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Wendy A. Woodward, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Service Chief, Breast Cancer Radiation Oncology Program, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Bio Statement

Dr. Woodward is an Associate Professor and the Section Chief of Breast Radiation in the Department of Radiation Oncology at The University of Texas MD Anderson Cancer Center (MDACC). She is a physician-scientist specializing in clinical breast radiation oncology with a lab focused on breast cancer stem cell biology and radiobiology.  She is deputy director of the MDACC Inflammatory Breast Cancer clinic and Research Program and is dedicated to advancing the radiation treatment and biologic understanding of inflammatory breast cancer through laboratory, translational, and clinical research.  Nationally, she serves as the liaison between the breast working group and the translational research program in the Radiation Therapy Oncology Group devoted to designing translational endpoints for multi-institutional trials in breast radiation therapy. Specific interests include studying molecular determinants of treatment resistance in breast cancer stem cells and novel treatment of inflammatory breast cancer. Finally, Dr. Woodward has a strong interest in education and mentoring trainees in both clinical and translational breast cancer research and was a finalist in the Chamberlain Outstanding Mentorship Award at MDACC in 2011.

Education & Training

Degree-Granting Education

2000 Jefferson Medical College, Philadelphia, PA, MD, Medicine
2000 Thomas Jefferson University, Philadelphia, PA, PHD, Biochemistry and Molecular Biology
1993 Mount Holyoke College, S. Hadley, MA, BA, Cum Laude, High Honors, Chemistry

Postgraduate Training

9/2003-9/2004 Research Fellowship, Mammary Gland Biology, Baylor College of Medicine, Houston, TX, Jeff M. Rosen, Ph.D.
7/2001-6/2005 Clinical Residency, Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, Thomas A. Buchholz, M.D
7/2001-8/2000 Internal Medicine, Albert Einstein Medical Center, Philadelphia, PA, Glenn Eiger, M.D.

Board Certifications

6/2006 American Board of Radiology (Radiation Oncology)

Experience/Service

Academic Appointments

Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 7/2005-8/2011

Honors and Awards

2014 Robert M. Chamberlain Distinguished Mentor Award, The University of Texas MD Anderson Cancer Center
2011 Finalist, 2011 Robert M. Chamberlain Distinguished Mentor Award, MD Anderson Postdoctoral Association
2008 RTOG Next Generation Investigator Award, Radiation Therapy Oncology Group
2006 Travel Grant to the Translational Research Symposium, ASTRO
2005 Gilbert H. Fletcher Award, The University of Texas M. D. Anderson Cancer Center, Residency Research Award
2005 Travel Grant to the Gordon Research Conference, ASTRO
2004 Roentgen Research Award, Radiological Society of North America
2003 Merit Award, American Society of Clinical Oncology
2003 Young Oncologist Essay Award, American Radium Society

Selected Publications

Peer-Reviewed Original Research Articles

1. Takiar V, Akay CL, Stauder MC, Tereffe W, Alvarez RH, Hoffman KE, Perkins GH, Strom EA, Buchholz TA, Ueno NT, Babiera G, Woodward WA. Predictors of durable no evidence of disease status in de novo metastatic inflammatory breast cancer patients treated with neoadjuvant chemotherapy and post-mastectomy radiation. Springer Plus. e-Pub 3/2014.
2. Shaitelman SF, Khan AJ, Woodward WA, Arthur DW, Cuttino LW, Bloom ES, Shah C, Freedman GM, Wilkinson JB, Babiera GV, Julian TB, Vicini FA. Shortened radiation therapy schedules for early-stage breast cancer: A review of hypofractionated whole-breast irradiation and accelerated partial breast irradiation. Breast J 20(2):131-46, 3/2014. e-Pub 1/2014. PMID: 24479632.
3. Yang J, Woodward WA, Reed VK, Strom EA, Perkins GH, Tereffe W, Buchhlz TA, Zhang L, Balter P, Court LE, Li XA, Dong L. Statistical modeling approach to quantitative analysis on inter-observer variability in breast contouring. Int J Radiat Oncol Biol Phys. e-Pub 3/2014. PMID: 24613812.
4. Bertucci F, Ueno NT, Finetti P, Vermeulen P, Lucci A, Robertson FM, Marsan M, Iwamoto T, Krishnamurthy S, Masuda H, Van Dam P, Woodward WA, Cristofanilli M, Reuben JM, Dirix L, Viens P, Symmans WF, Birnbaum D, Van Laere SJ. Gene expression profiles of inflammatory breast cancer: correlation with response to neoadjuvant chemotherapy and metastasis-free survival. Ann Oncol 25(2):358-65, 2/2014. e-Pub 12/2013. PMCID: PMC3905779.
5. Masuda H, Brewer TM, Liu DD, Iwamoto T, Shen Y, Hsu L, Willey JS, Gonzalez-Angulo AM, Chavez-MacGregor M, Fouad TM, Woodward WA, Reuben JM, Valero V, Alvarez RH, Hortobagyi GN, Ueno NT. Long-term treatment efficacy in primary inflammatory breast cancer by hormonal receptor- and HER2-defined subtypes. Ann Oncol 25(2):384-91, 2/2014. e-Pub 12/2013. PMCID: PMC3905780.
6. Akay CL, Ueno NT, Chisholm GB, Hortobagyi GN, Woodward WA, Alvarez RH, Bedrosian I, Kuerer HM, Hunt KK, Huo L, Babiera GV. Primary tumor resection as a component of multimodality treatment may improve local control and survival in stage IV inflammatory breast cancer. Cancer. e-Pub 2/2014. PMID: 24510381.
7. Woodward WA, Koay E, Takiar V. Radiation therapy for inflammatory breast cancer: technical considerations and diverse clinical scenarios. Breast Cancer Manage 3(1):43-52, 1/2014.
8. Anfossi S, Giordano A, Gao H, Cohen EN, Tin S, Wu Q, Garza RJ, Debeb BG, Alvarez RH, Valero V, Hortobagyi GN, Calin GA, Ueno NT, Woodward WA, Reuben JM. High serum miR-19a levels are associated with inflammatory breast cancer and are predictive of facorable clinical outcome in patients with metastatic HER2(+) inflammatory breast cancer. PLoS One 9(1):e83113, 2014. e-Pub 1/2014. PMCID: PMC3885405.
9. Gong Y, Wang J, Huo L, Wei W, Ueno NT, Woodward WA. Aldehyde dehydrogenase 1 expression in inflammatory breast cancer as measured by immunohistochemical staining. Clin Breast Cancer. e-Pub 12/2013. PMID: 24461456.
10. Masuda H, Baggerly KA, Wang Y, Iwamoto T, Brewer T, Pusztai L, Kai K, Kogawa T, Finetti P, Birnbaum D, Dirix L, Woodward WA, Reuben JM, Krishnamurthy S, Symmans WF, Van Laere SJ, Bertucci F, Hortobagyi GN, Ueno NT. Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers. Breast Cancer Res 15(6). e-Pub 11/2013. PMID: 24274653.
11. Wang X, Saso H, Iwamoto T, Xia W, Gong Y, Pusztai L, Woodward WA, Reuben JM, Warner SL, Bearss DJ, Hortobagyi GN, Hung MC, Ueno NT. TIG1 promotes the develpment and progression of inflammatory breast cancer through activation of Ax1 Kinase. Cancer Res 73(21):6516-25, 11/2013. e-Pub 9/2013. PMID: 24014597.
12. Giordano A, Gao H, Cohen EN, Anfossi S, Khoury J, Hess K, Krishnamurthy S, Tin S, Cristofanilli M, Hortobagyi GN, Woodward WA, Lucci A, Reuben JM. Clinical relevance of cancer stem cells in bone marrow of early breast cancer patients. Ann Oncol 24(10):2515-21, 10/2013. e-Pub 6/2013. PMCID: PMC3784333.
13. Wang X, Zhang X, Li X, Amos RA, Shaitelman SF, Hoffman K, Howell R, Salehpour M, Zhang SX, Sun TL, Smith B, Tereffe W, Perkins GH, Buchholz TA, Strom EA, Woodward WA. Accelerated partial-breast irradiation using intensity-modulated proton radiotherapy: do uncertainties outweigh potential benefits? Br J Radiol 86(1029):20130176, 9/2013. e-Pub 5/2013. PMCID: PMC3755395.
14. Atkinson RL, Yang WT, Rosen DG, Landis MD, Wong H, Lewis MT, Creighton CJ, Sexton KR, Hilsenbeck SG, Sahin AA, Brewster AM, Woodward WA, Chang JC. Cancer stem cell markers are enriched in normal tissue adjacent to triple negative breast cancer and inversely correlated with DNA repair deficiency. Breast Cancer Res 15(5). e-Pub 9/2013. PMID: 24008095.
15. Van Laere SJ, Ueno NT, Finetti P, Vermeulen P, Lucci A, Robertson FM, Marsan M, Iwamoto T, Krishnamurthy S, Masuda H, van Dam P, Woodward WA, Viens P, Cristofanilli M, Birnbaum D, Dirix L, Reuben JM, Bertucci F. Uncovering the molecular secrets of inflammatory breast cancer biology: An integrated analysis of three distinct affymetrix gene expression data sets. Clin Cancer Res 19(17):4685-4696, 9/2013. e-Pub 2/2013. PMID: 23396049.
16. Kim MM, Allen P, Gonzalez-Angulo AM, Woodward WA, Meric-Bernstam F, Buzdar AU, Hunt KK, Kuerer HM, Litton JK, Hortobagyi GN, Buchholz TA, Mittendorf EA. Pathologic complete response to neoadjuvant chemotherapy with Trastuzumab predicts for improved survival in women with HER2-overexpressing breast cancer. Ann Oncol 24(8):1999-2004, 8/2013. e-Pub 4/2013. PMCID: PMC3718505.
17. Xu W, Lacerda L, Debeb BG, Atkinson RL, Solley T, Li L, Orton D, McMurray JS, Hang BI, Lee E, Klopp A, Ueno NT, Reuben JM, Krishnamurthy S, Woodward WA. The antihelmintic drug pyrvinium pamoate targets aggressive breast cancer. PLoS One 8(e71508), 8, 8/2013. PMID: 24013655.
18. Brewer TM, Masuda H, Liu DD, Shen Y, Liu P, Iwamoto T, Kai K, Barnett CM, Woodward WA, Reuben JM, Yang P, Hortobagyi GN, Ueno NT. Statin use in primary inflammatory breast cancer: a cohort study. Br J Cancer. e-Pub 7/2013. PMID: 23820253.
19. MacDermed DM, Houtman KM, Thang SH, Allen PK, Caudle AS, Gainer SM, Hunt KK, Perkins GH, Shaitelman SF, Smith BD, Strom EA, Tereffe W, Woodward WA, Buchholz TA, Hoffman K. Therapeutic radiation dose delivered to the low axilla during whole breast radiotherapy in the prone posistion: implications for targeting the undissected axilla. Practical Radiation Oncology. e-Pub 6/2013.
20. Tsai CJ, Li J, Gonzalez-Angulo AM, Allen PK, Woodward WA, Ueno NT, Lucci A, Krishnamurthy S, Gong Y, Yang W, Cristofanilli M, Valero V, Buchholz TA. Outcomes after multidisciplinary treatment of inflammatory breast cancer in the era of neoadjuvant HER2-directed therapy. Am J Clin Oncol. e-Pub 5/2013. PMID: 23648437.
21. Woodward WA, Krishnamurthy S, Yamauchi H, El-Zein R, Ogura D, Kitadai E, Niwa S, Cristofanilli M, Vermeulen P, Dirix L, Viens P, van Laere S, Bertucci F, Reuben JM, Ueno NT. Genomic and expression analysis of microdissected inflammatory breast cancer. Breast Cancer Res Treat 138(3):761-72, 4/2013. e-Pub 4/2013. PMCID: PMC3677826.
22. Skinner HD, Strom EA, Motwani SB, Woodward WA, Green MC, Babiera G, Booser DJ, Meric-Bernstam F, Buchholz TA. Radiation dose escalation for loco-regional recurrence of breast cancer after mastectomy. Radiat Oncol 8(1):13, 1/2013. PMID: 23311297.
23. Nowicka A, Marini FC, Solley TN, Elizondo PB, Zhang Y, Sharp HJ, Broaddus R, Kolonin M, Mok SC, Thompson MS, Woodward WA, Lu K, Salimian B, Nagrath D, Klopp AH. Human omental-derived adipose stem cells increase ovarian cancer proliferation, migration, and chemoresistance. PLoS One 8(12):e81859, 2013. e-Pub 12/2013. PMCID: PMC3847080.
24. Debeb BG, Lacerda L, Xu W, Larson R, Solley T, Atkinson R, Sulman EP, Ueno NT, Krishnamurthy S, Reuben JM, Buchholz TA, Woodward WA. Histone deacetylase inhibitors stimulate dedifferentiation of human breast cancer cells through WNT/B-catenin signaling. Stem Cells 30(11):2366-2377, 11/2012. PMID: 22961641.
25. Kim MM, Dawood S, Allen P, Sahin AA, Woodward WA, Smith BD, Strom EA, Hunt KK, Meric-Bernstam F, Gonzalez-Angulo AM, Buchholz TA. Hormone receptor status influences the locoregional benefit of Trastuzumab in patients with non-metastatic breast cancer. Cancer 118(20):4936-43, 10/2012. e-Pub 4/2012. PMID: 22511276.
26. Iyengar P, Strom EA, Zhang YJ, Whitman GJ, Smith BD, Woodward WA, Yu TK, Buchholz TA. The value of ultrasound in detecting extra-axillary regional node involvement in patients with advanced breast cancer. Oncologist 17(11):1402-1408, 9/2012. PMID: 22982581.
27. Walker GV, Niikura N, Yang W, Rohren E, Valero V, Woodward WA, Alvarez RH, Lucci A, Ueno NT, Buchholz TA. Pretreatment staging positron emission tomography/computed tomography in patients with inflammatory breast cancer influences radiation treatment field designs. Int J Radiat Oncol Biol Phys 83(5):1381-6, 8/2012. e-Pub 1/2012. PMID: 22284689.
28. Debeb BG*, Cohen EN*, Boley K, Freiter EM, Li L, Robertson FM, Reuben JM, Cristofanilli M, Buchholz TA, Woodward WA (*co-first authors). Pre-clinical studies of notch signaling inhibitor RO4929097 in inflammatory breast cancer cells. Breast Cancer Res Treat 134(2):495-510, 7/2012. e-Pub 5/2012. PMID: 22547109.
29. Pinnix C, Perkins GH, Strom EA, Tereffe W, Woodward W, Oh JL, Arriaga L, Munsell MF, Kelly P, Hoffman KE, Smith BD, Buchholz TA, Yu TK. Topical hyaluronic acid vs. standard of care for the prevention of radiation dermatitis after adjuvant radiotherapy for breast cancer: single-blind randomized phase III clinical trial. Int J Radiat Oncol Biol Phys 83(4):1089-94, 7/2012. e-Pub 12/2011. PMID: 22172912.
30. Dawood S, Ueno NT, Valero V, Woodward WA, Buchholz TA, Hortobagyi GN, Gonzalez-Angulo AM, Cristofanilli M. Identifying factors that impact survival among women with inflammatory breast cancer. Ann Oncol 23(4):870-5, 4/2012. e-Pub 7/2011. PMID: 21765048.
31. Klopp AH, Zhang Y, Solley T, Amaya-Manzanares F, Marini F, Andreeff M, Debeb B, Woodward WA, Schmandt R, Broaddus R, Lu K, Kolonin MG. Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors. Clin Cancer Res 18(3):771-82, 2/2012. e-Pub 12/2011. PMCID: PMC3481843.
32. Sims-Mourtada J, Yang D, Tworowska I, Larson R, Smith D, Tsao N, Opdenaker L, Mourtada F, Woodward WA. Detection of Canonical Hedgehog Signaling in Breast Cancer by 131 iodine labeled derivatives of the Sonic Hedgehog protein. J Biomed Biotechnol 2012:639562, 2012. e-Pub 6/2012. PMCID: PMC3395403.
33. Amos RA, Woodward WA. Field match verification during combination proton, photon and electron therapy for oligometastatic inflammatory breast cancer. Med Dosim 37(4):442-4, 2012. e-Pub 5/2012. PMID: 22609618.
34. Nagar H, Mittendorf EA, Strom EA, Perkins GH, Oh JL, Tereffe W, Woodward WA, Gonzalez-Angulo AM, Hunt KK, Buchholz TA, Yu TK. Local-regional recurrence with and without radiation therapy after neoadjuvant chemotherapy and mastectomy for clinically-staged T3N0 breast cancer. Int J Radiat Oncol Biol Phys 81(3):782-7, 11/2011. e-Pub 8/2011. PMID: 21885207.
35. Theriault RL, Litton JK, Mittendorf EA, Chen H, Meric-Bernstam F, Chavez-Macgregor M, Morrow PK, Woodward WA, Sahin A, Hortobagyi GN, Gonzalez-Angulo AM. Age and survival estimates in patients who have node-negative T1ab breast cancer by breast cancer subtype. Clin Breast Cancer 11(5):325-331, 10/2011. e-Pub 7/2011. PMID: 21764391.
36. Adkins FC, Gonzalez-Angulo AM, Lei X, Hernandez-Aya LF, Mittendorf EA, Litton JK, Wagner J, Hunt KK, Woodward WA, Meric-Bernstam F. Triple-negative breast cancer is not a contraindication for breast conservation. Ann Surg Oncol 18(11):1364-1373, 10/2011. e-Pub 9/2011. PMID: 21947595.
37. Lang JY, Hsu JL, Meric-Bernstam F, Chang CJ, Wang Q, Bao Y, Yamaguchi H, Xie X, Woodward WA, Yu D, Hortobagyi GN, Hung MC. BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment. Cancer Cell 20(3):341-356, 9/2011. PMCID: PMC3172580.
38. Wang X, Amos RA, Zhang X, Taddei PJ, Woodward WA*, Hoffman KE, Yu TK, Tereffe W, Oh J, Perkins GH, Salehpour M, Zhang SX, Sun TL, Gillin M, Buchholz TA, Strom EA (*corresponding author). External-Beam Accelerated Partial Breast Irradiation Using Multiple Proton Beam Configurations. Int J Radiat Oncol Biol Phys 80(5):1464-72, 8/2011. e-Pub 8/2010. PMCID: PMC3249354.
39. Reddy JP, Levy L, Oh JL, Strom EA, Perkins GH, Buchholz TA, Woodward WA. Long-Term Outcomes in Patients with Isolated Supraclavicular Nodal Recurrence After Mastectomy and Doxorubicin-Based Chemotherapy for Breast Cancer. Int J Radiat Oncol Biol Phys 80(5):1453-7, 8/2011. e-Pub 12/2010. PMID: 21168284.
40. Woodward WA, Gao H*, Cohen E*, Li L, Xu W, Debeb BG, Jimenez CA, Krishnamurthy S, Tucker SL, Hortobagyi GN, Cristofanilli M, Buchholz TA, Reuben JM (*co-second authors). Percentage of CD45-CD326+ CD44+CD24-/lo cells in pleural effusion fluid of patients with metastatic breast cancer predicts for overall survival. Interventional Oncology 1(1):4-10, 8/2011.
41. Albert JM, Buzdar AU, Guzman R, Allen PK, Strom EA, Perkins GH, Woodward WA, Hoffman KE, Tereffe W, Hunt KK, Buchholz TA, Oh JL. Prospective randomized trial of 5-fluorouracil, doxorubicin, and cyclophosphamide (FAC) versus paclitaxel and FAC (TFAC) in patients with operable breast cancer: impact of taxane chemotherapy on locoregional control. Breast Cancer Res Treat 128(2):421-7, 7/2011. e-Pub 5/2011. PMID: 21553292.
42. Dawood S, Ueno NT, Valero V, Woodward WA, Buchholz TA, Hortobagyi GN, Gonzalez-Angulo AM, Cristofanilli M. Differences in survival among women with stage III inflammatory and noninflammatory locally advanced breast cancer appear early: a large population-based study. Cancer 117(9):1819-26, 5/2011. e-Pub 11/2010. PMID: 21509759.
43. Xu W, Debeb BG, Lacerda L, Li J, Woodward WA. Tetrandrine, a compound common in Chinese traditional medicine, preferentially kills breast cancer tumor initiating cells (TICs) in vitro. Cancers 3(2):2274-2285, 5/2011. PMID: 24212809.
44. Fontanilla HP, Woodward WA, Lindberg ME, Zhang L, Sharp HJ, Strom EA, Salehpour M, Buchholz TA, Dong L. Automating RTOG-defined target columes for postmastectomy radiation. Practical Radiation Oncology 1(2). e-Pub 4/2011. PMID: 24673923.
45. Dawood S, Merajver SD, Vients P, Vermeulen PB, Swain SM, Buchholz TA, Dirix LY, Levine PH, Lucci A, Krishnamurthy S, Robertson FM, Woodward WA, Yang WT, Ueno NT, Cristofanilli M. International expert panel on inflammatory breast cancer: consensus statement for standardized diagnosis and treatment. Ann Oncol 22(3):515-523, 3/2011. PMID: 20603440.
46. Chang CJ, Yang JY, Xia W, Chen CT, Xie X, Chao CH, Woodward WA, Hsu JM, Hortobagyi GN, Hung MC. EZH2 Promotes Expansion of Breast Tumor Initiating Cells through Activation of RAF1-ß-Catenin Signaling. Cancer Cell 19(1):86-100, 1/2011. e-Pub 1/2011. PMCID: PMC3041516.
47. Li J, Gonzalez-Angulo AM, Allen PK, Yu TK, Woodward WA, Ueno NT, Lucci A, Krishnamurthy S, Gong Y, Bondy ML, Yang W, Willey JS, Cristofanilli M, Valero V, Buchholz TA. Triple-negative subtype predicts poor overall survival and high locoregional relapse in inflammatory breast cancer. Oncologist 16(12):1675-83, 2011. e-Pub 12/2011. PMCID: PMC3248766.
48. Woodward WA, Truong PT, Yu TK, Tereffe W, Oh J, Perkins G, Strom E, Meric-Bernstam F, Gonzalez-Angulo AM, Speers C, Ragaz J, Buchholz TA. Among women who experience a recurrence after postmastectomy radiation therapy irradiation is not associated with more aggressive local recurrence or reduced survival. Breast Cancer Res Treat 123(2):597-605, 9/2010. e-Pub 3/2010. PMID: 20306128.
49. Walker GV, Smith GL, Perkins GH, Oh JL, Woodward W, Yu TK, Hunt KK, Hoffman K, Strom EA, Buchholz TA. Population-based analysis of occult primary breast cancer with axillary lymph node metastasis. Cancer 116(17):4000-6, 9/2010. e-Pub 6/2010. PMID: 20564117.
50. Albert JM, Gonzalez-Angulo AM, Guray M, Sahin A, Strom EA, Tereffe W, Woodward WA, Tucker SL, Hunt KK, Hortobagyi GN, Buchholz TA. Estrogen/progesterone receptor negativity and HER2 positivity predict locoregional recurrence in patients with T1a,bN0 breast cancer. Int J Radiat Oncol Biol Phys 77(5):1296-1302, 8/2010. e-Pub 5/2010. PMID: 20472353.
51. Robertson FM, Ogasawara MA, Ye Z, Chu K, Pickei R, Debeb BG, Woodward WA, Hittelman WN, Cristofanilli M, Barsky SH. Imaging and analysis of tumor cells within 3 dimensional tumor spheroids that are enriched for a cancer stem cell phenotype. J Biomol Screen 15(7):820-9, 8/2010. e-Pub 7/2010. PMID: 20639504.
52. Zhang YJ, Oh JL, Whitman GJ, Iyengar P, Yu TK, Tereffe W, Woodward WA, Perkins G, Buchholz TA, Strom EA. Clinically Apparent Internal Mammary Nodal Metastasis in Patients with Advanced Breast Cancer: Incidence and Local Control. Int J Radiat Oncol Biol Phys 77(4):1113-9, 7/2010. e-Pub 12/2009. PMID: 20004535.
53. Dawood S, Gonzalez-Angulo AM, Albarracin C, Yu TK, Hortobagyi GN, Buchholz TA, Woodward WA. Prognostic factors of survival in the trastuzumab era among women with breast cancer and brain metastases who receive whole brain radiotherapy: a single-institution review. Cancer 116(13):3084-92, 7/2010. PMID: 20564633.
54. Greenbaum MP, Strom EA, Allen PK, Perkins GH, Oh JL, Tereffe W, Yu TK, Buchholz TA, Woodward WA. Low locoregional recurrence rates in patients treated after 2000 with doxorubicin based chemotherapy, modified radical mastectomy, and post-mastectomy radiation. Radiother Oncol 95(3):312-6, 6/2010. e-Pub 3/2010. PMID: 20227126.
55. Robertson FM, Woodward WA, Pickei R, Ye Z, Bornmann W, Pal A, Peng Z, Hall CS, Cristofanilli M. Suberoylanilide hydroxamic acid blocks self-renewal and homotypic aggregation of inflammatory breast cancer spheroids. Cancer 116(11 Suppl):2760-7, 6/2010. PMID: 20503408.
56. Debeb BG, Xu W, Mok H, Li L, Robertson F, Ueno NT, Reuben J, Lucci A, Cristofanilli M, Woodward WA. Differential radiosensitizing effect of valproic acid in differentiation versus self renewal promoting culture conditions. Int J Radiat Oncol Biol Phys 76(3):889-895, 3/2010. PMID: 20159363.
57. Smith GL, Shih YC, Xu Y, Giordano SH, Smith BD, Perkins GH, Tereffe W, Woodward WA, Buchholz TA. Racial disparities in the use of radiotherapy after breast-conserving surgery: A national Medicare study. Cancer 116(3):734-41, 2/2010. e-Pub 1/2010. PMID: 20014181.
58. Debeb BG, Zhang X, Krishnamurthy S, Gao H, Cohen E, Li L, Rodriguez AA, Landis MD, Lucci A, Ueno NT, Robertson F, Xu W, Lacerda L, Buchholz TA, Cristofanilli M, Reuben JM, Lewis MT, Woodward WA. Characterizing cancer cells with cancer stem cell-like features in 293T human embryonic kidney cells. Mol Cancer 9(1):180, 2010. e-Pub 7/2010. PMCID: PMC2915978.
59. Klopp AH*, Lacerda L*, Gupta A, Debeb BG, Solley T, Li L, Spaeth E, Xu W, Zhang X, Lewis MT, Reuben JM, Krishnamurthy S, Ferrari M, Gaspar R, Buchholz TA, Cristofanilli M, Marini F, Andreeff M, Woodward WA (*co-first authors). Mesenchymal stem cells promote mammosphere formation and decrease E-cadherin in normal and malignant breast cells. PLoS One 5(8), 2010. PMCID: PMC2922340.
60. Liedtke C, Broglio K, Moulder S, Hsu L, Kau SW, Symmans WF, Albarracin C, Meric-Bernstam F, Woodward W, Theriault RL, Kiesel L, Hortobagyi GN, Pusztai L, Gonzalez-Angulo AM. Prognostic impact of discordance between triple-receptor measurements in primary and recurrent breast cancer. Ann Oncol 20(12):1953-8, 12/2009. e-Pub 7/2009. PMCID: PMC2791352.
61. Gilcrease MZ, Zhou X, Lu X, Woodward WA, Hall BE, Morrissey PJ. Alpha6beta4 integrin crosslinking induces EGFR clustering and promotes EGF-mediated Rho activation in breast cancer. Journal of Experimental and Clinical Cancer Research 28(67), 5/2009. PMCID: PMC2694164.
62. Gilcrease MZ, Woodward WA, Nicolas MM, Corley LJ, Fuller GN, Esteva FJ, Tucker SL, Buchholz TA. Even Low-level HER2 Expression May be Associated With Worse Outcome in Node-positive Breast Cancer. Am J Surg Pathol 33(5):759-67, 5/2009. e-Pub 2/2009. PMID: 19252432.
63. Reed VK, Woodward WA, Zhang L, Strom EA, Perkins GH, Tereffe W, Oh JL, Yu TK, Bedrosian I, Whitman GJ, Buchholz TA, Dong L. Automatic Segmentation of Whole Breast Using Atlas Approach and Deformable Image Registration. Int J Radiat Oncol Biol Phys 73(5):1493-500, 4/2009. e-Pub 9/2008. PMCID: PMC2729433.
64. Beadle BM, Woodward WA, Tucker SL, Outlaw ED, Allen PK, Oh JL, Strom EA, Perkins GH, Tereffe W, Yu TK, Meric-Bernstam F, Litton JK, Buchholz TA. Ten-Year Recurrence Rates in Young Women With Breast Cancer by Locoregional Treatment Approach. Int J Radiat Oncol Biol Phys 73(3):734-44, 3/2009. e-Pub 8/2008. PMID: 18707822.
65. Vinh-Hung V, Truong PT, Janni W, Nguyen NP, Vlastos G, Cserni G, Royce ME, Woodward WA, Promish D, Tai P, Soete G, Balmer-Majno S, Cutuli B, Storme G, Bouchardy C. The effect of adjuvant radiotherapy on mortality differs according to primary tumor location in women with node-positive breast cancer. Strahlenther Onkol 185(3):161-168, 3/2009. e-Pub 3/2009. PMID: 19330292.
66. Beadle BM, Woodward WA, Middleton LP, Tereffe W, Strom EA, Litton JK, Meric-Bernstam F, Theriault RL, Buchholz TA, Perkins GH. The impact of pregnancy on breast cancer outcomes in women </=35 years. Cancer 115(6):1174-84, 3/2009. PMID: 19204903.
67. Li XA, Tai A, Arthur DW, Buchholz TA, MacDonald S, Marks LB, Moran JM, Pierce LJ, Rabinovitch R, Taghian A, Vicini F, Woodward W, White JR. Variability of target and normal structure delineation for breast-cancer radiotherapy: a RTOG multi-institutional and multi-observer study. Int J Radiat Oncol Biol Phys 73(3):944-951, 3/2009. PMCID: PMC2911777.
68. Gilcrease MZ, Kilpatrick SK, Woodward WA, Zhou X, Nicolas MM, Corley LJ, Fuller GN, Tucker SL, Diaz LK, Buchholz TA, Frost JA. Coexpression of alpha6beta4 integrin and guanine nucleotide exchange factor Net1 identifies node-positive breast cancer patients at high risk for distant metastasis. Caner Epidemiol Biomarkers 18(1):80-86, 1/2009. PMCID: PMC2669542.
69. Debeb BG, Galat V, Epple-Farmer J, Iannaccone S, Woodward WA, Bader M, Iannaccone P, Binas B. Isolation of Oct4-expressing extraembryonic endoderm precursor cell lines. PLoS One 4(9):e7216, 2009. PMCID: PMC2747266.
70. Smith GL, Smith BD, Buchholz TA, Giordano SH, Garden AS, Woodward WA, Krumholz HM, Weber RS, Ang KK, Rosenthal DI. Cerebrovascular disease risk in older head and neck cancer patients after radiotherapy. J Clin Oncol 26(31):5119-25, 8/2008. e-Pub 8/2008. PMID: 18725647.
71. Garg AK, Frija EK, Sun TL, Strom EA, Perkins GH, Oh JL, Yu TK, Woodward WA, Tereffe WA, Salehpour M, Buchholz TA. Effects of Variable Placement of Superior Tangential/Supraclavicular Match Line on Dosimetric Coverage of Level III Axilla/Axillary Apex in Patients Treated with Breast and Supraclavicular Radiotherapy. Int J Radiat Oncol Biol Phys 73(2):370-4, 8/2008. PMID: 18676090.
72. Truong PT, Vinh-Hung V, Cserni G, Woodward WA, Tai P, Vlastos G, Vlastos G. The number of positive nodes and the ratio of positive to excised nodes are significant predictors of survival in women with micrometastatic node-positive breast cancer. Eur J Cancer 44(12):1670-1677, 8/2008. PMID: 18595686.
73. Buchholz TA, Woodward WA, Duan Z, Fang S, Oh JL, Tereffe W, Strom EA, Perkins GH, Yu TK, Hunt KK, Meric-Bernstam F, Hortobagyi GN, Giordano SH. Radiation use and long-term survival in breast cancer patients with T1, T2 primary tumors and 1-3 positive axillary lymph nodes. Int J Radiat Oncol Biol Phys 71(4):1022-7, 7/2008. e-Pub 1/2008. PMID: 18234447.
74. Bristol IJ, Woodward WA, Strom EA, Cristofanilli M, Domain D, Singletary SE, Perkins GH, Oh JL, Yu TK, Terrefe W, Sahin AA, Hunt KK, Hortobagyi GN, Buchholz TA. Locoregional Treatment Outcomes After Multimodality Management Of Inflammatory Breast Cancer. Int J Radiat Oncol Biol Phys 72(2):474-84, 4/2008. e-Pub 4/2008. PMID: 18439768.
75. Smith GL, Smith BD, Giordano SH, Shih YT, Woodward WA, Strom EA, Perkins GH, Tereffe W, Yu TK, Buchholz TA. Risk of hypothyroidism in older breast cancer patients treated with radiation. Cancer 112(6):1371-1379, 3/2008. PMID: 18213620.
76. Woodward WA, Durand JB, Tucker SL, Strom EA, Perkins GH, Oh JL, Arriaga L, Domain D, Buchholz TA. Prospective analysis of carotid flow in breast cancer patients treated with supraclavicular irradiation eight or more years prior to study: No increase in ipsilateral carotid stenosis after radiation. Cancer 112(2):268-273, 12/2007. PMID: 18000801.
77. Reed VK, Cavalcanti JL, Strom EA, Perkins GH, Oh JL, Tereffe W, Yu TK, Yeung H, Whitman GJ, Bedrosian I, Macapinlac HA, Buchholz TA, Woodward WA. Risk of subclinical micrometastatic disease in the supraclavicular nodal bed based on the anatomical distribution in patients with advanced breast cancer. Int J Radiat Oncol Biol Phys 71(2):435-40, 12/2007. PMID: 18164831.
78. Liengsawangwong R, Yu TK, Sun TL, Erasmus J, Perkins GH, Tereffe W, Oh JL, Woodward WA, Strom EA, Salehpour M, Buchholz TA. Treatment optimization using computed tomography-delineated targets should be used for supraclavicular irradiation for breast cancer. Int J Radiat Oncol Biol Phys 69(3):711-715, 12/2007. PMID: 17889264.
79. Klopp AH, Spaeth EL, Dembinski JL, Woodward WA, Munshi A, Meyn RE, Cox JD, Andreeff M, Marini FC. Tumor irradiation increases recruitment of circulating MSC into tumor microenvironment. Cancer Research 67(24):11687-11697, 12/2007. PMID: 18089798.
80. Oh JL, Nguyen G, Whitman GH, Hunt KK, Yu TK, Woodward WA, Tereffe W, Strom EA, Perkins GH, Buchholz TA. Placement of radiopaque clips for tumor localization in patients undergoing neoadjuvant chemotherapy and breast conservation therapy. Cancer 110(11). e-Pub 10/2007. PMID: 17941034.
81. Garg AK, Oh JL, Oswald MJ, Huang E, Strom EA, Perkins GH, Woodward WA, Yu TK, Tereffe W, Meric-Bernstam F, Hahn K, Buchholz TA. Effect of postmastectomy radiotherapy in patients <35 years old with stage II-III breast cancer treated with doxorubicin-based neoadjuvant chemotherapy and mastectomy. Int J Radiat Oncol Biol Phys 69(5):1478-1483, 9/2007. PMID: 17855016.
82. McGuire SE, Gonzales-Angulo AM, Tucker SL, Kau SW, Yu TK, Strom EA, Oh J, Woodward WA, Tereffe W, Hunt KK, Kuerer HM, Sahin A, Hortobagyi GH, Buchholz TA. Post-mastectomy radiation improves the outcome of patients with stage III breast cancer who achieve a pathologic complete response to neoadjuvant chemotherapy. Int J Radiat Oncol Biol Phys 68(4):1004-1009, 7/2007. PMID: 17418973.
83. Sher T, Henessy BT, Valero V, Brogio K, Woodward WA, Trent J, Hunt KK, Hortobagyi GN, Gonzales-Angulo AM. Primary angiosarcomas of the breast. Cancer 110(1):173-178, 7/2007. PMID: 17541936.
84. Truong PT, Woodward WA, Thames HD, Ragaz J, Olivotto TA, Buchholz TA. The ratio of positive to excised nodes identifies high-risk subsets and reduces inter-institutional differences in locoregional recurrence risk estimates in breast cancer patients with 1-3 positive nodes: An analysis of prospective data from British Columbia and the M. D. Anderson Cancer Center. Int J Radiat Oncol Biol Phys 68(1):59-65, 5/2007. PMID: 17321065.
85. Huang EH, Strom EA, Valero V, Fornage B, Perkins GH, Oh JL, Yu TK, Tereffe W, Woodward WA, Hunt KK, Meric-Bernstam F, Sahin AA, Bedorsian I, Hortobagyi GN, Buchholz TA. Local-regional treatment outcomes for breast cancer patients with ipsilateral supraclaficular metastases at diagnosis. Int J Rad Oncol Biol Phys 67(2):490-496, 2/2007. PMID: 17236970.
86. Chen MS*, Woodward WA*, Behbod F, Peddibhotla S, Alfaro M, Buchholz TA, Rosen JM (*co-first authors). Wnt/B-catenin mediates radiation resistance of Sca1+ progenitors in immortalized mammary gland cell line. J Cell Science 120(3):468-477, 2007. PMID: 17227796.
87. Woodward WA*, Chen MS*, Behbod F, Alfaro MP, Buchholz TA, Rosen JM (*co-first authors). WTN/B-catenin mediates radiation resistance of mouse mammary progenitor cells. PNAS 104(2):618-623, 2007. PMID: 17202265.
88. Woodward WA, Huang EH, McNeese MD, Perkins GH, Tucker SL, Strom EA, Middleton L, Gwyn K, Hortogabyi GN, Buchholz TA. African-American race is associated with a poorer overall survival rate for breast cancer patients treated with mastectomy and doxorubicin-based chemotherapy. Cancer 107(11):2662-2668, 12/2006. PMID: 17021247.
89. Oh JL, Dryden MJ, Woodward WA, Yu TK, Tereffe W, Strom EA, Perkins GH, Middleton L, Hunt KK, Giordano SH, Oswald MJ, Domain D, Buchholz TA. Local-regional control of clinically diagnosed multifocal or multicentric breast cancer after neoadjuvant chemotherapy and local-regional therapy. J Clin Oncol 24(31):4971-4975, 11/2006. PMID: 17075114.
90. Buchholz TA, Strom EA, Oswald MJ, Perkins GH, Oh J, Domain D, Yu Tk, Woodward WA, Tereffe W, Singletary SE, Thomas E, Buzdar AU, Hortogabyi GN, McNeese MD. Fifteen-year results of a randomized prospective trial of hyperfractionated chest wall irradiation versus once-daily chest wall irridation after chemotherapy and mastectomy for patients with locally advanced noninflammatory breast cancer. Int J Radiat Oncol Biol Phys 65(4):1155-1160, 7/2006. PMID: 16750325.
91. Woodward WA, Giordano SH, Duan Z, Hortobagyi GN, Buchholz TA. Supraclavicular radiation for breast cancer does not increase the 10-year risk of stroke. Cancer 106(12):2556-2562, 6/2006. PMID: 16691617.

Invited Articles

1. Yamauchi H, Woodward WA, Valero V, Alvarez RH, Lucci A, Buchholz TA, Iwamoto T, Krishnamurthy S, Yang W, Reuben JM, Hortobágyi GN, Ueno NT. Inflammatory breast cancer: what we know and what we need to learn. Oncologist 17(7):891-9, 2012. e-Pub 5/2012. PMCID: PMC3399643.

Abstracts

1. Singh B, Cook KR, vincent L, Hall C, Martin C, Krishnamurthy S, Woodward W, Cristofanilli M, Lucci A. Role of COX-2 in bone marrow micrometastasis and cancer initiating cell phenotype in breast cancer. Proceedings of The First International Inflammatory Breast Cancer Conference, 12/2008.

Last updated: 4/4/2014