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Stephen H. Settle, MD, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2005 Vanderbilt University School of Medicine, Nashville, TN, MD, Medicine
2001 Stanford University School of Medicine, Stanford, CA, PhD, Developmental Biology
1992 University of California, Davis, CA, BS, Genetics

Postgraduate Training

7/2008-6/2010 Research Fellowship, Baylor College of Medicine, Houston, TX, Bert O'Malley, M.D.
7/2006-6/2010 Clinical Residency, The University of Texas MD Anderson Cancer Center, Houston, TX, Christopher Crane, M.D.
7/2005-6/2006 Medical Intern, Vanderbilt University School of Medicine, Nashville, TN
8/2000-6/2005 Research Fellowship, Vanderbilt University School of Medicine, Nashville, TN, Robert Coffey, M.D.

Experience/Service

Academic Appointments

Assistant Professor, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 2010-present

Honors and Awards

2008 Fletcher Society Resident Essay Award
2005 Harrison Shull, Sr. Gastroenterology Award
2005 John L. Shapiro Award for Excellence in Pathology
2001-2005 Canby Robinson Scholarship, Vanderbilt University School of Medicine
1991 Departmental Citation for Outstanding Student, University of California, Davis, Department of Genetics
1990 President's Undergraduate Fellowship, University of California, Davis

Professional Memberships

ASTRO
Member, 2006-present
Sigma Xi, The Scientific Research Society
Member, 2003-present
Society for Neuro-Oncology
Member, 2010-present
The Tinsely Randolph Harrison Society of Physician-Scientists in Medicine
Member, 2002-2005

Selected Publications

Peer-Reviewed Original Research Articles
1. Welsh J, Settle SH, Amini A, Xiao L, Suzuki A, Hayashi Y, Hofstetter W, Komaki R, Liao Z, Ajani JA. Failure Patterns in Patients With Esophageal Cancer Treated With Definitive Chemoradiation. Cancer 118(10):2632-640, http://onlinelibrary.wiley.com/doi/10.1002/cncr.26586/pdf, 5/2012. e-Pub 10/2011. PMID: 22565611.
2. Welsh J, Palmer MB, Ajani JA, Liao Z, Swisher SG, Hofstetter WL, Allen PK, Settle SH, Gomez D, Likhacheva A, Cox JD, Komaki R. Esophageal Cancer Dose Escalation using a Simultaneous Integrated Boost Technique. Int J Radiat Oncol Biol Phys 82(1):468-74, 1/2012. e-Pub 12/2010. PMID: 21123005.
3. Kaiser S, Park YK, Franklin JL, Halberg RB, Yu M, Jessen WJ, Freudenberg J, Chen X, Haigis K, Jegga AG, Kong S, Sakthivel B, Xu H, Reichling T, Azhar M, Boivin GP, Roberts RB, Bissahoyo AC, Gonzales F, Bloom GC, Eschrich S, Carter SL, Aronow JE, Kleimeyer J, Kleimeyer M, Ramaswamy V, Settle SH, Boone B, Levy S, Graff JM, Doetschman T, Groden J, Dove WF, Threadgill DW, Yeatman TJ, Coffey RJ, Aronow BJ. Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol 8(7):R131, 2007. PMCID: PMC2323222.
4. Settle SH, Washington K, Lind C, Itzkowitz S, Fiske WH, Burdick JS, Jerome WG, Ray M, Weinstein W, Coffey RJ. Chronic treatment of Ménétrier's disease with Erbitux: clinical efficacy and insight into pathophysiology. Clin Gastroenterol Hepatol 3(7):654-59, 7/2005. PMID: 16206497.
5. Nomura S, Settle SH, Leys CM, Means AL, Peek RM, Leach SD, Wright CV, Coffey RJ, Goldenring JR. Evidence for repatterning of the gastric fundic epithelium associated with Ménétrier's disease and TGFalpha overexpression. Gastroenterology 128(5):1292-305, 5/2005. PMID: 15887112.
6. Park YK, Franklin JL, Settle SH, Levy SE, Chung E, Jeyakumar LH, Shyr Y, Washington MK, Whitehead RH, Aronow BJ, Coffey RJ. Gene expression profile analysis of mouse colon embryonic development. Genesis 41(1):1-12, 1/2005. PMID: 15645444.
7. Settle SH, Rountree RB, Sinha A, Thacker A, Higgins K, Kingsley DM. Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes. Dev Biol 254(1):116-30, 2/2003. PMID: 12606286.
8. Roberts RB, Min L, Washington MK, Olsen SJ, Settle SH, Coffey RJ, Threadgill DW. Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc Natl Acad Sci U S A 99(3):1521-526, 2/2002. e-Pub 1/2002. PMCID: PMC122223.
9. Settle S, Marker P, Gurley K, Sinha A, Thacker A, Wang Y, Higgins K, Cunha G, Kingsley DM. The bmp family member Gdf7 is required for seminal vesicle growth, branching morphogenesis, and cytodifferentiation. Dev Biol 234(1):138-50, 6/2001.
10. Settle SH, Green MM, and Burtis KC. The silver gene of Drosophila melanogaster encodes multiplle carboxypeptidases similar to mammalian prohormone-processing enzymes. Proc Natl Acad Sci USA 21(92):9470-474, 10/1995.
Other Articles
1. Settle SH, Sulman EP. Tumor Profiling: Development of Prognostic and Predictive Factors to Guide Brain Tumor Treatment. Curr Oncol Rep 13(1):26-36, 2/2011. e-Pub 11/2010. PMID: 21082294.
2. Crane CH, Varadhachary G, Settle S, Fleming JB, Evans DB, Wolff RA. The Integration of Chemoradiation in the Care of Patient with Localized Pancreatic Cancer. Cancer Radiotherapie. 13(2):123-43, 4/2009.
3. Settle SH, Meyer J, Crane CH. Developments in chemoradiation in advanced pancreatic cancer, in Handbook of Pancreatic Cancer. Springer, 2009.
4. Burdick JS, Settle S, Coffey R. Menetrier's Disease. Encyclopedia of Gastroenterology 1-3:645-646, 2004.

Last updated: 2/14/2013