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Simrit Parmar, MD, MSCI

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Stem Cell Transplantation, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd., Unit 423
Unit Number: 423
Houston, TX 77030
Room Number: Faculty Center, FC5.3014

Education & Training

Degree-Granting Education

2004 Northwestern University, Feinberg School of Medicine, Chicago, IL, MS, Clinical Investigation
1998 Dayanand Medical College and Hospital, Ludhiana, Punjab, India, MBBS, Medicine, Surgery, Midwifery

Postgraduate Training

7/2004-5/2005 Clinical Fellowship, Blood and Marrow Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX, Richard Champlin, MD
7/2001-6/2004 Clinical Fellowship, Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, William Gradishar, MD
6/1998-7/2001 Clinical Residency, Internal Medicine, University of Illinois/Michael Reese Hospital, Chicago, IL, Dennis Levinson
1/1997-3/1998 Research Internship, Safdarjung Hospital, New Delhi, India

Board Certifications

11/2015 ABIM Medical Oncology
11/2014 ABIM Hematology
12/2011 ABIM Internal Medicine

Honors and Awards

2004 Fellows' Forum Travel Grant, Glaxosmithkline National Medical and Hematology Oncology Fellows' Forum
1994-1995 Distinction in Pharmacology, Punjab University
1992-1993 Distinction in Biochemistry, Punjab University

Selected Publications

Peer-Reviewed Original Research Articles

1. Tung SS, Parmar S, Robinson SN, De Lima M, Shpall EJ. Ex vivo expansion of umbilical cord blood for transplantation. Best Practice Research Clinical Haematol 23(2):245-57, 11/2010. PMID: 20837337.
2. Yang H, Robinson SN, Lu J, Decker WK, Xing D, Steiner D, Parmar S, Shah N, Champlin RE, Munsell M, Leen A, Bollard C, Simmons PJ, Shpall EJ. CD3(+) and/or CD14(+) depletion from cord blood mononuclear cells before ex vivo expansion culture improves total nucleated cell and CD34(+) cell yields. Bone Marrow Transplant 45(6):1000-7, 6/2010. e-Pub 10/2009. PMID: 19838220.
3. Kelly SS, Parmar S, De Lima M, Robinson S, Shpall E. Overcoming the barriers to umbilical cord blood transplantation. Cytotherapy 12(2):121-30, 4/2010. PMID: 20196692.
4. Parmar S, de Lima M. Hematopoietic stem cell transplantation for myelodysplastic syndrome. Biol Blood Marrow Transplant 16(1 Suppl):S37-44, 1/2010. e-Pub 10/2009. PMID: 19857589.
5. Dumka D, Puri P, Carayol N, Lumby C, Balachandran H, Schuster K, Verma AK, Terada LS, Platanias LC, Parmar S. Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib. Leuk Lymphoma 50(12):1-13, 12/2009. e-Pub 8/2009. PMCID: PMC2888505.
6. Parmar S, Del Lima M, Zou Y, Patah PA, Liu P, Cano P, Rondon G, Pesoa S, de Padua Silva L, Qazilbash MH, Hosing C, Popat U, Kebriaei P, Shpall EJ, Giralt S, Champlin RE, Stastny P, Fernandez-Vina M. Donor-recipient mismatches in MHC class I chain-related gene A in unrelated donor transplantation lead to increased incidence of acute graft-versus-host disease. Blood 114(14):2884-7, 10/2009. e-Pub 8/2009. PMID: 19654407.
7. Zhou L, Nguyen AN, Sohal D, Ying Ma J, Pahanish P, Gundabolu K, Hayman J, Chubak A, Mo Y, Bhagat TD, Das B, Kapoun AM, Navas TA, Parmar S, Kambhampati S, Pellagatti A, Braunchweig I, Zhang Y, Wickrema A, Medicherla S, Boultwood J, Platanias LC, Higgins LS, List AF, Bitzer M, Verma A. Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS. Blood 112(8). e-Pub 5/2008. PMCID: PMC2569182.
8. Patah PA, Parmar S, McMannis J, Sadeghi T, Karandish S, Rondon G, Tarrand J, Champlin R, de Lima M, Shpall EJ. Microbial contamination of hematopoietic progenitor cell products: clinical outcome. Bone Marrow Transplant 40(4):365-8, 8/2007. e-Pub 6/2007. PMID: 17572714.
9. Navas TA, Mohindru M, Estes M, Ma JY, Sokol L, Pahanish P, Parmar S, Haghnazari E, Zhou L, Collins R, Kerr I, Nguyen AN, Xu Y, Platanias LC, List AA, Higgins LS, Verma A. Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors. Blood 108(13):4170-7, 12/2006. e-Pub 8/2006. PMCID: PMC1895446.
10. Parmar S, Robinson SN, Komanduri K, St John L, Decker W, Xing D, Yang H, McMannis J, Champlin R, de Lima M, Molldrem J, Rieber A, Bonyhadi M, Berenson R, Shpall EJ. Ex vivo expanded umbilical cord blood T cells maintain naive phenotype and TCR diversity. Cytotherapy 8(2):149-57, 2006. PMID: 16698688.
11. Parmar S, Smith J, Sassano A, Uddin S, Katsoulidis E, Majchrzak B, Kambhampati S, Eklund EA, Tallman MS, Fish EN, Platanias LC. Differential regulation of the p70 S6 kinase pathway by interferon alpha (IFNalpha) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells. Blood 106(7):2436-43, 10/2005. e-Pub 3/2005. PMCID: PMC1895266.
12. Katsoulidis E, Li Y, Yoon P, Sassano A, Altman J, Kannan-Thulasiraman P, Balasubramanian L, Parmar S, Varga J, Tallman MS, Verma A, Platanias LC. Role of the p38 mitogen-activated protein kinase pathway in cytokine-mediated hematopoietic suppression in myelodysplastic syndromes. Cancer Res 65(19):9029-37, 10/2005. PMID: 16204077.
13. Kaur S, Parmar S, Smith J, Katsoulidis E, Li Y, Sassano A, Majchrzak B, Uddin S, Tallman MS, Fish EN, Platanias LC. Role of protein kinase C-delta (PKC-delta) in the generation of the effects of IFN-alpha in chronic myelogenous leukemia cells. Exp Hematol 33(5):550-7, 5/2005. PMID: 15850832.
14. Lal L, Li Y, Smith J, Sassano A, Uddin S, Parmar S, Tallman MS, Minucci S, Hay N, Platanias LC. Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells. Blood 105(4):1669-77, 2/2005. e-Pub 10/2004. PMID: 15471950.
15. Parmar S, Rademaker AW, Fung BB, Kozlowski JM, Kuzel TM. Implications of therapy choice on overall survival in metastatic renal cell carcinoma: a single institution experience. Med Oncol 22(4):399-405, 2005. PMID: 16260858.
16. Parmar S, Platanias LC. Interferons. Cancer Treat Res 126:45-68, 2005. PMID: 16209062.
17. Kambhampati S, Verma A, Li Y, Parmar S, Sassano A, Platanias LC. Signalling pathways activated by all-trans-retinoic acid in acute promyelocytic leukemia cells. Leuk Lymphoma 45(11):2175-85, 11/2004. PMID: 15512805.
18. Parmar S, Rundhaugen LM, Boehlke L, Riley M, Nabhan C, Raji A, Frater JL, Tallman MS. Phase II trial of arsenic trioxide in relapsed and refractory acute myeloid leukemia, secondary leukemia and/or newly diagnosed patients at least 65 years old. Leuk Res 28(9):909-19, 9/2004. PMID: 15234567.
19. Parmar S, Katsoulidis E, Verma A, Li Y, Sassano A, Lal L, Majchrzak B, Ravandi F, Tallman MS, Fish EN, Platanias LC. Role of the p38 mitogen-activated protein kinase pathway in the generation of the effects of imatinib mesylate (STI571) in BCR-ABL-expressing cells. J Biol Chem 279(24):25345-52, 6/2004. e-Pub 3/2004. PMID: 15056660.
20. Verma A, Kambhampati S, Parmar S, Platanias LC. Jak family of kinases in cancer. Cancer Metastasis Rev 22(4):423-34, 12/2003. PMID: 12884916.
21. Shah AP, Parmar S, O'Regan R. Right atrial and ventricular thrombus infiltrated with osteoblastic osteosarcoma. J Cardiovasc Pharmacol Ther 8(4):307-11, 12/2003. PMID: 14740080.
22. Parmar S, Platanias LC. Interferons: mechanisms of action and clinical applications. Curr Opin Oncol 15(6):431-9, 11/2003. PMID: 14624225.
23. Kambhampati S, Li Y, Verma A, Sassano A, Majchrzak B, Deb DK, Parmar S, Giafis N, Kalvakolanu DV, Rahman A, Uddin S, Minucci S, Tallman MS, Fish EN, Platanias LC. Activation of protein kinase C delta by all-trans-retinoic acid. J Biol Chem 278(35):32544-51, 8/2003. e-Pub 6/2003. PMID: 12805378.
24. Parmar S, Tallman MS. Acute promyelocytic leukaemia:a review. Expert Opin Pharmacother 4(8):1379-92, 8/2003. PMID: 12877645.
25. Lekmine F, Uddin S, Sassano A, Parmar S, Brachmann SM, Majchrzak B, Sonenberg N, Hay N, Fish EN, Platanias LC. Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons. J Biol Chem 278(30):27772-80, 7/2003. e-Pub 5/2003. PMID: 12759354.
26. Mahmud N, Devine SM, Weller KP, Parmar S, Sturgeon C, Nelson MC, Hewett T, Hoffman R. The relative quiescence of hematopoietic stem cells in nonhuman primates. Blood 97(10):3061-8, 5/2001. PMID: 11342431.

Abstracts

1. Leandro de Padua Silva, Borje S. Andersson, Uday Popat, Lori Griffin, Michele Alvarez, Poliana Patah, Simrit Parmar, Sergio Giralt, Gabriela Rondon, Marcelo Fernandez-Vina, Pedro Cano, Richard E. Champlin, Marcos De Lima. Treatment of AML in First Remission (CR1) with Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) Using Unrelated Donors (UD). Blood 112(11) (#976), 11/2008.
2. Simrit P, M Fernandez-Vina, P Liu, P Cano, BS Andersson, M Munsell, S Giralt, J McMannis, EJ Shpall, D Couriel, S Ghosh, R Champlin, M de Lima. Influence of allele level HLA typing on unrelated donor (UD) transplantation for high risk myeloid leukemias. Blood 106 (#2916), 11/2005.
3. Simrit P, Rademaker AF, Fung BB, Kuzel T. High Dose (HD) IL-2 is associated with durable disease free survival and clinically important improvement in survival in metastatic renal cell cancer (MRCC). Journal of Clincal Oncology 22 (#1630), 2003.

Book Chapters

1. Tallman MS, Parmar S, Peterson LA. Acute Promyelocytic Leukemia. McGaw Hill publishers.
2. Parmar S and Platanias LC. Mechanism of Action. In: Interferons. Kluwer publishers.

Last updated: 7/16/2013