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Tongxin Xie

Present Title & Affiliation

Primary Appointment

Instructor, Department of Head and Neck Surgery - Research, Division of Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Bio Statement

Head and neck cancer is one of the most common cancers in the world.  Our research projects are to investigate the molecular mechanism of development and progression of head and neck cancer, including deregulation of tumor suppressor genes and oncogenes.  Also, our research involves the understanding of metabolic alterations in head and neck cancer, which are regulated with alterations of tumor suppressor genes and oncogenes.  Our goal is to develop novel therapeutic strategies.

 

Research Interests

1.  Signal tranduction regulation of oncogenes and tumor suppressor   genes

2.  Anoikis

3.  Gene therapy

Office Address

The University of Texas M. D. Anderson Cancer Center
1515 Holcombe Blvd.
Unit Number: 123
Houston, TX 77030
Room Number: T5.3944
Phone: (713) 794-5532
Fax: (713) 745-2234

Education & Training

Degree-Granting Education

2000 Oita Medical University, Oita, Japan, PHD, Philosophy
1987 Hebei Medical University, Shijiazhuang, Hebei, China, MS, Medicine/Pathology
1983 Hebei Medical University, Shijiazhuang, Hebei, China, MD, Medicine

Postgraduate Training

1/2005-1/2006 Postdoctoral Fellow, Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX
6/2002-1/2005 Postdoctoral Fellow, Neurosurgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX
12/2000-6/2002 Postdoctoral Fellow, Endocrine Neoplasia and Hormonal Disorders, The University of Texas M. D. Anderson Cancer Center, Houston, TX
8/1983-8/1984 Resident, Orthopedics, Baoding Hospital, Baoding, China, China
6/1981-6/1983 Intern, Hebei Medical University Affiliated Hospitals, Shijiazhuang, China

Honors and Awards

1998 The First Prize of Scientific and Technological Advance, The Scientific and Technological Committee of Hebei Province, China
1997 The Third Prize of Scientific and Technological Advance, The Scientific and Technological Committee of Hebei Province, China.

Professional Memberships

American Association for Cancer Research
Active Member, 2004-present

Selected Publications

Peer-Reviewed Original Research Articles
1. Xie TX, Aldape KD, Gong W, Kanzawa T, Suki D, Kondo S, Lang F, Ali-Osman F, Sawaya R, Huang S. Aberrant NF-kappaB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor. Int J Oncol 33(1):5-15, 7/2008. PMID: 18575745.
2. Zhou G, Xie TX, Zhao M, Jasser SA, Younes MN, Sano D, Lin J, Kupferman ME, Santillan AA, Patel V, Gutkind JS, Ei-Naggar AK, Emberley ED, Watson PH, Matsuzawa SI, Reed JC, Myers JN. Reciprocal negative regulation between S100A7/psoriasin and beta-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity. Oncogene 27(25):3527-38, 6/2008. PMID: 18223693.
3. Xie TX, Huang F, Aldape KD, Kang SH, Liu M, Gershenwald JE, Xie K, Sawaya R, Huang S. Activation of stat3 in human melanoma promotes brain metastasis. Cancer Research 66(6):3188-96, 2006.
4. Liu, MG, Dai BB, Kang SH, Ban KC, Huang FJ, Lang FF, Aldape KD, Xie TX, Pelloski CE, Xie K, Sawaya R, and Huang S. FoxM1 is Overexpressed in Human Glioblastomas and Critically Regulates Tumorigenecity of Glioma Cells. Cancer Research 66(7):3593-3602, 2006.
5. Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F, Sawaya R, Huang S. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene 23:3550-3560, 2004.

Last updated: 9/10/2009