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Suyun Huang, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Neurosurgery - Research, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Adjunct Professor, Department of Neurosurgery, Baylor College of Medicine, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Boulevard
Unit Number: 1004
Houston, TX 77030
Room Number: S5.8116
Fax: (713) 834-6257

Education & Training

Degree-Granting Education

1997 The University of Texas MD Anderson Cancer Center, Graduate School of Biomedical Sciences, Houston, TX, PHD, Cancer Biology
1985 Anhui Medical University, The People's Republic of China, Hefei, China, MD, Medicine

Postgraduate Training

1/1998-1/2000 Fellowship, The University of Texas MD Anderson Cancer Center, Houston, TX

Experience/Service

Academic Appointments

Faculty Member, The Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 8/2002-present

Professional Memberships

American Association for Cancer Research
Active Member, 2003-present
Metastasis Research Society
Active Member, 2004-present
Society for Neuro-Oncology
Active Member, 2003-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Li Q, Zhang N, Jia Z, Le X, Dai B, Wei D, Huang S, Tan D, Xie K. Critical role and regulation of transcription factor FoxM1 in human gastric cancer angiogenesis and progression. Cancer Research 69(8):2501-9, 4/2009.
2. Huang FJ, Steeg PS, Price JE, Chiu WT, Chou PC, Xie K, Sawaya R, Huang S. Molecular basis for the critical role of suppressor of cytokine signaling-1 in melanoma brain metastasis. Cancer Res 68(23):9634-42, 12/2008. PMID: 19047140.
3. Zhang Y, Zhang N, Dai B, Liu M, Sawaya R, Xie K, Huang S. FoxM1B transcriptionally regulates vascular endothelial growth factor expression and promotes the angiogenesis and growth of glioma cells. Cancer Res 68(21):8733-42, 11/2008. PMID: 18974115.
4. Xie TX, Aldape KD, Gong W, Kanzawa T, Suki D, Kondo S, Lang F, Ali-Osman F, Sawaya R, Huang S. Aberrant NF-kappaB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor. Int J Oncol 33(1):5-15, 7/2008. PMID: 18575745.
5. Dai B, Kang S-H, Gong W, Liu M, Aldape K, Sawaya R, and Huang S. Aberrant FoxM1B expression increases matrix metalloproteinase-2 transcription and enhances the invasion of glioma cells. Oncogene 26(42):6212-9, 2007.
6. Xie K, Wei D, Huang S. Transcriptional anti-angiogenesis therapy of human pancreatic cancer. Cytokine Growth Factor Rev 17(3):147-56, 6/2006. PMID: 16516532.
7. Liu M, Dai B, Kang SH, Ban K, Huang FJ, Lang FF, Aldape KD, Xie TX, Pelloski CE, Xie K, Sawaya R, Huang S. FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells. Cancer Res 66(7):3593-602, 4/2006. PMID: 16585184.
8. Xie TX, Huang FJ, Aldape KD, Kang SH, Liu M, Gershenwald JE, Xie K, Sawaya R, Huang S. Activation of stat3 in human melanoma promotes brain metastasis. Cancer Res 66(6):3188-96, 3/2006. PMID: 16540670.
9. Lee HY, Oh SH, Suh YA, Baek JH, Papadimitrakopoulou V, Huang S, Hong WK. Response of non-small cell lung cancer cells to the inhibitors of phosphatidylinositol 3-kinase/Akt- and MAPK kinase 4/c-Jun NH2-terminal kinase pathways: an effective therapeutic strategy for lung cancer. Clin Cancer Res 11(16):6065-74, 8/2005. PMID: 16115952.
10. Le X, Wei D, Huang S, Lancaster JR, Xie K. Nitric oxide synthase II suppresses the growth and metastasis of human cancer regardless of its up-regulation of protumor factors. Proc Natl Acad Sci U S A 102(24):8758-63, 6/2005. PMID: 15939886.
11. Gong W, Wang L, Yao JC, Ajani JA, Wei D, Aldape KD, Xie K, Sawaya R, Huang S. Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer. Clin Cancer Res 11(4):1386-93, 2/2005. PMID: 15746037.
12. Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F, Sawaya R, Huang S. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene 23(20):3550-60, 4/2004. PMID: 15116091.
13. Raza SM, Fuller GN, Rhee CH, Huang S, Hess K, Zhang W, Sawaya R. Identification of necrosis-associated genes in glioblastoma by cDNA microarray analysis. Clin Cancer Res 10(1 Pt 1):212-21, 2004. PMID: 14734472.
14. Huang S, Van Arsdall M, Tedjarati S, McCarty M, Wu W, Langley R, Fidler IJ. Contributions of stromal metalloproteinase-9 to angiogenesis and growth of human ovarian carcinoma in mice. J Natl Cancer Inst 94(15):1134-42, 8/2002. PMID: 12165638.
15. Huang S, Mills L, Mian B, Tellez C, McCarty M, Yang XD, Gudas JM, Bar-Eli M. Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. Am J Pathol 161(1):125-34, 7/2002. PMID: 12107097.
16. Huang S, Bucana CD, Van Arsdall M, Fidler IJ. Stat1 negatively regulates angiogenesis, tumorigenicity and metastasis of tumor cells. Oncogene 21(16):2504-12, 4/2002. PMID: 11971185.
17. Huang S, Pettaway CA, Uehara H, Bucana CD, Fidler IJ. Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene 20:4188-97, 7/2001. PMID: 11464285.
18. Huang S, Robinson JB, Deguzman A, Bucana CD, Fidler IJ. Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer Res 60:5334-9, 10/2000. PMID: 11034066.
19. Huang S, Jean D, Luca M, Tainsky MA, Bar-Eli M. Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis. Embo J 17:4358-69, 8/1998. PMID: 9687504.

Invited Articles

1. Devarajan E, Huang S. STAT3 as a central regulator of tumor metastasis. Curr Mol Med 9(5):626-33, 2009.
2. Huang S. Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implications. Clin Cancer Res 13(5):1362-6, 3/2007. PMID: 17332277.
3. Palmieri D, Chambers AF, Felding-Habermann B, Huang S, Steeg PS. The biology of metastasis to a sanctuary site. Clin Cancer Res 13(6):1656-62, 2007. PMID: 17363518.
4. Xie K, Wei D, Shi Q, Huang S. Constitutive and inducible expression and regulation of vascular endothelial growth factor. Cytokine Growth Factor Rev 15(5):297-324, 2004. PMID: 15450248.
5. Xie K, Huang S. Contribution of nitric oxide-mediated apoptosis to cancer metastasis inefficiency. Free Radic Biol Med 34(8):969-86, 4/2003. PMID: 12684082.
6. Xie K, Huang S. Regulation of cancer metastasis by stress pathways. Clin Exp Metastasis 20(1):31-43, 2003. PMID: 12650605.

Abstracts

1. Dai BB, Jing Z, Kang S-H, Li D, Xie K, Huang S. Foxm1 is regulated by HSF1 and protects glioma cells from heat shock stress induced cell death. Society for NeuroOncology 15th Scientific Meeting, 11/2010.
2. Xie TX, Gong W, Huang F, Kanzawa T, Kondo S, Lang FF, Sawaya R, Huang S. Constitutive JF-kB activity regulates growth, angiogenesis, and necrosis formation of human glioblastoma cells. AACR Special Conference on Chromatin, Chromosomes, and Cancer Epigenetics, 11/2004.

Grant & Contract Support

Title: Transcriptional regulation of gliomagenesis
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 7/5/2011 - 4/30/2016
 
Title: Brain Tumor SPORE
Funding Source: NIH/NCI
Role: Project Principal Investigator
Duration: 9/1/2010 - 8/31/2013
 
Title: Functional Validation of Pancreatic Cancer Progression Biomarker
Funding Source: NIH/NCI
Role: Co-Principal Investigator
Principal Investigator: Xie, Keping
Duration: 7/1/2010 - 6/30/2015
 
Title: Novel Molecular Mechanism of Glioma Pathogenesis
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 7/1/2010 - 6/30/2012
 
Title: The Role of FoxM1 in Human Glioma Development and Progression
Funding Source: National Institutes of Health
Role: Principal Investigator
Duration: 9/15/2006 - 7/31/2011
 
Title: Center of Excellent, Studies directed toward the eradication of brain metastases of breast cancer
Funding Source: DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP)
Role: Projector Principal Investigator and Animal Core Leader
Principal Investigator: Steeg, Patricia
Duration: 1/6/2006 - 5/31/2012

Last updated: 2/6/2013