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Veerabhadran Baladandayuthapani, Ph.D

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Biostatistics, Division of Quantitative Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2005 Texas A&M University, College Station, TX, PHD, Statistics
2000 University of Rochester, Rochester, NY, MA, Statistics
1999 Indian Institute of Technology, Kharagpur, WB, India, BSc (honors), Honors, Mathematics

Experience/Service

Academic Appointments

Assistant Professor, Department of Biostatistics, Division of Quantitative Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, 2005-2012

Selected Publications

Peer-Reviewed Original Research Articles
1. Wang, W. Baladandayuthapani, V, Holmes, C. C. and Do, K-A. Network-based Bayesian Analysis of Diverse Genomics Data. BMC Bioinformatics. In Press.
2. Kuhn DJ, Berkova Z, Jones RJ, Woessner R, Bjorklund CC, Ma W, Davis RE, Lin P, Wang H, Madden TL, Wei C, Baladandayuthapani V, Wang M, Thomas SK, Shah JJ, Weber DM, Orlowski RZ. Targeting the insulin-like growth factor-1 receptor to overcome bortezomib resistance in preclinical models of multiple myeloma. Blood 120(16):3260-70, 10/18/2012. e-Pub 8/29/2012. PMCID: PMC3476538.
3. Jones RJ, Bjorklund CC, Baladandayuthapani V, Kuhn DJ, Orlowski RZ. Drug Resistance to Inhibitors of the Human Double Minute-2 E3 Ligase Is Mediated by Point Mutations of p53, but Can Be Overcome with the p53 Targeting Agent RITA. Mol Cancer Ther 11(10):2243-53, 10/2012. e-Pub 8/28/2012. PMCID: PMC3469746.
4. Prasad S, Yadav VR, Sung B, Reuter S, Kannappan R, Deorukhkar A, Diagaradjane P, Wei C, Baladandayuthapani V, Krishnan S, Guha S, Aggarwal BB. Ursolic Acid Inhibits Growth and Metastasis of Human Colorectal Cancer in an Orthotopic Nude Mouse Model by Targeting Multiple Cell Signaling Pathways: Chemosensitization with Capecitabine. Clin Cancer Res 18(18):4942-53, 9/15/2012. e-Pub 7/25/2012. PMID: 22832932.
5. Garrett CR, George B, Viswanathan C, Bhadkamkar NA, Wen S, Baladandayuthapani V, You YN, Kopetz ES, Overman MJ, Kee BK, Eng C. Survival Benefit Associated With Surgical Oophorectomy in Patients With Colorectal Cancer Metastatic to the Ovary. Clin Colorectal Cancer 11(3):191-4, 9/2012. e-Pub 1/26/2012. PMID: 22280844.
6. Zheng Y, Yang J, Qian J, Zhang L, Lu Y, Li H, Lin H, Lan Y, Liu Z, He J, Hong S, Thomas S, Shah J, Baladandayuthapani V, Kwak LW, Yi Q. Novel Phosphatidylinositol 3-Kinase Inhibitor NVP- BKM120 Induces Apoptosis in Myeloma Cells and Shows Synergistic Anti-Myeloma Activity with Dexamethasone. J Mol Med (Berl) 90(6):695-706, 6/2012. e-Pub 12/30/2011. PMID: 22207485.
7. Hrafnkelsson, B., Morris, J. S., and Baladandayuthapani, V. Spatial Modeling of Annual Minimum and Maximum Temperature in Iceland. Meteorology and Atmospheric Physics 116(1):43-61, 4/2012.
8. Lu C, Stewart DJ, Lee JJ, Ji L, Ramesh R, Jayachandran G, Nunez MI, Wistuba II, Erasmus JJ, Hicks ME, Grimm EA, Reuben JM, Baladandayuthapani V, Templeton NS, McMannis JD, Roth JA. Phase I clinical trial of systemically administered TUSC2(FUS1)-nanoparticles mediating functional gene transfer in humans. PLoS One 7(4):e34833, 2012. e-Pub 4/25/2012. PMCID: PMC3338819.
9. Jones RJ, Baladandayuthapani V, Neelapu S, Fayad LE, Romaguera JE, Wang M, Sharma R, Yang D, Orlowski RZ. HDM-2 inhibition suppresses expression of ribonucleotide reductase subunit M2, and synergistically enhances gemcitabine-induced cytotoxicity in mantle cell lymphoma. Blood 118(15):4140-9, 10/13/2011. e-Pub 8/15/2011. PMCID: PMC3204731.
10. Bonato V, Baladandayuthapani V, Broom BM, Sulman EP, Aldape KD, Do KA. Bayesian ensemble methods for survival prediction in gene expression data. Bioinformatics 27(3):359-67, 2/1/2011. e-Pub 12/8/2010. PMCID: PMC3031034.
11. Morris JS, Baladandayuthapani V, Herrick RC, Sanna P, Gutstein H. Automated Analysis of Quantitative Image Data Using Isomorphic Functional Mixed Models with Application to Proteomics Data. Ann Appl Stat 5(2A):894-923, 1/1/2011. PMCID: PMC3298181.
12. Thompson PA, Brewster AM, Kim-Anh D, Baladandayuthapani V, Broom BM, Edgerton ME, Hahn KM, Murray JL, Sahin A, Tsavachidis S, Wang Y, Zhang L, Hortobagyi GN, Mills GB, Bondy ML. Selective genomic copy number imbalances and probability of recurrence in early-stage breast cancer. PLoS One 6(8):e23543, 2011. e-Pub 8/12/2011. PMCID: PMC3155554.
13. Baladandayuthapani V, Ji Y, Talluri R, Nieto-Barajas LE, Morris JS. Bayesian Random Segmentation Models to Identify Shared Copy Number Aberrations for Array CGH Data. J Am Stat Assoc 105(492):1358-1375, 12/2010. PMCID: PMC3079218.
14. Navas, M.*, Ordonez C., and Baladandayuthapani, V. On the Computation of Stochastic Search Variable Selection in Linear Regression with UDFs. Proc. IEEE ICDM Conference:941-946, (* graduate student), 7/2010.
15. Navas M*, Ordonez C. and Baladandayuthapani V. Fast PCA and Bayesian variable selection for large data sets based on SQL and UDFs. ACM KDD Large-scale Data Mining: Theory and Applications:941-946, (* graduate student), 6/2010.
16. Zhou L, Huang JZ, Martinez JG, Maity A, Baladandayuthapani V, Carroll RJ. Reduced rank mixed effects models for spatially correlated hierarchical functional data. J Am Stat Assoc 105(489):390-400, 3/1/2010. PMCID: PMC2853971.
17. Lin YX, Baladandayuthapani V, Bonato V, Do KA. Estimating Shared Copy Number Aberrations for Array CGH Data: the Linear-Median Method. Cancer Inform 9(9):229-49., 2010. e-Pub 10/12/2010. PMCID: PMC2978932.
18. Wang J, Xu J, Baladandayuthapani V. Contrast sensitivity of digital imaging display systems: contrast threshold dependency on object type and implications for monitor quality assurance and quality control in PACS. Med Phys 36(8):3682-92, 8/2009. PMID: 19746801.
19. Zhang N, Ge G, Meyer R, Sethi S, Basu D, Pradhan S, Zhao YJ, Li XN, Cai WW, El-Naggar AK, Baladandayuthapani V, Kittrell FS, Rao PH, Medina D, Pati D. Overexpression of Separase induces aneuploidy and mammary tumorigenesis. Proc Natl Acad Sci U S A 105(35):13033-8, 9/2/2008. e-Pub 8/26/2008. PMCID: PMC2529090.
20. Baladandayuthapani V, Mallick BK, Young Hong M, Lupton JR, Turner ND, Carroll RJ. Bayesian hierarchical spatially correlated functional data analysis with application to colon carcinogenesis. Biometrics 64(1):64-73, 3/2008. e-Pub 6/30/2007. PMCID: PMC2740995.
21. Nehete PN, Nehete BP, Hill L, Manuri PR, Baladandayuthapani V, Feng L, Simmons J, Sastry KJ. Selective induction of cell-mediated immunity and protection of rhesus macaques from chronic SHIV(KU2) infection by prophylactic vaccination with a conserved HIV-1 envelope peptide-cocktail. Virology 370(1):130-41, 1/5/2008. e-Pub 10/24/2007. PMCID: PMC2196441.
22. Nanda U, Eisen SJ, Baladandayuthapani V. Undertaking An Art-Survey to Compare Patient versus Student Art Preferences. Journal of Environment Behavior 40:269-301, 2008.
23. Aggarwal BB, Sethi G, Baladandayuthapani V, Krishnan S, Shishodia S. Targeting cell signaling pathways for drug discovery: an old lock needs a new key. J Cell Biochem 102(3):580-92, 10/15/2007. PMID: 17668425.
24. Phadke AP, de la Concha-Bermejillo A, Wolf AM, Andersen PR, Baladandayuthapani V, Collisson EW. Pathogenesis of a Texas feline immunodeficiency virus isolate: an emerging subtype of clade B. Vet Microbiol 115(1-3):64-76, 6/15/2006. e-Pub 3/29/2006. PMID: 16574348.
25. Baladandayuthapani V, Mallick BK, Caroll RJ. Spatially Adaptive Bayesian Penalized Regression Splines (Psplines). Journal of Computational and Graphical Statistics 14:378-394, 2005. PMID: Not in PubMed.

Book Chapters
1. Rossell D*, Baladandayuthapani V, Johnson VE. In: Bayes Factors Based on Test Statistics Under Order Restrictions: (* post-doctoral researcher), 2008.
2. Baladandayuthapani V, Holmes CC, Mallick BK, and Caroll RJ. Modeling Nonlinear Gene Interactions using Bayesian MARS. In: Bayesian Interference for Gene Expression and Proteomics. Ed(s) In Do KA, Mueller P, and Vannucci M. Cambridge University Press, 2006.
3. Baladandayuthapani V, Ray S, and Mallick BK. Bayesian Methods for DNA Microarray Data Analysis. In: Handbook in Statistics Bayesian Statistics: Modeling and Computation, 2005.

Books (edited and written)
1. Mallick BK, Gold DL, Baladandayuthapani V. Bayesian Methods for Gene Expression. Wiley: U.K., 2009.

Grant & Contract Support

Title: SPORE in Brain Cancer - Biostatistics Core (PC-C)
Funding Source: NIH/NCI
Role: Statistician
Principal Investigator: W K Alfred Yung
Duration: 9/1/2008 - 8/31/2011
 
Title: Cancer Center Support Grant – Biostatistics Shared Resource (PPSR-21)
Funding Source: NIH/NCI
Role: Statistician
Principal Investigator: Ronald DePinho
Duration: 8/28/2008 - 6/30/2013

Last updated: 3/7/2013