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Valsala Haridas, PhD

Present Title & Affiliation

N/A

Education & Training

Degree-Granting Education

1995 Jawaharlal Nehru University, New Delhi, India, PHD, Immunology
1988 Jawaharlal Nehru University, New Delhi, India, MS, Life Sciences
1986 Madras University, Madras, India, BS, Zoology

Postgraduate Training

9/2002-2012 Assistant Professor, The University of Texas MD Anderson Cancer Center, Houston, TX
8/1999-9/2002 Research Associate, The University of Texas MD Anderson Cancer Center, Houston, TX
4/1996-8/1999 Post-doctoral fellow, The University of Texas MD Anderson Cancer Center, Houston, TX

Experience/Service

Academic Appointments

Assistant Professor, Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2002-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Haridas V, Xu ZX, Kitchen D, Jiang A, Michels P, Gutterman JU. The anticancer plant triterpenoid, avicin D, regulates glucocorticoid receptor signaling: implications for cellular metabolism. PLoS One 6(11):e28037, 2011. e-Pub 11/2011. PMCID: PMC3221683.
2. Arias M, Quijano JC, Haridas V, Gutterman JU, Lemeshko VV. Red blood cell permeabilization by hypotonic treatments, saponin, and anticancer avicins. Biochim Biophys Acta. 1798(6), 6/2010.
3. Xu ZX, Ding T, Haridas V, Connolly F, Gutterman JU. Avicin D, a plant triterpenoid, induces cell apoptosis by recruitment of Fas and downstream signaling molecules into lipid rafts. PLoS One. 4(12), 12/2009.
4. Haridas V, Nishimura G, Xu ZX, Connolly F, Hanausek M, Walaszek Z, Zoltaszek R, Gutterman JU. Avicin D: A Protein Reactive Plant Isoprenoid Dephosphorylates Stat 3 by Regulating Both Kinase and Phosphatase Activities. PLoS One 4(5):e5578, 2009. e-Pub 5/18/2009. PMCID: PMC2680980.
5. Zhang C, Li B, Gaikwad AS, Haridas V, Xu Z, Gutterman JU, Duvic M. Avicin D Selectively Induces Apoptosis and Downregulates p-STAT-3, bcl-2, and Survivin in Cutaneous T-Cell Lymphoma Cells. J Invest Dermatol 128(11):2728-2735, 5/2008. PMID: 18496567.
6. Xu ZX, Liang J, Haridas V, Gaikwad A, Connolly FP, Mills GB, Gutterman JU. A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase. Cell Death Differ 14(11):1948-57, 11/2007. PMID: 17690712.
7. Lemeshko VV, Haridas V, Quijano Perez JC, Gutterman JU. Avicins, natural anticancer saponins, permeabilize mitochondrial membranes. Arch Biochem Biophys 454(2):114-22, 10/2006. PMID: 16962987.
8. Gutterman JU, Lai HT, Yang P, Haridas V, Gaikwad A, Marcus S. Effects of the tumor inhibitory triterpenoid avicin G on cell integrity, cytokinesis, and protein ubiquitination in fission yeast. Proc Natl Acad Sci U S A 102(36):12771-6, 9/2005. PMID: 16118282.
9. Haridas V, Kim SO, Nishimura G, Hausladen A, Stamler JS, Gutterman JU. Avicinylation (thioesterification): a protein modification that can regulate the response to oxidative and nitrosative stress. Proc Natl Acad Sci U S A 102(29):10088-93, 7/2005. PMID: 16030151.
10. Li XX, Davis B, Haridas V, Gutterman JU, Colombini M. Proapoptotic triterpene electrophiles (avicins) form channels in membranes: cholesterol dependence. Biophys J 88(4):2577-84, 4/2005. PMID: 15653745.
11. Blackstone NW, Kelly MM, Haridas V, Gutterman JU. Mitochondria as integrators of information in an early-evolving animal: insights from a triterpenoid metabolite. Proc Biol Sci 272(1562):527-31, 3/2005. PMID: 15799949.
12. Gaikwad A, Poblenz A, Haridas V, Zhang C, Duvic M, Gutterman J. Triterpenoid electrophiles (avicins) suppress heat shock protein-70 and x-linked inhibitor of apoptosis proteins in malignant cells by activation of ubiquitin machinery: implications for proapoptotic activity. Clin Cancer Res 11(5):1953-62, 3/2005. PMID: 15756021.
13. Haridas V, Hanausek M, Nishimura G, Soehnge H, Gaikwad A, Narog M, Spears E, Zoltaszek R, Walaszek Z, Gutterman JU. Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery. J Clin Invest 113(1):65-73, 2004. PMID: 14702110.
14. Jayatilake GS, Freeberg DR, Liu Z, Richheimer SL, Blake Nieto ME, Bailey DT, Haridas V, Gutterman JU. Isolation and structures of avicins D and G: in vitro tumor-inhibitory saponins derived from Acacia victoriae. J Nat Prod 66(6):779-83, 6/2003. PMID: 12828461.
15. Joshi L, Van Eck JM, Mayo K, Di Silvestro R, Blake Nieto ME, Ganapathi T, Haridas V, Gutterman JU, Arntzen CJ. Metabolomics of plant saponins: bioprospecting triterpene glycoside diversity with respect to mammalian cell targets. Omics 6(3):235-46, 2002. PMID: 12427275.
16. Haridas V, Arntzen CJ, Gutterman JU. Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), inhibit activation of nuclear factor-kappaB by inhibiting both its nuclear localization and ability to bind DNA. Proc Natl Acad Sci U S A 98(20):11557-62, 9/2001. PMID: 11572998.
17. Mujoo K, Haridas V, Hoffmann JJ, Wachter GA, Hutter LK, Lu Y, Blake ME, Jayatilake GS, Bailey D, Mills GB, Gutterman JU. Triterpenoid saponins from Acacia victoriae (Bentham) decrease tumor cell proliferation and induce apoptosis. Cancer Res 61(14):5486-90, 7/2001. PMID: 11454696.
18. Haridas V, Higuchi M, Jayatilake GS, Bailey D, Mujoo K, Blake ME, Arntzen CJ, Gutterman JU. Avicins: triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbation. Proc Natl Acad Sci U S A 98(10):5821-6, 5/2001. PMID: 11344312.
19. Manna SK, Haridas V, Aggarwal BB. Bcl-x(L) suppresses TNF-mediated apoptosis and activation of nuclear factor-kappaB, activation protein-1, and c-Jun N-terminal kinase. J Interferon Cytokine Res 20(8):725-35, 8/2000. PMID: 10954916.
20. Haridas V, Shrivastava A, Su J, Yu GL, Ni J, Liu D, Chen SF, Ni Y, Ruben SM, Gentz R, Aggarwal BB. VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth. Oncogene 18(47):6496-504, 11/1999. PMID: 10597252.
21. Darnay BG, Haridas V, Ni J, Moore PA, Aggarwal BB. Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. J Biol Chem 273(32):20551-5, 8/1998. PMID: 9685412.
22. Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett 431(3):351-6, 7/1998. PMID: 9714541.
23. Kwon BS, Wang S, Udagawa N, Haridas V, Lee ZH, Kim KK, Oh KO, Greene J, Li Y, Su J, Gentz R, Aggarwal BB, Ni J. TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption. Faseb J 12(10):845-54, 7/1998. PMID: 9657524.
24. Haridas V, Ni J, Meager A, Su J, Yu GL, Zhai Y, Kyaw H, Akama KT, Hu J, Van Eldik LJ, Aggarwal BB. TRANK, a novel cytokine that activates NF-kappa B and c-Jun N-terminal kinase. J Immunol 161(1):1-6, 7/1998. PMID: 9647199.
25. Haridas V, Darnay BG, Natarajan K, Heller R, Aggarwal BB. Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-kappa B activation, and c-Jun kinase activation. J Immunol 160(7):3152-62, 4/1998. PMID: 9531270.
26. Haridas V, Saxena RK. Mechanism of interaction of pH 3.0 treated tumor cells expressing lower levels of class I MHC antigens, with IL-2 activated NK cells. Immunol Lett 55(3):167-71, 3/1997. PMID: 9161883.
27. Haridas V, Saxena RK. Correlation of class I MHC antigen levels on some human tumor cell lines with susceptibility to LAK cells and performance in cold target inhibition assays. Cell Immunol 161(2):256-61, 4/1995. PMID: 7697736.
28. Haridas V, Saxena RK. Changes in LAK susceptibility of tumor cells as their MHC class I antigen expression levels regenerate after treatment at pH 3.0. Immunol Lett 44(1):7-11, 1995. PMID: 7721347.
29. Haridas, V., Sarin, A., Kochupillai, V and Saxena, R.K. Regulation of NK susceptibility by target cell class I MHC molecules. Indian Journal of Biochemistry and Biophysics 32:179-185, 1995.
30. Haridas V, Saxena RK. Role of major histocompatibility complex class I antigens in modulating the performance of murine tumour cells in cold target competition assays. Immunology 84(1):86-90, 1995. PMID: 7890307.
31. Haridas V, Sarin A, Anandhi R, Kochupillai V, Saxena RK. Effect of gamma interferon on the expression of class I MHC antigens on fresh leukemic cells and their susceptibility to lysis by lymphokine activated killer cells. Indian J Cancer 31(2):96-102, 6/1994. PMID: 7927456.
32. Sarin A, Haridas V, Saxena RK. MHC class I up-regulation protects some but not all targets against LAK-mediated lysis: possible implications for the existence of LAK cell subpopulations using different recognition strategies. Immunol Lett 38(1):59-62, 9/1993. PMID: 8300155.

Invited Articles

1. Wang H, Haridas V, Gutterman JU, Xu ZX. Natural triterpenoid avicins selectively induce tumor cell death. Commun Integr Biol. 3(3):205-208, 5/2010.

Abstracts

1. Lemeshko V, Haridas V, Ouijano C, Gutterman JU. Synergistic effects of avicins and hydroperoxides on mitochondria: a possible mechanism for the selective killing of cancer cells. ASBMB Annual Meeting, 2007.

Grant & Contract Support

Title: The role of LKB1 in the maintenance of genomic stability
Funding Source: NIH/NCI
Role: Collaborator
Principal Investigator: Zhi-Xiang Xu
Duration: 7/1/2009 - 7/1/2014
 
Title: Chemical biology of a pentacyclic triterpenoid compound : Modification of critical cysteine residues and redox regulation of G protein signaling by avicins.
Funding Source: Welch Foundation
Role: Investigator
Principal Investigator: Jordan U. Gutterman
Duration: 7/2006 - 7/2008

Last updated: 2/21/2013