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Wei Guo, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Instructor, Department of Thoracic and Cardiovascular Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1997 Shanxi Medical University, Taiyuan, China, M. Sc., Cardiovascular Physiology
1994 Shanxi Medical University, Taiyuan, China, MD, Public Health

Postgraduate Training

11/2003-2008 Postdoctoral Fellow, Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX, Bingliang Fang, Ph.D.
4/2003-10/2003 Postdoctoral Fellow, Cancer Biology & Nutrition, Texas A & M University, Houston, TX
1998-2002 Ph.D., Forensic Pathology, Sun Yat-sen University, Guangzhou, China

Selected Publications

Peer-Reviewed Original Research Articles
1. Wu S, Wang L, Guo W, Liu X, Liu J, Wei X, Fang B. Analogues and Derivatives of Oncrasin-1, a Novel Inhibitor of the C-Terminal Domain of RNA Polymerase II and Their Antitumor Activities. J Med Chem. e-Pub 4/6/2011. PMID: 21443218.
2. Wei X, Guo W, Wu S, Wang L, Huang P, Liu J, Fang B. Oxidative stress in NSC-741909-induced apoptosis of cancer cells. J Transl Med 8:37, 2010. PMCID: PMC2873373.
3. Wei X, Guo W, Wu S, Wang L, Lu Y, Xu B, Liu J, Fang B. Inhibiting JNK dephosphorylation and induction of apoptosis by novel anticancer agent NSC-741909 in cancer cells. J Biol Chem 284(25):16948-55, 6/2009. e-Pub 5/2009. PMCID: PMC2719332.
4. Hu W, Hofstetter WL, Wei X, Guo W, Zhou Y, Pataer A, Li H, Fang B, Swisher SG.. Double-stranded RNA-dependent protein kinase-dependent apoptosis induction by a novel small compound. J Pharmacol Exp Ther. 328(3):866-72, 3/2009. PMCID: PMC2658620.
5. Guo W, Wu S, Wang L, Wang RY, Wei X, Liu J, Fang B. Interruption of RNA processing machinery by 1-[(4-chlorophenyl)methyl]-1H-indole-3-carbozaldehyde(Oncorasin-1). Mol Cancer Ther 8(2):441-448, 2/2009. e-Pub 2/2009. PMCID: PMC2653085.
6. Guo W, Wu S, Liu J, Fang B. Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota. Cancer Res 68(18):7403-7408, 9/15/2008. PMCID: PMC2678915.
7. Hu W, Hofstetter W, Guo W, Li H, Pataer A, Peng HH, Guo ZS, Bartlett DL, Lin A, Swisher SG, Fang B. JNK-deficiency enhanced oncolytic vaccinia virus replication and blocked activation of double-stranded RNA-dependent protein kinase. Cancer Gene Ther 15(9):616-624, 9/2008. e-Pub 6/6/2008. PMCID: PMC2553758.
8. Hu W, Davis JJ, Zhu H, Dong F, Guo W, Ang J, Peng H, Guo ZS, Bartlett DL, Swisher SG, Fang B. Redirecting adaptive immunity against foreign antigens to tumors for cancer therapy. Cancer Biol Ther 6(11):1773-1779, 11/2007. PMCID: PMCPMC2387205.

Invited Articles
1. Guo W, Fang B. Potentiation of oncolytic virotherapy with armed shRNA. Cancer Biol Ther 8(1):92-3, 1/2009. e-Pub 1/2009. PMID: 19127117.
2. Guo W, Fang B. Enhancing anti-cancer virotherapy with heat-shock protein-mediated immune response. Cancer Biol Ther 7(2):196-197, 2/2008. e-Pub 2/2008. PMID: 18347427.

Last updated: 1/7/2013