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Sui Zhang, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Cardiology - Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

1.  Stem cell biology: differentiation of embryonic stem cells and induced pluripotent stem cells into endoderm and mesoderm derived cells, such as cardiac progenitor cells

2.  Physiological role of SUMO (Small Ubiquitin-like Modifier) and SENP (SUMO-Specific Protease):  embryonic development and cancer

Education & Training

Degree-Granting Education

1991 Graduate School of Biomedical Sciences, U.T. Health Sciences Center, Houston, TX, PHD, Immunology & Physiology
1983 Beijing Medical College and Second Medical College, Beijing, China, MD, Medicine

Postgraduate Training

1/1992-1/1994 Postdoctoral Fellowship, Department of Physiology and Cell Biology, The University of Texas Medical School at Houston, Houston, TX, Dr. Castro

Honors and Awards

2013 Cyrus Scholar Award for Basic/Translational Research, MD Anderson Internal Medicine Research Retreat
2013 Distinguished Paper Award, MD Anderson Cancer Center, Division of Internal Medicine
1992 Scholarship on mucosal immunology, Bristol-Myers Squibb Company
1982 Award for excellent research, City of Beijing

Selected Publications

Peer-Reviewed Original Research Articles

1. Zhang S, Liu X, Bawa-Khalfe T, Lu LS, Lyu YL, Liu LF, Yeh ET. Identification of the Molecular Basis of Doxorubicin-Induced Cardiotoxicity. Nat Med 18(11):1639-42, 11/2012. e-Pub 10/2012. PMID: 23104132.
2. Wang J, Najjar A, Zhang S, Rabinovich B, Willerson JT, Gelovani JG, Yeh ET. Molecular Imaging of Mesenchymal Stem Cell: Mechanistic Insight into Cardiac Repair following Experimental Myocardial Infarction. Circ Cardiovasc Imaging 5(1):94-101, 1/2012. e-Pub 12/1/2011. PMCID: PMC3273544.
3. Wang J, Zhang S, Rabinovich B, Bidaut L, Soghomonyan S, Alauddin MM, Bankson JA, Shpall E, Willerson JT, Gelovani JG, Yeh ET. Human CD34+ cells in experimental myocardial infarction: long-term survival, sustained functional improvement, and mechanism of action. Circ Res 106(12):1904-11, 6/2010. e-Pub 5/2010. PMCID: PMC2908245.
4. Chu K, Cheng C, Ye X, Lee Y, Zurita A, Chen D, Yu-Lee L, Zhang S, Yeh ETH, Hu M, Logothetis C, Lin S. Cadherin-11 Promotes the Metastasis of Prostate Cancer Cells to Bone. Mol Cancer Res 6(8):1259-67, 8/2008. PMCID: PMC2643879.
5. Cheng J, Kang X, Zhang S, Yeh ET. SUMO-specific protease 1 is essential for stabilization of HIF1α during hypoxia. Cell 131(3):584-95, 11/2007. PMCID: PMC2128732.
6. Zhang S, Shpall E, Willerson JT, Yeh ETH. Fusion of Human Hematopoietic Progenitor Cells and Murine Cardiomyocytes Is Mediated by α4β1/Vascular Cell Adhesion Molecule-1 Interaction. Circ Res 100(5):693-702, 2/2007. e-Pub 2/2007. PMID: 17303762.
7. Foster E, Zhang S, Kahn A. Insulin stimulates arterial neointima formation in normal rats after balloon injury. Diabetes Obes Metab 8(3):348-351, 2006. PMID: 16634996.
8. Zhang S, DWang, Estrov Z, Raj S, JT Willerson, Yeh ETH. Both Cell Fusion and transdifferentiation account for the transformation of human peripheral blood CD34-Positive cells into cardiomyocytes in vivo. Circulation 110(25):3803-3807, 2004. e-Pub 12/2004. PMID: 15596566.
9. Broaddus RR, Xie S, Hsu CJ, Wang J, Zhang S, Zou C. The chemopreventive agents 4-HPR and DFMO inhibit growth and induce apoptosis in uterine leiomyomas. Am J Obstet Gynecol 190(3):686-92, 2004. PMID: 15042000.
10. Zhang S, Yang Y, Kone BC, Allen JC, Kahn AM. Insulin-stimulated cyclic guanosine monophosphate inhibits vascular smooth muscle cell migration by inhibiting Ca/calmodulin-dependent protein kinase II. Circulation 107(11):1539-44, 3/2003. PMID: 12654613.
11. Yang M, Yang Y, Zhang S, Kahn AM. Insulin-stimulated hydrogen peroxide increases guanylate cyclase activity in vascular smooth muscle. Hypertension 41(4):569-573, 2003. e-Pub 9/2003. PMID: 12963680.
12. Yeh ETH, Zhang S, Korbling M, Willerson JT, Estrov Z. Transdifferentiation of human peripheral blood CD34+-enriched cell population into cardiomyocytes, endothelial cells, and smooth muscle cells in vivo. Circulation 108(17):2070-2073, 2003. e-Pub 10/2003. PMID: 14568894.
13. Kahn AM, Allen JC, Zhang S. Insulin increases NADH/NAD+ redox state, which stimulates guanylate cyclase in vascular smooth muscle. Am J Hypertens 15(3):273-9, 3/2002. PMID: 11939620.
14. Kahn AM, Allen JC, Seidel CL, Lichtenberg DS, Song T, Zhang S. Insulin increases NO-stimulated guanylate cyclase activity in cultured VSMC while raising redox potential. Am J Physiol Endocrinol Metab 278(4):E627-33, 2000. PMID: 10751195.
15. Kahn AM, Allen JC, Seidel CL, Zhang S. Insulin inhibits migration of vascular smooth muscle cells with inducible nitric oxide synthase. Hypertension 35(1 Pt 2):303-6, 2000. PMID: 10642315.
16. Kitagawa S, Zhang S, Harari Y, Castro GA. Relative allergenicity of cow's milk and cow's milk-based formulas in an animal model. Am J Med Sci 310(5):183-187, 1995. PMID: 7485221.
17. Kitagawa S, Zhang S, Castro GA. The role of histamine in milk-induced intestinal anaphylaxis in guinea pig colon. Pediatr Res 33:103A, 1993.
18. Zhang S, Castro GA. Boosted mucosal immune responsiveness in the rat intestine by actively transported hexose. Gastroenterology 103(4):1162-6, 10/1992. PMID: 1397873.
19. Zhang S, Myers S, Castro GA. Inhibition of anaphylaxis evoked intestinal fluid secretion by the dual application of an H1 antagonist and cyclooxygenase inhibitor. Gastroenterology 100(4):922-928, 1991. PMID: 1705907.
20. Zhang S, Castro GA. Involvement of type I hypersensitivity in rapid rejection of Trichinella spiralis from adult rats. Int Arch Allergy Appl Immunol 93:272-279, 1990.
21. Chen PH, Zheng X, Zhang S. Scanning electron microscopic observations on late sporogonic stages of development of Plasmodium falciparum. Chinese Medical Journal 100:561, 1987.
22. Chen PH, Zhang S. Scanning eletron microscopic observations of the oocyst, sporoblast and sporozoite of Plasmodium yoelii yoelii. J Parasitol 70:902, 1985.
23. Zhang S, Chen PH. In vitro cultivation of late sporogonic stage of Plasmodium yoelii. Journal of Beijing Second Medical College 6, 1983.

Invited Articles

1. Yeh ETH, Zhang S. A novel approach to studying transformation of human stem cells into cardiac cells in vivo. Can J Cardiol 22 Suppl B:66B-71B, 2006.

Abstracts

1. Kahn AM, Zhang S. Insulin stimulates cyclic GMP (cGMP) production in cultured vascular smooth muscle cells (VSMCs) with iNOS which decreases migration while inhibiting MAP kinase (MAPK) activity . 53nd Annual Fall Conference of High Blood Pressure Research Council of the American Heart Association, Submitted, 1999.
2. Kahn AM, Zhang S. Insulin inhibits vascular smooth muscle cell (VSMC) contraction by stimulating guanylate cyclase activity while increasing aerobic glycolysis and the redox potential. Hypertension 32:621, 1998.
3. Zhang S, Kitagawa S, Zhao Z, Herndon DN. Enhanced expression of retinoic acid receptor-b following thermal injury in the mucosa of rat ileum. Gastroenterology 112(Suppl):A422, 1997.
4. Zhang S, Kitagawa S, Zhao Z, Herndon D. Induction of retinoic acid receptor-b in the mucosa of rat ileum after thermal injury. Pediatr Res 39(4):129A, 1996.
5. Kitagawa S, Zhang S, Zhao Z, Herndon DN. Physiological and immunological changes in the gut after burn injury. J Pediatr Gastroenterolo Nutr 23:373, 1996.
6. Zhang S, Kitagawa S, Zhao Z, Herndon D. The impact of burn on intestinal immune response to Trichinella spiralis in rat. Accepted for presentation for the Annual Meeting of the American Burn Association, Nashville, TN, 1996.
7. Zhang S Kitagawa S. Expression of cyclooxygenase gene in the intestinal mucosa of guinea pigs sensitized to cow’s milk. J Pedi Gastro Nutri 348:21, 1995.
8. Zhang S, Kitagawa S, Diaz R. Glucose transport and lactase activity in the jejunum of guinea pig sensitized to cow's milk. J Invest Med. 43:111A, 1995.
9. Kitagawa S Zhang S. Immune mediators involved in intestinal anaphylaxis caused by cow’s milk proteins. J Pedi Gastro Nutri 348:21, 1995.
10. Kitagawa S, Zhang S, Castro GA. Chemical mediators involved in milk protein-induced intestinal anaphylaxis in colon from guinea pigs sensitized to cow's milk formula. Pediatr Res 35:764, 1994.
11. Zhang, S, Kitagawa S, Castro GA. Chloride secretion induced by hydrolyzed formula. Gastroenterology 106:A281, 1994.
12. Kitagawa S, Zhang S, Castro GA. Relative allergenicity of cow's milk and cow's milk formula and pharmacological modulation of gut hypersensitization. Clin Res 40:804A, 1993.
13. Zhang S, Kitagawa S, Castro GA. Release of serotonin by milk protein in distal colon of Guinea pig sensitized to cow's milk formula. Accepted for presentation to Annual Meeting of the North American Society for Pediatric Gastroenterology and Nutrition, Chicago, IL, 1993.
14. Kitagawa W, Zhang S, Castro GA. The role of histamine in milk-induced intestinal anaphylaxis in guinea pig colon. Pediatr Res 33:103A, 1993.
15. Kitagawa S, Harari Y, Zhang S, Castro, GA. An animal model for alimentary protein allergy. Pediatr Res 31:110A, 1992.
16. Zhang S Castro GA. Anaphylaxis-mediated intestinal fluid secretion: Augmentation by active transport of hexose. Gastroenterology 102 (Suppl):A949, 1992.
17. Zhang S Castro GA. Augmenting effect of active glucose transport on intestinal immunity to Trichinella spiralis. The American Society of Parasitologists 67th Annual Meeting, Philadelphia, 1992.
18. Zhang S Castro GA. Endogenous regulation of immune-mediated, histamine-induced intestinal secretion by cyclooxygenase products. Gastroenterology 98(Suppl):A560, 1990.
19. Zhang S Castro GA. Inhibition of anaphylaxis-evoked intestinal fluid secretion in vivo by the combined action of an H1 antagonist and indomethacin. Gastroenterology 96(Suppl):A565, 1989.

Book Chapters

1. Zhang S, Cheng J, Yeh ETH. Ubiquitination, Sumoylation and De-Sumoylation of HIF-1α, a key molecule involved in brain development and adaptation to hypoxia in adult brain. In: The ubiquitin proteasome system in the central nervous system: from physiology to pathology-2008 Update. Ed(s) Di Napoli M, Wojcik C. Nova Science Publishers Inc: New York, 441-468, 2010.
2. Zhang S Castro GA. Mechanism of gut injury. In: Enteric Infection: Mechanisms, Manifestations and Management. II. Chapman and Hall, 31-48, 1995.

Last updated: 7/19/2013