Peer-Reviewed Original Research Articles |
| 1. | Buchanan FG, Holla V, Katkuri S, Matta P and DuBois RN. Targeting Cyclooxygenase-2 and the Epidermal Growth Factor Receptor for the Prevention and Treatment of Intestinal Cancer. Cancer Res. 67(19):9380-9388, 2007. |
| 2. | Holla VR, Nakagawa K, Wei Y, Wang WH, Gatica A, Wei S, Mei S, Miller CM, Cha DR, Price E Jr., Zent R, Pozzi A, Breyer MD, Guan Y, Falck JR, Waterman MR, and Capdevila JH. Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. J Clin Invest. 116:1696-1702, 2006. |
| 3. | Mann JR, Backlund MG, Buchanan FG, Daikoku T, Holla VR, Rosenberg DW, Dey SK, and DuBois RN. Repression of Prosagladin Dehydrogenase by Epidermal Growth Factor and Snail Increases Prostagladin E2 and Promotes Cancer Progression. Cancer Res. 66(13):6649-56, 2006. |
| 4. | Holla VR, Wang D, Brown JR, Mann JR, Katkuri S and DuBois RN. Prostaglandin E2 Regulates the Complement Inhibitor CD55/Decay-accelerating Factor in Colorectal Cancer. J Biol Chem. 280:476-483, 2005. |
| 5. | Backlund MG, Mann JR, Holla VR, Buchanan FG, Tai HH, Musiek ES, Milne GL, Katkuri S and Dubois RN. 15-Hydroxyprostagladin dehydrogenase is down-regulated in colorectal cancer. J Biol Chem. 280:3217-3223, 2005. |
| 6. | Buchanan FG, McReynolds M, Couvillon A, Kam Y, Holla VR, DuBois RN and Exton JH. Requirement of phospholipase D1 activity in HRasV12-induced transformation. PNAS 102:1638-1642, 2005. |
| 7. | Capdevila JH, Nakagawa K and Holla VR. The CYP P450 Arachidonic Monooxygenases:Enzymatic Relays for the control of Kidney Function and Blood Pressure. Adv Exp Med Biol 525:39-46, 2003. |
| 8. | Holla VR, Adas F, Ichihara S, Price E Jr., Olsen N, Kovacs WS, Magnuson MA, Keeney DS, Breyer MD, Falk JR, Waterman MR and Capdevila JH. Alterations in the Regulation of Androgen-Sensitive Cyp 4a monooxygenases cause Sexually Dimorphic Hypertension. PNAS 98:5211-5216, 2001. |
| 9. | Holla VR, Makita K, Zaphiropoulos PG and Capdevila JH. The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading. J Clin Invest 104:751-760, 1999. |
| 10. | Capdevila JH, Holla VR, Helvig C and Falck JR. Microsomal cytochrome P450 and eicosanoid metabolism. Mol Aspects Med 20(1-2):42-55, 1999. |
| 11. | Madyastha KM, Charry NK, Holla VR and Karegoudar TB. Purification and partial characterization of microsomal NADH-cytochrome b5 reductase from higher plant Catharanthus roseus. Biom. Biophys. Res. Commun. 197:518-522, 1993. |
| 12. | Holla VR, Mann JR, Shi Q, DuBois RN. Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer. J Biol Chem 281(5):2676-82, 2/2006. e-Pub 11/2005. PMID: 16293616. |
| 13. | Xia D, Holla VR, Wang D, Menter DG, DuBois RN. HEF1 is a crucial mediator of the proliferative effects of prostaglandin E(2) on colon cancer cells. Cancer Res 70(2):824-31, 1/15/2010. e-Pub 1/12/2010. PMCID: PMC2943830. |
| 14. | Kim SH, Xia D, Kim SW, Holla V, Menter DG, Dubois RN. Human enhancer of filamentation 1 Is a mediator of hypoxia-inducible factor-1alpha-mediated migration in colorectal carcinoma cells. Cancer Res 70(10):4054-63, 5/15/2010. e-Pub 5/4/2010. PMCID: PMC2871069. |
