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Suyun Huang, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Neurosurgery - Research, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Adjunct Professor, Department of Neurosurgery, Baylor College of Medicine, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Boulevard
Unit Number: 1004
Houston, TX 77030
Room Number: S5.8116
Fax: (713) 834-6257

Education & Training

Degree-Granting Education

1997 The University of Texas MD Anderson Cancer Center, Graduate School of Biomedical Sciences, Houston, TX, PHD, Cancer Biology
1985 Anhui Medical University, The People's Republic of China, Hefei, China, MD, Medicine

Postgraduate Training

1/1998-1/2000 Fellowship, The University of Texas MD Anderson Cancer Center, Houston, TX

Experience/Service

Academic Appointments

Faculty Member, The Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 8/2002-present

Professional Memberships

American Association for Cancer Research
Active Member, 2003-present
Metastasis Research Society
Active Member, 2004-present
Society for Neuro-Oncology
Active Member, 2003-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Dai B, Gong A, Jing Z, Aldape KD, Kang SH, Sawaya R, Huang S. Forkhead Box M1 Is Regulated by Heat Shock Factor 1 and Promotes Glioma Cells Survival under Heat Shock Stress. J Biol Chem 288(3):1634-42, 1/2013. e-Pub 11/2012. PMCID: PMC3548473.
2. Li D, Wei P, Peng Z, Huang C, Tang H, Jia Z, Cui J, Le X, Huang S, Xie K. The Critical Role of Dysregulated FOXM1-PLAUR Signaling in Human Colon Cancer Progression and Metastasis. Clin Cancer Res 19(1):62-72, 1/2013. e-Pub 11/2012. PMCID: PMC3537853.
3. Gong A, Huang S. FoxM1 and Wnt/β-catenin signaling in glioma stem cells. Cancer Res 72(22):5658-62, 11/2012. e-Pub 11/2012. PMCID: PMC3500394.
4. Zhang N, Wu X, Yang L, Xiao F, Zhang H, Zhou A, Huang Z, Huang S. FoxM1 inhibition sensitizes resistant glioblastoma cells to temozolomide by downregulating the expression of DNA-repair gene Rad51. Clin Cancer Res 18(21):5961-71, 11/2012. e-Pub 9/2012. PMID: 22977194.
5. Huang C, Qiu Z, Wang L, Peng Z, Jia Z, Logsdon CD, Le X, Wei D, Huang S, Xie K. A Novel FoxM1-Caveolin Signaling Pathway Promotes Pancreatic Cancer Invasion and Metastasis. Cancer Res 72(3):655-65, 2/2012. e-Pub 12/2011. PMCID: PMC3271134.
6. Zhang N, Wei P, Gong A, Chiu WT, Lee H, Colman H, Huang H, Xue J, Liu M, Wang Y, Sawaya R, Xie K, Yung WK, Medema RH, He X, and Huang S. FoxM1 Promotes β-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis. Cancer Cell 20(4):427-42, 10/2011. PMCID: PMC3199318.
7. Gao Y, Jia Z, Kong X, Li Q, Chang DZ, Wei D, Le X, Huang, SD, Huang S, Wang L, Xie K. Combining betulinic acid and mithramycin A effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis. Cancer Res 71(15):5182-93, 8/2011. PMID: 21673052.
8. Chiu WT, Lee HT, Huang FJ, Aldape KD, Yao J, Steeg PS, Chou CY, Lu Z, Xie K, Huang S. Caveolin-1 Upregulation Mediates Suppression of Primary Breast Tumor Growth and Brain Metastases by Stat3 Inhibition. Cancer Res 71(14):4932-43, 7/2011. PMID: 21622714.
9. Lockman PR, Mittapalli RK, Taskar KS, Rudraraju V, Gril B, Bohn KA, Adkins CE, Roberts A, Thorsheim HR, Gaasch JA, Huang S, Palmieri D, Steeg PS, Smith QR. Heterogeneous blood-tumor barrier permeability determines drug efficacy in experimental brain metastases of breast cancer. Clinical Cancer Res 16(23):5664-78, 12/2010.
10. Li Q, Wei D, Wang L, Wang L, Jia Z, Le X, Gao Y, Huang S, Xie K. Modeling liver metastasis using a tumor cell line derived from an enhanced green fluorescent protein transgenic mouse. Clin Exp Metastasis 27(1):11-8, 2010. PMID: 19882218.
11. Li Q, Zhang N, Jia Z, Le X, Dai B, Wei D, Huang S, Tan D, Xie K. Critical role and regulation of transcription factor FoxM1 in human gastric cancer angiogenesis and progression. Cancer Research 69(8):2501-9, 4/2009.
12. Huang FJ, Steeg PS, Price JE, Chiu WT, Chou PC, Xie K, Sawaya R, Huang S. Molecular basis for the critical role of suppressor of cytokine signaling-1 in melanoma brain metastasis. Cancer Res 68(23):9634-42, 12/2008. PMID: 19047140.
13. Zhang Y, Zhang N, Dai B, Liu M, Sawaya R, Xie K, Huang S. FoxM1B transcriptionally regulates vascular endothelial growth factor expression and promotes the angiogenesis and growth of glioma cells. Cancer Res 68(21):8733-42, 11/2008. PMID: 18974115.
14. Xie TX, Aldape KD, Gong W, Kanzawa T, Suki D, Kondo S, Lang F, Ali-Osman F, Sawaya R, Huang S. Aberrant NF-kappaB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor. Int J Oncol 33(1):5-15, 7/2008. PMID: 18575745.
15. Dai B, Kang S-H, Gong W, Liu M, Aldape K, Sawaya R, and Huang S. Aberrant FoxM1B expression increases matrix metalloproteinase-2 transcription and enhances the invasion of glioma cells. Oncogene 26(42):6212-9, 2007.
16. Xie K, Wei D, Huang S. Transcriptional anti-angiogenesis therapy of human pancreatic cancer. Cytokine Growth Factor Rev 17(3):147-56, 6/2006. PMID: 16516532.
17. Liu M, Dai B, Kang SH, Ban K, Huang FJ, Lang FF, Aldape KD, Xie TX, Pelloski CE, Xie K, Sawaya R, Huang S. FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells. Cancer Res 66(7):3593-602, 4/2006. PMID: 16585184.
18. Xie TX, Huang FJ, Aldape KD, Kang SH, Liu M, Gershenwald JE, Xie K, Sawaya R, Huang S. Activation of stat3 in human melanoma promotes brain metastasis. Cancer Res 66(6):3188-96, 3/2006. PMID: 16540670.
19. Lee HY, Oh SH, Suh YA, Baek JH, Papadimitrakopoulou V, Huang S, Hong WK. Response of non-small cell lung cancer cells to the inhibitors of phosphatidylinositol 3-kinase/Akt- and MAPK kinase 4/c-Jun NH2-terminal kinase pathways: an effective therapeutic strategy for lung cancer. Clin Cancer Res 11(16):6065-74, 8/2005. PMID: 16115952.
20. Le X, Wei D, Huang S, Lancaster JR, Xie K. Nitric oxide synthase II suppresses the growth and metastasis of human cancer regardless of its up-regulation of protumor factors. Proc Natl Acad Sci U S A 102(24):8758-63, 6/2005. PMID: 15939886.
21. Gong W, Wang L, Yao JC, Ajani JA, Wei D, Aldape KD, Xie K, Sawaya R, Huang S. Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer. Clin Cancer Res 11(4):1386-93, 2/2005. PMID: 15746037.
22. Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F, Sawaya R, Huang S. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene 23(20):3550-60, 4/2004. PMID: 15116091.

Invited Articles

1. Siu TL, Huang S. Cerebral Metastases from Malignant Melanoma: Current Treatment Strategies, Advances in Novel Therapeutics and Future Directions. Cancers 2(2):364-75, 2010.
2. Devarajan E, Huang S. STAT3 as a central regulator of tumor metastasis. Curr Mol Med 9(5):626-33, 2009.
3. Huang S. Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implications. Clin Cancer Res 13(5):1362-6, 3/2007. PMID: 17332277.
4. Palmieri D, Chambers AF, Felding-Habermann B, Huang S, Steeg PS. The biology of metastasis to a sanctuary site. Clin Cancer Res 13(6):1656-62, 2007. PMID: 17363518.
5. Xie K, Wei D, Shi Q, Huang S. Constitutive and inducible expression and regulation of vascular endothelial growth factor. Cytokine Growth Factor Rev 15(5):297-324, 2004. PMID: 15450248.
6. Xie K, Huang S. Contribution of nitric oxide-mediated apoptosis to cancer metastasis inefficiency. Free Radic Biol Med 34(8):969-86, 4/2003. PMID: 12684082.
7. Xie K, Huang S. Regulation of cancer metastasis by stress pathways. Clin Exp Metastasis 20(1):31-43, 2003. PMID: 12650605.

Abstracts

1. Dai BB, Jing Z, Kang S-H, Li D, Xie K, Huang S. Foxm1 is regulated by HSF1 and protects glioma cells from heat shock stress induced cell death. Society for NeuroOncology 15th Scientific Meeting, 11/2010.
2. Xie TX, Gong W, Huang F, Kanzawa T, Kondo S, Lang FF, Sawaya R, Huang S. Constitutive JF-kB activity regulates growth, angiogenesis, and necrosis formation of human glioblastoma cells. AACR Special Conference on Chromatin, Chromosomes, and Cancer Epigenetics, 11/2004.

Grant & Contract Support

Title: Signal Integration of Transcriptional Pathways in Gliomagenesis
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 1/1/2014 - 12/31/2018
 
Title: Brain Tumor SPORE
Funding Source: NIH/NCI
Role: Project Principal Investigator
Duration: 9/1/2013 - 8/31/2015
 
Title: Transcriptional regulation of gliomagenesis
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 7/5/2011 - 4/30/2016
 
Title: Functional Validation of Pancreatic Cancer Progression Biomarker
Funding Source: NIH/NCI
Role: Co-Principal Investigator
Principal Investigator: Xie, Keping
Duration: 7/1/2010 - 6/30/2015

Last updated: 7/31/2014