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Stefan O. Ciurea

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Stem Cell Transplantation, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Research Interests

  

Mismatched related donors are a potential source of stem cells for virtually all patients who lack a matched sibling or unrelated donor. Expanding the use of stem cells from mismatched relatives by identifying barriers against successful transplantation, optimizing conditioning regimens, separating the graft-versus-tumor effect from graft-versus-host disease and incorporating novel strategies to enhance anti-tumor immunity, like the use of cellular therapy, represents a priority of my research.

Office Address

Education & Training

Degree-Granting Education

1996 Gr. T. Popa University of Medicine and Pharmaceuticals, Iasi, Romania, MD, Medicine

Postgraduate Training

7/2007-6/2008 Clinical Fellowship, Stem Cell Transplantation and Cellular Therapy, The University of Texas M.D. Anderson Cancer Center, Housotn, TX
7/2004-6/2007 Clinical Fellowship, Hematology-Oncology, University of Illinois at Chicago College of Medicine, Chicago, IL
7/2000-6/2003 Clinical Residency, Internal Medicine, PennState University/PinnacleHealth at Harrisburg Hospital, Harrisburg, PA

Board Certifications

2007 Diplomate, Hematology
2003 Diplomate, Internal Medicine

Honors and Awards

2006 American Society of Hematology Merit/Travel Award
2002-2003 Chief Medical Resident
2001 Resident of the Year Award

Selected Publications

Peer-Reviewed Original Research Articles
1. Ciurea, SO, de Lima M, Cano P, Korbling M, Giralt S, Shpall EJ, Wang X, Thall PF, Champlin R, Fernandez-Vina M. High Risk of Graft Failure in Patients with Anti-HLA Antibodies Undergoing Haploidentical Stem Cell Transplantation. Transplantation 88(8):1019-1024, 10/2009.
2. Ciurea SO, Saliba R, Rondon G, Pesoa S, Cano P, Fernandez-Vina M, Qureshi S, Worth LL, McMannis J, Kebriaei P, Jones RB, Korbling M, Qazilbash M, Shpall EJ, Giralt S, Lima MD, Champlin RE, Gajewski J. Reduced-intensity conditioning using fludarabine, melphalan and thiotepa for adult patients undergoing haploidentical SCT. Bone Marrow Transplant. e-Pub 8/2009. PMID: 19668237.
3. Ciurea SO, Andersson BS. Busulfan in hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 15(5). e-Pub 2/12/2009. PMID: 19361744.
4. Chunduri S, Gaitonde S, Ciurea SO, Hoffman R, Rondelli D. Pulmonary extramedullary hematopoiesis in patients with myelofibrosis undergoing allogeneic stem cell transplantation. Haematologica 93(10):1593-5, 7/2008. e-Pub 7/2008. PMID: 18641018.
5. Lee HJ, Gulbis A, De Padua Silva L, Hosing C, Khouri I, de Lima M, Champlin RE, Ciurea SO. Rituximab for passenger lymphocyte syndrome associated with allogeneic SCT. Bone Marrow Transplant 42(1):67-9, May-Jun, 7/2008. PMID: 18347568.
6. Tam CS, Nussenzveig RM, Popat U, Bueso-Ramos CE, Thomas DA, Cortes JA, Champlin RE, Ciurea SE, Manshouri T, Pierce SM, Kantarjian HM, Verstovsek S. The natural history and treatment outcome of blast phase BCR-ABL- myeloproliferative neoplasms. Blood 112(5). e-Pub 6/2008. PMCID: PMC2518875.
7. Ciurea SO, Sadegi B, Wilbur A, Alagiozian-Angelova V, Gaitonde S, Dobogai LC, Akard LP, Hoffman R, Rondelli D. Effects of extensive splenomegaly in patients with myelofibrosis undergoing a reduced intensity allogeneic stem cell transplantation. Br J Haematol 141(1):80-3, May-Jun, 4/2008. PMID: 18324970.
8. Ciurea SO, Merchant D, Mahmud N, Ishii T, Zhao Y, Hu W, Bruno E, Barosi G, Xu M, Hoffman R. Pivotal contributions of megakaryocytes to the biology of idiopathic myelofibrosis. Blood 110(3):986-93, May-Jun, 8/2007. PMID: 17473062.
9. Ciurea SO, Hoffman R. Cytokines for the treatment of thrombocytopenia. Semin Hematol 44(3):166-82, May-Jun, 7/2007. PMID: 17631181.
10. Ishii T, Xu M, Zhao Y, Hu WY, Ciurea S, Bruno E, Hoffman R. Recurrence of clonal hematopoiesis after discontinuing pegylated recombinant interferon-alpha 2a in a patient with polycythemia vera. Leukemia 21(2):373-4, May-Jun, 2/2007. PMID: 17122864.
11. Hoffman R, Prchal JT, Samuelson S, Ciurea SO, Rondelli D. Philadelphia chromosome-negative myeloproliferative disorders: biology and treatment. Biol Blood Marrow Transplant 13(1 Suppl 1):64-72, May-Jun, 1/2007. PMID: 17222772.
12. Ciurea S, Beri R, Dobogai L, Chunduri S, Mahmud N, Rondelli D, Peace D. The use of blood conservation methods in addition to erythropoietin allows myeloablative allogeneic stem cell transplantation without the use of blood products. Bone Marrow Transplant 37(3):325-7, Jan-Feb, 2/2006. PMID: 16314850.

Abstracts
1. Ciurea SO, de Lima M, Giralt S, Qazilbash MH, Alousi A, Kebriaei P, Khouri IF, Anderlini P, Andersson BS, Hosing C, Verstovsek S, Kantarjian H, Champlin R, Popat U. Allogeneic Stem Cell Transplantation for Patients with Acute Leukemia Transformed from Myelofibrosis. Blood 112(11):1131 (#3293), 11/2008.
2. de Lima M, McMannis J, Saliba R, Worth L, Kebriaei P, Popat U, Qazilbash M, Jones R, Giralt S, Silva L, Cooper L, Petropoulos D, Lee D, Kelly S, Thall P, Robinson S, Khouri I, Hosing C, Korbling M, Alousi A, Rondon G, Andersson BS, Nieto Y, Ciurea SO, Komanduri K, Champlin RE, Shpall EJ. Double Cord Blood Transplantation (CBT) with and without Ex-Vivo Expansion (EXP): A Randomized, Controlled Study. Blood 112(11):63 (#154), 11/2008.
3. Ciurea SO, Kebriaei P, Khouri IF, Qazilbash MH, Jones RB, Petropoulos D, Worth LL, Alousi A, Hosing CM, Patah P, Cano P, McMannis J, Giralt SA, Fernandez-Vina M, Champlin RE, Shpall EJ, de Lima M. High Rate of Engraftment and Low Regimen-Related Toxicity Using Fludarabine, Melphalan and Thiotepa Conditioning for Unrelated Donor Cord Blood Transplantation. Blood 112(11) (#4414), 11/2008.
4. Jabbour E, de Lima M, de Padua Silva L, Giralt S, Cortes J, Qazilbash M, Rondon G, Ciurea S, Jones R, Nieto Y, Korbling M, Couriel D, Kantarjian H, Champlin R. Long-Term Efficacy of Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in Patients pts with Advanced Chronic Myeloid Leukemia (CML) Post Imatinib Failure. Blood 112(11):360-361 (#979), 11/2008.
5. Ciurea SO, de Lima M, Cano P, Korbling M, McMannis J, Giralt SA, Andersson BS, Shpall EJ, Champlin RE, Fernandez-Vina M. The Presence of Moderate to High Donor-Specific Anti-HLA Antibody Titers Is Associated with a High Risk of Graft Failure in Haploidentical Stem Cell Transplantation. Blood 112(11):1036-1037 (#3013), 11/2008.
6. Ciurea SO, Qureshi S, Rondon G, McMannis J, Pesoa S, Cano P, Fernandez-Vina M, Giralt S, de Lima M, Champlin RE, Gajewski. Improved outcomes of patients with AML/MDS undergoing haploidentical stem-cell transplantation using fludarabine, melphalan and thiotepa conditioning chemotherapy. Biol Blood Marrow Transplant 14(2):50 (#132), 4/2008.
7. Ciurea SO, Sadegi B, Wilbur A, Alagiozian-Angelova V, Gaitonde S, Dobogai L, Aker LP, Hoffman R, Rondelli D. Role of extensive splenomegaly in patients with myelofibrosis undergoing a reduced-intensity conditioning allogeneic stem cell transplantation. Biol Blood Marrow Transplant 14(2):112 (#303), 3/2008.
8. Ciurea S, Mahmud N, Bruno E, Ishii T, Xu M, Hoffman R. Identification of the Origins and Characterization of the Consequences of Megakaryocytic Hyperplasia in Idiopathic Myelofibrosis. Blood:119a (#663), 12/2006.

Book Chapters
1. Ciurea SO, Hoffman R. The Polycythemias. In: Oxford Textbook of Medicine, 5th Edition. In Press.
2. Ciurea SO, Hoffman R. Thrombocytosis. In: Oxford Textbook of Medicine, 5th Edition. In Press.

Last updated: 11/11/2009