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Thomas M Guerrero, MD, PhD

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Associate Professor, Rice University, Houston, TX
Assistant Professor, Department of Computational and Applied Mathematics, Rice University, Houston, TX

Education & Training

Degree-Granting Education

1997 University of California Los Angeles, Drew/UCLA Medical Education Program, Los Angeles, CA, MD, Medicine
1994 University of California Los Angeles, Los Angeles, CA, PHD, Biomedical Physics
1987 San Diego State University, San Diego, CA, MS, Radiological Health Physics
1983 University of California San Diego, San Diego, CA, BA, Physics

Postgraduate Training

6/1998-6/2002 Clinical Residency, Stanford University Radiation Oncology, Palo Alto, CA
6/1997-6/1998 Internal Medicine Program, UCLA San Fernando Valley, Sylmar, CA

Board Certifications

6/2003 American Board of Radiology, Radiation Oncology


Academic Appointments

Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 1/2002-8/2008

Honors and Awards

2010-2015 Director's New Innovator Award, National Institutes of Health
2007 Top 10 Award, Radiation Oncology/Cancer Researcher, Medical Imaging Industry
2006 Top 10 Award, Radiation Oncology/Cancer Researcher, Medical Imaging Industry
2005-2010 Physician Scientist Award, The University of Texas MD Anderson Cancer Center
2004 Basic Science Travel Grant (co-author & mentor), American Society of Radiation Oncology

Professional Memberships

American Society for Therapeutic Radiology Oncology
Member, 2005-present
Radiation Research Society
Member, 2006-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Mathew L, Wheatley A, Castillo R, Castillo E, Rodrigues G, Guerrero T, and Parraga G. Hyperpolarized 3He magnetic resonance imaging: comparison with four-dimensional x-ray computed tomography imaging in lung cancer. Acad Radiol. In Press.
2. McCurdy M, Bergsma D, Hyun E, Kim T, Choi E, Castillo R, Castillo E, Guerrero T. Radiation pneumonitis prediction and anatomic variation of 18F-FDG PET radiation dose response in lung: a retrospective study. Journal of Radiation Oncology. In Press.
3. Vinogradskiy YY, Castillo R, Castillo E, Tucker SL, Liao Z, Guerrero T, Martel MK. Using 4DCT-based ventilation imaging to correlate lung dose and function with clinical outcomes. Int J Radiat Oncol Biol Phys. In Press.
4. Echeverria AE, McCurdy M, Castillo R, Bernard V, Ramos NV, Buckley W, Castillo E, Liu P, Martinez J, Guerrero T. Proton therapy radiation pneumonitis local dose-response in esophagus cancer patients. Radiother Oncol 106(1):124-129, 1/2013. e-Pub 11/2012. PMID: 23127772.
5. Skinner HD, McCurdy MR, Echeverria AE, Lin SH, Welsh JW, O'Reilly MS, Hofstetter WL, Ajani JA, Komaki R, Cox JD, Sandulache VC, Myers JN, Guerrero TM. Metformin use and improved response to therapy in esophageal adenocarcinoma. Acta Oncol. e-Pub 9/2012. PMID: 22950385.
6. Castillo E, Castillo R, White B, Rojo J, Guerrero T. Least median of squares filtering of locally optimal point matches for compressible flow image registration. Phys Med Biol 57(15):4827-4833, 8/2012. e-Pub 7/2012. PMCID: PMC3448271.
7. Castillo R, Castillo E, McCurdy M, Gomez DR, Block AM, Bergsma D, Joy S, Guerrero T. Spatial correspondence of 4D CT ventilation and SPECT pulmonary perfusion defects in patients with malignant airway stenosis. Phys Med Biol 57(7):1855-1871, 4/2012. e-Pub 3/2012. PMID: 22411124.
8. Guerrero T, Martinez J, McCurdy MR, Wolski M, McAleer MF. Elevation in exhaled nitric oxide predicts for radiation pneumonitis. Int J Radiat Oncol Biol Phys 82(2):981-988, 2/2012. e-Pub 3/2011. PMID: 21377296.
9. Vinogradskiy YY, Castillo R, Castillo E, Chandler A, Martel MK, Guerrero T. Use of weekly 4DCT-based ventilation maps to quantify changes in lung function for patients undergoing radiation therapy. Med Phys 39(1):289-298, 1/2012. PMID: 22225299.
10. McCurdy M, Castillo R, Martinez J, Hallack MNA, Litcher J, Zouain N, Guerrero TM. [18F]-FDG uptake dose response correlates with radiation pneumonitis in lung cancer patients. Radiother Oncol 104(1):52-57, 2012.
11. McCurdy MR, Wazni MW, Martinez J, McAleer MF, Guerrero T. Exhaled nitric oxide predicts radiation pneumonitis in esophageal and lung cancer patients receiving thoracic radiation. Radiother Oncol 101(3):443-448, 2011. e-Pub 10/2011. PMID: 21981878.
12. Gu X, Pan H, Liang Y, Castillo R, Yang D, Choi D, Castillo E, Majumdar A, Guerrero T, Jiang SB. Implementation and evaluation of various demons deformable image registration algorithms on a GPU. Phys Med Biol 55(1):207-219, 2011. PMID: 20009197.
13. Castillo R, Castillo E, Martinez J, Guerrero T. Ventilation from four dimensional computed tomography: density versus Jacobian methods. Phys Med Biol 55(16):4661-4685, 8/2010. e-Pub 7/2010. PMID: 20671351.
14. McCurdy M, McAleer MF, Wei W, Ezhil M, Johnson V, Khan M, Baker J, Luo D, Ajani J, Guerrero T. Induction and concurrent taxanes enhance both the pulmonary metabolic radiation response and the radiation pneumonitis response in patients with esophagus cancer. Int J Radiat Oncol Biol Phys 76(3):816-823, 3/2010. e-Pub 6/2009. PMID: 19525073.
15. Castillo E, Castillo R, Martinez J, Shenoy M, Guerrero T. Four dimensional deformable image registration using trajectory modeling. Phys Med Biol 55(1):305-327, 2010. PMID: 20009196.
16. Gu X, Pan H, Liang Y, Castillo R, Yang D, Choi D, Castillo E, Majumdar A, Guerrero T, Jiang SB. Implementation and evaluation of various demons deformable image registration algorithms on GPU. Phys Med Biol 55(1):207-219, 2010.
17. Castillo R, Castillo E, Guerra R, Johnson VE, McPhail T, Garg AK, Guerrero T. A framework for evaluation of deformable image registration spatial accuracy using large landmark point sets. Phys Med Biol 54(7):1849-1870, 4/2009. e-Pub 3/2009. PMID: 19265208.
18. Castillo E, Castillo R, Zhang Y, Tapia R, Guerrero T. Compressible image registration for thoracic computed tomography images. Journal of Medical and Biological Engineering 29(5):236-247, 2009.
19. Zhang X, Zhao KL, Guerrero TM, McGuire SE, Yaremko B, Komaki R, Cox JD, Hui Z, Li Y, Newhauser WD, Mohan R, Liao Z. Four-dimensional computed tomography-based treatment planning for intensity-modulated radiation therapy and proton therapy for distal esophageal cancer. Int J Radiat Oncol Biol Phys 72(1):278-287, 9/2008. PMCID: PMC2610812.
20. Hart JP, McCurdy MR, Ezhil M, Wei W, Khan M, Luo D, Munden RF, Johnson VE, Guerrero TM. Radiation pneumonitis: correlation of toxicity with pulmonary metabolic radiation response. Int J Radiat Oncol Biol Phys 71(4):967-971, 7/2008. e-Pub 5/2008. PMID: 18495373.
21. Zhang GG, Huang TC, Forster KM, Lin KP, Stevens C, Harris E, Guerrero T. Dose mapping: validation in 4D dosimetry with measurements and application in radiotherapy follow-up evaluation. Comput Methods Programs Biomed 90(1):25-37, 4/2008. e-Pub 2/2008. PMID: 18178288.
22. Yaremko BP, Guerrero TM, McAleer MF, Bucci MK, Noyola-Martinez J, Nguyen LT, Balter PA, Guerra R, Komaki R, Liao Z. Determination of respiratory motion for distal esophagus cancer using four-dimensional computed tomography. Int J Radiat Oncol Biol Phys 70(1):145-153, 1/2008. e-Pub 9/2007. PMID: 17855008.
23. Zhang GG, Huang TC, Guerrero T, Lin KP, Stevens C, Starkschall G, Forster K. Use of three-dimensional (3D) optical flow method in mapping 3D anatomic structure and tumor contours across four-dimensional computed tomography data. J Appl Clin Med Phys 9(1):2738, 2008. e-Pub 2/2008. PMID: 18449166.
24. Rice DC, Smythe WR, Liao Z, Guerrero T, Chang JY, McAleer MF, Jeter MD, Correa A, Vaporciyan AA, Liu HH, Komaki R, Forster KM, Stevens CW. Dose-dependent pulmonary toxicity after postoperative intensity-modulated radiotherapy for malignant pleural mesothelioma. Int J Radiat Oncol Biol Phys 69(2):350-357, 10/2007. e-Pub 4/2007. PMID: 17467922.
25. Lu J, Guerrero TM, Munro P, Jeung A, Chi PC, Balter P, Zhu XR, Mohan R, Pan T. Four-dimensional cone beam CT with adaptive gantry rotation and adaptive data sampling. Med Phys 34(9):3520-3529, 9/2007. PMID: 17926955.
26. Shioyama Y, Jang SY, Liu HH, Guerrero T, Wang X, Gayed IW, Erwin WD, Liao Z, Chang JY, Jeter M, Yaremko BP, Borghero YO, Cox JD, Komaki R, Mohan R. Preserving functional lung using perfusion imaging and intensity-modulated radiation therapy for advanced-stage non-small cell lung cancer. Int J Radiat Oncol Biol Phys 68(5):1349-1358, 8/2007. e-Pub 4/2007. PMID: 17446001.
27. Huang EH, Liao Z, Cox JD, Guerrero TM, Chang JY, Jeter M, Borghero Y, Wei X, Fossella F, Herbst RS, Blumenschein GR, Moran C, Allen PK, Komaki R. Comparison of outcomes for patients with unresectable, locally advanced non-small-cell lung cancer treated with induction chemotherapy followed by concurrent chemoradiation vs. concurrent chemoradiation alone. Int J Radiat Oncol Biol Phys 68(3):779-785, 7/2007. e-Pub 4/2007. PMID: 17418967.
28. Guerrero T, Johnson V, Hart J, Pan T, Khan M, Luo D, Liao Z, Ajani J, Stevens C, Komaki R. Radiation pneumonitis: local dose versus [18F]-fluorodeoxyglucose uptake response in irradiated lung. Int J Radiat Oncol Biol Phys 68(4):1030-1035, 7/2007. e-Pub 3/2007. PMID: 17398033.
29. Yaremko BP, Guerrero TM, Noyola-Martinez J, Guerra R, Lege DG, Nguyen LT, Balter PA, Cox JD, Komaki R. Reduction of normal lung irradiation in locally advanced non-small cell lung cancer patients using ventilation images for functional avoidance. Int J Radiat Oncol Biol Phys 68(2):562-571, 6/2007. e-Pub 3/2007. PMID: 17398028.
30. Guerrero T, Castillo R, Noyola-Martinez J, Torres M, Zhou X, Guerra R, Cody D, Komaki R, Travis E. Reduction of pulmonary compliance found with high-resolution computed tomography in irradiated mice. Int J Radiat Oncol Biol Phys 67(3):879-887, 3/2007. PMID: 17293238.
31. Huang TC, Zhang G, Guerrero T, Starkschall G, Lin KP, Forster K. Semi-automated CT segmentation using optic flow and Fourier interpolation techniques. Comput Methods Programs Biomed 84(2-3):124-134, 12/2006. e-Pub 10/2006. PMID: 17027116.
32. Fang LC, Komaki R, Allen P, Guerrero T, Mohan R, Cox JD. Comparison of outcomes for patients with medically inoperable Stage I non-small-cell lung cancer treated with two-dimensional vs. three-dimensional radiotherapy. Int J Radiat Oncol Biol Phys 66(1):108-116, 9/1/2006. PMID: 16904517.
33. Wang S, Liao Z, Chen Y, Chang JY, Jeter M, Guerrero T, Ajani J, Phan A, Swisher S, Allen P, Cox JD, Komaki R. Esophageal cancer located at the neck and upper thorax treated with concurrent chemoradiation: a single-institution experience. J Thorac Oncol 1(3):252-259, 3/2006. PMID: 17409865.
34. Guerrero T, Sanders K, Castillo E, Zhang Y, Bidaut L, Pan T, Komaki R. Dynamic ventilation imaging from four-dimensional computed tomography. Phys Med Biol 51(4):777-791, 2/2006. e-Pub 1/2006. PMID: 16467578.
35. Guerrero T, Castillo R, Sanders K, Price R, Komaki R, Cody D. Novel method to calculate pulmonary compliance images in rodents from computed tomography acquired at constant pressures. Phys Med Biol 51:1101-1112, 2006. PMID: 16481680.
36. Zhu XR, Prado K, Liu HH, Guerrero TM, Jeter M, Liao Z, Rice D, Forster K, Stevens CW. Intensity-modulated radiation therapy for mesothelioma: impact of multileaf collimator leaf width and pencil beam size on planning quality and delivery efficiency. Int J Radiat Oncol Biol Phys 62(5):1525-1534, 8/2005. PMID: 16029815.
37. Guerrero T, Sanders K, Noyola-Martinez J, Castillo E, Zhang Y, Tapia R, Guerra R, Borghero Y, Komaki R. Quantification of regional ventilation from treatment planning CT. Int J Radiat Oncol Biol Phys 62(3):630-634, 7/2005. PMID: 15936537.
38. Ragan D, Starkschall G, McNutt T, Kaus M, Guerrero T, Stevens CW. Semiautomated four-dimensional computed tomography segmentation using deformable models. Med Phys 32(7):2254-2261, 7/2005. PMID: 16121580.
39. Liao Z, Komaki R, Milas L, Yuan C, Kies M, Chang JY, Jeter M, Guerrero T, Blumenschien G, Smith CM, Fossella F, Brown B, Cox JD. A phase I clinical trial of thoracic radiotherapy and concurrent celecoxib for patients with unfavorable performance status inoperable/unresectable non-small cell lung cancer. Clin Cancer Res 11(9):3342-3348, 5/2005. PMID: 15867233.
40. Fitzpatrick MJ, Starkschall G, Balter P, Antolak JA, Guerrero T, Nelson C, Keall P, Mohan R. A novel platform simulating irregular motion to enhance assessment of respiration-correlated radiation therapy procedures. J Appl Clin Med Phys 6(1):13-21, 2005. e-Pub 1/2005. PMID: 15770194.
41. Zhang Z, Liao Z, Jin J, Ajani J, Chang JY, Jeter M, Guerrero T, Stevens CW, Swisher S, Ho L, Yao J, Allen P, Cox JD, Komaki R. Dose-response relationship in locoregional control for patients with stage II-III esophageal cancer treated with concurrent chemotherapy and radiotherapy. Int J Radiat Oncol Biol Phys 61:656-664, 2005. PMID: 15708243.
42. Guerrero T, Zhang G, Segars W, Huang TC, Bilton S, Ibbott G, Dong L, Forster K, Lin KP. Elastic image mapping for 4-D dose estimation in thoracic radiotherapy. Radiat Prot Dosimetry 115(1-4):497-502, 2005. PMID: 16381774.
43. Chandra A, Guerrero TM, Liu HH, Tucker SL, Liao Z, Wang X, Murshed H, Bonnen MD, Garg AK, Stevens CW, Chang JY, Jeter MD, Mohan R, Cox JD, Komaki R. Feasibility of using intensity-modulated radiotherapy to improve lung sparing in treatment planning for distal esophageal cancer. Radiother Oncol 77:247-253, 2005. PMID: 16298001.
44. Guerrero T, Zhang G, Huang TC, Lin KP. Intrathoracic tumor motion estimation from CT imaging using the 3D optical flow method. Phys Med Biol 49(17):4147-4161, 9/2004. PMID: 15470929.
45. Deng J, Guerrero T, Ma CM, Nath R. Modelling 6 MV photon beams of a stereotactic radiosurgery system for Monte Carlo treatment planning. Phys Med Biol 49(9):1689-1704, 5/2004. PMID: 15152924.
46. Liu HH, Wang X, Dong L, Wu Q, Liao Z, Stevens CW, Guerrero TM, Komaki R, Cox JD, Mohan R. Dose and volume reduction for normal lung using intensity-modulated radiation therapy for advanced-stage non-small cell lung cancer. Int J Radiat Oncol Biol Phys 58(4):1268-1279, 3/2004. PMID: 15001272.
47. Murshed H, Liu HH, Liao Z, Barker JL, Wang X, Tucker SL, Chandra A, Guerrero T, Stevens C, Chang JY, Jeter M, Cox JD, Komaki R, Mohan R, Change JY. Dose and volume reduction for normal lung using intensity-modulated radiotherapy for advanced-stage non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 58(4):1258-1267, 3/2004. PMID: 15001271.
48. Taylor NA, Liao ZX, Cox JD, Stevens C, Roth J, Walsh G, Chang JY, Guerrero T, Jeter M, Putnam J, Fossella FV, Allen P, Komaki R. Equivalent outcome of patients with clinical stage IIIA non-small-cell lung cancer treated with concurrent chemoradiation compared with induction chemotherapy followed by surgical resection. Int J Radiat Oncol Biol Phys 58(1):204-212, 1/2004. PMID: 14697440.
49. Keall PJ, Starkschall G, Shukla H, Forster KM, Ortiz V, Stevens CW, Vedam SS, George R, Guerrero T, Mohan R. Acquiring 4D thoracic CT scans using a multilice helical method. Phys Med Biol 49:2053-2067, 2004. PMID: 15214541.
50. Jin J, Liao Z, Zhang Z, Ajani J, Swisher S, Chang JY, Jeter M, Guerrero T, Stevens CW, Vaporciyan A, Putnam J Jr, Walsh G, Smythe R, Roth J, Yao J, Allen P, Cox JD, Komaki R. Induction chemotherapy improved outcomes of patients with resectable esophageal cancer who received chemoradiotherapy followed by surgery. Int J Radiat Oncol Biol Phys 60:427-436, 2004. PMID: 15380576.
51. Riley B, Garcia J, Guerrero T. The utilization of a 3-dimensional noncoplanar treatment plan to avoid pacemaker complications. Med Dosim 29(2):92-96, 2004. PMID: 15191754.
52. Ahamad A, Stevens CW, Smythe WR, Liao Z, Vaporciyan AA, Rice D, Walsh G, Guerrero T, Chang J, Bell B, Komaki R, Forster KM. Promising early local control of malignant pleural mesothelioma following postoperative intensity modulated radiotherapy (IMRT) to the chest. Cancer J 9(6):476-484, Nov-Dec, 11/2003. PMID: 14740977.
53. Guerrero TM, Ricci AR, Dahlbom M, Cherry SR, Hoffman EJ. Parallel image reconstruction for 3D PET from incomplete 2D projection data. Proc SPIE 1905:978-986, 1993.
54. Guerrero TM, Cherry SR, Dahlbom M, Ricci AR, Hoffman EJ. Fast implementation of 3D PET reconstruction using vector and parallel programming techniques. IEEE Trans Nucl Sci 40:1082-1086, 1992.
55. Hoffman EJ, Cutler PD, Guerrero TM, Digby WM, Mazziotta JC. Assessment of accuracy of PET utilizing a 3-D phantom to simulate the activity distribution of [18F]fluorodeoxyglucose uptake in the human brain. J Cereb Blood Flow Metab 11:A17-A25, 1991. PMID: 1997482.
56. Guerrero TM, Hoffman EJ, Dahlbom M, Cutler PD, Hawkins RA, Phelps ME. Characterization of a whole body imaging technique for PET. IEEE Trans Nucl Sci 37:676- 680, 1990.
57. Hoffman EJ, Guerrero TM, Germano G, Digby WM, Dahlbom M. PET system calibration and corrections for quantitative and spatially accurate images. IEEE Trans Nucl Sci 36:1109-1112, 1989.

Last updated: 2/15/2013