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Stefan Octavian Ciurea

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Stem Cell Transplantation, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests


Mismatched related donors are a potential source of stem cells for virtually all patients who lack a matched sibling or unrelated donor. Expanding the use of stem cells from mismatched relatives by identifying barriers against successful transplantation, optimizing conditioning regimens, separating the graft-versus-tumor effect from graft-versus-host disease and incorporating novel strategies to enhance anti-tumor immunity, like the use of cellular therapy, represents a priority of my research.

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd.
Unit 0423
Unit Number: 423
Houston, TX 77030

Education & Training

Degree-Granting Education

1996 Gr. T. Popa University of Medicine and Pharmaceuticals, Iasi, Romania, MD, Medicine

Postgraduate Training

7/2007-6/2008 Clinical Fellowship, Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
7/2004-6/2007 Clinical Fellowship, Hematology-Oncology, University of Illinois at Chicago College of Medicine, Chicago, IL
7/2000-6/2003 Clinical Residency, Internal Medicine, PennState University/PinnacleHealth at Harrisburg Hospital, Harrisburg, PA

Board Certifications

2007 Diplomate, Hematology
2003 Diplomate, Internal Medicine


Academic Appointments

Assistant Professor, Department of Stem Cell Transplantation, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2008-8/2014

Honors and Awards

2006 American Society of Hematology Merit/Travel Award
2002-2003 Chief Medical Resident
2001 Resident of the Year Award

Selected Publications

Peer-Reviewed Original Research Articles

1. Jabbour E, Daver N, Champlin R, Mathisen M, Oran B, Ciurea S, Khouri I, Cornelison AM, Ghanem H, Cardenas-Turanzas M, Popat U, Ravandi F, Giralt S, Garcia-Manero G, Cortes J, Kantarjian H, de Lima M. Allogeneic stem cell transplantation as initial salvage for patients with acute myeloid leukemia refractory to high-dose cytarabine-based induction chemotherapy. Am J Hematol 89(4):395-8, 4/2014. e-Pub 3/2014. PMID: 24375514.
2. Zhou Y, Slack R, Jorgensen JL, Wang SA, Rondon G, de Lima M, Shpall E, Popat U, Ciurea S, Alousi A, Qazilbash M, Hosing C, O'Brien S, Thomas D, Kantarjian H, Medeiros LJ, Champlin RE, Kebriaei P. The Effect of Peritransplant Minimal Residual Disease in Adults With Acute Lymphoblastic Leukemia Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. Clin Lymphoma Myeloma Leuk. e-Pub 1/2014. PMID: 24548609.
3. Jin L, Tabe Y, Kojima K, Shikami M, Benito J, Ruvolo V, Wang RY, McQueen T, Ciurea SO, Miida T, Andreeff M, Konopleva M. PI3K inhibitor GDC-0941 enhances apoptotic effects of BH-3 mimetic ABT-737 in AML cells in the hypoxic bone marrow microenvironment. J Mol Med (Berl) 91(12):1383-97, 12/2013. e-Pub 8/2013. PMCID: PMC3834093.
4. Bayraktar UD, Ciurea SO. Strategies in Haploidentical Stem Cell Transplantation in Adults. Turk J Haematol 30(4):342-350, 12/2013. e-Pub 12/2013. PMCID: PMC3874970.
5. Bayraktar UD, Shpall EJ, Liu P, Ciurea SO, Rondon G, de Lima M, Cardenas-Turanzas M, Price KJ, Champlin RE, Nates JL. Hematopoietic cell transplantation-specific comorbidity index predicts inpatient mortality and survival in patients who received allogeneic transplantation admitted to the intensive care unit. J Clin Oncol 31(33):4207-14, 11/2013. e-Pub 10/2013. PMID: 24127454.
6. Bashir Q, Khan H, Thall PF, Liu P, Shah N, Kebriaei P, Parmar S, Oran B, Ciurea S, Nieto Y, Jones R, Hosing CM, Popat UR, Dinh YT, Rondon G, Orlowski RZ, Shah JJ, De Lima M, Shpall E, Champlin R, Giralt S, Qazilbash MH. A randomized phase II trial of fludarabine/melphalan 100 versus fludarabine/melphalan 140 followed by allogeneic hematopoietic stem cell transplantation for patients with multiple myeloma. Biol Blood Marrow Transplant 19(10):1453-8, 10/2013. e-Pub 7/2013. PMID: 23872222.
7. Chakhachiro ZI, Saliba RM, Okoroji GJ, Korbling M, Alousi AM, Betul O, Anderlini P, Ciurea SO, Popat U, Champlin R, Samuels BI, Medeiros LJ, Bueso-Ramos C, Khouri IF. Cytarabine, Ki-67, and SOX11 in patients with mantle cell lymphoma receiving rituximab-containing autologous stem cell transplantation during first remission. Cancer 119(18):3318-25, 9/2013. e-Pub 6/2013. PMID: 23775587.
8. Smith VR, Popat U, Ciurea S, Nieto Y, Anderlini P, Rondon G, Alousi A, Qazilbash M, Kebriaei P, Khouri I, de Lima M, Champlin R, Hosing C. Just-in-time rescue plerixafor in combination with chemotherapy and granulocyte-colony stimulating factor for peripheral blood progenitor cell mobilization. Am J Hematol 88(9):754-7, 9/2013. e-Pub 7/2013. PMCID: PMC3935820.
9. Poon LM, Hamdi A, Saliba R, Rondon G, Ledesma C, Kendrick M, Qazilbash M, Hosing C, Jones RB, Popat UR, Nieto Y, Alousi A, Ciurea S, Shpall EJ, Champlin RE, Kebriaei P. Outcomes of adults with acute lymphoblastic leukemia relapsing after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 19(7):1059-64, 7/2013. e-Pub 4/2013. PMID: 23644077.
10. Kebriaei P, Wilhelm K, Ravandi F, Brandt M, de Lima M, Ciurea S, Worth L, O'Brien S, Thomas D, Champlin RE, Kantarjian H. Feasibility of Allografting in Patients with Advanced Acute Lymphoblastic Leukemia After Salvage Therapy With Inotuzumab Ozogamicin. Clin Lymphoma Myeloma Leuk 13(3):296-301, 6/2013. e-Pub 1/2013. PMID: 23313065.
11. Bayraktar UD, Bashir Q, Qazilbash M, Champlin RE, Ciurea SO. Fifty Years of Melphalan Use in Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant 19(3):344-56, 3/2013. e-Pub 8/2012. PMID: 22922522.
12. Aung FM, Lichtiger B, Bassett R, Liu P, Alousi A, Bashier Q, Ciurea SO, de Lima MJ, Hosing C, Kebriaei P, Nieto Y, Oran B, Parmar S, Qazilbash M, Shah N, Khouri I, Champlin RE, Popat U. Incidence and natural history of pure red cell aplasia in major ABO-mismatched haematopoietic cell transplantation. Br J Haematol 160(6):798-805, 3/2013. e-Pub 1/2013. PMID: 23330820.
13. Ciurea SO, Champlin RE. Donor selection in T-cell replete haploidentical hematopoietic stem-cell transplantation: knowns, unknowns and controversies. Biol Blood Marrow Transplant 19(2):180-4, 2/2013. e-Pub 8/2012. PMID: 22892554.
14. Najera JE, Alousi A, De Lima M, Ciurea SO. Akinetic mutism-a serious complication to tacrolimus-based GVHD prophylaxis. Bone Marrow Transplant 48(1):157-8, 1/2013. e-Pub 6/2012. PMID: 22705799.
15. Poon LM, Di Stasi A, Popat U, Champlin RE, Ciurea SO. Romiplostim for delayed platelet recovery and secondary thrombocytopenia following allogeneic stem cell transplantation. Am J Blood Res 3(3):260-4, 2013. e-Pub 8/2013. PMCID: PMC3755526.
16. Kebriaei P, Basset R, Ledesma C, Ciurea S, Parmar S, Shpall EJ, Hosing C, Khouri I, Qazilbash M, Popat U, Alousi A, Nieto Y, Jones RB, de Lima M, Champlin RE, Andersson BS. Clofarabine Combined with Busulfan Provides Excellent Disease Control in Adult Patients with Acute Lymphoblastic Leukemia Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant 18(12):1819-26, 12/2012. e-Pub 6/2012. PMID: 22750645.
17. de Lima M, McNiece I, Robinson SN, Munsell M, Eapen M, Horowitz M, Alousi A, Saliba R, McMannis JD, Kaur I, Kebriaei P, Parmar S, Popat U, Hosing C, Champlin R, Bollard C, Molldrem JJ, Jones RB, Nieto Y, Andersson BS, Shah N, Oran B, Cooper LJ, Worth L, Qazilbash MH, Korbling M, Rondon G, Ciurea S, Bosque D, Maewal I, Simmons PJ, Shpall EJ. Cord-Blood Engraftment with Ex Vivo Mesenchymal-Cell Coculture. N Engl J Med 367(24):2305-15, 12/2012. PMCID: PMC3805360.
18. Ciurea SO , Mulanovich V, Saliba RM, Bayraktar UD, Jiang Y, Bassett R, Wang SA, Konopleva M, Fernandez-Vina M, Montes N, Bosque D, Chen J, Rondon G, Alatrash G, Alousi A, Bashir Q, Korbling M, Qazilbash M, Parmar S, Shpall E, Nieto Y, Hosing C, Kebriaei P, Khouri I, Popat U, de Lima M, Champlin RE. Improved Early Outcomes Using a T-cell Replete Graft Compared with T-cell Depleted Haploidentical Hematopoietic Stem-Cell Transplantation. Biol Blood Marrow Transplant 18(12):1835-44, 12/2012. e-Pub 7/2012. PMID: 22796535.
19. Nieto Y, Thall P, Valdez B, Andersson B, Popat U, Anderlini P, Shpall EJ, Bassett R, Alousi A, Hosing C, Kebriaei P, Qazilbash M, Frazier E, Gulbis A, Chancoco C, Bashir Q, Ciurea S, Khouri I, Parmar S, Shah N, Worth L, Rondon G, Champlin R, Jones RB. High-Dose Infusional Gemcitabine Combined with Busulfan and Melphalan with Autologous Stem-Cell Transplant in Patients with Refractory Lymphoid Malignancies. Biol Blood Marrow Transplant 18(11):1677-86, 11/2012. e-Pub 5/2012. PMID: 22643322.
20. Khouri IF, Saliba RM, Erwin WD, Samuels BI, Korbling M, Medeiros LJ, Valverde R, Alousi AM, Anderlini P, Bashir Q, Ciurea S, Gulbis AM, de Lima M, Hosing C, Kebriaei P, Popat UR, Fowler N, Neelapu SS, Samaniego F, Champlin RE, Macapinlac HA. Nonmyeloablative allogeneic transplantation with or without 90yttrium ibritumomab tiuxetan is potentially curative for relapsed follicular lymphoma: 12-year results. Blood 119(26):6373-78, 6/2012. e-Pub 5/2012. PMID: 22586182.
21. Mulanovich VE, Jiang Y, de Lima M, Shpall EJ, Champlin RE, Ciurea SO. Infectious complications in cord blood and T-cell depleted haploidentical stem cell transplantation. Am J Blood Res 1(1):98-105, 2011. PMCID: PMC3301419.
22. Ciurea SO, Mulanovich V, Jiang Y, Bassett R, Rondon G, McMannis J, de Lima M, Shpall EJ, Champlin RE. Lymphocyte Recovery Predicts Outcomes in Cord Blood and T-cell Depleted Haploidentical Stem Cell Transplantation. Biol Blood Marrow Transplant 17(8):1169-75, 2011. PMID: 21126598.
23. Ciurea SO, Saliba RM, Rondon G, Patah PA, Aung F, Cano P, Andersson BS, Kebriaei P, Popat U, Fernandez-Vina M, Champlin RE, de Lima M. Outcomes of patients with myeloid malignancies treated with allogeneic hematopoietic stem cell transplantation from matched unrelated donors compared with one-human leukocyte antigen mismatched related donors using HLA typing at 10 loci. Biol Blood Marrow Transplant 17(6):923-9, 2011. PMID: 20969970.
24. Khan H, Oberoi S, Mahvash A, Sharma M, Rondon G, Alousi A, Shpall EJ, Kontoyiannis DP, Champlin RE, Ciurea SO. Reversible Ureteral Obstruction due to Polyomavirus Infection after Precutaneous Nephrostomy Catheter Placement. Biol Blood Marrow Transplant 17(10):1551-5, 2011. PMID: 21396475.
25. Ciurea SO, de Lima M, Giralt S, Saliba R, Bueso-Ramos C, Andersson BS, Hosing CM, Verstovsek S, Champlin RE, Popat U. Allogeneic stem cell transplantation for myelofibrosis with leukemic transformation. Biol Blood Marrow Transplant 16(4):555-9, 2010. PMID: 20005966.
26. Ciurea SO, Saliba R, Rondon G, Pesoa S, Cano P, Fernandez-Vina M, Qureshi S, Worth LL, McMannis J, Kebriaei P, Jones RB, Korbling M, Qazilbash M, Shpall EJ, Giralt S, de Lima M, Champlin RE, Gajewski J. Reduced-intensity conditioning using fludarabine, melphalan and thiotepa for adult patients undergoing haploidentical SCT. Bone Marrow Transplant 45(3):429-36, 2010. PMID: 19668237.
27. Ciurea SO, Rodrigues M, Giralt S, de Lima M. Aging, acute myelogenous leukemia and allogeneic transplantation: do they belong in the same sentence? Clin Lymphoma Myeloma 9(4):289-97, 2009. PMID: 19717378.
28. Ciurea SO, Andersson BS. Busulfan in hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 15(5):523-36, 2009. PMID: 19361744.
29. Ciurea SO, de Lima M, Cano P, Korbling M, Giralt S, Shpall EJ, Wang X, Thall PF, Champlin RE, Fernandez-Vina M. High Risk of Graft Failure in Patients with Anti-HLA Antibodies Undergoing Haploidentical Stem Cell Transplantation. Transplantation 88(8):1019-24, 2009. PMID: 19855248.
30. Ciurea SO, Sadegi B, Wilbur A, Alagiozian-Angelova V, Gaitonde S, Dobogai LC, Akard LP, Hoffman R, Rondelli D. Effects of extensive splenomegaly in patients with myelofibrosis undergoing a reduced intensity allogeneic stem cell transplantation. Br J Haematol 141(1):80-3, 2008. PMID: 18324970.
31. Chunduri S, Gaitonde S, Ciurea SO, Hoffman R, Rondelli D. Pulmonary extramedullary hematopoiesis in patients with myelofibrosis undergoing allogeneic stem cell transplantation. Haematologica 93(10):1593-5, 2008. PMID: 18641018.
32. Lee HJ, Gulbis A, De Padua Silva L, Hosing C, Khouri I, de Lima M, Champlin RE, Ciurea SO. Rituximab for passenger lymphocyte syndrome associated with allogeneic SCT. Bone Marrow Transplant 42(1):67-9, 2008. PMID: 18347568.
33. Tam CS, Nussenzveig RM, Popat U, Bueso-Ramos CE, Thomas DA, Cortes JA, Champlin RE, Ciurea SO, Manshouri T, Pierce SM, Kantarjian HM, Verstovsek S. The natural history and treatment outcome of blast phase BCR-ABL- myeloproliferative neoplasms. Blood 112(5):1628-37, 2008. PMCID: PMC2518875.
34. Ciurea SO, Hoffman R. Cytokines for the treatment of thrombocytopenia. Semin Hematol 44(3):166-82, 2007. PMID: 17631181.
35. Hoffman R, Prchal JT, Samuelson S, Ciurea SO, Rondelli D. Philadelphia chromosome-negative myeloproliferative disorders: biology and treatment. Biol Blood Marrow Transplant 13(1 Suppl 1):64-72, 2007. PMID: 17222772.
36. Ciurea SO, Merchant D, Mahmud N, Ishii T, Zhao Y, Hu W, Bruno E, Barosi G, Xu M, Hoffman R. Pivotal contributions of megakaryocytes to the biology of idiopathic myelofibrosis. Blood 110(3):986-93, 2007. PMCID: PMC1924766.
37. Ishii T, Xu M, Zhao Y, Hu WY, Ciurea S, Bruno E, Hoffman R. Recurrence of clonal hematopoiesis after discontinuing pegylated recombinant interferon-alpha 2a in a patient with polycythemia vera. Leukemia 21(2):373-4, 2007. PMID: 17122864.
38. Ciurea SO, Thulborn KR, Gowhari M. Dural venous sinus thrombosis in a patient with sickle cell disease: case report and literature review. Am J Hematol 81(4):290-3, 2006. PMID: 16550522.
39. Ciurea S, Beri R, Dobogai L, Chunduri S, Mahmud N, Rondelli D, Peace D. The use of blood conservation methods in addition to erythropoietin allows myeloablative allogeneic stem cell transplantation without the use of blood products. Bone Marrow Transplant 37(3):325-7, 2006. PMID: 16314850.

Invited Articles

1. Bayraktar UD, Ciurea SO. Strategies in Haploidentical Stem Cell Transplantation. Turkish Journal of Hematology. In Press.
2. Farhan S, Lee DA, Champlin RE,Ciurea SO. NK cell therapy: targeting disease relapse after hematopoietic stem cell transplantation. Immunotherapy 4(3):305-13, 3/2012. e-Pub 2/2012. PMID: 22329587.
3. Bayraktar UD, Champlin RE, Ciurea SO. Progress in Haploidentical Stem Cell Transplantation. Biol Blood Marrow Transplant 18(3):372-80, 3/2012. e-Pub 8/2011. PMID: 21835146.
Other Articles
1. Ciurea SO, Champlin RE. Outcomes of Patients Treated and One Human Leukocyte Antigen Mismatched Related Compared with Matched Unrelated Donors. Biol Blood Marrow Transplant 17(8):1261, 2011. PMID: 21699878.

Book Chapters

1. Ciurea SO, Jimenez AM. Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia. In: Expert Clinical Perspective on Diagnosis and Management of Cancer. In Press.
2. Ciurea SO, Hoffman R. The Polycythemias. In: Oxford Textbook of Medicine, 5th Edition. Oxford University Press: Oxford, UK, 2010.
3. Ciurea SO, Hoffman R. Thrombocytosis. In: Oxford Textbook of Medicine, 5th Edition. Oxford University Press: Oxford, UK, 2010.
4. Sozer S, Ciurea SO, Hoffman R. Hematopoietic Stem Cells and Regenerative Medicine. In: Translational Approaches in Tissue Engineering and Regenerative Medicine, 2007.

Grant & Contract Support

Title: NK Cells to Prevent Disease Relapse for Patients High Risk Myeloid Malignancies
Funding Source: MDACC
Role: Principal Investigator
Duration: 5/1/2014 - 4/30/2015
Title: Mechanisms of Graft Failure and Disease Relapse after Haploidentical Stem Cell Transplantation, Institutional Research grant (IRG)
Funding Source: The University of Texas M D Anderson Cancer Center
Role: Principal Investigator
Duration: 4/1/2010 - 3/31/2012
Title: The Therapy of CML
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Champlin
Duration: 2/12/1997 - 6/30/2015

Last updated: 10/10/2014