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Xiangwei Wu, Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Head and Neck Surgery, Division of Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Associate Professor, Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Research Interests

1.  Function of tumor suppressor p53.

2.  Mechanisms of apoptosis and application in cancer treatment and prevention.

3.  Novel pathways in stress reponse.

Office Address

The University of Texas M. D. Anderson Cancer Center
1515 Holcombe Blvd.
Unit Number: 123
Houston, TX 77030
Room Number: T5.3900
Phone: (713) 745-2867
Fax: (713) 745-2234

Education & Training

Degree-Granting Education

1991 Baylor College of Medicine, Houston, TX, PHD, Biochemistry
1985 Shanghai Institute of Organic Chemistry, Shanghai, China, MS, Graduate Student, Organic Chemistry
1984 Peking University, Beijing, China, BS, Chemistry

Postgraduate Training

1992-1995 Research Residency, Department of Molecular Biology, Princeton University, Princeton, NJ

Experience/Service

Other Appointments/Responsibilities

Director of Basic Science Research, Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2006-present

Professional Memberships

American Association for Cancer Research
Member, 2009-present

Selected Publications

Peer-Reviewed Original Research Articles
1. Ren X, Xu Z, Myers JN, Wu X. Bypass NFkappaB-Mediated Survival Pathways by TRAIL and Smac. Cancer Biol Ther 6(7)(7), 2007. e-Pub 3/29/2007. PMID: 17611406.
2. Deng, Y, Ren, X, Lin, Y., Yang, L., and Wu, X. A JNK-dependent pathway is required for TNFa-induced apoptosis. Cell 115:61-70, 2004.
3. Wu, X. and Deng, Y. Bax and BH3-Domain- Only Proteins in in p53-Apoptosis. Frontiers in Bioscience 7:151-156, 2002.
4. Deng Y., Lin, Y., and Wu, X. Trail Induced Apoptosis Requires Bax-Dependent Mitochondrial Release of Smac/DIABLO. Genes & Develop 16:33-45, 2002.
5. Deng, Y. and Wu. X. Peg3/Pw1 Promotes p53-Mediated Apoptosis by Inducing Bax Translocation from Cytosol to Mitochondria. Proc Natl Acad Sci USA 97(22):12050-12055, Oct. 24, 2000. PMCID: PMC11050235.

Grant & Contract Support

Title: Regulation of TNFa Response
Funding Source: NIH
Role: Principal Investigator-MDACC
Duration: 2004 - 2009

Last updated: 9/22/2009