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Tse-Kuan Yu, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2000 University of Texas Health Science Center - Houston Medical School, Houston, TX, MD, Medicine
2000 University of Texas Health Science Center / M.D. Anderson Cancer Center, Houston, TX, PHD, Cancer Biology
1992 Boston University, Boston, MA, BS, Magna Cum Laude, Biomedical Engineering

Board Certifications

6/2006 American Board of Radiology (Radiation Oncology)

Selected Publications

Peer-Reviewed Original Research Articles
1. Ruocco NA, Bergelson BA, Yu TK, Gavras I, Gavras H. Augmentation of coronary blood flow by ACE inhibition: role of angiotensin and bradykinin. Clin Exp Hypertens 17(7):1059-1072, 10/1995.
2. Bergelson BA, Yu TK, Ruocco NA. Effects of hypercholesterolaemia on physiological recruitment of coronary vascular reserve in swine. Clin Sci (Lond) 90(4):261-268, 4/1996.
3. Frederick MJ, Yu TK, Krohn EG, Johnston DA, Grimm EA. Protein tyrosine kinase inhibition blocks granule exocytosis and cytolytic function of lymphokine-activated killer cells. Immunopharmacology 35(2):83-102, 11/1996.
4. Frederick M, Grimm E, Krohn E, Smid C, Yu TK. Cytokine-induced cytotoxic function expressed by lymphocytes of the innate immune system: distinguishing characteristics of NK and LAK based on functional and molecular markers. Review. J Interferon Cytokine Res 17(8):435-447, 8/1997. PMID: 9282823.
5. Yu TK, Caudell EG, Smid C, Grimm EA. IL-2 activation of NK cells: involvement of MKK1/2/ERK but not p38 kinase pathway. J Immunol 164(12):6244-6251, 6/2000.
6. Caudell EG, Caudell JJ, Tang CH, Yu TK, Frederick MJ, Grimm EA. Characterization of human copine III as a phosphoprotein with associated kinase activity. Biochemistry 39(42):13034-13043, 10/2000.
7. Yu TK, Whitman GJ, Thames HD, Buzdar AU, Strom EA, Perkins GH, Schechter N, McNeese MD, Kau SW, Thomas ES, Hortobagyi GN, Buchholz TA. Clinically relevant pneumonitis after sequential paclitaxel-based chemotherapy and radiotherapy in breast cancer patients. J Natl Cancer Inst 96(22):1676-1681, 11/2004.
8. Akyurek S, Chang EL, Yu TK, Little D, Allen PK, McCutcheon I, Mahajan A, Maor MH, Woo SY. Spinal myxopapillary ependymoma outcomes in patients treated with surgery and radiotherapy at M.D. Anderson Cancer Center. J Neurooncol 80(2)(2):177-183, 11/2006. PMID: 16648988.
9. Buchholz TA, Strom EA, Oswald MJ, Perkins GH, Oh J, Domain D, Yu TK, Woodward WA, Tereffe W, Singletary SE, Thomas E, Buzdar AU, Hortobagyi GN, McNeese MD. Fifteen-year results of a randomized prospective trial of hyperfractionated chest wall irradiation versus once-daily chest wall irradiation after chemotherapy and mastectomy for patients with locally advanced noninflammatory breast cancer. Int J Radiat Oncol Biol Phys 65(4)(4):1155-1160, 7/2006. PMID: 16750325.
10. Peintinger F, Symmans WF, Gonzalez-Angulo AM, Boughey JC, Buzdar AU, Yu TK, Hunt KK, Singletary SE, Babiera GV, Lucci A, Meric-Bernstam F, Kuerer HM. The safety of breast-conserving surgery in patients who achieve a complete pathologic response after neoadjuvant chemotherapy. Cancer 107(6)(6):1248-1254, 7/2006. PMID: 16862596.
11. Lu J, Wei Q, Bondy ML, Li D, Brewster A, Shete S, Yu TK, Sahin A, Meric-Bernstam F, Hunt KK, Singletary SE, Ross MI, Wang LE. Polymorphisms and haplotypes of the NBS1 gene are associated with risk of sporadic breast cancer in non-Hispanic white women <or=55 years. Carcinogenesis 27(11)(11):2209-2216, 11/2006. PMID: 16714331.
12. Oh JL, Dryden MJ, Woodward WA, Yu TK, Tereffe W, Strom EA, Perkins GH, Middleton L, Hunt KK, Giordano SH, Oswald MJ, Domain D, Buchholz TA. Locoregional control of clinically diagnosed multifocal or multicentric breast cancer after neoadjuvant chemotherapy and locoregional therapy. J Clin Oncol 24(31)(31):4971-4975, 11/2006. PMID: 17075114.
13. Lu J, Wei Q, Bondy ML, Yu TK, Li D, Brewster A, Shete S, Sahin A, Meric-Bernstam F, Wang LE. Promoter polymorphism (-786t>C) in the endothelial nitric oxide synthase gene is associated with risk of sporadic breast cancer in non-Hispanic white women age younger than 55 years. Cancer 107(9):2245-2253, 11/2006. PMID: 17063466.
14. Borghero YO, Salehpour M, McNeese MD, Stovall M, Smith SA, Johnson J, Perkins GH, Strom EA, Oh JL, Kirsner SM, Woodward WA, Yu TK, Buchholz TA. Multileaf field-in-field forward-planned intensity-modulated dose compensation for whole-breast irradiation is associated with reduced contralateral breast dose: a phantom model comparison. Radiother Oncol 82(3)(3):324-328, 3/2007. PMID: 17157944.
15. Huang EH, Strom EA, Valero V, Fornage B, Perkins GH, Oh JL, Yu TK, Tereffe W, Woodward WA, Hunt KK, Meric-Bernstam F, Sahin AA, Bedrosian I, Hortobagyi GN, Buchholz TA. Locoregional treatment outcomes for breast cancer patients with ipsilateral supraclavicular metastases at diagnosis. Int J Radiat Oncol Biol Phys 67(2)(2):490-496, 2/2007. PMID: 17236970.
16. McGuire SE, Gonzalez-Angulo AM, Huang EH, Tucker SL, Kau SW, Yu TK, Strom EA, Oh JL, Woodward WA, Tereffe W, Hunt KK, Kuerer HM, Sahin AA, Hortobagyi GN, Buchholz TA. Postmastectomy radiation improves the outcome of patients with locally advanced breast cancer who achieve a pathologic complete response to neoadjuvant chemotherapy. Int J Radiat Oncol Biol Phys 68(4)(4):1004-1009, 7/2007. e-Pub 4/2007. PMID: 17418973.
17. Liengsawangwong R, Yu TK, Sun TL, Erasmus JJ, Perkins GH, Tereffe W, Oh JL, Woodward WA, Strom EA, Salephour M, Buchholz TA. Treatment optimization using computed tomography-delineated targets should be used for supraclavicular irradiation for breast cancer. Int J Radiat Oncol Biol Phys 69(3)(3):711-715, 11/2007. PMID: 17889264.
18. Garg AK, Oh JL, Oswald MJ, Huang E, Strom EA, Perkins GH, Woodward WA, Yu TK, Tereffe W, Meric-Bernstam F, Hahn K, Buchholz TA. Effect of postmastectomy radiotherapy in patients <35 years old with stage II-III breast cancer treated with doxorubicin-based neoadjuvant chemotherapy and mastectomy. Int J Radiat Oncol Biol Phys 69(5)(5):1478-1483, 12/2007. e-Pub 9/2007. PMID: 17855016.
19. Oh JL, Nguyen G, Whitman GJ, Hunt KK, Yu TK, Woodward WA, Tereffe W, Strom EA, Perkins GH, Buchholz TA. Placement of radiopaque clips for tumor localization in patients undergoing neoadjuvant chemotherapy and breast conservation therapy. Cancer 110(11)(11):2420-2427, 12/2007. e-Pub 10/2007. PMID: 17941034.
20. Lu J, Wei Q, Bondy ML, Brewster AM, Bevers TB, Yu TK, Buchholz TA, Meric-Bernstam F, Hunt KK, Singletary SE, Wang LE. Genetic variants in the H2AFX promoter region are associated with risk of sporadic breast cancer in non-Hispanic white women aged <= 55 years. Breast Cancer Res Treat 110(2):357-366, 7/2008. PMID: 17851762.
21. Reed VK, Cavalcanti JL, Strom EA, Perkins GH, Oh JL, Tereffe W, Yu TK, Yeung H, Whitman GJ, Bedrosian I, Macapinlac HA, Buchholz TA, Woodward WA. Risk of subclinical micrometastatic disease in the supraclavicular nodal bed based on the anatomical distribution in patients with advanced breast cancer. Int J Radiat Oncol Biol Phys 71(2):435-440, 6/2008. PMID: 18164831.
22. Wahl AO, Rademaker A, Kiel KD, Jones EL, Marks LB, Croog V, McCormick BM, Hirsch A, Karkar A, Motwani SB, Tereffe W, Yu TK, Sher D, Silverstein J, Kachnic LA, Kesslering C, Freedman GM, Small W. Multi-institutional review of repeat irradiation of chest wall and breast for recurrent breast cancer. Int J Radiat Oncol Biol Phys 70(2)(2):477-484, 2/2008. e-Pub 9/2007. PMID: 17869019.
23. Smith GL, Smith BD, Giordano SH, Shih YC, Woodward WA, Strom EA, Perkins GH, Tereffe W, Yu TK, Buchholz TA. Risk of hypothyroidism in older breast cancer patients treated with radiation. Cancer 112(6)(6):1371-1379, 3/2008. PMID: 18213620.
24. Buchholz TA, Woodward WA, Duan Z, Fang S, Oh JL, Tereffe W, Strom EA, Perkins GH, Yu TK, Hunt KK, Meric-Bernstam F, Hortobagyi GN, Giordano SH. Radiation use and long-term survival in breast cancer patients with T1,T2 primary tumors and 1-3 positive axillary lymph nodes. Int J Radiat Oncol Biol Phys 71(4):1022-1027, 7/2008. e-Pub 1/2008. PMID: 18234447.
25. Yu TK, Bhosale PR, Crane CH, Iyer RB, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Eng C, Wolff RA, Janjan NA, Delclos ME, Krishnan S, Das P. Patterns of Locoregional Recurrence After Surgery and Radiotherapy or Chemoradiation for Rectal Cancer. Int J Radiat Oncol Biol Phys 71(4):1175-1180, 7/2008. PMID: 18207667.
26. Dawood S, Broglio K, Esteva FJ, Ibrahim NK, Kau SW, Islam R, Aldape KD, Yu TK, Hortobagyi GN, Gonzalez-Angulo AM. Defining prognosis for women with breast cancer and CNS metastases by HER2 status. Ann Oncol 19(7):1242-1248, 7/2008. PMID: 18334512.
27. Fu K, Sun J, Bickford LR, Lin A, Halas NJ, Yu TK, Drezek RA. Measurement of immunotargeted plasmonic nanoparticles' cellular binding: a key factor in optimizing diagnostic efficacy. Nanotechnology 19:1-6, stacks.iop.org/Nano/19/045103, 1/2008. e-Pub 1/2008.
28. Bickford LR, Chang J, Fu K, Sun J, Hu Y, Gobin AM, Yu T-K, Drezek RA. Evaluation of Immunotargeted Gold Nanoshells as Rapid Diagnostic Imaging Agents for HER2-Overexpressing Breast Cancer Cells: A Temporal-Based Analysis. Nanobiotechnology (online), 5/2008.
29. Dawood S, Broglio K, Esteva FJ, Yang W, Kau SW, Islam R, Albarracin C, Yu TK, Green M, Hortobagyi GN, Gonazlez-Angulo AM. Survival among women with triple-receptor-negative breast cancer and brain metastases. Ann Oncol. e-Pub 1/15/2009. PMID: 19150943.
30. Garg AK, Frija EK, Sun TL, Strom EA, Perkins GH, Oh JL, Yu TK, Woodward WA, Tereffe WA, Salehpour M, Buchholz TA. Effects of Variable Placement of Superior Tangential/Supraclavicular Match Line on Dosimetric Coverage of Level III Axilla/Axillary Apex in Patients Treated with Breast and Supraclavicular Radiotherapy. Int J Radiat Oncol Biol Phys 73(2):370-4, 8/1/2008. PMID: 18676090.
31. Beadle BM, Woodward WA, Tucker SL, Outlaw ED, Allen PK, Oh JL, Strom EA, Perkins GH, Tereffe W, Yu TK, Meric-Bernstam F, Litton JK, Buchholz TA. Ten-Year Recurrence Rates in Young Women With Breast Cancer by Locoregional Treatment Approach. Int J Radiat Oncol Biol Phys, 8/14/2008. PMID: 18707822.
32. Strom EA, Yu TK, Rabinovitch RA, Haffty BG, Halbert FE, Taylor ME, White JR, Cobleigh MA, Edge SB. American College of Radiology Appropriateness Criteria on Locally Advanced Breast Cancer. ACR Appropriateness Criteria:6-12, 10/2008.
33. Bristol IJ, Woodward WA, Strom EA, Cristofanilli M, Domain D, Singletary SE, Perkins GH, Oh JL, Yu TK, Terrefe W, Sahin AA, Hunt KK, Hortobagyi GN, Buchholz TA. Locoregional treatment outcomes after multimodality management of inflammatory breast cancer. Int J Radiat Oncol Biol Phys 72(2):474-84, 10/1/2008. e-Pub 4/24/2008. PMID: 18439768.
34. Buchholz TA, Avritscher R, Yu TK. Identifying the "sentinel lymph nodes" for arm drainage as a strategy for minimizing the lymphedema risk after breast cancer therapy. Breast Cancer Res Treat. e-Pub 1/31/2009. PMID: 19184413.
35. Reed VK, Woodward WA, Zhang L, Strom EA, Perkins GH, Tereffe W, Oh JL, Yu TK, Bedrosian I, Whitman GJ, Buchholz TA, Dong L. Automatic Segmentation of Whole Breast Using Atlas Approach and Deformable Image Registration. Int J Radiat Oncol Biol Phys. e-Pub 9/17/2008. PMID: 18804333.
36. Wang X, Yu TK, Salehpour M, Zhang SX, Sun TL, Buchholz TA. Breast Cancer Regional Radiation Fields for Supraclavicular and Axillary Lymph Node Treatment: Is a Posterior Axillary Boost Field Technique Optimal? Int J Radiat Oncol Biol Phys. e-Pub 9/19/2008. PMID: 18805650.
37. Zhang SX, Gao J, Buchholz TA, Wang Z, Salehpour MR, Drezek RA, Yu TK. Quantifying tumor-selective radiation dose enhancements using gold nanoparticles: a monte carlo simulation study. Biomed Microdevices. e-Pub 4/21/2009. PMID: 19381816.
38. Bickford LR, Agollah G, Drezek R, Yu TK. Silica-gold nanoshells as potential intraoperative molecular probes for HER2-overexpression in ex vivo breast tissue using near-infrared reflectance confocal microscopy. Breast Cancer Res Treat. e-Pub 5/6/2009. PMID: 19418216.

Invited Articles
1. Bickford LR, Drezek RA, Yu TK. Intraoperative techniques and tumor margin status--room for improvement for cervical cancer patients of childbearing age. Gynecol Oncol 107(1 Suppl 1)(1 Suppl 1):S180-186, 10/2007. e-Pub 8/2007. PMID: 17727938.

Last updated: 9/25/2009