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Sun-Jin Kim, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1993 Seoul National University Graduate School, Seoul, PHD, Medical Science
1989 Seoul National University Graduate School, Seoul, MS, Medical Science
1986 Seoul National University College of Medicine, Seoul, MD
1982 Seoul National University, College of Natural Science, Seoul, BS

Honors and Awards

2002 Bristol-Myers Squibb Award in Clinical Translation Research, Bristol-Myers Squibb
2002 Scholar in Training Award, American Association for Cancer Research
2001 Bristol-Myers Squibb Award in Clinical Translation Research, Bristol-Myers Squibb
2001 Scholar in Training Award, American Association for Cancer Research,

Selected Publications

Peer-Reviewed Original Research Articles

1. Kim SJ, Kim JS, Kim SW, Yun SJ, He J, Brantley E, Fan D, Strickner P, Lehembre F, Regenass U, Fidler IJ. Antivascular therapy for multidrug-resistant ovarian tumors by macitentan, a dual endothelin receptor antagonist. Transl Oncol 5(1):39-47, 2/2012. e-Pub 2/2012. PMCID: PMC3281406.
2. Kim SJ, Kim JS, Park ES, Lee JS, Lin Q, Langley RR, Maya M, He J, Kim SW, Weihua Z, Balasubramanian K, Fan D, Mills GB, Hung MC, Fidler IJ. Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy. Neoplasia 13(3):286-98, 3/2011. PMCID: PMC3050871.
3. Kim SJ, Kim JS, Kim SW, Brantley E, Yun SJ, He J, Maya M, Zhang F, Wu Q, Lehembre F, Regenass U, Fidler IJ. Macitentan (ACT-064992), a Tissue-Targeting Endothelin Receptor Antagonist, Enhances Therapeutic Efficacy of Paclitaxel by Modulating Survival Pathways in Orthotopic Models of Metastatic Human Ovarian Cancer. Neoplasia 13(2):167-79, 2/2011. PMCID: PMC3033595.
4. Ahn JH, Lee HJ, Lee EK, Yu HK, Lee TH, Yoon Y, Kim SJ, Kim JS. Antiangiogenic kringles derived from human plasminogen and apolipoprotein(a) inhibit fibrinolysis through a mechanism that requires a functional lysine-binding site. Biol Chem. e-Pub 1/2011. PMID: 21194375.
5. Kim SW, Kim JS, Papadopoulos J, Choi HJ, He J, Maya M, Langley RR, Fan D, Fidler IJ, Kim SJ. Consistent interactions between tumor cell IL-6 and macrophage TNF-a enhance the growth of human prostate cancer cells in the bone of nude mouse. Int Immunopharmacol. e-Pub 1/2011. PMID: 21251905.
6. Yokoi K, Hawke D, Oborn CJ, Jang JY, Nishioka Y, Fan D, Kim SW, Kim SJ, Fidler IJ. Identification and validation of Src and phospho-Src family proteins in circulating mononuclear cells as novel biomarkers for pancreatic cancer. Transl Oncol 4(2):83-91, 2011. e-Pub 4/2011. PMCID: PMC3069651.
7. Park SI, Kim SJ, McCauley LK, Gallick GE. Pre-Clinical Mouse Models of Human Prostate Cancer and their Utility in Drug Discovery. Curr Protoc Pharmacol 51:14.15-14.15.27, 12/2010. PMCID: PMC3072580.
8. Lin Q, Balasubramanian K, Fan D, Kim SJ, Guo L, Wang H, Bar-Eli M, Aldape KD, Fidler IJ. Reactive astrocytes protect melanoma cells from chemotherapy by sequestering intracellular calcium through gap junction communication channels. Neoplasia 12(9):748-54, 9/2010. PMCID: PMC2933695.
9. Fidler IJ, Balasubramanian K, Lin Q, Kim SW, Kim SJ. The brain microenvironment and cancer metastasis. Mol Cells 30(2):93-8, 8/2010. e-Pub 8/2010. PMID: 20799011.
10. Brantley EC, Guo L, Zhang C, Lin Q, Yokoi K, Langley RR, Kruzel E, Maya M, Kim SW, Kim SJ, Fan D, Fidler IJ. Nitric Oxide-mediated Tumoricidal Activity of Murine Microglial Cells. Transl Oncol 3(6):380-8, 2010. e-Pub 12/2010. PMCID: PMC3000463.
11. Kim SJ, Kim JS, Papadopoulos J, Wook Kim S, Maya M, Zhang F, He J, Fan D, Langley R, Fidler IJ. Circulating monocytes expressing CD31: implications for acute and chronic angiogenesis. Am J Pathol 174(5). e-Pub 4/2009. PMCID: PMC2671284.
12. Kuwai T, Nakamura T, Sasaki T, Kim SJ, Fan D, Villares GJ, Zigler M, Wang H, Bar-Eli M, Kerbel RS, Fidler IJ. Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells is a primary target for therapy with tyrosine kinase inhibitors. Neoplasia 10(5):489-500, 5/2008. PMCID: PMC2373870.
13. Kuwai T, Nakamura T, Kim SJ, Sasaki T, Kitadai Y, Langley RR, Fan D, Hamilton SR, Fidler IJ. Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotopic tumors. Am. J Pathol., 172:358-366, 2008. PMCID: PMC2312354.
14. Park, S.I,. Zhang, J., Phillips, K.A., Araujo, J.C., Najjar, A.M., Volgin, A. Y., Gelovani J.G.,Kim, S.-J., Wang, Z., and Gallick, G.E.. Targeting Src Family Kinases Inhibits Growth and Lymph Node Metastases of Prostate Cancer in an Orthotopic Nude Mouse Mode. Cancer Res., 68:3323-3333, 2008. PMID: 18451159.
15. Kuwai T, Nakamura T, Sasaki T, Kitadai Y, Kim JS, Langley RR, Fan D, Wang X, Do KA, Kim SJ, Fidler IJ. Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy. Clin. Exp. Metastasis 25:411-489, 2008. PMID: 18324358.
16. Sasaki T, Kitadai Y, Nakamura T, Kim JS, Tsan RZ, Kuwai T, Langley RR, Fan D, Kim SJ, Fidler IJ. Inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation on tumor-associated endothelial cells leads to treatment of orthotopic human colon cancer in nude mice. Neoplasia 9(12):1066-77, 12/2007. PMCID: PMC2134903.
17. Mathew P, Thall PF, Bucana CD, Oh WK, Morris MJ, Jones DM, Johnson MM, Wen S, Pagliaro LC, Tannir NM, Tu SM, Meluch AA, Smith L, Cohen L, Kim SJ, Troncoso P, Fidler IJ, Logothetis CJ. Platelet-derived growth factor receptor inhibition and chemotherapy for castration-resistant prostate cancer with bone metastases. Clin Cancer Res 13(19):5816-24, 10/1/2007. PMID: 17908974.
18. Nakamura T, Kuwai T, Kitadai Y, Sasaki T, Fan D, Coombes KR, Kim SJ, Fidler IJ. Zonal heterogeneity for gene expression in human pancreatic carcinoma. Cancer Res 67(16):7597-604, 8/15/2007. PMID: 17699763.
19. Yokoi K, Kim SJ, Thaker P, Yazici S, Nam DH, He J, Sasaki T, Chiao PJ, Sclabas GM, Abbruzzese JL, Hamilton SR, Fidler IJ. Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice. Neoplasia 7(7):696-704, 7/2005. PMCID: PMC1501424.
20. Kim SJ, Uehara H, Yazici S, He J, Langley RR, Mathew P, Fan D, Fidler IJ. Modulation of bone microenvironment with zoledronate enhances the therapeutic effects of STI571 and paclitaxel against experimental bone metastasis of human prostate cancer. Cancer Res 65(9):3707-15, 5/2005. PMID: 15867366.
21. Lev DC, Kim SJ, Onn A, Stone V, Nam DH, Yazici S, Fidler IJ, Price JE. Inhibition of platelet-derived growth factor receptor signaling restricts the growth of human breast cancer in the bone of nude mice. Clin Cancer Res 11(1):306-14, 2005. PMID: 15671560.
22. Kim SJ, Uehara H, Yazici S, Langley RR, He J, Tsan R, Fan D, Killion JJ, Fidler IJ. Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy for human prostate cancer metastasis in bone of nude mice. Cancer Res 64(12):4201-8, 6/2004. PMID: 15205332.
23. Slaton JW, Karashima T, Perrotte P, Inoue K, Kim SJ, Izawa J, Kedar D, McConkey DJ, Millikan R, Sweeney P, Yoshikawa C, Shuin T, Dinney CP. Treatment with low-dose interferon-alpha restores the balance between matrix metalloproteinase-9 and E-cadherin expression in human transitional cell carcinoma of the bladder. Clin Cancer Res 7(9):2840-53, 9/2001. PMID: 11555602.
24. Takashi A, Sasaki H, Kim SJ, Kakizoe T, Tsukamoto T, Kumamoto Y, Sugimura T, Terada M. Markedly Increased Amounts of Messenger RNAs for Vascular Endothelial Growth Factor and Placental Growth Factor in Renal Cell Carcinoma Associated with Angiogenesis. Cancer Res 54:4233-7, 1994.
25. Kim YK, Kim KM, Kim SJ. Hypothalamic-Pituitary-Gonadal Function in Hepatic Failure, Clinical Study. Korean J of Urol 29:538-42, 1988.

Book Chapters

1. Fan D, Kim SJ, Langley RR Fidler IJ. Metastasis and drug resistance. In: Drug Resistance in Cancer Cells. Ed(s) Mehta K, Siddik Z. Springer: New York, 21-52, 2009.
2. Kim SJ, Baker CH, Kitadai Y, Nakamura T, Kuwai T, Sasaki T, Langley R, Fidler IJ. The pathogenesis of cancer metastasis: relevance to therapy. In: Principles of Cancer Biotherapy, 5. Ed(s) Oldham RK, Dillman RO. Kluwer Academic Publishers: London, UK, 17-40, 2009.
3. Lanlgey RR, Kim SJ, Fidler IJ. The use of orthotopic models to validate antivascular therapies for cancer. In: Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy. Ed(s) D. Marme and N, Fuesenig, 2008.

Grant & Contract Support

Title: Molecular Determinants of Brain-metastatic Melanoma
Funding Source: NIH/NCI
Role: Collaborator
Duration: 6/3/2008 - 5/31/2012

Last updated: 12/5/2012