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Xin Lin, Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Molecular and Cellular Oncology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Graduate School of Biomedical Sciences, The University of Texas, Houston, TX
Professor, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX
Director, Cancer Biology Program, Graduate School of Biomedical Sciences, The University of Texas, Houston, TX
Co-director, Center for Inflammation and Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

My research activities are focusing on revealing signaling pathways that activate NF-kB family of transcription factors. NF-kB is a family of transcription factors that play critical roles in inflammatory, anti-apoptotic, and immune responses. Revealing of various signaling pathways that lead to activation of NF-kB will provide molecular insight for developing therapeutic agents to treat cancer, autoimmune diseases, and inflammation. The major research in my lab is to determine the molecular mechanism by which NF-kB is activated by epidermal growth factor receptor (EGFR) family members. We have recently discovered a new signaling pathway, in which CARMA3 and Bcl10, two caspase-recruitment domanin (CARD)-containing adaptor/scaffold proteins, mediate EGFR-induced NF-kB activation and contribute to tumor progression and metastasis. We are currently investigating the mechanism by which CARMA3 is linked to EGFR signaling and its contribution to the malignancy of various cancers. The second research area in my lab is to determine the molecular mechanisms by which NF-kB is activated by antigen receptors. Antigen receptors play a critical role in the regulation of immune responses. Dysregulation of antigen receptor pathways results in leukemia, autoimmune, and immunodeficiency. Therefore, we are also studying the role of antigen receptor-induced NF-kB and other transcription factors in lymphocyte malignancy. The third research area in my lab is to determine the mechanism by which C-type lectin receptors activate NF-kB and other signaling and the role of C-type lectin receptors in innate immune responses.

 

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd.
Unit Number: Unit 108
Houston, TX 77030
Room Number: Y7.6024
Phone: (713) 792-8969
Fax: (713) 794-3270
Email: xllin@mdanderson.org

Education & Training

Degree-Granting Education

1995 The University of Texas Health Science Center, Houston, TX, PHD, Biochemistry and Molecular Biology
1988 Chinese Academy of Sciences, Beijing, China, MS, Molecular and Cellular Biology
1982 Shanghai University of Science and Technology, Shanghai, Shanghai, China, BS, Macromolecular Chemistry

Postgraduate Training

10/1995-8/2000 Postdoctoral Fellow, Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA, Dr. Warner C. Greene

Experience/Service

Academic Appointments

Associate Professor, Graduate School of Biomedical Sciences, The University of Texas, Houston, TX, 11/2004-8/2009
Associate Professor, Department of Molecular and Cellular Oncology, Division of Basic Science Research, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 9/2004-8/2009
Assistant Professor, Departments of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY, 9/2000-9/2004

Honors and Awards

2010-present United Resources Endowed Professorship, UT MD Anderson Cancer Center
2008-2011 Faculty Scholar Award, UT M. D. Anderson Cancer Center
2007 Faculty Educator of the Month, UT M. D. Anderson Cancer Center
2004-2009 Scholar Award, The Leukemia and Lymphoma Society
2004-2008 Investigator Award, Cancer Research Institute
2003 Young Investigator Award, Exceptional Scholar Program, SUNY at Buffalo

Selected Publications

Peer-Reviewed Original Research Articles

1. Gorjestani S, Darnay BG, Lin X. Tumor necrosis factor receptor-associated factor 6 (TRAF6) and TGFβ-activated kinase 1 (TAK1) play essential roles in the C-type lectin receptor signaling in response to Candida albicans infection. J Biol Chem 287(53):44143-50, 12/2012. e-Pub 11/2012. PMCID: PMC3531730.
2. Blonska M, Joo D, Zweidler-McKay PA, Zhao Q, Lin X. CARMA1 controls Th2 cell-specific cytokine expression through regulating JunB and GATA3 transcription factors. J Immunol 188(7):3160-8, 4/2012. e-Pub 2/2012. PMCID: PMC3311756.
3. Gorjestani S, Yu M, Tang B, Zhang D, Wang D, Lin X. Phospholipase Cγ2 (PLCγ2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses. J Biol Chem 286(51):43651-9, 12/2011. e-Pub 10/2011. PMCID: PMC3243564.
4. Jiang T, Grabiner B, Zhu Y, Jiang C, Li H, You Y, Lang J, Hung MC, Lin X. CARMA3 is crucial for EGFR-Induced activation of NF-kB and tumor progression. Cancer Res 71(6):2183-92, 3/2011. PMCID: PMC3059846.
5. Bi L, Gojestani S, Wu W, Hsu YM, Zhu J, Ariizumi K, Lin X. CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans. J Biol Chem 285(34):25969-77, 8/2010. e-Pub 6/2010. PMCID: PMC2923990.
6. Wu W, Hsu YM, Bi L, Songyang Z, Lin X. CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex. Nat Immunol 10(11):1208-14, 11/2009. e-Pub 9/20/2009. PMID: 19767757.
7. Sun J, Lin X. Beta-arrestin 2 is required for lysophosphatidic acid-induced NF-kappaB activation. Proc Natl Acad Sci U S A 105(44). e-Pub 10/2008. PMCID: PMC2579382.
8. Tanner MJ, Hanel W, Gaffen SL, Lin X. CARMA1 coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1 and is required for T cell receptor-induced NF-kappaB activation. J Biol Chem 282(23):17141-7, 6/2007. PMID: 17428801.
9. Shambharkar PB, Blonska M, Pappu BP, Li H, You Y, Sakurai H, Darnay BG, Hara H, Penninger J, Lin X. Phosphorylation and ubiquitination of IKK complex by two distinct signaling pathways. EMBO J 26(7):1794-805, 4/4/2007. e-Pub 3/15/2007. PMCID: PMC1847656.
10. Grabiner BC, Blonska M, Lin PC, You Y, Wang D, Sun J, Darnay BG, Dong C, Lin X. CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-{kappa}B activation. Genes Dev 21(8):984-96, 4/2007. PMID: 17438001.
11. Hsu YM, Zhang Y, You Y, Wang D, Li H, Duramad O, Qin XF, Dong C, Lin X. The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol 8(2):198-205, 2/2007. PMID: 17187069.
12. Wang D, You Y, Lin PC, Xue L, Morris SW, Zeng H, Wen R, Lin X. Bcl10 plays a critical role in NF-kappaB activation induced by G protein-coupled receptors. Proc Natl Acad Sci U S A 104:145-50, 1/2007. PMID: 17179215.
13. Blonska M, Pappu BP, Matsumoto R, Li H, Su B, Wang D, Lin X. The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway. Immunity 26(1):55-66, 1/2007. PMID: 17189706.
14. Pappu BP, Lin X. Potential role of CARMA1 in CD40-induced splenic B cell proliferation and marginal zone B cell maturation. Eur J Immunol 36:3033-43, 11/2006. PMID: 17048267.
15. Li H, Kobayashi M, Blonska M, You Y, Lin X. Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation. J Biol Chem 281:13636-13643, 5/2006. PMID: 16543241.
16. Matsumoto R, Wang D, Blonska M, Li H, Kobayashi M, Pappu B, Chen Y, Wang D, Lin X. Phosphorylation of CARMA1 plays a critical role in T cell receptor-induced NF-kB activation. Immunity 23(6):1-11, 12/2005. PMID: 16356856.
17. Blonska M, Shambharkar PB, Kobayashi M, Zhang D, Sakurai H, Su B, Lin X. TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation. J. Biol. Chem. 280(52):43056-43063, 2005. PMID: 16260783.
18. Blonska M, You Y, Geleziunas R, Lin X. Restoration of NF-kappaB activation by tumor necrosis factor alpha receptor complex-targeted MEKK3 in receptor-interacting protein-deficient cells. Mol Cell Biol 24(24):10757-65, 12/2004. PMID: 15572679.
19. Che T, You Y, Wang D, Tanner MJ, Dixit VM, Lin X. MALT1/paracaspase is a signaling component downstream of CARMA1 and mediates T cell receptor-induced NF-kappaB activation. J Biol Chem 279(16):15870-6, 4/2004. PMID: 14754896.
20. Wang D, Matsumoto R, You Y, Che T, Lin XY, Gaffen SL, Lin X. CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1. Mol Cell Biol 24(1):164-71, 2004. PMID: 14673152.
21. Wang D, You Y, Case SM, McAllister-Lucas LM, Wang L, DiStefano PS, Nunez G, Bertin J, Lin X. A requirement for CARMA1 in TCR-induced NF-kappa B activation. Nat Immunol 3(9):830-5, 9/2002. PMID: 12154356.

Invited Articles

1. Blonska M, Lin X. NF-kB signaling pathways regulated by CARMA family of scaffold proteins. Cell Res 21(1):55-70, 1/2011. e-Pub 12/2010. PMID: 21187856.
2. Blonska, M, and Lin, X. CARMA1-mediated NF-kB and JNK activation in lymphocytes. Immunological Reviews 228(1):199-211, 2009. PMID: 19290929.
3. Li H and Lin X.. Positive and Negative Signaling Components involved in TNFa-induced NF-kB activation. Cytokine 4(1):1-8, 2008. PMID: 18068998.
4. Lin X, Wang D. The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling. Seminars in Immunology 16(6):429-35, 2004. PMID: 15541657.

Last updated: 3/11/2013