Skip to Content

'
Warren S. Liao, Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1980 Hershey Medical Center, Hershey, PA, PHD, Biochemistry
1976 Hershey Medical Center, Hershey, PA, MS, Genetics
1974 Pennsylvania State University, University Park, PA, BS, Biochemistry

Postgraduate Training

1/1985 Postgraduate Training, Stanford Medical School, Stanford, CA
1/1981 Postgraduate Training, Hershey Medical Center, Hershey, PA

Honors and Awards

1998-1999 Dean's Teaching Excellence Award
1994 Shannon Award, NIH
1992-1996 Dean's Teaching Excellence Award
1988 Dean's Teaching Excellence Award
1983 Postdoctoral Fellowship, NIH
1981 Postdoctoral Fellowship, Anna Fuller Foundation
1975 Graduate Traineeship, American Cancer Society

Selected Publications

Peer-Reviewed Original Research Articles
1. Mandal PK, Liao WS, McMurray JS. Synthesis of Phosphatase-Stable, Cell-Permeable Peptidomimetic Prodrugs That Target the SH2 Domain of Stat3. Org Lett. e-Pub 7/13/2009. PMID: 19594124.
2. Samanta AK, Huang HJ, Le XF, Mao W, Lu KH, Bast RC, Liao WS. MEKK3 expression correlates with nuclear factor kappa B activity and with expression of antiapoptotic genes in serous ovarian carcinoma. Cancer, 6/10/2009. e-Pub 6/10/2009. PMID: 19517469.
3. Huang S, Chang IS, Lin W, Ye W, Luo RZ, Lu Z, Lu Y, Zhang K, Liao WS, Tao T, Bast Jr RC, Chen X, Yu Y. ARHI (DIRAS 3), an imprinted tumor suppressor gene, binds to importins, and blocks nuclear import process of cargo proteins. Biosci Rep, 5/13/2009. e-Pub 5/13/2009. PMID: 19435463.
4. McMurray JS, Mandal PK, Liao WS, Ren Z, Chen X. Inhibition of Stat3 by cell-permeable peptidomimetic prodrugs targeted to its SH2 domain. Adv Exp Med Biol 611:545-6, 2009. PMID: 19400306.
5. Lu Z, Luo RZ, Lu Y, Zhang X, Yu Q, Khare S, Kondo S, Kondo Y, Yu Y, Mills GB, Liao WS, Bast RC. The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells. J Clin Invest 118(12):3917-29, 12/2008. e-Pub 11/2008. PMCID: PMC2582930.
6. Chang PY, Lu SC, Lee CM, Chen YJ, Dugan TA, Huang WH, Chang SF, Liao WS, Chen CH, Lee YT. Homocysteine inhibits arterial endothelial cell growth through transcriptional downregulation of fibroblast growth factor-2 involving G protein and DNA methylation. Circ Res 102(8). e-Pub 2/2008. PMID: 18309099.
7. Lu J, Jiang W, Yang JH, Chang PY, Walterscheid JP, Chen HH, Marcelli M, Tang D, Lee YT, Liao WS, Yang CY, Chen CH. Electronegative LDL impairs vascular endothelial cell integrity in diabetes by disrupting fibroblast growth factor 2 (FGF2) autoregulation. Diabetes 57(1). e-Pub 10/2007. PMID: 17959932.
8. Feng W, Lu Z, Luo RZ, Zhang X, Seto E, Liao WS, Yu Y. Multiple histone deacetylases repress tumor suppressor gene ARHI in breast cancer. Int J Cancer 120(8):1664-8, 4/2007. PMID: 17230502.
9. Lu Z, Luo RZ, Peng H, Rosen DG, Atkinson EN, Warneke C, Huang M, Nishmoto A, Liu J, Liao WS, Yu Y, Bast RC Jr. Transcriptional and posttranscriptional down-regulation of the imprinted tumor suppressor gene ARHI (DRAS3) in ovarian cancer. Clin Cancer Res 12(8):2404-13, 4/2006. PMID: 16638845.
10. Lu Z, Luo RZ, Peng H, Huang M, Nishmoto A, Hunt KK, Helin K, Liao WS, Yu Y. E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer. Oncogene 25(2):230-9, 1/2006. PMID: 16158053.
11. Nishimoto A, Yu Y, Lu Z, Mao X, Ren Z, Watowich SS, Mills GB, Liao WS, Chen X, Bast RC Jr, Luo RZ. A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells. Cancer Res 65(15):6701-10, 8/2005. PMID: 16061651.
12. Wang H, Wang H, Zhang W, Huang HJ, Liao WS, Fuller GN. Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas. Lab Invest 84(8):941-51, 8/2004. PMID: 15184909.
13. Reddy SA, Lin YF, Huang HJ, Samanta AK, Liao WS. The IL-1 receptor accessory protein is essential for PI 3-kinase recruitment and activation. Biochem Biophys Res Commun 316(4):1022-8, 4/2004. PMID: 15044087.
14. Samanta AK, Huang HJ, Bast RC Jr, Liao WS. Overexpression of MEKK3 confers resistance to apoptosis through activation of NFkappaB. J Biol Chem 279(9):7576-83, 2/2004. PMID: 14662759.
15. Wang H, Wang H, Shen W, Huang H, Hu L, Ramdas L, Zhou YH, Liao WS, Fuller GN, Zhang W. Insulin-like growth factor binding protein 2 enhances glioblastoma invasion by activating invasion-enhancing genes. Cancer Res 63(15):4315-21, 8/2003. PMID: 12907597.
16. Luo RZ, Fang X, Marquez R, Liu SY, Mills GB, Liao WS, Yu Y, Bast RC. ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers. Oncogene 22(19):2897-909, 5/2003. PMID: 12771940.
17. Wang H, Liao WS. Functional analysis of a minimal mouse serum amyloid A3 promoter in transgenic mice. Amyloid 8(4):250-6, 12/2001. PMID: 11791617.
18. Zheng JB, Zhou YH, Maity T, Liao WS, Saunders GF. Activation of the human PAX6 gene through the exon 1 enhancer by transcription factors SEF and Sp1. Nucleic Acids Res 29(19):4070-8, 10/2001. PMID: 11574690.
19. Yang J, Lin Y, Guo Z, Cheng J, Huang J, Deng L, Liao W, Chen Z, Liu Z, Su B. The essential role of MEKK3 in TNF-induced NF-kappaB activation. Nat Immunol 2(7):620-4, 7/2001. PMID: 11429546.
20. Luo RZ, Peng H, Xu F, Bao J, Pang Y, Pershad R, Issa JP, Liao WS, Bast RC Jr, Yu Y. Genomic structure and promoter characterization of an imprinted tumor suppressor gene ARHI. Biochim Biophys Acta 1519(3):216-22, 6/2001. PMID: 11418188.
21. Ren Y, Liao WS. Transcription factor AP-2 functions as a repressor that contributes to the liver-specific expression of serum amyloid A1 gene. J Biol Chem 276(21):17770-8, 5/2001. PMID: 11278660.
22. Bing Z, Huang JH, Liao WS. NFkappa B interacts with serum amyloid A3 enhancer factor to synergistically activate mouse serum amyloid A3 gene transcription. J Biol Chem 275(41):31616-23, 10/2000. PMID: 10899169.
23. Reddy SA, Huang JH, Liao WS. Phosphatidylinositol 3-kinase as a mediator of TNF-induced NF-kappa B activation. J Immunol 164(3):1355-63, 2/2000. PMID: 10640750.

Last updated: 9/19/2012