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Xin-Qiao Zhang, MD, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Dept. of Genitourinary Medical Oncology, Division of Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd
Unit Number: 0018-5
Houston, TX 77030
Room Number: T7.3871

Education & Training

Degree-Granting Education

1996 Institute of Virology, Chinese Academy of Preventive Medicine, Beijing, PHD, Immunology (Virology Branch)
1987 Guiyang Medical College, Guiyang, MS, Medical Microbiology
1982 Shanxi Medical College, Taiyuan, MD, Preventive Medicine

Postgraduate Training

1/1999-2/2003 Post-Doctoral Fellow, The University of Texas MD Anderson Cancer Center, Houston, TX, Dr. William Benedict
9/1997-1/1999 Post-Doctoral Fellow, The University of Texas MD Anderson Cancer Center, Houston, TX, Dr. Hong-Ji Xu
4/1996-9/1997 Post-Doctoral Fellow, Institute of Virology Chinese Academy of Preventive Medicine, Beijing, China

Experience/Service

Academic Appointments

Instructor, Dept. of Genitourinary Medical Oncology, Division of Medicine, U.T. M. D. Anderson Cancer Center, Houston, TX, 1/2003-8/2006
Assistant Professor, Dept. of Virology, Center for Health & Diseases Control of Shanxi Province, Taiyuan, China, China, 1/1987-1/1992
Junior Scientist, Dept. of Virology, Center for Health & Diseases Control of Shanxi Province, Taiyuan, China, China, 1/1982-1/1984

Honors and Awards

1994 Outstanding Ph. D student, Chinese Academy of Preventive Medicine
1992 Second Prize of Shanxi Province Medical New Technology Award
1987 Third Prize of Science and Technology Achievement, Guizhou Province Government

Selected Publications

Peer-Reviewed Original Research Articles

1. Benedict WF, Fisher M, Zhang XQ, Yang Z, Munsell MF, Dinney CN. Use of monitoring levels of soluble forms of cytokeratin 18 in the urine of patients with superficial bladder cancer following intravesical Ad-IFNα/Syn3 treatment in a phase l study. Cancer Gene Ther. e-Pub 2/2014. PMID: 24503570.
2. Akli S, Zhang XQ, Bondaruk J, Tucker SL, Czerniak PB, Benedict WF, Keyomarsi K. Low molecular weight cyclin E is associated with p27-resistant, high-grade, high-stage and invasive bladder cancer. Cell Cycle 11(7):1468-1476, 4/2012. e-Pub 4/2012. PMCID: PMC3350882.
3. Yang Z, Zhang XQ, Dinney CN, Benedict WF. Direct cytotoxicity produced by adenoviral-mediated interferon a infection in interferon resistant cancer cells Involves ER stress and caspase 4 activation. Cancer Gene Therapy. Cancer Gene Ther 18(9):609-616, 9/2011. e-Pub 6/2011. PMID: 21681220.
4. Zhang XQ, Yang Z, Benedict WF. Direct gene transfer of adenoviral-mediated interferon α into human bladder cancer cells but not the bystander factors produced induces endoplasmic reticulum stress-related cytotoxicity. Cancer Gene Ther 18(4):260-264, 4/2011. e-Pub 12/24/2010. PMID: 21183949.
5. Zhang XQ, Dunner K, Benedict WF. Autophagy is induced by adenoviral-mediated interferon alpha treatment in interferon resistant bladder cancer and normal urothelial cells as a cell death protective mechanism but not by the bystander factors produced. Cancer Gene Ther 17(8):579-584, 8/2010. e-Pub 5/21/2010. PMCID: PMC2906639.
6. Fisher MB, Zhang XQ, McConkey DJ, Benedict WF. Measuring soluble forms of extracellular cytokeratin 18 identifies both apoptotic and necrotic mechanisms of cell death produced by adenoviral-mediated interferon alpha: possible use as a surrogate marker. Cancer Gene Therapy 16(7). e-Pub 2/2009. PMCID: PMC2906639.
7. Zhou J, Zhang XQ, Ashoori F, McConkey DJ, Knowles MA, Dong L, Benedict WF. Early RB94-produced cytotoxicity in cancer cells is independent of caspase activation or 50 kb DNA fragmentation. Cancer Gene Ther 16(1):13-19, 01/2009, 1/2009. PMID: 18654611.
8. Zhang X, Dong L, Chapman E, Benedict WF. Conditioned medium from ad-IFN-alpha-infected bladder cancer and normal urothelial cells is cytotoxic to cancer cells but not normal cells: further evidence for a strong bystander effect. Cancer Gene Ther, 7/2008. PMID: 18617914.
9. Nakamizo A, Amano T, Zhang W, Zhang XQ, Ramdas L, Liu TJ, Bekele BN, Shono T, Sasaki T, Benedict WF, Sawaya R, Lang FF. Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53-induced apoptosis. Neuro Oncol 10(3):275-91, 6/2008. PMID: 18443131.
10. Pirollo KF, Rait A, Zhou Q, Zhang XQ, Zhou J, Kim CS, Benedict WF, Chang EH. Tumor-targeting nanocomplex delivery of novel tumor suppressor RB94 chemosensitizes bladder carcinoma cells in vitro and in vivo. Clin Cancer Res 14(7):2190-8, 4/2008. PMID: 18381961.
11. Sterman DH, Recio A, Carroll RG, Gillespie CT, Haas A, Vachani A, Kapoor V, Sun J, Hodinka R, Brown JL, Corbley MJ, Parr M, Ho M, Pastan I, Machuzak M, Benedict W, Zhang XQ, Lord EM, Litzky LA, Heitjan DF, June CH, Kaiser LR, Vonderheide RH, Albelda SM, Kanther M. A phase I clinical trial of single-dose intrapleural IFN-beta gene transfer for malignant pleural mesothelioma and metastatic pleural effusions: high rate of antitumor immune responses. Clin Cancer Res 13(15 Pt 1):4456-66, 8/2007. PMID: 17671130.
12. Zhang X, Yang Z, Dong L, Papageorgiou A, McConkey DJ, Benedict WF. Adenoviral-mediated interferon alpha overcomes resistance to the interferon protein in various cancer types and has marked bystander effects. Cancer Gene Ther 14(3):241-50, 3/2007. PMID: 17096027.
13. Benedict WF, Tao Z, Kim CS , Zhang X, Zhou JH, Adam L, McConkey DJ, Papageorgiou A, Munsell M, Philopena J, Engler H, Demers W, Maneval DC, Dinney CPN, Connor RJ. Intravesical Ad-IFN Overcomes Tumor Cell Resistance to IFNa Protein and Causes Tumor Regression in an Orthotopic Mouse Model. J Mol Ther 10:525-535, 7/2004.
14. Zhang X, Multani A, Zhou JH , Shay JW , McConkey D , Dong L, Kim CS, Rosser CJ , Pathak S, Benedict WF. Adenoviral-mediated retinoblastoma 94 produces Rapid telomere erosion, chromosomal crisis, and caspase-dependent apoptosis in bladder cancer and immortalized human urothelial cells but not in normal urothelial cells. Cancer Research 63:760-765, 7/2003.
15. Yamashita M, Rosser CJ , Zhou JH, Zhang X, Connor RJ , Engler H, Maneval DC, Karashima T, Czerniak BA, Dinney CPN , Benedict WF. Syn3 provides high levels of intravesical adenoviral-mediated gene transfer for gene therapy of genetically altered urothelium and superficial bladder cancer. Cancer Gene Ther 9:687-691, 7/2002.
16. Zhang Huifeng , Li Qiuying, Zhang Xin-qiao , Yao Rulin. Influence of Foreign wild-type P53 gene on proliferation of fibroblasts under the effect of alveolar macrophage exposed to dust. Chinese Journal of Public Health 18(3):143-145, 7/1999.
17. Zhang H, Li Q, Zhang XQ, Yao R. Influence of foreign wild-type P53 gene on proliferation of fibroblasts under the effect of alveolar macrophage exposed to dust. Chinese Journal of Public Health 18:143-5, 1999.
18. Zhang H, Li Q, Zhang X. An approach to pneumoconiosis with liposome mediated transfection gene transfer technique. China Public Health 13(1):37-38, 7/1997.
19. Zhang X. Construction of Adenovirus Type four vector and expression of foreign genes. Chinese Academy of Preventive Medicine, 1996.
20. Wang J, Wang J, Zhang X, Zhang X, Yang X. Research on the connection between chronic hepatitis, hepatic cirrhosis, hepatoma and infection of HBV, HCV. Modern Preventive Medicine 21(1):14-17, 7/1994.
21. Wang J, Wang J, Zhang X, Zhang X, Yang X. Research on the connection between chronic hepatitis, hepatic cirrhosis, hepatoma and infection of HBV, HCV. Modern Preventive Medicine 21(1):14-17, 7/1994.
22. Zhang X, Tianlin L. Quality control of diagnosis of HBV infection. The J. of Shanxi Preventive Medicine 4:14-18, 7/1993.
23. Zhang , Huang J. Investigation for the early diagnosis of children adenovirus pneumonia by detection of the antibodies to human adenovirus early antigens. J of Guiyang Medical College 15(3):199-204, 7/1990.
24. Dexiu S, Zhang X. Seroepidemiological Study on the infection of HBV in Mine Area of Shanxi Province. The J of Shanxi Preventive Medicine 4:5-20, 7/1990.
25. Lu T, Zhang X. Seroepidemological study of HAV in Shanxi Province. The J. of Shanxi Preventive Medicine 3:8-11, 7/1990.
26. Jiangzhu H, Jiuje T, Zhang X. Identification of the sac brood bee virus in Guiyang. J of Guiyang Medical College 12(4):341-343, 7/1987.

Last updated: 4/8/2014