Xiangwei Wu, Ph.D.
Department of Clinical Cancer Prevention, Division of Cancer Prevention and Population Sciences
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Clinical Cancer Prevention - Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
1. Function of tumor suppressor p53.
2. Mechanisms of apoptosis and application in cancer treatment and prevention.
3. Novel pathways in stress reponse.
Education & Training
Degree-Granting Education
| 1991 | Baylor College of Medicine, Houston, TX, USA, PHD, Biochemistry |
| 1985 | Shanghai Institute of Organic Chemistry, Shanghai, CHN, MS, Graduate Student, Organic Chemistry |
| 1984 | Peking University, Beijing, CHN, BS, Chemistry |
Postgraduate Training
| 1992-1995 | Postdoctoral Fellowship, Department of Molecular Biology, Princeton University, Princeton, NJ |
Experience & Service
Academic Appointments
Associate Professor, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2007 - 2011
Associate Professor, Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2006 - 2011
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Wang H, Davis JS, Wu X. Immunoglobulin Fc Domain Fusion to TRAIL Significantly Prolongs Its Plasma Half-Life and Enhances Its Antitumor Activity. Mol Cancer Ther 13(3):643-50, 2014. e-Pub 2014. PMID: 24431076.
- Xu E, Gu J, Hawk ET, Wang KK, Lai M, Huang M, Ajani J,Wu X. Genome-wide methylation analysis shows similar patterns in Barrett's esophagus and esophageal adenocarcinoma. Carcinogenesis 34(12):2750-6, 2013. e-Pub 2013. PMID: 23996928.
- Zhang L, Ren X, Alt E, Bai X, Huang S, Xu Z, Lynch PM, Moyer MP, Wen XF, Wu X. Chemoprevention of Colorectal Cancer by Targeting APC-Deficient Cells for Apoptosis. Nature 464(7291):1058-61, 2010. e-Pub 2010. PMID: 20348907.
- Ren X, Xu Z, Myers JN, Wu X. Bypass NFkappaB-Mediated Survival Pathways by TRAIL and Smac. Cancer Biol Ther 6(7):1031-5, 2007. e-Pub 2007. PMID: 17611406.
- Yang L, Deng YB, Wu X. [Bcl-xl blocks tumor necrosis factor alpha-induced caspase 8 activation and apoptosis]. Zhonghua Gan Zang Bing Za Zhi 13(4):286-9, 2005.
- Deng Y, Ren X, Yang L, Lin Y, Wu X. A JNK-dependent pathway is required for TNFa-induced apoptosis. Cell 115(1):61-70, 2003. PMID: 14532003.
- Deng Y, Lin Y, Wu X. Trail Induced Apoptosis Requires Bax-Dependent Mitochondrial Release of Smac/DIABLO. Genes Dev 16(1):33-45, 2002. PMID: 11782443.
- Deng Y, Wu X. Peg3/Pw1 Promotes p53-Mediated Apoptosis by Inducing Bax Translocation from Cytosol to Mitochondria. Proc Natl Acad Sci U S A 97(22):12050-12055, 2000. PMID: 11050235.
Invited Articles
- Wu X, Patterson S, Hawk E. Chemoprevention - History and General Principles. Best Pract Res Clin Gastroenterol 25(4-5):445-59, 2011. PMID: 22122762.
- Wu X, Deng Y. Bax and BH3-Domain-Only Proteins in p53-mediated apoptosis. Front Biosci 7:151-156, 2002. e-Pub 2002. PMID: 11779719.
Editorials
- Wu X, Lippman SM. An intermittent approach for cancer chemoprevention. Nat Rev Cancer 11(12):879-85, 2011. PMID: 22071977.
Grant & Contract Support
| Title: | Chemoprevention of Colon Cancer by Targeting APC-Deficient Cells for Apoptosis |
| Funding Source: | MDACC |
| Role: | Principal Investigator |
| Title: | Therapeutic Prevention for Colon Cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Early tumor dissemination as biomarker for colon cancer early detection |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator |
| Title: | Project 2, p53 - regulators and effectors |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Regulation of TNFa Response |
| Funding Source: | NIH/NIAID |
| Role: | Principal Investigator |
| Title: | A Therapeutic Approach for Lung Cancer Chemoprevention |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator |
| Title: | Chemoprevention of pancreatic cancer by induction of synthetic lethality in mutant K-ras cells |
| Funding Source: | Duncan Family Institute |
| Role: | Principal Investigator |
| Title: | Cell Theranostics with Tunable Plasmonic Nonobubbles |
| Funding Source: | NIH, PI-Lapotko |
| Role: | Co-Principal Investigator |
| Title: | Chemoprevention of Colon Cancer by Targeting APC-deficient Cells for Apoptosis |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator |
| Title: | Mechanisms of p53-mediated apoptois and carcinogenesis |
| Funding Source: | NCI |
| Role: | Principal Investigator |
| Title: | MDM2 inhibitor for pancreatic cancer chemoprevention |
| Funding Source: | DFI |
| Role: | Principal Investigator |
| Title: | Activating p53 for colorectal cancer prevention |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Targeting Kras in precursor lesions for pancreatic Cancer Prevention |
| Funding Source: | Institutional Research Grant (IRG) |
| Role: | Principal Investigator |
| Title: | MDM2 inhibitor in colorectal cancer chemoprevention |
| Funding Source: | CRC Moon Shot |
| Role: | Principal Investigator |
| Title: | Chemoprevention of pancreatic cancer by targeting mutant K-ras cells |
| Funding Source: | MDACC Bridge Fund |
| Role: | Principal Investigator |
Patient Reviews
CV information above last modified August 26, 2024