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Xiangwei Wu, Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Clinical Cancer Prevention - Research, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Associate Professor, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

1.  Function of tumor suppressor p53.

2.  Mechanisms of apoptosis and application in cancer treatment and prevention.

3.  Novel pathways in stress reponse.

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd.
Unit Number: 1013
Houston, TX 77030
Room Number: S7.8336A
Phone: (713) 745-2867
Fax: (713) 745-4230

Education & Training

Degree-Granting Education

1991 Baylor College of Medicine, Houston, TX, PHD, Biochemistry
1985 Shanghai Institute of Organic Chemistry, Shanghai, China, MS, Graduate Student, Organic Chemistry
1984 Peking University, Beijing, China, BS, Chemistry

Postgraduate Training

1992-1995 Postdoctoral Fellowship, Department of Molecular Biology, Princeton University, Princeton, NJ

Experience/Service

Academic Appointments

Associate Professor, Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 3/2006-8/2011

Administrative Appointments/Responsibilities

Director of Basic Science Research, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2006-2011

Professional Memberships

American Association for Cancer Research
Member, 2009-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Wang H, Davis JS,Wu, X. Immunoglobulin Fc Domain Fusion to TRAIL Significantly Prolongs Its Plasma Half-Life and Enhances Its Antitumor Activity. Mol Cancer Ther 13(3):643-50, 3/2014. e-Pub 1/2014. PMID: 24431076.
2. Xu E, Gu J, Hawk ET, Wang KK, Lai M, Huang M, Ajani J,Wu, X. Genome-wide methylation analysis shows similar patterns in Barrett's esophagus and esophageal adenocarcinoma. Carcinogenesis 34(12):2750-6, 12/2013. e-Pub 8/2013. PMCID: PMC3845893.
3. Ren X, Xu Z, Myers JN, Wu, X. Bypass NFkappaB-Mediated Survival Pathways by TRAIL and Smac. Cancer Biol Ther 6(7):1031-5, 2007. PMID: 17611406.
4. Yang L, Deng YB, Wu, X. [Bcl-xl blocks tumor necrosis factor alpha-induced caspase 8 activation and apoptosis]. Zhonghua Gan Zang Bing Za Zhi. 13(4):286-9, 2005, 2005. PMCID: PMC15850519.
5. Deng, Y, Ren, X, Lin, Y., Yang, L., and Wu, X. A JNK-dependent pathway is required for TNFa-induced apoptosis. Cell 115:61-70, 2004. PMID: 14532003.
6. Deng Y., Lin, Y., and Wu, X. Trail Induced Apoptosis Requires Bax-Dependent Mitochondrial Release of Smac/DIABLO. Genes & Develop 16:33-45, 2002.
7. Deng, Y. and Wu, X. Peg3/Pw1 Promotes p53-Mediated Apoptosis by Inducing Bax Translocation from Cytosol to Mitochondria. Proc Natl Acad Sci USA 97(22):12050-12055, Oct. 24, 2000. PMCID: PMC11050235.

Invited Articles

1. Wu X, Patterson S, Hawk E. Chemoprevention - History and General Principles. Best Pract Res Clin Gastroenterol 25(4-5):445-59, 8/2011. PMID: 22122762.
2. Wu, X. and Bax, Y. Bax and BH3-Domain-Only Proteins in p53-mediated apoptosis. Frontiers in Bioscience 7:151-156, 2002.

Editorials

1. Wu X, Lippman SM. An intermittent approach for cancer chemoprevention. Nat Rev Cancer 11(12):879-85, 2011. e-Pub 11/2011. PMID: 22071977.

Abstracts

1. Zhang, L. Ren, X., Wen, XF., Wu, X. Chemoprevention of Colorectal Cancer by Targeting APC-Deficient Cells to Apoptosis. Frontiers in Cancer Prevention Research, 2008.

Grant & Contract Support

Title: Multi-modal Universal Cancel Cell-Specific Therapy
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 9/1/2013 - 8/31/2018
 
Title: Targeting Kras in prescursor lesions for pancreatic cancer chemoprevention
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 7/1/2013 - 6/30/2018
 
Title: Chemoprevention of Colon Cancer by Targeting APC-deficient Cells for Apoptosis
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Principal Investigator
Duration: 12/1/2011 - 11/30/2014
 
Title: Cell Theranostics with Tunable Plasmonic Nanobubbles
Funding Source: NIH
Role: Principal Investigator
Duration: 9/1/2011 - 8/31/2014
 
Title: Chemoprevention of pancreatic cancer by induction of synthetic lethality in mutant K-ras cells
Funding Source: Duncan Family Institute
Role: Principal Investigator
Duration: 9/1/2011 - 8/31/2013
 
Title: A Therapeutic Approach for Lung Cancer Chemoprevention
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Principal Investigator
Duration: 12/1/2010 - 11/20/2013
 
Title: Chemoprevention of Colon Cancer by Targeting APC-Deficient Cells for Apoptosis
Funding Source: MDACC
Role: Principal Investigator
Duration: 8/1/2010 - 7/31/2011
 
Title: Regulation of TNFa Response
Funding Source: NIH/NIAID
Role: Principal Investigator-MDACC
Duration: 12/15/2004 - 11/30/2010
 
Title: Mechanisms of p53-mediated apoptosis and carcinogenesis (competitively renewed once)
Funding Source: NCI
Role: Principal Investigator
Duration: 4/1/1997 - 3/31/2008

Last updated: 9/9/2014