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Stephen E. Ullrich, Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
7455 Fannin St
Unit Number: Unit 902
Houston, TX 77054
Room Number: SCR4.3011

Education & Training

Degree-Granting Education

1979 Georgetown University, Washington, DC, PHD, Microbiology
1975 St. Bonaventure University, Olean, NY, BS, Biology

Postgraduate Training

10/1979-8/1982 Research Fellowship, Pathology, New York University Medical Center, New York, NY, Dr. Susan Zolla-Pazner


Academic Appointments

Regular Member, Graduate Faculty, The University of Texas Graduate School of Biomedical Sciences, Houston, TX, 9/1987-present

Administrative Appointments/Responsibilities

Associate Director, The University of Texas MD Anderson Cancer Center, The Center for Cancer Immunology Research, Houston, TX, 9/2003-present

Endowed Positions

Dallas/Fort Worth Living Legends Professorship, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2004-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Chacón-Salinas R, Limón-Flores AY, Chávez-Blanco AD, Gonzalez-Estrada A, Ullrich SE. Mast cell-derived IL-10 suppresses germinal center formation by affecting T follicular helper cell function. J Immunol 186(1):25-31, 1/1/2011. e-Pub 11/22/2010. PMCID: PMC3059502.
2. Puebla-Osorio N, Miyahara Y, Coimbatore S, Limón-Flores AY, Kazimi N, Ullrich SE, Zhu C. Induction of B-cell lymphoma by UVB radiation in p53 haploinsufficient mice. BMC Cancer 11:36-46, 2011. e-Pub 1/2011. PMCID: PMC3041776.
3. Fukunaga A, Khaskhely NM, Ma Y, Sreevidya CS, Taguchi K, Nishigori C, Ullrich SE. Langerhans cells serve as immunoregulatory cells by activating NKT cells. J Immunol 185(8):4633-40, 10/15/2010. e-Pub 9/15/2010. PMCID: PMC2950871.
4. Tavana O, Benjamin CL, Puebla-Osorio N, Sang M, Ullrich SE, Ananthaswamy HN, Zhu C. Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence. Cell Cycle 9(16):3328-36, 8/15/2010. e-Pub 8/16/2010. PMID: 20703098.
5. Sreevidya CS, Fukunaga A, Khaskhely NM, Masaki T, Ono R, Nishigori C, Ullrich SE. Agents that reverse UV-Induced immune suppression and photocarcinogenesis affect DNA repair. J Invest Dermatol 130(5):1428-37, 5/2010. e-Pub 10/15/2009. PMCID: PMC2855396.
6. Limón-Flores AY, Chacón-Salinas R, Ramos G, Ullrich SE. Mast Cells Mediate the Immune Suppression Induced by Dermal Exposure to JP-8 jet fuel1. Toxicol Sci 112(1):144-52, 11/2009. e-Pub 9/2/2009. PMCID: PMC2769063.
7. Ramos G, Limon-Flores AY, Ullrich SE. JP-8 induces immune suppression via a reactive oxygen species NF-kappabeta-dependent mechanism. Toxicol Sci 108(1):100-9, 3/2009. e-Pub 12/18/2008. PMCID: PMC2721654.
8. Sreevidya CS, Khaskhely NM, Fukunaga A, Khaskina P, Ullrich SE. Inhibition of photocarcinogenesis by platelet-activating factor or serotonin receptor antagonists. Cancer Res 68(10):3978-84, 5/15/2008. PMCID: PMC2394717.
9. Byrne SN, Limón-Flores AY, Ullrich SE. Mast cell migration from the skin to the draining lymph nodes upon ultraviolet irradiation represents a key step in the induction of immune suppression. J Immunol 180(7):4648-55, 4/1/2008. PMCID: PMC2391302.
10. Fukunaga A, Khaskhely NM, Sreevidya CS, Byrne SN, Ullrich SE. Dermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response. J Immunol 180(5):3057-64, 3/1/2008. PMCID: PMC2408377.
11. Ramos G, Limon-Flores AY, Ullrich SE. Dermal Exposure to Jet Fuel Suppresses Delayed Type Hypersensitivity: A Critical Role for Aromatic Hydrocarbons. Toxicol Sci 100(2):415-422, 12/2007. e-Pub 9/22/2007. PMID: 17890764.
12. Ullrich SE, Nghiem DX, and Khaskina P. Suppression of an established immune response by UVA: A critical role for mast cells. Photochem Photobiol 83(5):1095-1100, Sep-Oct, 9/2007. PMCID: PMC2515596.
13. Walterscheid JP, Nghiem DX, Kazimi N, Nutt LK, McConkey DJ, Norval M, Ullrich SE. Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor. Proc Natl Acad Sci U S A 103(46):17420-5, 11/2006. PMID: 17085585.
14. Matsumura Y, Byrne SN, Nghiem DX, Miyahara Y, Ullrich SE. A role for inflammatory mediators in the induction of immunoregulatory B cells. J Immunol 177(7):4810-7, 10/2006. PMID: 16982922.
15. Vijayalaxmi , Kligerman AD, Prihoda TJ, Ullrich SE. Micronucleus studies in the peripheral blood and bone marrow of mice treated with jet fuels, JP-8 and Jet-A. Mutat Res 608(1):82-7, 9/19/2006. e-Pub 7/3/2006. PMID: 16815737.
16. Wolf P, Nghiem DX, Walterscheid JP, Byrne S, Matsumura Y, Matsumura Y, Bucana C, Ananthaswamy HN, Ullrich SE. Platelet-activating factor is crucial in psoralen and ultraviolet A-induced immune suppression, inflammation, and apoptosis. Am J Pathol 169(3):795-805, 9/2006. PMCID: PMC1579250.
17. Jimenez-Flores R, Mendez-Cruz R, Ojeda-Ortiz J, Muñoz-Molina R, Balderas-Carrillo O, de la Luz Diaz-Soberanes M, Lebecque S, Saeland S, Daneri-Navarro A, Garcia-Carranca A, Ullrich SE, Flores-Romo L. High-risk human papilloma virus infection decreases the frequency of dendritic Langerhans' cells in the human female genital tract. Immunology 117(2):220-8, 2/2006. PMCID: PMC1782223.
18. Matsumura Y, Moodycliffe AM, Nghiem DX, Ullrich SE, Ananthaswamy HN. Inverse relationship between increased apoptosis and decreased skin cancer in UV-irradiated CD1d-/- mice. Photochem Photobiol 81(1):46-51, 2005. PMID: 15496135.
19. Matsumura Y, Moodycliffe AM, Nghiem DX, Ullrich SE, Ananthaswamy HN. Resistance of CD1d-/- mice to ultraviolet-induced skin cancer is associated with increased apoptosis. Am J Pathol 165(3):879-87, 9/2004. PMID: 15331412.
20. Ramos G, Kazimi N, Nghiem DX, Walterscheid JP, Ullrich SE. Platelet activating factor receptor binding plays a critical role in jet fuel-induced immune suppression. Toxicol Appl Pharmacol 195(3):331-8, 3/2004. PMID: 15020195.
21. Vijayalaxmi V, Kligerman AD, Prihoda TJ, Ullrich SE. Cytogenetic studies in mice treated with the jet fuels, Jet-A and JP-8. Cytogenet Genome Res 104(1-4):371-5, 2004. PMID: 15162067.
22. Sims-Mourtada JC, Guzman-Rojas L, Rangel R, Nghiem DX, Ullrich SE, Guret C, Cain K, Martinez-Valdez H. In vivo expression of interleukin-8, and regulated on activation, normal, T-cell expressed, and secreted, by human germinal centre B lymphocytes. Immunology 110(3):296-303, 11/2003. PMID: 14632656.
23. Kim TH, Moodycliffe AM, Yarosh DB, Norval M, Kripke ML, Ullrich SE. Viability of the antigen determines whether DNA or urocanic acid act as initiator molecules for UV-induced suppression of delayed-type hypersensitivity. Photochem Photobiol 78(3):228-34, 9/2003. PMID: 14556308.
24. Kim TH, Ananthaswamy HN, Kripke ML, Ullrich SE. Advantages of using hairless mice versus haired mice to test sunscreen efficacy against photoimmune suppressions. Photochem Photobiol 78(1):37-42, 7/2003. PMID: 12929746.
25. Nghiem DX, Kazimi N, Mitchell DL, Vink AA, Ananthaswamy HN, Kripke ML, Ullrich SE. Mechanisms underlying the suppression of established immune responses by ultraviolet radiation. J Invest Dermatol 119(3):600-9, 9/2002. PMID: 12230501.
26. Guo Z, Clydesdale G, Cheng J, Kim K, Gan L, McConkey DJ, Ullrich SE, Zhuang Y, Su B. Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction. Mol Cell Biol 22(16):5761-8, 8/2002. PMID: 12138187.
27. Santamaria AB, Davis DW, Nghiem DX, McConkey DJ, Ullrich SE, Kapoor M, Lozano G, Ananthaswamy HN. p53 and Fas ligand are required for psoralen and UVA-induced apoptosis in mouse epidermal cells. Cell Death Differ 9(5):549-60, 5/2002. PMID: 11973613.
28. Ramos G, Nghiem DX, Walterscheid JP, Ullrich SE. Dermal application of jet fuel suppresses secondary immune reactions. Toxicol Appl Pharmacol 180(2):136-44, 4/2002. PMID: 11969381.
29. Walterscheid JP, Ullrich SE, Nghiem DX. Platelet-activating factor, a molecular sensor for cellular damage, activates systemic immune suppression. J Exp Med 195(2):171-9, 1/2002. PMID: 11805144.
30. Nghiem DX, Kazimi N, Clydesdale G, Ananthaswamy HN, Kripke ML, Ullrich SE. Ultraviolet a radiation suppresses an established immune response: implications for sunscreen design. J Invest Dermatol 117(5):1193-9, 11/2001. PMID: 11710932.
31. Jiang W, Ananthaswamy HN, Muller HK, Ouhtit A, Bolshakov S, Ullrich SE, El-Naggar AK, Kripke ML. UV irradiation augments lymphoid malignancies in mice with one functional copy of wild-type p53. Proc Natl Acad Sci U S A 98(17):9790-5, 8/2001. PMID: 11481437.
32. Brown EL, Ullrich SE, Pride M, Kripke ML. The effect of UV irradiation on infection of mice with Borrelia burgdorferi. Photochem Photobiol 73(5):537-44, 5/2001. PMID: 11367577.
33. Moodycliffe AM, Nghiem D, Clydesdale G, Ullrich SE. Immune suppression and skin cancer development: regulation by NKT cells. Nat Immunol 1(6):521-5, 12/2000. PMID: 11101875.
34. Ullrich SE, Lyons HJ. Mechanisms involved in the immunotoxicity induced by dermal application of JP-8 jet fuel. Toxicol Sci 58(2):290-8, 12/2000. PMID: 11099641.
35. Schmitt DA, Ullrich SE. Exposure to ultraviolet radiation causes dendritic cells/macrophages to secrete immune-suppressive IL-12p40 homodimers. J Immunol 165(6):3162-7, 9/2000. PMID: 10975830.
36. Schmitt DA, Walterscheid JP, Ullrich SE. Reversal of ultraviolet radiation-induced immune suppression by recombinant interleukin-12: suppression of cytokine production. Immunology 101(1):90-6, 9/2000. PMID: 11012758.
37. Moodycliffe AM, Shreedhar V, Ullrich SE, Walterscheid J, Bucana C, Kripke ML, Flores-Romo L. CD40-CD40 ligand interactions in vivo regulate migration of antigen-bearing dendritic cells from the skin to draining lymph nodes. J Exp Med 191(11):2011-20, 6/2000. PMID: 10839815.
38. Ouhtit A, Muller HK, Davis DW, Ullrich SE, McConkey D, Ananthaswamy HN. Temporal events in skin injury and the early adaptive responses in ultraviolet-irradiated mouse skin. Am J Pathol 156(1):201-7, 2000. PMID: 10623668.
39. Shreedhar V, Moodycliffe AM, Ullrich SE, Bucana C, Kripke ML, Flores-Romo L. Dendritic cells require T cells for functional maturation in vivo. Immunity 11(5):625-36, 11/1999. PMID: 10591187.
40. Ullrich SE. Dermal application of JP-8 jet fuel induces immune suppression. Toxicol Sci 52(1):61-7, 11/1999. PMID: 10568699.
41. Yarosh DB, Kibitel J, Ullrich SE, Kim TH, Ananthaswamy HN, Krien P, Fourtanier A, Kripke ML. Direct comparison of DNA damage, isomerization of urocanic acid and edema in the mouse produced by three commonly used artificial UV light sources. Photochem Photobiol 69(5):571-4, 5/1999. PMID: 10333763.
42. Ananthaswamy HN, Ullrich SE, Mascotto RE, Fourtanier A, Loughlin SM, Khaskina P, Bucana CD, Kripke ML. Inhibition of solar simulator-induced p53 mutations and protection against skin cancer development in mice by sunscreens. J Invest Dermatol 112(5):763-8, 5/1999. PMID: 10233769.
43. Moodycliffe AM, Maiti S, Ullrich SE. Splenic NK1.1-negative, TCR alpha beta intermediate CD4+ T cells exist in naive NK1.1 allelic positive and negative mice, with the capacity to rapidly secrete large amounts of IL-4 and IFN-gamma upon primary TCR stimulation. J Immunol 162(9):5156-63, 5/1999. PMID: 10227987.
44. Kim TH, Ullrich SE, Ananthaswamy HN, Zimmerman S, Kripke ML. Suppression of delayed and contact hypersensitivity responses in mice have different UV dose responses. Photochem Photobiol 68(5):738-44, 11/1998. PMID: 9825703.
45. Nishigori C, Yarosh D, O'Connor A, Shreedhar VK, Ullrich SE, Cox P, Kripke ML. HindIII liposomes suppress delayed-type hypersensitivity responses in vivo and induce epidermal IL-10 in vitro. J Immunol 161(6):2684-91, 9/1998. PMID: 9743324.
46. Ullrich SE, Pride MW, Moodycliffe AM. Antibodies to the costimulatory molecule CD86 interfere with ultraviolet radiation-induced immune suppression. Immunology 94(3):417-23, 7/1998. PMID: 9767426.
47. Byeon SW, Pelley RP, Ullrich SE, Waller TA, Bucana CD, Strickland FM. Aloe barbadensis extracts reduce the production of interleukin-10 after exposure to ultraviolet radiation. J Invest Dermatol 110(5):811-7, 5/1998. PMID: 9579551.
48. Shreedhar V, Giese T, Sung VW, Ullrich SE. A cytokine cascade including prostaglandin E2, IL-4, and IL-10 is responsible for UV-induced systemic immune suppression. J Immunol 160(8):3783-9, 4/1998. PMID: 9558081.
49. Ananthaswamy HN, Fourtanier A, Evans RL, Tison S, Medaisko C, Ullrich SE, Kripke ML. p53 Mutations in hairless SKH-hr1 mouse skin tumors induced by a solar simulator. Photochem Photobiol 67(2):227-32, 2/1998. PMID: 9487800.
50. Ananthaswamy HN, Loughlin SM, Cox P, Evans RL, Ullrich SE, Kripke ML. Sunlight and skin cancer: inhibition of p53 mutations in UV-irradiated mouse skin by sunscreens. Nat Med 3(5):510-4, 5/1997. PMID: 9142118.
51. Vink AA, Moodycliffe AM, Shreedhar V, Ullrich SE, Roza L, Yarosh DB, Kripke ML. The inhibition of antigen-presenting activity of dendritic cells resulting from UV irradiation of murine skin is restored by in vitro photorepair of cyclobutane pyrimidine dimers. Proc Natl Acad Sci U S A 94(10):5255-60, 5/1997. PMID: 9144224.
52. Huang S, Xie K, Bucana CD, Ullrich SE, Bar-Eli M. Interleukin 10 suppresses tumor growth and metastasis of human melanoma cells: potential inhibition of angiogenesis. Clin Cancer Res 2(12):1969-79, 12/1996. PMID: 9816156.
53. Moodycliffe AM, Bucana CD, Kripke ML, Norval M, Ullrich SE. Differential effects of a monoclonal antibody to cis-urocanic acid on the suppression of delayed and contact hypersensitivity following ultraviolet irradiation. J Immunol 157(7):2891-9, 10/1996. PMID: 8816394.
54. Nishigori C, Yarosh DB, Ullrich SE, Vink AA, Bucana CD, Roza L, Kripke ML. Evidence that DNA damage triggers interleukin 10 cytokine production in UV-irradiated murine keratinocytes. Proc Natl Acad Sci U S A 93(19):10354-9, 9/1996. PMID: 8816804.
55. Jeevan A, Ullrich SE, De Gracia M, Shah R, Sun Y. Mechanism of UVB-induced suppression of the immune response to Mycobacterium bovis bacillus Calmette-Guerin: role of cytokines on macrophage function. Photochem Photobiol 64(2):259-66, 8/1996. PMID: 8760565.
56. O‘Conner A, Nishigori C, Yarosh D, Alas L, Kibitel J, Burley L, Cox P, Bucana C, Ullrich S, Kripke ML. DNA double-strand breaks in epidermal cells cause immune suppression in vivo and cytokine production in vitro. J. Immunol. 157:271-278, 1996.
57. Brown EL, Rivas JM, Ullrich SE, Young CR, Norris SJ, Kripke ML. Modulation of immunity to Borrelia burgdorferi by ultraviolet irradiation: differential effect on Th1 and Th2 immune responses. Eur J Immunol 25(11):3017-22, 11/1995. PMID: 7489737.
58. Lachman LB, Shih LC, Rao XM, Hu X, Bucana CD, Ullrich SE, Cleland JL. Cytokine-containing liposomes as adjuvants for HIV subunit vaccines. AIDS Res Hum Retroviruses 11(8):921-32, 8/1995. PMID: 7492439.
59. Beissert S, Ullrich SE, Hosoi J, Granstein RD. Supernatants from UVB radiation-exposed keratinocytes inhibit Langerhans cell presentation of tumor-associated antigens via IL-10 content. J Leukoc Biol 58(2):234-40, 8/1995. PMID: 7643016.
60. Schmitt DA, Owen-Schaub L, Ullrich SE. Effect of IL-12 on immune suppression and suppressor cell induction by ultraviolet radiation. J Immunol 154(10):5114-20, 5/1995. PMID: 7730617.
61. Gottesfeld Z, Ullrich SE. Prenatal alcohol exposure selectively suppresses cell-mediated but not humoral immune responsiveness. Int J Immunopharmacol 17(3):247-54, 3/1995. PMID: 7558520.
62. Rivas JM, Ullrich SE. The role of IL-4, IL-10, and TNF-alpha in the immune suppression induced by ultraviolet radiation. J Leukoc Biol 56(6):769-75, 12/1994. PMID: 7996051.
63. Ullrich SE. Mechanism involved in the systemic suppression of antigen-presenting cell function by UV irradiation: Keratinocyte-derived IL-10 modulates antigen-presenting cell function of splenic adherent cells. J. Immunol 152:3410-3416, 1994.
64. Chen P, Ullrich SE, Ananthaswamy HN. Presentation of endogenous tumor antigens to CD4+ T lymphocytes by murine melanoma cells transfected with major histocompatibility complex II genes. J. Leuko. Biol 56:469-473, 1994.
65. Rivas JM, Ullrich SE. Systemic suppression of delayed-type hypersensitivity by supernatants from UV-irradiated keratinocytes. An essential role for keratinocyte-derived IL-10. J Immunol 149(12):3865-71, 12/1992. PMID: 1460278.
66. Ullrich SE, Fidler IJ. Liposomes containing muramyl tripeptide phosphatidylethanolamine (MTP-PE) are excellent adjuvants for induction of an immune response to protein and tumor antigens. J Leukoc Biol 52(5):489-94, 11/1992. PMID: 1431559.
67. Jeevan A, Ullrich SE, Dizon VV, Kripke ML. Supernatants from UV-irradiated keratinocytes decrease the resistance and delayed-type hypersensitivity response to Mycobacterium Bovis BCG in mice and impair the phagocytic ability of macrophages. Photodermatology Photoimmunology & Photomedicine 9:255-263, 1992.
68. Yarosh D, Alas L, Kibitel J, Ullrich SE. Urocanic acid isomers, immunosuppressive cytokines, and the induction of Human Immunodeficiency Virus. Photodermatology Photoimmunology & Photomedicine 9:127-130, 1992.
69. Aubin F, Kripke ML, Ullrich SE. Activation of keratinocytes with psoralen plus UVA radiation induces the release of soluble factors that suppress delayed and contact hypersensitivity. J Invest Dermatol 97(6):995-1000, 12/1991. PMID: 1748824.
70. Ullrich SE. Systemic immunosuppression of cell-mediated immune reactions by a monofunctional psoralen plus ultraviolet A radiation. Photodermatol Photoimmunol Photomed 8(3):116-22, 6/1991. PMID: 1839504.
71. Ullrich SE. Photoinactivation of T-cell function with psoralen and UVA radiation suppresses the induction of experimental murine graft-versus-host disease across major histocompatibility barriers. J Invest Dermatol 96(3):303-8, 3/1991. PMID: 2002250.
72. Ullrich SE, McIntyre BW, Rivas JM. Suppression of the immune response to alloantigen by factors released from ultraviolet-irradiated keratinocytes. J Immunol 145(2):489-98, 7/1990. PMID: 2142179.
73. Yee GK, Levy JG, Kripke ML, Ullrich SE. The role of suppressor factors in the regulation of immune responses by ultraviolet radiation-induced suppressor T lymphocytes. III. Isolation of a suppressor factor with the B16G monoclonal antibody. Cell Immunol 126(2):255-67, 4/1990. PMID: 2138059.
74. Hostetter RB, Campbell DE, Kerckhoff S, Cleary KR, Ullrich S, Thomas P, Jessup JM. Carcinoembryonic antigen enhances metastatic potential of colorectal carcinoma. Archives of Surgery 125:300-304, 1990.
75. Kim TY, Kripke ML, Ullrich SE. Immunosuppression by factors released from UV-irradiated epidermal cells: selective effects on the generation of contact and delayed hypersensitivity after exposure to UVA or UVB radiation. J Invest Dermatol 94(1):26-32, 1990. PMID: 2295834.
76. Magee MJ, Kripke ML, Ullrich SE. Inhibition of the immune response to alloantigen in the rat by exposure to ultraviolet radiation. Photochem Photobiol 50(2):193-9, 8/1989. PMID: 2780815.
77. Alcalay J, Ullrich SE, Kripke ML. Local suppression of contact hypersensitivity in mice by a monofunctional psoralen plus UVA radiation. Photochem Photobiol 50(2):217-20, 8/1989. PMID: 2780817.
78. Magee MJ, Kripke ML, Ullrich SE. Suppression of the elicitation of the immune response to alloantigen by ultraviolet radiation. Transplantation 47(6):1008-13, 6/1989. PMID: 2472022.
79. Yee GK, Ullrich SE, Kripke ML. The role of suppressor factors in the regulation of immune responses by ultraviolet radiation-induced suppressor T lymphocytes. I. Activity of suppressor cell culture supernatants. Cell Immunol 121(1):74-87, 6/1989. PMID: 2524279.
80. Yee GK, Ullrich SE, Kripke ML. The role of suppressor factors in the regulation of immune responses by ultraviolet radiation-induced suppressor T lymphocytes. II. Activity of suppressor cell culture sonicates. Cell Immunol 121(1):88-98, 6/1989. PMID: 2524280.
81. Ullrich SE, Magee M. Specific suppression of allograft rejection after treatment of recipient mice with ultraviolet radiation and allogeneic spleen cells. Transplantation 46(1):115-9, 7/1988. PMID: 2969152.
82. Ullrich SE. The effect of ultraviolet radiation-induced suppressor cells on T-cell activity. Immunology 60(3):353-60, 3/1987. PMID: 2952584.
83. Ullrich SE. Suppression of the immune response to allogeneic histocompatibility antigens by a single exposure to ultraviolet radiation. Transplantation 42(3):287-91, 9/1986. PMID: 3750386.
84. Ullrich SE, Azizi E, Kripke ML. Suppression of the induction of delayed-type hypersensitivity reactions in mice by a single exposure to ultraviolet radiation. Photochem Photobiol 43(6):633-8, 6/1986. PMID: 2944137.
85. Ullrich SE, Yee GK, Kripke ML. Suppressor lymphocytes induced by epicutaneous sensitization of UV-irradiated mice control multiple immunological pathways. Immunology 58(2):185-90, 6/1986. PMID: 2940172.
86. Ullrich SE. Suppression of lymphoproliferation by hapten-specific suppressor T lymphocytes from mice exposed to ultraviolet radiation. Immunology 54(2):343-52, 2/1985. PMID: 2578432.
87. Ullrich SE, Kripke ML. Mechanisms in the suppression of tumor rejection produced in mice by repeated UV irradiation. J Immunol 133(5):2786-90, 11/1984. PMID: 6237155.
88. Ullrich SE, Herscowitz HB. Immunological function of alveolar macrophages: interaction with a soluble protein antigen and the immunogenicity of alveolar macrophage-associated antigen. J Reticuloendothel Soc 28(2):111-27, 8/1980. PMID: 6967975.
89. Ullrich SE, Zolla-Pazner S. A disposable diffusion chamber system used to study immunoregulation by soluble factors. J Immunol Methods 39(1-2):147-54, 1980. PMID: 7462643.

Invited Articles

1. Ullrich SE, Byrne SN. The Immunologic Revolution: Photoimmunology. J Invest Dermatol 132(3 Pt 2):896-905, 3/2012. PMCID: PMC3279601.
2. Benjamin CA, Ullrich SE, Kripke ML, Ananthaswamy HN. p53 Tumor Suppressor Gene: A critical molecular target for UV induction and prevention of skin cancer. Photochem Photobiol 84(1):55-62, Jan-Feb, 1/2008. PMID: 18173701.
3. Ullrich SE. Sunlight and Skin Cancer: Lessons from the Immune System. Mol Carcinog 46(8):629-633, 8/2007. PMCID: PMC2661262.
4. Greinix HT, Socié G, Bacigalupo A, Holler E, Edinger MG, Apperley JF, Schwarz T, Ullrich SE, Albert ML, Knobler RM, Peritt D, Ferrara JL. Assessing the potential role of photopheresis in hematopoietic stem cell transplant. Bone Marrow Transplant 38(4):265-73, 8/2006. PMID: 16883310.
5. Ullrich SE. Mechanisms underlying UV-induced immune suppression. Mutat Res 571(1-2):185-205, 4/2005. PMID: 15748647.
6. Walterscheid JP, Nghiem DX, Ullrich SE. Determining the role of cytokines in UV-induced immunomodulation. Methods 28(1):71-8, 9/2002. PMID: 12231190.
7. Nghiem DX, Walterscheid JP, Kazimi N, Ullrich SE. Ultraviolet radiation-induced immunosuppression of delayed-type hypersensitivity in mice. Methods 28(1):25-33, 9/2002. PMID: 12231185.
8. Ullrich SE. Photoimmune suppression and photocarcinogenesis. Front Biosci 7:d684-703, 3/2002. PMID: 11861222.
9. Ullrich SE, Schmitt DA. The role of cytokines in UV-induced systemic immune suppression. J Dermatol Sci 23 Suppl 1:S10-2, 3/2000. PMID: 10764984.
10. Huang S, Ullrich SE, Bar-Eli M. Regulation of tumor growth and metastasis by interleukin-10: the melanoma experience. J Interferon Cytokine Res 19(7):697-703, 7/1999. PMID: 10454339.
11. Black HS, deGruijl FR, Forbes PD, Cleaver JE, Ananthaswamy HN, deFabo EC, Ullrich SE, Tyrrell RM. Photocarcinogenesis: an overview. J Photochem Photobiol B 40(1):29-47, 8/1997. PMID: 9301042.
12. Selgrade MK, Lawrence DA, Ullrich SE, Gilmour MI, Schuyler MR, Kimber I. Modulation of T-helper cell populations: potential mechanisms of respiratory hypersensitivity and immune suppression. Toxicol Appl Pharmacol 145(1):218-29, 7/1997. PMID: 9221840.
13. Ullrich SE. Does exposure to UV radiation induce a shift to a Th2-like immune reaction? . Photochem Photobiol 64(2):254-258, 8/1996. PMID: 8760564.
14. Ullrich SE. The role of TNF-a and interleukin-10 in UVB-induced immune suppression. Biologic Effects of Light:484-491, 1996.
15. Yarosh DB, Ullrich SE, Kripke ML. Treatment of UV-induced DNA damage by topical application of liposomal DNA repair enzymes. Biologic effects of Light:499-506, 1996.
16. Ullrich SE. The role of epidermal cytokines in the generation of cutaneous immune reactions and ultraviolet radiation-induced immune suppression. Photochem Photobiol 62(3):389-401, 9/1995. PMID: 8570698.
17. Ullrich SE. Modulation of immunity by ultraviolet radiation: key effects on antigen presentation. J Invest Dermatol 105(1 Suppl):30S-36S, 7/1995. PMID: 7615994.
18. Kawabata TT, Burleson GR, Ernst PB, Ullrich SE. Immunotoxicology of regional lymphoid tissue: the respiratory and gastrointestinal tracts and skin. Fundam Appl Toxicol 26(1):8-19, 6/1995. PMID: 7657065.
19. Ullrich SE. Potential for immunotoxicity due to environmental exposure to ultraviolet radiation. Hum Exp Toxicol 14(1):89-91, 1/1995. PMID: 7748625.
20. Ullrich SE. Review of Immunosuppression and Human Malignancy . Cancer Cells 3:30-31, 1991.
21. Ullrich SE. Sun Exposure and the Lupus Patient. Lupus News. 11:4, 1991.
22. Ullrich SE, Kripke ML. Effects of UV radiation on the immune system. The Skin Cancer Foundation Journal 7:37-38, 1989.
23. Ullrich SE. UV-induced suppression of the immune response to alloantigens. Transplant Proc 19(1 Pt 1):624-5, 2/1987. PMID: 3274829.
24. Ullrich SE, Zolla-Pazner S. Purification of a soluble immunoregulatory substance released by plasmacytoma cells. B and T cell tumors: Biological and Clinical Aspects XXIV:293-299, 1982.
25. Zolla-Pazner S, Ullrich SE. The Plasma cell: A regulator of the immune response. B Lymphocytes in the immune response. 4:493-500, 1980.


1. Ullrich SE. Immune Modulation by Phototherapy: Why Immune Suppression? Expert Review of Dermatology 3:7-9, 2008.
Other Articles
1. Ullrich SE. Introduction to the symposium-in-print honoring Professor Margaret L Kripke. Photochem Photobiol 84:1, 2008.

Book Chapters

1. Ramos G, Ullrich SE. "Immune Modulation by Dermal Exposure to Jet Fuel". In: Jet Fuel Toxicology. Ed(s) M Witten, G Ritchie, E Zeiger. Taylor and Francis Publishing: London, UK, 103-118, 2010.
2. Ullrich SE. "Skin Immunology and Immunotoxicity". In: Comprehensive Toxicology. 5, 2. Ed(s) CA McQueen, D Lawrence (section ed). Elsevier Ltd. Oxford, United Kingdom, 217-234, 2010.
3. Ullrich SE. "Mechanism by which ultraviolet radiation, a ubiquitous environmental agent, suppresses the immune response". In: Immunotoxicology and Immunopharmacology, Target organ toxicology series, 3. Ed(s) RW Luebke, RV House, I Kimber. CRC Press: Boca Raton, 259-276, 2007.
4. Ullrich SE, Schmitt DA. "Dissection of the immunosuppressive effects of UV radiation". In: Melanoma Techniques and Protocols: molecular diagnosis, treatment, and monitoring, 1. Ed(s) BJ Nickoloff. Humana Press: Totowa, 85-98, 2001.
5. Ullrich SE. "The effects of ultraviolet radiation on the immune response". In: Biomedical Modulations of Skin Reactions: transdermals, topicals, cosmetics. Ed(s) AF Kydonieus, JJ Wille. CRC Press: Boca Raton, 281-300, 2000.
6. Ullrich SE. "Cytokines and UV-induced immune suppression". In: Landmarks in Photobiology. Ed(s) RM Honigsmann, F Trautinger, G Jori. OEMF: Milano, Italy, 1998.
7. Kim T-H, Ullrich SE, Kripke ML. "Dose responses for UV-induced suppression of various immune responses". In: Protection of the Skin against Ultraviolet Radiations. Ed(s) A Kougier, H Schaefer. John Libbey Eurotext: Paris, 87-88, 1998.
8. Ullrich SE, Kripke ML. "Photoimmunology". In: Encyclopedia of Immunology, 2. Ed(s) PJ Delves, IM Roitt. Academic Press: San Diego, 1942-1946, 1998.
9. Ullrich SE. "T lymphocyte subpopulations and UVB-mediated Immunotoxicity". In: T lymphocyte subpopulations in Immunotoxicology. Ed(s) I Kimber, MK Selgrade. John Wiley & Sons: Chichester, 121-142, 1998.
10. Ananthaswamy HN, Loughlin SM, Cox P, Evans RL, Ullrich SE, Kripke ML. "p53 mutation as an endpoint for photoprotection". In: Landmarks in Photobiology. American Society for Photobiology, 353-356, 1997.
11. Ullrich SE. "Skin Immunology". In: Comprehensive Toxicology: toxicology of the immune system. 5. Ed(s) DH Lawrence. Pergamon Press: Oxford, 153-173, 1997.
12. Lachman LB, Shih L-CN, Rao X-M, Ullrich SE, Cleland JL. "Cytokine-containing liposomes as adjuvants for subunit vaccines". In: Vaccine Design: the subunit and adjuvant approach, pharmaceutical biotechnology series. 6. Ed(s) MF Powell, MK Newman, JR Burdman. Plenum: New York, 659-671, 1995.
13. Moodycliffe AM, Ullrich SE. "The role of cytokines in the regulation of hypersensitivity responses". In: Human cytokines: their role in disease and therapy. Ed(s) BB Aggarwal, R Puri. Blackwell Scientific: Boston, 131-151, 1994.
14. Deeg HJ, Ullrich SE. "Ultraviolet irradiation for the prevention and treatment of Allosensitization and Graft-Versus-Host Disease". In: Clinical Bone Marrow Transplantation: a reference textbook. Ed(s) K Atkinson. Cambridge University Press: New York, 668-675, 1994.
15. Rivas JM, Ullrich SE. "UVB Radiation and Skin Immunity". In: Immunotoxicology and Immunopharmacology, Target organ toxicology series, 2. Ed(s) JH Dean. Raven Press: New York, 435-53, 1994.
16. Ullrich SE. "Photoimmunology". In: In Vitro Toxicology-Mechanisms and New Technology, proceedings from the tenth international Center for alternatives to animal testing symposium. Mary Ann Liebert: New York, 55-72, 1993.
17. Ullrich SE. "Sun Exposure and the Lupus Patient". In: A Decade of Lupus: selected articles from Lupus News. Ed(s) H Aladjem. The Lupus Foundation of America: Rockville, 135-136,, 1991.
18. Ullrich SE. "The role of keratinocyte-derived immunosuppressive cytokines in the systemic immunosuppression induced by ultraviolet radiation". In: Trends in Photochemistry and Photobiology. 2. Research Trends: India, 137-154, 1991.
19. Ullrich SE, Alcalay J, Applegate LA, Kripke ML. "Immunosuppression in Phototherapy". In: Photosensitizing Compounds: Their chemistry, Biology and Clinical Use, Ciba Foundation Symposium No. 146,. Ed(s) G Bock, S Harnett. John Wiley & Sons: Chichester, 131-147, 1989.
20. Ullrich, SE and Zolla-Pazner, S. "Immunoregulatory circuits in myeloma". In: Clinics in Haematology. 11. W.B. Sanders: Philadelphia, 87-111, 1982.

Letters to the Editor

1. Grewe M, Duvic M, Aragane Y, Schwarz, Ullrich, SE, Krutmann J. Induction of IL-10 expression in human keratinocytes-reply. J. Invest. Dermatol 106:1330-1331, 1996.

Last updated: 12/7/2012