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Victor Krasnykh, Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd.
Unit Number: 59
Houston, TX 77030
Room Number: T8.3900
Phone: 713 563-4873
Fax: 713 563-4894
Email: vkrasnykh@mdanderson.org

Education & Training

Degree-Granting Education

1999 Division of Gene Therapy, Department of Medical Oncology, Free University of Amsterdam, Amsterdam, the Netherlands, PHD, Medical Science
1982 Novosibirsk State University, Novosibirsk, Russia, MS, Microbiology

Experience/Service

Academic Appointments

Associate Professor, Department of Experimental Diagnostic Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 8/2003-5/2013

Selected Publications

Peer-Reviewed Original Research Articles

1. Dreier B, Honegger A, Hess C, Nagy-Davidescu G, Mittl PR, Grütter MG, Belousova N, Mikheeva G, Krasnykh V, Plückthun A. Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters. Proc Natl Acad Sci U S A 110(10):E869-77, 3/2013. e-Pub 2/2013. PMCID: PMC3593905.
2. Dreier B, Mikheeva G, Belousova N, Parizek P, Boczek E, Jelesarov I, Forrer P, Plückthun A, Krasnykh V. Her2-specific multivalent adapters confer designed tropism to adenovirus for gene targeting. J Mol Biol 405(405):410-426, 1/2011. e-Pub 11/2010. PMCID: PMC3149894.
3. Yeh HH, Ogawa K, Balatoni J, Mukhopadhyay U, Pal A, Gonzalez-Lepera C, Shavrin A, Soghomonyan S, Flores L, Young D, Volgin AY, Najjar AM, Krasnykh V, Tong W, Alauddin MM, Gelovani JG. Molecular imaging of active mutant L858R EGF receptor (EGFR) kinase-expressing nonsmall cell lung carcinomas using PET/CT. Proc Natl Acad Sci U S A 108(4):1603-1608, 1/2011. e-Pub 1/2011. PMCID: PMC3029752.
4. Belousova N, Mikheeva G, Xiong C, Soghomonian S, Young D, Le Roux L, Naff K, Bidaut L, Wei W, Li C, Gelovani J, Krasnykh V. Development of a targeted gene vector platform based on simian adenovirus serotype 24. J Virol 84(19):10087-1001, 10/2010. e-Pub 7/2010. PMCID: PMC2937776.
5. Piao Y, Jiang H, Alemany R, Krasnykh V, Marini FC, Xu J, Alonso MM, Conrad CA, Aldape KD, Gomez-Manzano C, Fueyo J. Oncolytic adenovirus retargeted to Delta-EGFR induces selective antiglioma activity. Cancer Gene Ther 16(3):256-65, 3/2009. e-Pub 10/2008. PMCID: PMC3793894.
6. Glasgow JN, Mikheeva G, Krasnykh V, Curiel DT. A strategy for adenovirus vector targeting with a secreted single chain antibody. PLoS One 4(12):e8355, 2009. e-Pub 12/2009. PMCID: PMC2791226.
7. Wu Y, Fang B, Yang XQ, Wang L, Chen D, Krasnykh V, Carter BZ, Morris JS, Shureiqi I. Therapeutic molecular targeting of 15-lipoxygenase-1 in colon cancer. Mol Ther 16(5):886-92, 5/2008. e-Pub 3/2008. PMCID: PMC2377397.
8. Belousova N, Mikheeva G, Gelovani J, Krasnykh V. Modification of adenovirus capsid with a designed protein ligand yields a gene vector targeted to a major molecular marker of cancer. J Virol 82(2):630-637, 1/2008. e-Pub 11/2007. PMCID: PMC2224583.
9. Hosokawa M, Kadota R, Shichijo S, Itoh K, Dmitriev I, Krasnykh V, Curiel DT, Takue Y, Wakasugi H, Takashima S, Heike Y. Cell cycle arrest and apoptosis induced by SART-1 gene transduction. Anticancer Res 25(3B):1983-1990, May-Jun, 5/2005. PMID: 16158934.
10. Wu H, Han T, Belousova N, Krasnykh V, Kashentseva E, Dmitriev I, Kataram M, Mahasreshti PJ, Curiel DT. Identification of sites in adenovirus hexon for foreign peptide incorporation. J Virol 79(6):3382-3390, 3/2005. PMCID: PMC1075677.
11. Wang M, Hemminki A, Siegal GP, Barnes MN, Dmitriev I, Krasnykh V, Liu B, Curiel DT, Alvarez RD. Adenoviruses with an RGD-4C modification of the fiber knob elicit a neutralizing antibody response but continue to allow enhanced gene delivery. Gynecol Oncol 2(2):341-8, 2/2005. PMID: 15661219.
12. Ono HA, Davydova JG, Adachi Y, Takayama K, Barker SD, Reynolds PN, Krasnykh VN, Kunisaki C, Shimada H, Curiel DT, Yamamoto M. Promoter-controlled infectivity-enhanced conditionally replicative adenoviral vectors for the treatment of gastric cancer. J Gastroenterol 40(1):31-42, 1/2005. PMID: 15692787.
13. Rivera AA, Davydova J, Schierer S, Wang M, Krasnykh V, Yamamoto M, Curiel DT, Nettelbeck DM. Combining high selectivity of replication with fiber chimerism for effective adenoviral oncolysis of CAR-negative melanoma cells. Gene Ther 23(23):1694-702, 12/2004. PMID: 15496964.
14. Zinn KR, Szalai AJ, Stargel A, Krasnykh V, Chaudhuri TR. Bioluminescence imaging reveals a significant role for complement in liver transduction following intravenous delivery of adenovirus. Gene Ther 11(19):1482-1486, 10/2004. PMID: 15295616.
15. Davydova J, Le LP, Gavrikova T, Wang M, Krasnykh V, Yamamoto M. Infectivity-enhanced cyclooxygenase-2-based conditionally replicative adenoviruses for esophageal adenocarcinoma. Cancer Res 64(12):4319-4327, 6/2004. PMID: 15205347.
16. Grandi P, Wang S, Schuback D, Krasnykh V, Spear M, Curiel DT, Manservigi R, Breakefield XO. HSV-1 virions engineered for specific binding to cell surface receptors. Mol Ther 9(3):419-427, 3/2004. PMID: 15006609.
17. Rivera AA, Wang M, Suzuki K, Uil TG, Krasnykh V, Curiel DT, Nettelbeck DM. Mode of transgene expression after fusion to early or late viral genes of a conditionally replicating adenovirus via an optimized internal ribosome entry site in vitro and in vivo. Virology 320(1):121-134, 3/2004. PMID: 15003868.
18. Timares L, Douglas JT, Tillman BW, Krasnykh V, Curiel DT. Adenovirus-mediated gene delivery to dendritic cells. Methods Mol Biol 246:139-54, 2004. PMID: 14970589.
19. Korokhov N, Mikheeva G, Krendelshchikov A, Belousova N, Simonenko V, Krendelshchikova V, Pereboev A, Kotov A, Kotova O, Triozzi PL, Aldrich WA, Douglas JT, Lo KM, Banerjee PT, Gillies SD, Curiel DT, Krasnykh V. Targeting of adenovirus via genetic modification of the viral capsid combined with a protein bridge. J Virol 77(24):12931-12940, 12/2003. PMCID: PMC296051.
20. Belousova N, Korokhov N, Krendelshchikova V, Simonenko V, Mikheeva G, Triozzi PL, Aldrich WA, Banerjee PT, Gillies SD, Curiel DT, Krasnykh V. Genetically targeted adenovirus vector directed to CD40-expressing cells. J Virol 77(21):11367-11377, 11/2003. PMCID: PMC229360.
21. Yamamoto M, Davydova J, Wang M, Siegal GP, Krasnykh V, Vickers SM, Curiel DT. Infectivity enhanced, cyclooxygenase-2 promoter-based conditionally replicative adenovirus for pancreatic cancer. Gastroenterology 125(4):1203-1218, 10/2003. PMID: 14517802.
22. Takayama K, Reynolds PN, Short JJ, Kawakami Y, Adachi Y, Glasgow JN, Rots MG, Krasnykh V, Douglas JT, Curiel DT. A mosaic adenovirus possessing serotype Ad5 and serotype Ad3 knobs exhibits expanded tropism. Virology 309(2):282-293, 5/2003. PMID: 12758175.
23. Kim M, Sumerel LA, Belousova N, Lyons GR, Carey DE, Krasnykh V, Douglas JT. The coxsackievirus and adenovirus receptor acts as a tumour suppressor in malignant glioma cells. Br J Cancer 88(9):1411-1416, 5/2003. PMCID: PMC2741053.
24. Chaudhuri TR, Cao Z, Krasnykh VN, Stargel AV, Belousova N, Partridge EE, Zinn KR. Blood-based screening and light based imaging for the early detection and monitoring of ovarian cancer xenografts. Technol Cancer Res Treat 2(2):171-180, 4/2003. PMID: 12680799.
25. Pereboeva L, Komarova S, Mikheeva G, Krasnykh V, Curiel DT. Approaches to utilize mesenchymal progenitor cells as cellular vehicles. Stem Cells 21(4):389-404, 2003. PMID: 12832693.

Abstracts

1. Dreier B, Hess C, Boczek E, Krasnykh V, Pluckthun A. Affinity maturation of DARPins for efficient adenoviral gene transfer. VIII European Symposium of The Protein Society, Zurich, Switzerland, 2009.
2. Mikheeva G, Derier B, Hess C, Boczek E, Belousova N, Pluckthun A, Krasnykh V. Design of bi-specific DARPin-derived adapters for targeting of adenovirus vectors. The 12th Annual Meeting of American Society of Gene Therapy, San Diego, CA, 2009.

Grant & Contract Support

Title: Tumor-specific gene vectors for imaging and therapy of metastatic disease,
Funding Source: NIH/NIBIB
Role: Principal Investigator
Duration: 4/1/2011 - 3/31/2014

Last updated: 11/6/2013