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Thomas A Buchholz, M.D., F.A.C.R.

Present Title & Affiliation

Primary Appointment

Division Head, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Frank T. McGraw Memorial Chair in the Study of Cancer, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Department Chair, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor (tenure), Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Bio Statement

Dr. Buchholz is Professor and Division Head of the Department of Radiation Oncology at The University of Texas M. D. Anderson Cancer Center. He holds the Frank T. McGraw Chair for the Study of Cancer. His academic interests focus on clinical and translational research in breast cancer and radiation oncology. Specific interests include studying molecular determinants of treatment resistance and investigating novel combinations of targeted therapy with radiation to improve the therapeutic outcome. Finally, Dr. Buchholz has a strong interest in education and mentoring junior faculty and trainees in both clinical and translational research. 

Education & Training

Degree-Granting Education

1988 Tufts University School of Medicine, Boston, MA, MD, Medicine
1984 Bucknell University, Lewisburg, PA, BA, Philosophy

Postgraduate Training

1/2005-12/2005 Faculty Leadership Training, The University of Texas MD Anderson Cancer Center, Houston, TX
7/1992-6/1993 Research Fellowship, Radiobiology Research, University of Washington Medical Center, Seattle, WA, George E. Laramore, M.D., Ph.D., Janet S. Rasey, P
7/1989-6/1992 Clinical Residency, Radiation Oncology, University of Washington Medical Center, Seattle, WA, Wui-Jin Koh, M.D.
7/1988-6/1989 Clinical Internship, Medical Internship, Mount Auburn Hospital, Cambridge, MA, Charles Hatem, M.D.

Board Certifications

6/1993 American Board of Radiology (Radiation Oncology)
1/1989 National Board of Medical Examiners

Honors and Awards

2011 Consumers' Checkbook's Top Doctor, Doximity
2011 America's Top Doctors for Cancer, Castle Connolly, LTD.
2008 Fellow, American College of Radiology, American College of Radiology
2003-2010 Top Doctors in America/America's Top Doctors, Castle Connolly Medical Ltd
2002-2010 Best Doctors in America, Best Doctors Inc

Selected Publications

Peer-Reviewed Original Research Articles
1. Smith GL, Xu Y, Buchholz TA, Giordano SH, Jiang J, Shih YC, Smith BD. Association between treatment with brachytherapy vs whole-breast irradiation and subsequent mastectomy, complications, and survival among older women with invasive breast cancer. JAMA 307(17):1827-1837, 5/2012. PMID: 22550197.
2. McGovern SL, Qi Y, Pusztai L, Symmans WF, Buchholz TA. CENP-A, an essential centromere protein, is a prognostic marker for relapse in estrogen receptor-positive breast cancer. Breast Cancer Research 14(R72). e-Pub 5/2012.
3. Buchholz TA. How does biology affect local therapy decisions? ASCO Educational Book, 5/2012.
4. Debeb BG, Cohen EN, Boley K, Freiter EM, Li L, Robertson FM, Reuben JM, Cristofanilli M, Buchholz TA, Woodward WA. Pre-clinical studies of notch signaling inhibitor RO4929097 in inflammatory breast cancer cells. Breast Cancer Research and Treatment. e-Pub 5/2012. PMID: 22547109.
5. Carkaci S, Adrada BE, Rohren E, Wei W, Quraishi MA, Mawlawi O, Buchholz TA, Yang W. Semiquantitative analysis of maximum standardized uptake values of regional lymph nodes in inflammatory breast cancer: Is there a reliable threshold for differentiating benign from malignant? Acad Radiol 19(5):535-41, 5/2012. e-Pub 2/1/2012. PMID: 22300741.
6. Dawood S, Ueno NT, Valero V, Woodward WA, Buchholz TA, Hortobagyi GN, Gonzalez-Angulo AM, Cristofanilli M. Identifying factors that impact survival among women with inflammatory breast cancer. Ann Oncol 23(4):870-5, 4/2012. e-Pub 7/15/2011. PMID: 21765048.
7. Cheng L, Swartz M, Zhao H, Kapadia A, Lai D, Rowan P, Buchholz TA, Giordano S. Hazard of recurrent among women after primary breast cancer treatment – a 10-year follow-up using data from SEER-Medicare. Cancer Epidemiol Biomarkers Prev. e-Pub 3/16/2012. PMID: 22426147.
8. Wu Y, Mittendorf EA, Kelten C, Tucker SL, Wei W, Middleton LP, Broglio K, Buchholz TA, Hunt KK, Sahin AA. Occult axillary lymph node metastasis do not have prognostic significance in early stage breast cancer. Cancer 118(6):1507-14, 3/15/2012. e-Pub 8/25/2011. PMID: 22009292.
9. Akay CL, Meric-Bernstam F, Hunt KK, Grubbs EG, Bedrosian I, Tucker SL, Kuerer HM, Hoffman KE, Babiera GV, Strom EA, Buchholz TA, Mittendorf EA. Evaluation of the MD Anderson Prognostic Index for local-regional recurrence after breast conserving therapy in patients receiving neoadjuvant chemotherapy. Ann Surg Oncol 19(3):901-907, 3/2012. e-Pub 8/23/2011. PMID: 21861223.
10. Wang X, Pan T, Pinnix C, Zhang SX, Salehpour M, Sun TL, Gladish G, Strom EA, Perkins GH, Tereffe W, Woodward W, Hoffman KE, Buchholz TA, Yu TK. Cardiac motion during deep-inspiration breath-hold: implications for breast cancer radiotherapy. Int J Radiat Oncol Biol Phys 82(2):708-14, 2/1/2012. e-Pub 3/26/2011. PMID: 21444161.
11. Dawood S, Lei X, Litton JK, Buchholz TA, Hortobagyi GN, Gonzalez-Angulo AM. Incidence of brain metastases as a first site of recurrence among women with triple receptor-negative breast cancer. Cancer. e-Pub 2/22/2012. PMID: 22359359.
12. Wang LE, Han CH, Xiong P, Bondy ML, Yu TK, Brewster AM, Shete S, Arun BK, Buchholz TA, Wei Q. Gamma-ray-induced mutagen sensitivity and risk of sporadic breast cancer in young women: a case-control study. Breast Cancer Res Treat. e-Pub 1/5/2012. PMID: 22218884.
13. Walker GV, Niikura N, Yang W, Rohren E, Valero V, Woodward WA, Alvarez RH, Lucci A, Ueno NT, Buchholz TA. Pretreatment staging positron emission tomography/computed tomography in patients with inflammatory breast cancer influences radiation treatment field design. Int J Radiat Oncol Biol Phys. e-Pub 1/25/2012. PMID: 22284689.
14. Chien CR, Pan IW, Tsai YW, Tsai T, Liang JA, Buchholz TA, Shih YC. Radiation Therapy After Breast-Conserving Surgery: Does Hospital Surgical Volume Matter? A Population-Based Study in Taiwan. Int J Radiat Oncol Biol Phys 82(1):43-50, 1/1/2012. e-Pub 11/13/2010. PMID: 21075558.
15. Barcenas CH, Zhang N, Zhao H, Duan Z, Buchholz TA, Hortobagyi GN, Giordano SH. Anthracycline regimen adherencein older patients with early breast cancer. Oncologist 17(3):303-11, 2012. e-Pub 2/27/2012. PMID: 22371383.
16. Smith BD, Jiang J, McLaughlin SS, Hurria A, Smith GL, Giordano SH, Buchholz TA. Improvement in breast cancer outcomes over time: Are older women missing out? J Clin Oncol 29(35):4647-53, 12/10/2011. e-Pub 11/7/2011. PMID: 22067407.
17. Yi M, Mittendorf EA, Cormier JN, Buchholz TA, Bilimoria K, Sahin AA, Hortobagyi GN, Gonzalez-Angulo AM, Luo S, Buzdar AU, Crow JR, Kuerer HM, Hunt KK. Novel staging system for predicting disease-specific survival in patients with breast cancer treated with surgery as the first invervention: Time to modify the current American Joint Committee on Cancer staging system. J Clin Oncol 29(35):4654-61, 12/10/2011. e-Pub 11/14/2011. PMCID: PMC3236648.
18. Gong Y, Huo L, Liu P, Sneige N, Sun X, Ueno NT, Lucci A, Buchholz TA, Valero V, Cristofanilli M. Polycomb group protein EZH2 is frequently expressed in inflammatory breast cancer and is predictive of worse clinical outcome. Cancer 117(24):5476-84, 12/15/2011. e-Pub 6/28/2011. PMID: 21713757.
19. Haffty BG, Hunt KK, Harris JR, Buchholz TA. Positive sentinel nodes without axillary dissection: Implications for the radiation oncologist. J Clin Oncol 29(34):4479-81, 12/1/2011. e-Pub 10/31/2011. PMID: 22042942.
20. Pinnix C, Perkins GH, Strom EA, Tereffe W, Woodward W, Oh JL, Arriaga L, Munsell MF, Kelly P, Hoffman KE, Smith BD, Buchholz TA, Yu TK. Topical hyaluronic acid vs. standard of care for the prevention of radiation dermatitis after adjuvant radiotherapy for breast cancer: single-blind randomized phase III clinical trial. Int J Radiat Oncol Biol Phys. e-Pub 12/14/2011. PMID: 22172912.
21. Nagar H, Mittendorf EA, Strom EA, Perkins GH, Oh JL, Tereffe W, Woodward WA, Gonzalez-Angulo AM, Hunt KK, Buchholz TA, Yu TK. Local-regional recurrence with and without radiation therapy after neoadjuvant chemotherapy and mastectomy for clinically-staged T3N0 breast cancer. Int J Radiat Oncol Biol Phys 81(3):782-7, 11/2011. e-Pub 8/2011. PMID: 21885207.
22. Wang L, Mason KA, Ang KK, Buchholz T, Valdecanas D, Mathur A, Buser-Doepner C, Toniatti C, Milas L. MK-4827, a PARP-1/-2 inhibitor, strongly enhances response of human lung and breast cancer xenografts to radiation. Invest New Drugs. e-Pub 11/2011. PMID: 22127459.
23. Buchholz TA. Radiotherapy and survival in breast cancer. Lancet 378(9804):1680-1682, 11/2011. e-Pub 10/2011. PMID: 22019143.
24. Chavez-MacGregor M, Zhao H, Kroll M, Fang S, Zhang N, Hortobagyi GN, Buchholz TA, Shih YC, Giordano SH. Risk factors and incidence of thromboembolic events (TEEs) in older men and women with breast cancer. Ann Oncol 22(11):2394-2402, 11/2011. PMID: 21393379.
25. Bridges KA, Hirai H, Buser CA, Brooks C, Liu H, Buchholz TA, Molkentine JM, Mason KA, Meyn RE. MK-1775, a novel Wee1 kinase inhibitor, radiosensitized p53-defective human tumor cells. Clin Cancer Res 17(17):5638-48, 9/1/2011. e-Pub 7/28/2011. PMCID: PMC3167033.
26. Caudle AS, Hunt KK, Kuerer HM, Meric-Bernstam F, Lucci A, Bedrosian I, Babiera GV, Hwang RF, Ross MI, Feig BW, Hoffman K, Litton JK, Sahin AA, Yang W, Hortobagyi GN, Buchholz TA, Mittendorf EA. Multidisciplinary considerations concerning implementation of the findings from the ACOSOG Z0011 Study. Ann Surg Oncol 18(9):2407-12, 9/2011. e-Pub 2/2011. PMID: 21327455.
27. Wang X, Amos RA, Zhang X, Taddei PJ, Woodward WA, Hoffman KE, Yu TK, Tereffe W, Oh J, Perkins GH, Salehpour M, Zhang SX, Sun TL, Gillin M, Buchholz TA, Strom EA. External-Beam Accelerated Partial Breast Irradiation Using Multiple Proton Beam Configurations. Int J Radiat Oncol Biol Phys 80(5):1464-72, 8/1/2011. e-Pub 8/12/2010. PMID: 20708848.
28. Reddy JP, Levy L, Oh JL, Strom EA, Perkins GH, Buchholz TA, Woodward WA. Long-term outcomes in patients with isolated supraclavicular nodal recurrence after mastectomy and Doxorubicin-based chemotherapy for breast cancer. Int J Radiat Oncol Biol Phys 80(5):1453-7, 8/1/2011. e-Pub 12/16/2010. PMID: 21168284.
29. Hernandez-Aya LF, Chavez-Macgregor M, Lei X, Meric-Bernstam F, Buchholz TA, Hsu L, Sahin AA, Do KA, Valero V, Hortobagyi GN, Gonzalez-Angulo AM. Nodal status and clinical outcomes in a large cohort of patients with triple-negative breast cancer. J Clin Oncol 29(19):2628-34, 7/2011. PMCID: PMC3139370.
30. Albert JM, Buzdar AU, Guzman R, Allen PK, Strom EA, Perkins GH, Woodward WA, Hoffman KE, Tereffe W, Hunt KK, Buchholz TA, Oh JL. Prospective randomized trial of 5-fluorouracil, doxorubicin, and cyclophosphamide (FAC) versus paclitaxel and FAC (TFAC) in patients with operable breast cancer: impact of taxane chemotherapy on locoregional control. Breast Cancer Res Treat 128(2):421-7, 7/2011. e-Pub 5/8/2011. PMID: 21553292.
31. Shirvani SM, Pan IW, Buchholz TA, Shih YC, Hoffman KE, Giordano SH, Smith BD. Impact of evidence-based clinical guidelines on the adoption of postamastectomy radiation in older women. Cancer. e-Pub 6/27/2011. PMID: 21710653.
32. Smith BD, Pan IW, Shih YC, Smith GL, Harris JR, Punglia R, Pierce LJ, Jagsi R, Hayman JA, Giordano SH, Buchholz TA. Adoption of intensity modulated radiation therapy for breast cancer in the United States. J Natl Cancer Inst 103(10):798-809, 5/18/2011. e-Pub 4/27/2011. PMID: 21525437.
33. Dawood S, Ueno NT, Valero V, Woodward WA, Buchholz TA, Hortobagyi GN, Gonzalez-Angulo AM, Cristofanilli M. Differences in survival among women with stage III inflammatory and noninflammatory locally advanced breast cancer appear early: a large population-based study. Cancer 117(9):1819-26, 5/2011. e-Pub 11/2010. PMID: 21509759.
34. Buchholz TA. Radiation in the setting of marked cytoreduction: do we radiate a cleared nodal basin or breast? ASCO Educational Book, 5/2011.
35. Guadagnolo BA, Xu Y, Zagars GK, Cormier JN, Pollock RE, Feig BW, Giordano S, Buchholz TA, Shih YC. A Population-Based Study of the Quality of Care in the Diagnosis of Large (≥5 cm) Soft Tissue Sarcomas. Am J Clin Oncol. e-Pub 4/29/2011. PMID: 21537147.
36. Shih YC, Chien CR, Xu Y, Pan IW, Smith GL, Buchholz TA. Economic burden of renal cell carcinoma: Part I--an updated review. Pharmacoeconomics 29(4):315-329, 4/2011. PMID: 21395351.
37. Shih YC, Chien CR, Xu Y, Pan IW, Smith GL, Buchholz TA. Economic burden of renal cell carcinoma in the US: Part II--an updated analysis. Pharmacoeconomics 29(4):331-41, 4/2011. PMID: 21395352.
38. Yi M, Buchholz TA, Meric-Bernstam F, Bedrosian I, Hwang RF, Ross MI, Kuerer HM, Luo S, Gonzalez-Angulo AM, Buzdar AU, Symmans WF, Feig BW, Lucci A, Huang EH, Hunt KK. Classification of ipsilateral breast tumor recurrences after breast conservation therapy can predict patient prognosis and facilitate treatment planning. Ann Surg 253(3):572-579, 3/2011. e-Pub 1/2011. PMID: 21209588.
39. Dawood S, Merajver SD, Viens P, Vermeulen PB, Swain SM, Buchholz TA, Dirix LY, Levine PH, Lucci A, Krishnamurthpy S, Robertson FM, Woodward WA, Yang WT, Ueno NT, Cristofanilli M. International expert panel on inflammatory breast cancer: consensus statement for standardized diagnosis and treatment. Ann Oncol 22(3):515-523, 3/2011. PMID: 20603440.
40. Li J, Gonzalez-Angulo AM, Allen PK, Yu TK, Woodward WA, Ueno NT, Lucci A, Krishnamurthy S, Gong Y, Bondy ML, Yang W, Willey JS, Cristofanilli M, Valero V, Buchholz TA. Triple-negative subtype predicts poor overall survival and high locoregional relapse in inflammatory breast cancer. Oncologist 16(12):1675-83, 2011. e-Pub 12/2011. PMID: 22147002.
41. Dawood S, Ueno NT, Valero V, Andreopoulou E, Hsu L, Lara J, Woodward W, Buchholz TA, Hortobagyi GN, Cristofanilli M. Incidence of and survival following brain metastases among women with inflammatory breast cancer. Ann Oncol 21(12):2348-55, 12/2010. e-Pub 5/3/2010. PMID: 20439340.
42. Smith BD, Haffty BG, Wilson LD, Smith GL, Patel AN, Buchholz TA. The Future of Radiation Oncology in the United States From 2010 to 2020: Will Supply Keep Pace With Demand? J Clin Oncol 28(35):5160-5165, 12/2010. PMID: 20956628.
43. Walker GV, Smith GL, Perkins GH, Oh JL, Woodward W, Yu TK, Hunt KK, Hoffman K, Strom EA, Buchholz TA. Population-based analysis of occult primary breast cancer with axillary lymph node metastasis. Cancer 116(17):4000-6, 9/1/2010. e-Pub 6/2010. PMID: 20564117.
44. Woodward WA, Truong PT, Yu TK, Tereffe W, Oh J, Perkins G, Strom E, Meric-Bernstam F, Gonzalez-Angulo AM, Speers C, Ragaz J, Buchholz TA. Among women who experience a recurrence after postmastectomy radiation therapy irradiation is not associated with more aggressive local recurrence or reduced survival. Breast Cancer Res Treat 123(2):597-605, 9/2010. e-Pub 3/20/2010. PMID: 20306128.
45. Burstein HJ, Prestrud AA, Seidenfeld J, Anderson H, Buchholz TA, Davidson NE, Gelmon KE, Giordano SH, Hudis CA, Malin J, Mamounas EP, Rowden D, Solky AJ, Sowers MR, Stearns V, Winer EP, Somerfield MR, Griggs JJ, American Society of Clinical Oncology. American Society of Clinical Oncology Practice Guideline: 2009 update on adjuvant endocrine therapy for women with hormone-receptor positive breast cancer. J Clin Oncol 28(23):3784-3796, 8/10/2010. e-Pub 7/12/2010. PMID: 20625130.
46. Albert JM, Gonzalez-Angulo AM, Guray M, Sahin A, Strom EA, Tereffe W, Woodward WA, Tucker SL, Hunt KK, Hortobagyi GN, Buchholz TA. Estrogen/progesterone receptor negativity and HER2 positivity predict locoregional recurrence in patients with T1a,bN0 breast cancer. Int J Radiat Oncol Biol Phys 77(5):1296-1302, 8/1/2010. e-Pub 5/14/2010. PMID: 20472353.
47. Zhang YJ, Oh JL, Whitman GJ, Iyengar P, Yu TK, Tereffe W, Woodward WA, Perkins G, Buchholz TA, Strom EA. Clinically apparent internal mammary nodal metastasis in patients with advanced breast cancer: Incidence and local control. Int J Radiat Oncol Biol Phys 77(4):1113-9, 7/15/2010. e-Pub 12/11/2009. PMID: 20004535.
48. Debeb BG, Zhang X, Krishnamurthy S, Gao H, Cohen E, Li L, Rodriguez AA, Landis MD, Lucci A, Ueno NT, Robertson F, Xu W, Lacerda L, Buchholz TA, Cristofanilli M, Reuben JM, Lewis MT, Woodward WA. Characterizing cancer cells with cancer stem cell-like features in 293T human embryonic kidney cells. Mol Cancer 9(1). e-Pub 7/2010. PMID: 20615238.
49. Dawood S, Gonzalez-Angulo AM, Albarracin C, Yu TK, Hortobagyi GN, Buchholz TA, Woodward WA. Prognostic factors of survival in the trastuzumab era among women with breast cancer and brain metastases who receive whole brain radiotherapy: a single-institution review. Cancer 116(13):3084-92, 7/2010. PMID: 20564633.
50. Han CH, Lu J, Wei Q, Bondy ML, Brewster AM, Yu TK, Buchholz TA, Arun BK, Wang LE. The functional promoter polymorphism (-842G>C) in the PIN1 gene is associated with decreased risk of breast cancer in non-Hispanic white women 55 years and younger. Breast Cancer Res Treat 122(1):243-9, 7/2010. e-Pub 12/2009. PMCID: PMC2883663.
51. Homann KL, Gates E, Salehpour M, Followill DS, Kirsner SM, White A, Buchholz TA, Prado KL. Use of a matchline dosimetry analysis tool (MDAT) to quantify dose homogeneity in the region between abutting radiation fields. J Appl Clin Med Phys 11(4):3294, 7/2010. PMID: 21081889.
52. Greenbaum MP, Strom EA, Allen PK, Perkins GH, Oh JL, Tereffe W, Yu TK, Buchholz TA, Woodward WA. Low locoregional recurrence rates in patients treated after 2000 with doxorubicin based chemotherapy, modified radical mastectomy, and post-mastectomy radiation. Radiother Oncol 95(3):312-6, 6/2010. e-Pub 3/2010. PMID: 20227126.
53. Woodward WA, Debeb BG, Xu W, Buchholz TA. Overcoming radiation resistance in inflammatory breast cancer. Cancer 116(11 Suppl):2840-5, 6/2010. PMID: 20503417.
54. Cristofanilli M, Buchholz TA. Proceedings of the first international inflammatory breast cancer conference. Cancer 116(11 Suppl):2729, 6/2010. PMID: 20503400.
55. Kaufmann M, Morrow M, von Minckwitz G, Harris JR, and The Biedenkopf Expert Panel Members (i.e. Buchholz TA, et al). Locoregional treatment of primary breast cancer: Consensus recommendations from an international expert panel. Cancer 1(116(5)):1184-1191, 3/2010. PMID: 20087962.
56. Smith GL, Shih YC, Xu Y, Giordano SH, Smith BD, Perkins GH, Tereffe W, Woodward WA, Buchholz TA. Racial disparities in the use of radiotherapy after breast-conserving surgery: A national Medicare study. Cancer 116(3):734-41, 2/1/2010. e-Pub 1/2010. PMID: 20014181.
57. Smith GL, Shih YC, Giordano SH, Smith BD, Buchholz TA. A method to predict breast cancer stage using Medicare claims. Epidemiol Perspect Innov 7:1, 2010. PMCID: PMC2818641.
58. Robertson FM, Bondy M, Yang WT, Yamauchi H, Wiggins S, Kamrudin S, Krishnamurthy S, Le-Petross H, Bidaut L, Player A, Barsky S. Woodward WA, Buchholz TA, Lucci A, Ueno NT, Cristofanilli M. Inflammatory Breast Cancer: the disease, the biology, the treatment. CA Cancer J Clin 60(6):351-375, 2010. PMID: 20959401.
59. Klopp AH, Lacerda L, Gupta A, Debeb BG, Solley T, Li L, Spaeth E, Xu W, Zhang X, Lewis MT, Reuben JM, Krishnamurthy S, Ferrari M, Gaspar R, Buchholz TA, Cristofanilli M, Marini F, Andreeff M, Woodward WA. Mesenchymal stem cells promote mammosphere formation and decrease E-cadherin in normal andmalignant breast cells. PLoS One 5(8), 2010. PMCID: PMC2922340.
60. Gonzalez-Angulo AM, Litton JK, Broglio KR, Meric-Bernstam F, Rakkhit R, Cardoso F, Peintinger F, Hanrahan EO, Sahin A, Guray M, Larsimont D, Feoli F, Stranzl H, Buchholz TA, Valero V, Theriault R, Piccart-Gebhart M, Ravdin PM, Berry DA, Hortobagyi GN. High risk of recurrence for patients with breast cancer who have human epidermal growth factor receptor 2-positive, node-negative tumors 1 cm or smaller. J Clin Oncol 27(34):5700-5706, 12/2009. e-Pub 11/2009. PMCID: PMC2792998.
61. Smith GL, Xu Y, Shih YC, Giordano SH, Smith BD, Hunt KK, Strom EA, Perkins GH, Hortobagyi GN, Buchholz TA. Breast conserving surgery in older patients with invasive breast cancer: current patterns of treatment across the United States. J Am Coll Surg 209(4):425-433.e2, 10/2009. e-Pub 8/2009. PMID: 19801315.
62. Smith BD, Arthur DW, Buchholz TA, Haffty BG, Hahn CA, Hardenbergh PH, Julian TB, Marks LB, Todor DA, Vicini FA, Whelan TJ, White J, Wo JY, Harris JR. Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO). J Am Coll Surg 209(2):269-77, 8/2009. e-Pub 4/2009. PMID: 19632605.
63. Smith BD, Smith GL, Roberts KB, Buchholz TA. Baseline utilization of breast radiotherapy prior to Institution of the Medicare Practice Quality Reporting Initiative. Int J Radiat Oncol Biol Phys 74(5):1506-12, 8/2009. e-Pub 4/2009. PMID: 19395182.
64. Smith GL, Smith BD, Garden AS, Rosenthal DI, Sherman SI, Morrison WH, Schwartz DL, Weber RS, Buchholz TA. Hypothyroidism in older patients with head and neck cancer after treatment with radiation: a population-based study. Head Neck 31(8):1031-8, 8/2009. e-Pub 4/2009. PMID: 19360741.
65. Zhang SX, Gao J, Buchholz TA, Wang Z, Salehpour MR, Drezek RA, Yu TK. Quantifying Tumor-Selective Radiation Dose Enhancements Using Gold Nanoparticles: A Monte Carlo Simulation Study. Biomed Microdevices 11(4):925-33, 8/2009. e-Pub 4/2009. PMID: 19381816.
66. Smith BD, Arthur DW, Buchholz TA, Haffty BG, Hahn CA, Hardenbergh PH, Julian TB, Marks LB, Todor DA, Vicini FA, Whelan TJ, White J, Wo JY, Harris JR. Accelerated partial breast irradiation consensus statement from the American Society for radiation Oncology (ASTRO). Int J Radiat Oncol Biol Phys 74(4):987-1001, 7/2009. PMID: 19545784.
67. Smith BD, Smith GL, Hurria A, Hortobagyi GN, Buchholz TA. Future of cancer incidence in the United States: Burdens upon an aging, changing nation. J Clin Oncol 27(17):2758-65, 6/2009. e-Pub 4/2009. PMID: 19403886.
68. Smith GL, Smith BD, Buchholz TA, Liao Z, Jeter M, Swisher SG, Hofstetter WL, Ajani JA, McAleer MF, Komaki R, Cox JD. Patterns of care and locoregional treatment outcomes in older esophageal cancer patients: The SEER-Medicare Cohort. Int J Radiat Oncol Biol Phys 74(2):482-9, 6/2009. e-Pub 3/2009. PMID: 19289262.
69. Wang X, Yu TK, Salehpour M, Zhang SX, Sun TL, Buchholz TA. Breast Cancer Regional Radiation Fields for Supraclavicular and Axillary Lymph Node Treatment: Is a Posterior Axillary Boost Field Technique Optimal? Int J Radiat Oncol Biol Phys 74(1):86-91, 5/2009. e-Pub 9/2008. PMID: 18805650.
70. Lott ST, Chen N, Chandler DS, Yang Q, Wang L, Rodriguez M, Xie H, Balasenthil S, Buchholz TA, Sahin AA, Chaung K, Zhang B, Olufemi SE, Chen J, Adams H, Band V, El-Naggar AK, Frazier ML, Keyomarsi K, Hunt KK, Sen S, Haffty B, Hewitt SM, Krahe R, Killary AM. DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence-free survival in early onset breast cancer. PLoS Med 6(5):e1000068, 5/2009. e-Pub 5/2009. PMCID: PMC2673042.
71. Gilcrease MZ, Woodward WA, Nicolas MM, Corley LJ, Fuller GN, Esteva FJ, Tucker SL, Buchholz TA. Even Low-level HER2 Expression May be Associated With Worse Outcome in Node-positive Breast Cancer. Am J Surg Pathol 33(5):759-67, 5/2009. e-Pub 2/2009. PMID: 19252432.
72. Reed VK, Woodward WA, Zhang L, Strom EA, Perkins GH, Tereffe W, Oh JL, Yu TK, Bedrosian I, Whitman GJ, Buchholz TA, Dong L. Automatic Segmentation of Whole Breast Using Atlas Approach and Deformable Image Registration. Int J Radiat Oncol Biol Phys 73(5):1493-500, 4/2009. e-Pub 9/2008. PMCID: PMC2729433.
73. Shih YC, Xu Y, Cormier JN, Giordano S, Ridner SH, Buchholz TA, Perkins GH, Elting LS. Incidence, treatment costs, and complications of lymphedema after breast cancer among women of working age: a two-year follow-up study. J Clin Oncol 27(12):2007-2014, 4/2009. e-Pub 3/2009. PMID: 19289624.
74. Loya A, Guray M, Hennessy BT, Middleton LP, Buchholz TA, Valero V, Sahin AA. Prognostic significance of occult axillary lymph node metastases after chemotherapy-induced pathologic complete response of cytologically proven axillary lymph node metastases from breast cancer. Cancer 115(8):1605-12, 4/2009. e-Pub 2/2009. PMID: 19197997.
75. Ludwig MS, McNeese MD, Buchholz TA, Perkins GH, Strom EA. The lateral decubitus breast boost: description, rationale and efficacy. Int J Radiat Oncol Biol Phys 76(1). e-Pub 4/2009. PMID: 19394161.
76. Beadle BM, Woodward WA, Tucker SL, Outlaw ED, Allen PK, Oh JL, Strom EA, Perkins GH, Tereffe W, Yu TK, Meric-Bernstam F, Litton JK, Buchholz TA. Ten year recurrence rates in young women with breast cancer by locoregional treatment approach. Int J Radiat Oncol Biol Phys 73(3):734-44, 3/1/2009. e-Pub 8/15/2008. PMID: 18707822.
77. Beadle BM, Woodward WA, Middleton LP, Tereffe W, Strom EA, Litton JK, Meric-Bernstam F, Theriault RL, Buchholz TA, Perkins GH. The impact of pregnancy on breast cancer outcomes in women </=35 years. Cancer 115(6):1174-84, 3/2009. PMID: 19204903.
78. Li XA, Tai A, Arthur DW, Buchholz TA, Macdonald S, Marks LB, Moran JM, Pierce LJ, Rabinovitch R, Taghian A, Vicini F, Woodward W, White JR. Variability of target and normal structure delineation for breast cancer radiotherapy: an RTOG Multi-Institutional and Multiobserver Study. Int J Radiat Oncol Biol Phys 73(3):944-51, 3/2009. PMID: 19215827.
79. Garg AK, Frija EK, Sun TL, Strom EA, Perkins GH, Oh JL, Yu TK, Woodward WA, Tereffe WA, Salehpour M, Buchholz TA. Effects of variable placement of superior tangential/supraclavicular match line on dosimetric coverage of level III axilla/axillary apex in patients treated with breast and supraclavicular radiotherapy. Int J Radiat Oncol Biol Phys 73(2):370-4, 2/2009. PMID: 18676090.
80. Gilcrease MZ, Kilpatrick SK, Woodward WA, Zhou X, Nicolas MM, Corley LJ, Fuller GN, Tucker SL, Diaz LK, Buchholz TA, Frost JA. Coexpression of {alpha}6{beta}4 Integrin and Guanine Nucleotide Exchange Factor Net1 Identifies Node-Positive Breast Cancer Patients at High Risk for Distant Metastasis. Cancer Epidemiol Biomarkers Prev 18(1):80-6, 1/2009. PMID: 19124484.
81. Buchholz TA. Radiation therapy in the management of early-stage breast cancer after breast-conserving surgery. N Engl J Med 360(1):63-70, 1/2009. PMID: 19118305.
82. Kronowitz SJ, Kuerer HM, Buchholz TA, Valero V, Hunt KK. A management algorithm and practical oncoplastic surgical techniques to repair partial mastectomy defects. Plat Reconstr Surg 122(6):1631-1647, 12/2008. PMID: 19050516.
83. Ballo MT, Postma KE, Washington CM, Buchholz TA, Cox JD. Development of a successful outreach program at M. D. Anderson Cancer Center: a global perspective. J Am Coll Radiol 5(12):1170-1173, 12/2008. PMID: 19027677.
84. Moulder SL, Symmans WF, Booser DJ, Madden TL, Lipsanen C, Yuan L, Brewster AM, Cristofanilli M, Hunt KK, Buchholz TA, Zwiebel J, Valero V, Hortobagyi GN, Esteva FJ. Phase I/II study of G3139 (Bcl-2 antisense oligonucleotide) in combination with doxorubicin and docetaxel in breast cancer. Clin Cancer Res 14(23):7909-7916, 12/2008. PMID: 19047121.
85. Dawood S, Broglio K, Kau SW, Green MC, Giordano SH, Meric-Bernstam F, Buchholz TA, Albarracin C, Yang WT, Hennessy BT, Hortobagyi GN, Gonzalez-Angulo AM. Triple receptor-negative breast cancer: the effect of race on response to primary systemic treatment and survival outcomes. J Clin Oncol 27(2). e-Pub 12/2008. PMID: 19047281.
86. Stovall M, Smith SA, Langholz BM, Boice JD, Shore RE, Andersson M, Buchholz TA, Capanu M, Bernstein L, Lynch CF, Malone KE, Anton-Culver H, Haile RW, Rosenstein BS, Reiner AS, Thomas DC, Bernstein JL, Bernstein JL. Dose to the Contralateral Breast from Radiotherapy and Risk of Second Primary Breast Cancer in the WECARE Study. Int J Radiat Oncol Biol Phys 72(4):1021-1030, 11/2008. e-Pub 6/2008. PMID: 18556141.
87. Bristol IJ, Woodward WA, Strom EA, Cristofanilli M, Domain D, Singletary SE, Perkins GH, Oh JL, Yu TK, Tereffe W, Sahin AA, Hunt KK, Hortobagyi GN, Buchholz TA. Local-regional treatment outcomes after multimodality management of inflammatory breast cancer. Int J Radiat Oncol Biol Phys 72(2):474-84, 10/2008. e-Pub 4/2008. PMID: 18439768.
88. Smith GL, Smith BD, Buchholz TA, Giordano SH, Garden AS, Woodward WA, Krumholz HM, Weber RS, Ang KK, Rosenthal DI. Cerebrovascular disease risk in older head and neck cancer patients after radiotherapy. J Clin Oncol 26(31):5119-25, 8/2008. e-Pub 8/2008. PMID: 18725647.
89. Jeruss JS, Mittendorf EA, Tucker SL, Gonzalez-Angulo AM, Buchholz TA, Sahin AA, Cormier JN, Buzdar AU, Hortobagyi GN, Hunt KK. Staging of breast cancer in the neoadjuvant setting. Cancer Res 68(16):6477-6481, 8/2008. PMID: 18701468.
90. Wang X, Du W, Smith SA, Stoval M, Buchholz TA, Salehpour M. The radiation exposure from portal images during the course of breast radiotherapy. Am J Clin Oncol 31(4):345-351, 8/2008. PMID: 18845993.
91. Srokowski TP, Fang S, Duan Z, Buchholz TA, Hortobagyi GN, Goodwin JS, Giordano SH. Completion of adjuvant radiation therapy among women with breast cancer. Cancer 113(1):22-9, 7/2008. e-Pub 4/2008. PMID: 18442124.
92. Buchholz TA, Woodward WA, Duan Z, Fang S, Oh JL, Tereffe W, Strom EA, Perkins GH, Yu TK, Hunt KK, Meric-Bernstam F, Hortobagyi GN, Giordano SH. Radiation use and long-term survival in breast cancer patients with T1, T2 primary tumors and 1-3 positive axillary lymph nodes. Int J Radiat Oncol Biol Phys 71(4):1022-7, 7/2008. PMID: 18234447.
93. Reed VK, Cavalcanti JL, Strom EA, Perkins GH, Oh JL, Tereffe W, Yu TK, Yeung H, Whitman GJ, Bedrosian I, Macapinlac HA, Buchholz TA, Woodward WA. Risk of subclinical micrometastatic disease in the supraclavicular nodal bed based on the anatomical distribution in patients with advanced breast cancer. Int J Radiat Oncol Biol Phys 71(2):435-440, 6/2008. PMID: 18164831.
94. Klopp AH, Jhingran A, Ramdas L, Story MD, Broadus RR, Lu KH, Eifel PJ, Buchholz TA. Gene expression changes in cervical squamous cell carcinoma after initiation of chemoradiation and correlation with clinical outcome. Int J Radiat Oncol Biol Phys 71(1):226-236, 5/2008. PMID: 18406887.
95. Smith BD, Haffty BG, Smith GL, Hurria A, Buchholz TA, Gross CP. Use of post-mastectomy radiotherapy in older women. Int J Radiat Oncol Biol Phys 71(1):98-106, 5/2008. PMID: 17996393.
96. Smith GL, Smith BD, Giordano SH, Shih YT, Woodward WA, Strom EA, Perkins GH, Tereffe W, Yu TK, Buchholz TA. Risk of hypothyroidism in older breast cancer patients treated with radiation. Cancer 112(6):1371-1379, 3/2008. PMID: 18213620.
97. Dawood S, Broglio K, Gong Y, Yang WT, Cristofanilli M, Kau SW, Meric-Bernstam F, Buchholz TA, Hortobagyi GN, Gonzalez-Angulo AM, Gonzalez-Angulo AM. Prognostic significance of HER2 status in women with inflammatory breast cancer. Cancer 112(9). e-Pub 2/2008. PMID: 18300243.
98. Buchholz TA, Lehman CD, Harris JR, Pockaj BA, Khouri N, Hylton NF, Miller MJ, Whelan T, Pierce LJ, Esserman LJ, Newman LA, Smith BL, Bear HD, Mamounas EP. Statement of the science concerning loco-regional treatments after preoperative chemotherapy for breast cancer: a National Cancer Institute Conference. J Clin Oncol 26(5):791-797, 2/2008. PMID: 18258988.
99. Jeruss JS, Mittendorf EA, Tucker SL, Gonzalez-Angulo AM, Buchholz TA, Sahin AA, Cormier JN, Buzdar AU, Hortobagyi GN, Hunt KK. Combined use of clinical and pathologic staging variables to define outcomes for breast cancer patients treated with neoadjuvant therapy. J Clin Oncol 26(2):246-252, 1/2008. e-Pub 12/2007. PMID: 18056680.
100. Dawood S, Broglio K, Kau SW, Symmans WF, Buchholz TA, McGuire SE, Meric F, Cristofanilli M, Hortobagyi GN, Gonzalez-Angulo AM. Prognostic value of initial clinical disease stage after achieving pathological complete response. Oncologist 13(1):6-15, 1/2008. PMID: 18245008.
101. Kronowitz SJ, Hunt KK, Kuerer HM, Strom EA, Buchholz TA, Youssef A, Koutz CA, Robb GL. Practical guidelines for the breast reduction technique for repair of partial mastectomy defects in patients undergoing breast conservation therapy. Plastic Reconstructive Surg 120(7):1755-1768, 12/2007. PMID: 18090737.
102. Oh JL, Nguyen G, Whitman GJ, Hunt KK, Yu TK, Woodward WA, Tereffe W, Strom EA, Perkins GH, Buchholz TA. Placement of radiopaque clips for tumor localization in patients undergoing neoadjuvant chemotherapy and breast conservation therapy. Cancer 110(11):2420-2427, 11/2007. e-Pub 10/2007. PMID: 17941034.
103. Woodward WA, Durand JB, Tucker SL, Strom EA, Perkins GH, Oh JL, Arriaga L, Domain D, Buchholz TA. Prospective analysis of carotid flow in breast cancer patients treated with supraclavicular irradiation eight or more years prior to study: No increase in ipsilateral carotid stenosis after radiation. Cancer 112(2):268-273, 11/2007. PMID: 18000801.
104. Liengsawangwong R, Yu TK, Sun TL, Erasmus J, Perkins GH, Tereffe W, Oh JL, Woodward WA, Strom EA, Salehpour M, Buchholz TA. Treatment optimization using computed tomography-delineated targets should be used for supraclavicular irradiation for breast cancer. Int J Radiat Oncol Biol Phys 69(3):711-715, 11/2007. PMID: 17889264.
105. Cristofanilli M, Valero V, Buzdar AU, Kau SW, Broglio KR, Gonzalez-Angulo AM, Islam R, Hortobagyi GN, Sneige N, Ueno NT, Buchholz TA, Singletary SE. Inflammatory breast cancer (IBC) and patterns of recurrence: Understanding the biology of a unique disease. Cancer 110(7):1436-1444, 10/2007. PMID: 17694554.
106. Vo T, Xing Y, Meric-Bernstam F, Mirza N, Vlastos G, Symmans, WF, Perkins GH, Buchholz TA, Babiera GV, Kuerer HM, Bedrosian I, Akins JS, Hunt KK. Long-term outcomes in patients with mucinous, medullary, tubular, and invasive ductal carcinomas after lumpectomy. Am J Surg 194(4):527-531, 10/2007. PMID: 17826073.
107. Garg AK, Oh JL, Oswald MJ, Huang E, Strom EA, Perkins GH, Hahn K, Buchholz TA. Effect of postmastectomy radiotherapy in patients <35 years old with stage II-III breast cancer treated with doxorubicin-based neoadjuvant chemotherapy and mastectomy. Int J Rad Oncol Biol Phys 69:1478-1483, 9/2007. PMID: 17855016.
108. Lu J, Wei Q, Bondy ML, Brewster AM, Bevers TB, Yu TK, Buchholz TA, Meric-Bernstam F, Hunt KK, Singletary SE, Wang LE. Genetic variants in the promoter region of H2AX are associated with risk of sporadic breast cancer in non-Hispanic white women 55 years. Breast Cancer Res Treat 110(2):357-66, 9/2007. PMID: 17851762.
109. Hwang RF, Gonzalez-Angulo AM, Yi M, Buchholz TA, Meric-Bernstam F, Kuerer HM, Babiera GV, Tereffe W, Liu DD, Hunt KK. Low local-regional failure rates in selected breast cancer patients with tumor-positive sentinel nodes who do not undergo completion axillary dissection. Cancer 110(4):723-730, 8/2007. PMID: 17587208.
110. Gonzalez-Angulo MA, Hennessy BT, Broglio K, Meric-Bernstam F, Cristofanilli M, Giordano SH, Buchholz TA, Sahin A, Singletary SE, Buzdar AU, Hortobagyi GN. Trends for inflammatory breast cancer: Is survival improving? Oncologist 12(8):904-912, 8/2007. PMID: 17766649.
111. McGuire SE, Gonzalez-Angulo AM, Tucker SL, Kau SW, Yu TK, Strom EA, Oh J, Woodward WA, Tereffe W, Hunt KK, Kuerer HM, Sahin A, Hortobagyi GN, Buchholz TA. Post-mastectomy radiation improves the outcome of patients with stage III breast cancer who achieve a pathologic complete response to neoadjuvant chemotherapy. Int J Radiat Oncol Biol Phys 68(4):1004-1009, 7/2007. PMID: 17418973.
112. Mazouni C, Kau SW, Frye D, Andre F, Kuerer HM, Buchholz TA, Symmans WF, Anderson K, Hess KR, Gonzales-Angulo AM, Hortobagyi GN, Buzdar AU, Pusztai L. Inclusion of taxanes, particularly weekly paclitaxel, in preoperative chemotherapy improves pathologic complete response rate in ER-positive breast cancers. Ann Oncol 18(5):874-880, 5/2007. e-Pub 2/2007. PMID: 17293601.
113. Truong PT, Woodward WA, Thames HD, Ragaz J, Olivotto IA, Buchholz TA. The ratio of positive to excised nodes identifies high-risk subsets and reduces inter-institutional differences in locoregional recurrence risk estimates in breast cancer patients with 1-3 positive nodes: An analysis of prospective data from British Columbia and the M. D. Anderson Cancer Center. Int J Radiat Oncol Biol Phys 68(1):59-65, 5/2007. PMID: 17321065.
114. Wiedenmann N, Valdecanas D, Hunter N, Hyde S, Buchholz TA, Milas L, Mason KA. 130-nm albumin-bound paclitaxel enhances tumor radiocurability and therapeutic gain. Clin Cancer Res 13(6):1868-1874, 3/2007. PMID: 17363543.
115. Borghero YO, Salehpour M, McNeese MD, Stovall M, Smith SA, Johnson J, Perkins GH, Strom EA, Oh JL, Kirsner SM, Woodward WA, Yu TK, Buchholz TA. Multileaf field-in-field forward-planned intensity-modulated dose compensation for whole-breast irradiation is associated with reduced contralateral breast dose: A phantom model comparison. Radiother Oncol 82(3):324-328, 3/2007. PMID: 17157944.
116. Huang EH, Strom EA, Valero V, Fornage B, Perkins GH, Oh JL, Yu TK, Tereffe W, Woodward WA, Hunt KK, Meric-Bernstam F, Sahin AA, Bedrosian I, Hortobagyi GN, Buchholz TA. Locoregional treatment outcomes for breast cancer patients with ipsilateral supraclavicular metastases at diagnosis. Int J Radiat Oncol Biol Phys 67(2):490-6, 2/2007. PMID: 17236970.
117. Chen MS, Woodward WA, Behbod F, Peddibhotla S, Alfaro MP, Buchholz TA, Rosen JM. Wnt/(beta)-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line. J Cell Sci 120(3):468-477, 2/2007.
118. Cabioglu N, Hunt KK, Sahin A, Mirza N, Lopez A, Kuerer HM, Babiera GV, Singletary SE, Whitman GJ, Ross MI, Ames FC, Feig BW, Buchholz TA. Intraoperative margin assessment for breast-conserving surgery. Ann Surg Oncol 14(4):1458-1471, 1/2007. e-Pub 1/2007. PMID: 17260108.
119. Buzdar AU, Valero V, Ibrahim NK, Francis D, Broglio KR, Theriault RL, Pusztai L, Green MC, Singletary SE, Hunt KK, Sahin AA, Esteva F, Symmans WF, Ewer MS, Buchholz TA, Hortobagyi GN. Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in human epidermal growth factor receptor 2-positive operable breast cancer: an update of the initial randomized study population and data of additional patients treated with the same regimen. Clin Cancer Res 13(1):228-33, 1/2007. PMID: 17200359.
120. Woodward WA, Chen MS, Behbod F, Mohsin S, Alfaro MP, Kittrel F, Buchholz TA, Rosen JM. Wnt/B-catenin-mediated radiation resistance of mouse mammary stem-like/progenitor cells. Proc Nat Acad Sciences 104(2):618-623, 1/2007.

Last updated: 5/7/2012