Commun 281(4):872-7, 3/2001. PMID: 11237740.
14. Song S, Byrd J, Guha S, Liu K-F, Koul D, Bresalier R. Induction of MUC5AC mucin by conjugated bile acids involves P13K/AKT/AP-1 pathway in Esophagus. Cancer. Submitted.

Grant & Contract Support

Title: Inhibition of Hedgehog Signaling in Gli-1 + Adeno CA
Funding Source: NIH/NCI
Role: Co-Investigator
Duration: 7/1/2013 - 6/30/2018
 
Title: Dual pathway inhibition in biomarker
Funding Source: NIH/NCI
Role: Co-Investigator
Duration: 4/1/2013 - 3/31/2018
 
Title: the role of Galectin-3 in pancreatic stromal-epithelial interactions and associated tumor fibrosis
Funding Source: Texas Medical Center Digestive Disease Center
Role: Principal Investigator
Duration: 3/1/2010 - 2/28/2012
 
Title: Mucin glycoproteins in colorectal cancer metastasis
Funding Source: NIH/NCI
Role: Investigator
Principal Investigator: Robert S. Bresalier
Duration: 9/1/2006 - 8/1/2011
 
Title: The role of bile acids and Benzo(a)pyrene diol epoxide in the development of esophageal adenocarcinoma
Funding Source: AGA Foundation for Digestive Health and Nutrition
Role: Principal Investigator
Duration: 7/1/2006 - 7/1/2009

Last updated: 2/15/2013