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William Bornmann, Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Director, Translational Chemistry Core Facility, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Adjunct Professor of Bioengineering, Rice University, Houston, TX

Education & Training

Degree-Granting Education

1988 University of Vermont, Burlington, VT, PHD, Organic Chemistry
1977 Montana State University, Bozeman, MT, MS, Synthetic Organic Chemistry
1975 University of Wisconsin, River Falls, WI, BS, Chemistry and Biology

Selected Publications

Peer-Reviewed Original Research Articles
1. Faderl S, Bueso-Ramos C, Liu Z, Pal A, Bornmann W, Ciurea DV, Harris D, Hazan-Halevy I, Kantarjian HM, Estrov Z. Kit inhibitor APcK110 extends survival in an AML xenograft mouse model. Invest New Drugs 29(5), 10/2011. e-Pub 6/2010. PMID: 20517635.
2. Ying Y, Ghosh P, Guo L, Pal A, Mukhapadhyay U, Peng Z, Yeh HH, Bertolini S, Flores LG, Young D, Volgin A, Soghomonyan S, Bornmann W, Logsdon C, Alauddin MM, Gelovani JG. Synthesis and Ex Vivo Autoradiographic Evaluation of Ethyl-beta-D: -galactopyranosyl-(1,4')-2'-deoxy-2'-[(18)F]fluoro-beta-D: -glucopyranoside-A Novel Radioligand for Lactose-Binding Protein: Implications for Early Detection of Pancreatic Carcinomas with PET. Mol Imaging Biol 13(3), 6/2011. e-Pub 7/2010. PMID: 20593279.
3. Chen MY, Liao WS, Lu Z, Bornmann WG, Hennessey V, Washington MN, Rosner GL, Yu Y, Ahmed AA, Bast RC. Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy. Cancer. e-Pub 3/2011. PMID: 21491416.
4. Dai B, Meng J, Peyton M, Girard L, Bornmann WG, Ji L, Minna JD, Fang B, Roth JA. STAT3 mediates resistance to MEK inhibitor through microRNA miR-17. Cancer Res. e-Pub 3/2011. PMID: 21444672.
5. Sun H, Kapuria V, Peterson LF, Fang D, Bornmann WG, Bartholomeusz G, Talpaz M, Donato NJ. Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis. Blood. e-Pub 1/2011. PMID: 21248063.
6. Li LS, Bey EA, Dong Y, Meng J, Patra B, Yan J, Xie XJ, Brekken RA, Barnett CC, Bornmann WG, Gao J, Boothman DA. Modulating Endogenous NQO1 Levels Identifies Key Regulatory Mechanisms of Action of {beta}-Lapachone for Pancreatic Cancer Therapy. Clin Cancer Res 17(2):275-85, 1/2011. e-Pub 1/2011. PMID: 21224367.
7. Pham LV, Tamayo AT, Li C, Bornmann W, Priebe W, Ford RJ. Degrasyn potentiates the antitumor effects of bortezomib in mantle cell lymphoma cells in vitro and in vivo: therapeutic implications. Mol Cancer Ther 9(7):2026-36, 7/2010. e-Pub 7/2010. PMID: 20606045.
8. Robertson FM, Woodward WA, Pickei R, Ye Z, Bornmann W, Pal A, Peng Z, Hall CS, Cristofanilli M. Suberoylanilide hydroxamic acid blocks self-renewal and homotypic aggregation of inflammatory breast cancer spheroids. Cancer 116(11 Suppl):2760-7, 6/2010. PMID: 20503408.
9. Swimm AI, Bornmann W, Jiang M, Imperiale MJ, Lukacher AE, Kalman D. Abl-family Tyrosine Kinases Regulate Sialylated Ganglioside Receptors for Polyomavirus. J Virol 84(9), 5/2010. e-Pub 2/2010. PMCID: PMC2863717.
10. Blanco E, Bey EA, Khemtong C, Yang SG, Setti-Guthi J, Chen H, Kessinger CW, Carnevale KA, Bornmann WG, Boothman DA, Gao J. Beta-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy. Cancer Res 70(10):3896-904, 5/2010. e-Pub 5/2010. PMCID: PMC2873165.
11. Wu J, Meng F, Ying Y, Peng Z, Daniels L, Bornmann WG, Quintás-Cardama A, Roulston D, Talpaz M, Peterson LF, Donato NJ. ON012380, a putative BCR-ABL kinase inhibitor with a unique mechanism of action in imatinib-resistant cells. Leukemia 24(4):869-72, 4/2010. e-Pub 1/2010. PMID: 20111070.
12. Samudio I, Harmancey R, Fiegl M, Kantarjian H, Konopleva M, Korchin B, Kaluarachchi K, Bornmann W, Duvvuri S, Taegtmeyer H, Andreeff M. Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction. J Clin Invest 120(1):142-56, 1/2010. e-Pub 12/2009. PMCID: PMC2799198.
13. McNulty S, Bornmann W, Schriewer J, Werner C, Smith SK, Olson VA, Damon IK, Buller RM, Heuser J, Kalman D. Multiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesis. PLoS One 5(5):e10884, 2010. PMCID: PMC2878334.
14. Flores LG, Bertolini S, Yeh HH, Young D, Mukhopadhyay U, Pal A, Ying Y, Volgin A, Shavrin A, Soghomonyan S, Tong W, Bornmann W, Alauddin MM, Logsdon C, Gelovani JG. Detection of pancreatic carcinomas by imaging lactose-binding protein expression in peritumoral pancreas using [18F]fluoroethyl-deoxylactose PET/CT. PLoS One 4(11):e7977, 2009. PMCID: PMC776527.

Grant & Contract Support

Title: Cancer Center Support Grant
Funding Source: NIH/NCI
Role: Shared Resource Director
Principal Investigator: John Mendelsohn
Duration: 7/1/2008 - 6/30/2011

Last updated: 2/26/2013