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Sunil Krishnan, MD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1993 Christian Medical College, Vellore, Tamil Nadu, India, MBBS, Medicine

Postgraduate Training

3/2000-3/2004 Clinical Residency, Radiation Oncology, Mayo Clinic, Rochester, MN, Dr. Ivy A. Petersen
1/1997-1/2000 Clinical Residency, Internal Medicine, Penn State Geisinger Medical Center, Danville, PA, Dr. Robert Palinkas
1/1994-1/1995 Clinical Internship, Christian Medical College and Hospital, Vellore, Tamil Nadu, India, Dr. Bhooshanam V. Moses

Board Certifications

6/2005 American Board of Radiology (Radiation Oncology)
2000 American Board of Internal Medicine

Experience/Service

Administrative Appointments/Responsibilities

Director, Gastrointestinal Translational Research, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2007-present

Selected Publications

Peer-Reviewed Original Research Articles
1. Katz MHG, Wang H, Fleming JB, Sun CC, Hwang RF, Wolff RA, Varadhachary G, Abbruzzese JL, Crane CH, Krishnan S, Vauthey J-N, Abdalla EK, Lee JE, Pisters PWT, Evans DB.. Long-term survival after multidisciplinary management of resected pancreatic adenocarcinoma. Ann Surg Oncol 16(4). e-Pub 2/5/2009. PMID: 19194760.
2. Hodges JC, Das P, Eng C, Reish AG, Beddar AS, Delclos ME, Krishnan S, Crane CH. Intensity-Modulated Radiation Therapy for the Treatment of Squamous Cell Anal Cancer with Para-aortic Nodal Involvement. Int J Radiat Oncol Biol Phys. e-Pub 2/2009. PMID: 19231109.
3. Park HC, Janjan NA, Mendoza TR, Lin EH, Vadhan-Raj S, Hundal M, Zhang Y, Delclos ME, Crane CH, Das P, Wang XS, Cleeland CS, Krishnan S. Temporal Patterns of Fatigue Predict Pathologic Response in Patients Treated with Preoperative Chemoradiation Therapy for Rectal Cancer. Int J Radiat Oncol Biol Phys. e-Pub 2/2009. PMID: 19231100.
4. Herman MP, Kopetz S, Bhosale PR, Eng C, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Janjan NA, Delclos ME, Krishnan S, Crane CH, Das P.. Sacral insufficiency fractures after preoperative chemoradiation for rectal cancer: incidence, risk factors and clinical course. Int J Radiat Oncol Biol Phys 74(3). e-Pub 1/2009. PMID: 19147305.
5. Badgwell B, Yao J, Bose D, Oiao W, Krishnan S, Pisters P, Feig B, Mansfield P.. Attempted salvage resection for recurrent gastric or gastroesophageal cancer. Ann Surg Oncol 16(1):42-50, 2009. e-Pub 11/2008. PMID: 18985270.
6. Harikumar KB, Kunnumakkara AB, Ahn KS, Anand P, Krishnan S, Guha S, Aggarwal BB. Modification of the cysteine residues in IκBα kinase and NF-kB (p65) by xanthohumol leads to suppression of NF-κB-regulated gene products and potentiation of apoptosis in leukemia cells. Blood. e-Pub 10/2008.
7. Wang H, Krishnan S, Wang X, Beddar AS, Briere TM, Crane CH, Mohan R, Dong L. Improving soft-tissue contrast in four-dimensional computed tomography images of liver cancer patients using a deformable image registration method. Int J Radiat Oncol Biol Phys 72(1):201-209, 9/2008. PMID: 18722271.
8. Reed VK, Krishnan S, Mansfield PF, Bhosale PR, Kim M, Das P, Janjan NA, Delclos ME, Lowy AM, Feig BW, Pisters PW, Ajani JA, Crane CH. Incidence, natural history, and patterns of locoregional recurrence in gastric cancer patients treated with preoperative chemoradiotherapy. Int J Radiat Oncol Biol Phys 71(3):741-747, 7/2008. e-Pub 12/2007. PMID: 18164837.
9. Kunnumakkara AB, Diagaradjane P, Guha S, Deorukhkar A, Shentu S, Aggarwal BB, Krishnan S. Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. Clin Cancer Res 14(7)(7):2128-2136, 4/2008. PMID: 18381954.
10. Diagaradjane P, Orenstein-Cardona JM, E Colón-Casasnovas N, Deorukhkar A, Shentu S, Kuno N, Schwartz DL, Gelovani JG, Krishnan S. Imaging epidermal growth factor receptor expression in vivo: pharmacokinetic and biodistribution characterization of a bioconjugated quantum dot nanoprobe. Clin Cancer Res 14(3):731-741, 2/2008. PMID: 18245533.
11. Beddar AS, Briere TM, Balter P, Pan T, Tolani N, Ng C, Szklaruk J, Krishnan S. 4D-CT imaging with synchronized intravenous contrast injection to improve delineation of liver tumors for treatment planning. Radiother Oncol 87(3):445-448, 2008. e-Pub 1/2008. PMID: 18194819.
12. Brown PD, Krishnan S, Sarkaria JN, Wu W, Jaeckle KA, Uhm JH, Geoffroy F, Arusell R, Kitange G, Jenkins RB, Kugler JW, Morton R, Rowland K, Mischel P, Yong WH, Scheithauer B, Schiff D, Giannini C, Buckner J. A North Central Cancer Treatment Group phase I/II trial (N0177) of erlotinib and temozolomide combined with radiation therapy in the treatment of newly-diagnosed glioblastoma multiforme. J Clin Oncol 26(34):5603-5609, 2008.
13. Kim MM, Mansfield PF, Das P, Janjan NA, Badgwell Bd, Phan AT, Delclos ME, Maru D, Ajani JA, Crane CH, Krishnan S. Chemoradiation therapy for potentially resectable gastric cancer: clinical outcomes among patients who do not undergo planned surgery. Int J Radiat Oncol Biol Phys 71(1):167-172, 2008. PMID: 18406886.
14. Kim MM, Rana V, Janjan NA, Das P, Phan AT, Delclos ME, Mansfield PF, Ajani JA, Crane CH, Krishnan S. Clinical benefit of palliative radiation therapy in advanced gastric cancer. Acta Oncol 47(3):421-427, 2008. PMID: 17899453.
15. Badgwell B, Cormier JN, Krishnan S, Yao J, Staerkel GA, Lupo PJ, Pisters PW, Feig B, Mansfield P.. Does neoadjuvant treatment for gastric cancer patients with positive peritoneal cytology at staging laparoscopy improve survival? Ann Surg Oncol 15(10):2684-2691, 2008. e-Pub 7/2008. PMID: 18649106.
16. Wagener M, Zhang X, Villarreal HG, Levy L, Allen P, Shentu S, Fang B, Krishnan S, Chang JY, Cheung MR. Effect of combining anti-epidermal growth factor receptor antibody C225 and radiation on DU145 prostate cancer. Oncol Rep 19(5):1071-1077, 2008. PMID: 18425360.
17. Borghero Y, Crane CH, Szklaruk J, Oyarzo M, Thomas MB, Brown T, Curley S, Evans D, Abdalla EK, Delclos M, Das P, Krishnan S, Wistuba II, Vauthey JN. Extrahepatic bile duct adenocarcinoma: patients at high-risk for local recurrence treated with surgery and adjuvant chemoradiation have an equivalent overall survival to patients with standard-risk treated with surgery alone. Ann Surg Oncol 15(11):3147-3156, 2008. e-Pub 2008. PMID: 18754070.
18. Diagaradjane P, Shetty A, Wang JC, Elliott AM, Schwartz J, Shentu S, Park HC, Deorukhkar A, Stafford RJ, Cho SH, Tunnell JW, Hazle JD, Krishnan S. Modulation of in Vivo Tumor Radiation Response via Gold Nanoshell-Mediated Vascular-Focused Hyperthermia: Characterizing an Integrated Antihypoxic and Localized Vascular Disrupting Targeting Strategy. Nano Lett 8(5):1492-1500, 2008. e-Pub 4/2008. PMID: 18412402.
19. Tong Z, Kunnumakkara AB, Wang H, Matsuo Y, Diagaradjane P, Harikumar KB, Ramachandran V, Sung B, Chakraborty A, Logsdon C, Aggarwal BB, Krishnan S, Guha S. Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer. Cancer Res 68(15):6100-6108, 2008. PMID: 18676832.
20. Yu TK, Bhosale PR, Crane CH, Iyer RB, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Eng C, Wolff RA, Janjan NA, Delclos ME, Krishnan S, Das P. Patterns of locoregional recurrence after surgery and radiotherapy or chemoradiation for rectal cancer. Int J Radiat Oncol Biol Phys 71(4):1175-1180, 2008. e-Pub 1/2008. PMID: 18207667.
21. Varadhachary GR, Wolff RA, Crane CH, Sun CC, Tamm EP, Wang H, Lee JE, Pisters PWT, Vauthey J-N, Abdalla E, Lee JH, Ho L, Staerkel GA, Bhosale PR, Ross WA, Krishnan S, Xiong H, Das P, Abbruzzese JL, Evans DB. Preoperative gemcitabine and cisplatin followed by gemcitabine-based chemoradiation for resectable adenocarcinoma of the pancreatic head. J Clin Oncol 26(21):3487-3495, 2008. PMID: 18640929.
22. Wang X, Krishnan S, Zhang X, Dong L, Briere T, Crane CH, Gillin M, Mohan R, Beddar S. Proton Radiotherapy for Liver Tumors: Dosimetric Advantages over Photon Plans. Med Dosim 33(4):259-267, 2008. PMID: 18973852.
23. Krishnan S, Dawson LA, Seong J, Akine Y, Beddar S, Briere TM, Crane CH, Mornex F. Radiotherapy for hepatocellular carcinoma: an overview. Ann Surg Oncol 15(4):1015-1024, 2008. e-Pub 1/2008. PMID: 18236114.
24. Maru DM, Khurana H, Rashid A, Correa A, Anandasabapathy S, Krishnan S, Komaki R, Ajani JA, Swisher SG, Hofstetter WL. Retrospective study of clinicopathologic features and prognosis of high-grade neuroendocrine carcinoma of the esophagus. Am J Surg Pathol 32(9):1404-1411, 2008. PMID: 18670347.
25. Krishnan S, Rana V, Evans DB, Varadhachary G, Das P, Bhatia S, Delclos ME, Janjan NA, Wolff RA, Crane CH, Pisters PW. Role of adjuvant chemoradiation therapy in adenocarcinomas of the ampulla of Vater. Int J Radiat Oncol Biol Phys 70(3):735-743, 2008. e-Pub 11/2007. PMID: 17980502.
26. Verma A, Guha S, Diagaradjane P, Kunnumakkara AB, Sanguino AM, Lopez-Berestein G, Sood AK, Aggarwal BB, Krishnan S, Gelovani JG, Mehta K. Therapeutic significance of elevated tissue transglutaminase expression in pancreatic cancer. Clin Cancer Res 14(8)(8):2476-2483, 2008. PMID: 18413840.
27. Krishnan S*, Deorukhkar A*, Sethi G, Aggarwal BB. Back to basics: how natural products can provide the basis for new therapeutics. Expert Opin Investig Drugs 16(11):1753-1773, 2007.
28. Bedi M, Das P, Skibber JM, Rodriguez-Bigas MA, Chang GJ, Eng C, Wolff RA, Janjan NA, Krishnan S, Crane CH. Capecitabine and timing of radiotherapy during preoperative chemoradiation for rectal cancer. Gastrointest Cancer Res 1:44-48, 2007.
29. Beddar AS, Kainz K, Briere TM, Tsunashima Y, Pan T, Prado K, Mohan R, Gillin M, Krishnan S. Correlation between internal fiducial tumor motion and external marker motion for liver tumors imaged with 4D-CT. Int J Radiat Oncol Biol Phys 67(2):630-638, 2007. PMID: 17236980.
30. Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani JG, Aggarwal BB. Curcumin potentiates antitumor activity of gemcitabine in an othotopic model pancreatic cancer through suppression of proliferation, angiogenesis and inhibition of NF-kB-regulated gene products. Cancer Res 67(8):3853-3861, 2007.
31. Krishnan S, Briere TM, Dong L, Murthy R, Ng C, Balter P, Mohan R, Gillin MT, Beddar AS. Daily targeting of liver tumors: Screening patients with a mock treatment and using a combination of internal and external fiducials for image-guided respiratory-gated radiotherapy. Med Phys 34(12):4591-4593, 2007.
32. Murthy R, Brown DB, Salem R, Meranze SG, Coldwell DM, Krishnan S, Nunez R, Habbu A, Liu D, Ross W, Choen AM, Censullo M. Gastrointestinal ulceration following hepatic arterial Yttrium-90 microsphere therapy. J Vasc Interv Radiol 18(4):553-561, 2007.
33. Murthy R, Eng C, Krishnan S, Madoff DC, Habbu A, Canet S, Hicks ME. Hepatic yttrium-90 radioembolotherapy in metastatic colorectal cancer treated with cetuzimab or bevacizumab. J Vasc Interv Radiol 18(12):1588-1591, 2007.
34. Zaman RT, Diagaradjane P, Wang J, Swartz J, Gill-Sharp K, Rajaram N, Payne DJ, Krishnan S, Tunnell JW. In vivo detection of gold nanoshells in tumors using diffuse optical spectroscopy. IEEE J Sel Top Quant Elec 13(6):1715-1720, 2007.
35. Krishnan S, Rana V, Janjan NA, Varadhachary GR, Abbruzzese JL, Das P, Delclos ME, Gould MS, Evans DB, Wolff RA, Crane CH. Induction chemotherapy selects locally advanced unresectable pancreatic cancer patients for optimal benefit from consolidative chemoradiation therapy. Cancer 110(1):47-55, 2007.
36. Krishnan S, Goble J, Frederick L, James CD, Uhm J, Babovic-Vuksanovic D. Inhibitory effect of pirfenidone on glioblastoma cell lines: implications for treatment of neurofibromatosis. J Appl Sci 7(1):58-68, 2007.
37. Das P, Bhatia S, Eng C, Ajani JA, Skibber JM, Rodriguez-Bigas MA, Chang GJ, Bhosale P, Delclos ME, Krishnan S, Janjan NA, Crane CH. Predictors and patterns of recurrence after definitive chemoradiation for anal cancer. Int J Radiat Oncol Biol Phys 109(9):1750-1755, 2007.
38. Das P, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Wolff RA, Eng C, Krishnan S, Janjan NA, Crane CH. Predictors of tumor response and downstaging in patients treated with preoperative chemoradiation for rectal cancer. Cancer 109:1750-1755, 2007.
39. Aggarwal BB, Sethi G, Baladandayuthapani V, Krishnan S, Shishodia S. Targeting cell signaling pathways for drug discovery: an old lock needs a new key. J Cell Biochem 102(30):580-592, 2007.
40. Bhatia S, Miller RC, Haddock MG, Donohue JH, Krishnan S. Adjuvant therapy and improved survival for patients with node-positive ampullary carcinoma. Int J Radiat Oncol Biol Phys 66(2):514-519, 2006.
41. Das P, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Hoff PM, Eng C, Wolff RA, Janjan NA, Delclos ME, Krishnan S, Levy LB, Ellis LM, Crane CH. Clinical and pathologic predictors of locoregional recurrence, distant metastasis, and overall survival in patients treated with chemoradiation and mesorectal excision for rectal cancer. Am J Clin Oncol 29(3):219-224, 2006. PMID: 16755173.
42. Das P, Wolff RA, Abbruzzese JL, Varadhachary GR, Evans DB, Vauthey JN, Baschnagel A, Delclos ME, Krishnan S, Janjan NA, Crane CH. Concurrent capecitabine and upper abdominal radiation therapy is well tolerated. Radiat Oncol 1(1):41, 2006.
43. Krishnan S, Lin EH, Gunn GB, Chandra A, Beddar AS, Briere TM, Das P, Delclos ME, Janjan NA, Crane CH. Conformal radiotherapy of the dominant liver metastasis: a viable strategy for treatment of unresectable chemotherapy refractory colorectal cancer liver metastases. Am J Clin Oncol 29(6):562-567, 2006. PMID: 17148992.
44. Krishnan S, Brown PD, Ballman KV, Fiveash JB, Uhm JH, Giannini C, Jaeckle KA, Geoffroy FJ, Nabors LB, Buckner JC, Buckner JC. Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: Results of North Central Cancer Treatment Group Protocol N0177. Int J Radiat Oncol Biol Phys 65(4):1192-1199, 2006. PMID: 16626884.
45. Krishnan S, Janjan NA, Skibber JM, Rodriguez-Bigas MA, Wolff RA, Das P, Delclos ME, Chang GJ, Hoff PM, Eng C, Brown TD, Crane CH, Feig BW, Morris J, Vadhan-Raj S, Hamilton SR, Lin EH. Phase II study of capecitabine (Xeloda) and concomitant boost radiotherapy in patients with locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 66(3):762-771, 2006. PMID: 17011451.
46. Das P, Lin EH, Bhatia S, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Hoff PM, Eng C, Wolff RA, Delclos ME, Krishnan S, Janjan NA, Crane CH. Preoperative chemoradiotherapy with capecitabine versus protracted infusion 5-fluorouracil for rectal cancer: a matched-pair analysis. Int J Radiat Oncol Biol Phys 66(5):1378-1383, 2006. PMID: 17056196.
47. Krishnan S, Rana V, Janjan NA, Abbruzzese JL, Gould MS, Das P, Delclos ME, Palla S, Guha S, Varadhachary G, Evans DB, Wolff RA, Crane CH. Prognostic factors in patients with unresectable locally advanced pancreatic adenocarcinoma treated with chemoradiation. Cancer 107(11):2589-2596, 2006. PMID: 17083124.
48. Beddar AS, Krishnan S, Briere TM, Wang X, Delclos ME, Ballo MT, Das P, Gould S, Horton JL, Crane CH. The optimization of dose delivery for intraoperative high-dose-rate radiation therapy using curved HAM applicators. Radiother Oncol 78(2):207-212, 2006. PMID: 16376445.

Last updated: 9/8/2009