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Susan M. Fischer, MS, PhD

Present Title & Affiliation

Primary Appointment

Professor, Department of Molecular Carcinogenesis, Science Park, University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX

Dual/Joint/Adjunct Appointment

Adjunct Professor, Pharmacology, Nutritional Sciences, The University of Texas, Austin, TX

Office Address

The University of Texas MD Anderson Cancer Center
Science Park - Department of Molecular Carcinogenesis
1808 Park Road 1C - PO Box 389
Unit Number: 116
Smithville, TX 78957
Room Number: Lab 2
Phone: (512) 237-2482
Email: smfischer@mdanderson.org

Education & Training

Degree-Granting Education

1974 University of Wyoming, Laramie, WY, PHD, Physiology
1971 University of Wyoming, Laramie, WY, MS, Physiology
1969 High Point College, High Point, NC, BS, Biology

Postgraduate Training

9/1974-8/1976 Postdoctoral Fellowship, Department of Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, Dr. Charles Shaw

Experience/Service

Academic Appointments

Associate Professor, Department of Molecular Carcinogenesis, Science Park, University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX, 9/1987-8/1993
Assistant Professor, Department of Molecular Carcinogenesis, Science Park, University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX, 10/1982-8/1987
Permanent Research Staff, Cancer and Toxicology Program, Oak Ridge National Laboratory, Oak Ridge, TN, 7/1980-8/1982
Junior Staff, Cancer and Toxicology, Oak Ridge National Laboratory, Oak Ridge, TN, 9/1976-6/1980

Honors and Awards

2001-2006 Ashbel Smith Professorship, University of Texas MD Anderson Cancer Center
1997 Excellence in Cancer Prevention, finalist, Julie and Ben Rogers Award
1997 Outstanding Faculty Achievement Award in Cancer Prevention, The University of Texas at MD Anderson
1980 ICRETT Award, International Union Against Cancer
1974-1976 Postdoctoral Training Grant Fellow, NIH
1974 Summer Scholarship, American Cancer Society
1969-1973 Predoctoral Fellowship, NDEA

Selected Publications

Peer-Reviewed Original Research Articles

1. Yang P, Jiang Y, Fischer SM. Prostaglandin E3 metabolism and cancer. Cancer Lett 348(1-2):1-11, 6/28/2014. e-Pub 3/18/2014. PMID: 24657656.
2. Gong J, Xie J, Bedolla R, Rivas P, Chakravarthy D, Freeman JW, Reddick R, Kopetz S, Peterson A, Wang H, Fischer SM, Kumar AP. Combined targeting of STAT3/NF-κB/COX-2/EP4 for effective management of pancreatic cancer. Clin Cancer Res 20(5):1259-73, 3/1/2014. e-Pub 2/11/2014. PMCID: PMC3969421.
3. Jiao J, Mikulec C, Ishikawa TO, Magyar C, Dumlao DS, Dennis EA, Fischer SM, Herschman H. Cell-type specific roles for COX-2 in UVB-induced skin cancer. Carcinogenesis. e-Pub 2/17/2014. PMID: 24469308.
4. Harvey AE, Lashinger LM, Hays D, Harrison LM, Lewis K, Fischer SM, Hursting SD. Calorie Restriction Decreases Murine and Human Pancreatic Tumor Cell Growth, Nuclear Factor-κB Activation, and Inflammation-Related Gene Expression in an Insulin-like Growth Factor-1-Dependent Manner. PLoS One 9(5):e94151, 2014. e-Pub 5/7/2014. PMCID: PMC4013119.
5. Gong J, Xie J, Rivas P, Chakravarthy D, Freeman JM, Reddick R, Fischer SM, Kumar AP. Therapeutic targeting Stat2/NFKB interaction for pancreatic cancer management in vitro and in vivo studies. Clin Cancer Res 20:1259-73, 2014.
6. Badeaux MA, Jeter CR, Gong S, Liu B, Suraneni MV, Rundhaug J, Fischer SM, Yang T, Kusewitt D, Tang DG. In vivo functional studies of tumor-specific retrogene NanogP8 in transgenic animals. Cell Cycle 12(5):2395-408, 8/1/2013. e-Pub 6/26/2013. PMCID: PMC3841319.
7. Mikulec CD, Rundhaug JE, Simper MS, Lubet RA, Fischer SM. The Chemopreventive Efficacies of Nonsteroidal Anti-inflammatory Drugs: The Relationship of Short-term Biomarkers to Long-term Skin Tumor OUtcome. Cancer Prev Res (Phila) 6(7):675-85, 7/2013. e-Pub 5/16/2013. PMCID: PMC3701752.
8. Yang P, Cartwright C, Chan D, Ding J, Felix E, Pan Y, Pang J, Rhea P, Block K, Fischer SM, Newman RA. Anticancer activity of fish oils against human lung cancer is associated with changes in formation of PGE(2) and PGE(3) and Alteration of Akt Phosphorylation. Mol Carcinog. e-Pub 1/31/2013. PMID: 23371504.
9. Pirman DA, Efuet E, Ding XP, Pan Y, Tan L, Fischer SM, DuBois RN, Yang P. Changes in cancer cell metabolism revealed by direct sample analysis with MALDI mass spectrometry. PLoS One 8(4):e61379, 2013. e-Pub 4/26/2013. PMCID: PMC3637300.
10. Sengupta A,Lichti UF, Carlson BA, Cataisson C, Ryscavage AO, Mikulec C, Conrad M, Fischer SM, Hatfield DL, Yespa SH. Targeted disruption of glutathione peroxidase 4 in mouse skin epithelial cells impairs postnatal hair follicle morphogenesis that is partially rescued through inhibition of CO-2. J Invest Dermatol 133(7):1731-41, 2013.
11. Tian J, Lambertz I, Berton TR, Rundhaug JE, Kiguchi K, Shirley SH, Digiovanni J, Conti CJ, Fischer SM, Fuchs-Young R. Transgenic insulin-like growth factor-1 stimulates activation of COX-2 signaling in mammary glands. Mol Carcinog 51(12):973-83, 12/2012. e-Pub 10/17/2011. PMCID: PMC3790642.
12. Lago CU, Nowinski SM, Rundhaug JE, Pfeiffer ME, Kiguchi K, Hirasaka K, Yang X, Abramson EM, Bratton SB, Rho O, Colavitti R, Kenaston MA, Nikawa T, Trempus C, Digiovanni J, Fischer SM, Mills EM. Mitochondrial respiratory uncoupling promotes keratinocyte differentiation and blocks skin carcinogenesis. Oncogene 31(44):4725-31, 11/2012. e-Pub 1/2012. PMCID: PMC3688278.
13. Smith KA, Tong X, Abu-Yousif AO, Mikulec CC, Gottardi CJ, Fischer SM, Pelling JC. UVB radiation-induced ß-catenin signaling is enhanced by COX-2 expression in keratinocytes. Mol Carcinog 51(9):734-45, 9/2012. e-Pub 8/2011. PMID: 21853475.
14. Surh I, Rundhaug JE, Pavone A, Mikulec C, Abel E, Simper M, Fischer SM. The EP1 receptor for prostaglandin E2 promotes the development and progression of malignant murine skin tumors. Mol Carcinog 51(7):553-64, 7/2012. e-Pub 7/7/2011. PMCID: PMC3270117.
15. Zuo X, Peng Z, Wu Y, Moussalli MJ, Yang XL, Wang Y, Parker-Thornburg J, Morris JS, Broaddus RR, Fischer SM, Shureiqi I. Effects of gut-targeted 15-LOX-1 transgene expression on colonic tumorigenesis in mice. J Natl Cancer Inst 104(9):709-16, 5/2/2012. e-Pub 4/2/2012. PMCID: PMC3341308.
16. Garza LA, Liu Y, Yang Z, Alagesan B, Lawson JA, Norberg SM, Loy DE, Zhao T, Hanz BB, Stanton DC, Carrasco L, Ahluwalia G, Fischer SM, FitzGerald GA, Cotsarelis G. Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Sci Transl Med 21(4):126-34, 3/2012. PMCID: PMC3319975.
17. Perez C, Parker-Thornburg J, Mikulec C, Kusewitt DF, Fischer SM, Digiovanni J, Conti CJ, Benavides F. SKHIN/Sprd, a new genetically defined inbred hairless mouse strain for UV-induced skin carcinogenesis studies. Exp Dermatol 21(3):217-20, 3/2012. PMCID: PMC3881295.
18. Liu B, Willette-Brown J, Liu S, Chen X, Fischer SM, Hu Y. IKKa represses a network of inflammation and proliferation pathways and elevates c-Myc antagonists and differentiation in a dose-dependent manner in the skin. Cell Death Differ 18(12):1854-64, 12/2011. e-Pub 5/13/2011. PMCID: PMC3214909.
19. Fischer SM. Protein growth factors and cytokines are typically thought to drive the proliferative/invasive/survival hallmarks of cancer. Preface. Cancer Metastasis Rev 30(3-4):275-6, 12/2011. PMID: 22080287.
20. Rundhaug JE, Simper MS, Surh I, Fischer SM. The role of the EP receptors for prostaglandin E(2) in skin and skin cancer. Cancer Metastasis Rev 30(3-4):465-80, 12/2011. e-Pub 10/2011. PMCID: PMC3236828.
21. Fischer SM, Hawk ET, Lubet RA. Non-steroidal Anti-inflammatory Drugs and Coxibs In Chemoprevention: A Commentary Based Primarily on Animal Studies. Cancer Prev Res (Phila) 4(11):1728-35, 11/2011. e-Pub 7/21/2011. PMCID: PMC3208782.
22. Lashinger LM, Malone LM, McArthur MJ, Goldberg JA, Daniels EA, Pavone A, Colby JK, Smith NC, Perkins SN, Fischer SM, Hursting SD. Genetic reduction of insulin-like growth factor-1 mimics the anticancer effects of calorie restriction on cyclooxygenase-2-driven pancreatic neoplasia. Cancer Prev Res (Phila) 4(7):1030-40, 7/2011. e-Pub 5/18/2011. PMCID: PMC3131443.
23. Lashinger LM, Malone LM, Brown GW, Daniels EA, Goldberg JA, Otto G, Fischer SM, Hursting SD. Rapamycin partially mimics the anticancer effects of calorie restriction in a murine model of pancreatic cancer. Cancer Prev Res (Phila) 4(7):1041-51, 7/2011. e-Pub 5/18/2011. PMCID: PMC3131470.
24. Surh I, Rundhaug J, Pavone A, Mikulec C, Abel E, Fischer SM. Upregulation of the EP1 receptor for prostaglandin E2 promotes skin tumor progression. Mol Carcinog 50(6):458-68, 6/2011. e-Pub 1/25/2011. PMID: 21268127.
25. Benavides F, Perez C, Blando J, Contreras O, Shen J, Coussens LM, Fischer SM, Kusewitt DF, Digiovanni J, Conti CJ. Protective role of cathepsin L in mouse skin carcinogenesis. Mol Carcinog. e-Pub 5/2/2011. PMCID: PMC3155742.
26. Blando JM, Carbajal S, Abel E, Beltran L, Conti C, Fischer S, DiGiovanni J. Cooperation between Stat3 and Akt signaling leads to prostate tumor development in transgenic mice. Neoplasia 13(3):254-265, 3/2011. PMCID: PMC3050868.
27. Xia X, Park E, Liu B, Willette-Brown J, Gong W, Wang J, Mitchell D, Fischer SM, Hu Y. Reduction of IKKalpha expression promotes chronic ultraviolet B exposure-induced skin inflammation and carcinogenesis. Am J Pathol 176(5):2500-8, 5/2010. e-Pub 3/2010. PMCID: PMC2861114.
28. Ishikawa TO, Kumar IP, Machado HB, Wong KP, Kusewitt D, Huang SC, Fischer SM, Herschman HR. Positron emission tomography imaging of DMBA/TPA mouse skin multi-step tumorigenesis. Mol Oncol 4(2):119-25, 4/2010. e-Pub 2/2010. PMCID: PMC2838935.
29. Rundhaug JE, and Fischer SM. Molecular Mechanisms of Mouse Skin Tumor. Cancers 2(2):436-482, 2010. PMCID: PMC3033564.
30. Shen J, Fischer SM. Molecular profiling of the epidermis: a proteomics approach. Methods Molec Biol. 585:225-252, 2010.
31. Cekanova M, Lee SH, Donnell RL, Sukhthankar M, Eling TE, Fischer SM, Baek SJ. Nonsteroidal anti-inflammatory drug-activated gene-1 expression inhibits urethane-induced pulmonary tumorigenesis in transgenic mice. Cancer Prev Res (Phila Pa) 2(5):450-8, 5/2009. PMCID: PMC2697576.
32. Zuo X, Peng Z, Moussalli MJ, Morris JS, Broaddus RR, Fischer SM, Shureiqi I. Targeted genetic disruption of peroxisome proliferator-activated receptor-delta and colonic tumorigenesis. J Natl Cancer Inst 101(10):762-7, May 12, 5/2009. PMCID: PMC2684551.
33. Zhu F, Park E, Liu B, Xia X, Fischer SM, Hu Y. Critical role of IkappaB kinase alpha in embryonic skin development and skin carcinogenesis. Histol Histopathol 24(2):265-71, 2/2009. PMID: 19085841.
34. Wang X, Colby JK, Rengel RC, Fischer SM, Clinton SK, Klein RD. Overexpression of cyclooxygenase-2 (COX-2) in the mouse urinary bladder induces the expression of immune- and cell proliferation-related genes. Mol Carcinog 48(1):1-13, 2009. PMID: 18444251.
35. Lubet AR, Fischer SM, Steele VE, Juliana MM, Desmond R, Grubbs CJ. Rosiglitazone, a PPAR gamma agonist: Potent promoter of hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers. Int J Cancer 123(10):2254-9, 11/2008. PMID: 18712722.
36. Liu B, Xia X, Zhu F, Park E, Carbajal S, Kiguchi K, DiGiovanni J, Fischer SM, Hu Y. IKKa is required to maintain skin homeostasis and prevent skin cancer. Cancer Cell 14(3):212-25, 9/2008. PMID: 18772111.
37. Yamaguchi K, Cekanova M, McEntee MF, Yoon JH, Fischer SM, Renes IB, Van Seuningen I, Baek SJ. Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways. Mol Cancer Ther 7(9):2779-87, 9/2008. PMCID: PMC2597004.
38. Colby JK, Klein RD, McArthur MJ, Conti CJ, Kiguchi K, Kawamoto T, Riggs PK, Pavone AI, Sawicki J, Fischer SM. Progressive metaplastic and dysplastic changes in mouse pancreas induced by cyclooxygenase-2 overexpression. Neoplasia 10(8):782-96, 8/2008. PMCID: PMC2481568.
39. Ansari KM, Rundhaug JE, Fischer SM. Multiple signaling pathways are responsible for prostaglandin e2-induced murine keratinocyte proliferation. Mol Cancer Res 6(6):1003-16, 6/2008. NIHMSID: NIHMS82465.
40. Rundhaug JE, Fischer SM. Cyclo-oxygenase-2 plays a critical role in UV-induced skin carcinogenesis. Photochem Photobiol 84(2):322-9, Mar-Apr, 3/2008. PMID: 18194346.
41. Tseng-Rogenski S, Lee IL, Gebhardt D, Fischer SM, Wood C, Park JM, Liebert M. Loss of 15-hydroxyprostaglandin dehydrogenase expression disrupts urothelial differentiation. Urology 71(2):346-50, 2/2008. PMCID: PMC2474790.
42. Riedel SB, Fischer SM, Sanders BG, Kline K. Vitamin E analog, alpha-tocopherol ether-linked acetic acid analog, alone and in combination with celecoxib, reduces multiplicity of ultraviolet-induced skin cancers in mice. Anticancer Drugs 19(2):175-81, 2/2008. PMID: 18176114.
43. Wang X, Colby JK, Yang P, Fischer SM, Newman RA, Klein RD. The resistance to the tumor suppressive effects of COX inhibitors and COX-2 gene disruption in TRAMP mice is associated with the loss of COX expression in prostate tissue. Carcinogenesis 29(1):120-8, 1/2008. PMID: 17942462.

Book Chapters

1. Rundhaug JE, Fischer SM. Cellular and molecular mechanisms of tumor promotion. In: Chemical Carcinogenesis. 14, Comprehensive Toxicologey, 2nd. Ed(s) McQueen. Elsevier Science: Oxford, 311-333, 2010.
2. Rundhaug JE, Fischer SM. Cyclooxygenase-2 signaling in squamous cell carcinomas. In: Signaling Pathways in Squamous Cancer. Ed(s) AB Glick and C van Waes. Springer: New York, NY, 131-147, 2010.
3. Shen J, Fischer SM. Molecular profiling of the epidermis: a proteomics approach. In: Methods Mol Biol. 585, 2nd, 225-52, 2010. ISBN: 19908007.

Last updated: 6/4/2014