Xiongbin Lu, PhD
Present Title & Affiliation
Genomic DNA of human cells is under the constant attack of chemicals, free radicals, and UV or ionizing radiation from environmental exposure, by-products of intracellular metabolism, or medical therapy. In response to diverse genotoxic stresses, cells activate DNA damage checkpoint pathways to protect genomic integrity and promote survival of the organism. DNA damage response are a cascade of phosphorylation events initiated by the activation of phosphoinositide 3-kinase (PI3K)-related protein kinases including ATM, ATR and DNA-PK. A vast network of over 700 ATM/ATR targets have been identified and shown to play pivotal roles in the complex cellular response to DNA damage.
In my labortory, we are interested to identify and investigate regulators that modulate the activity of the DNA damage response. Current areas of emphasis include:
(1) Regulation of the ATM-p53 signaling pathway.
(2) Therapeutic intervention of p53 deficiency in human cancers.
(3) Regulation of miRNA and other non-coding RNAs in the DNA damage response.
A combined approach of proteomics, genomics and mouse cancer models will be used in our studies.
7777 Knight Road
Unit Number: 173
Houston, TX 77054
Room Number: Smith Research Building, SRB1.705
Education & Training
|1998||Shanghai Institute of Biochemistry, Chinese Academy of Sciences, Shanghai, China, PHD, Biochemistry|
|1993||Zhejiang University, Hangzhou, Zhejiang, China, BS, Biological Sciences|
|2000-2003||Postdoctoral Fellow, Cancer Biology, Baylor College of Medicine, Houston, TX, Lawrence Donehower|
|1998-2000||Postdoctoral Fellow, Retrovirology, National Institutes of Health, Bethesda, MD, Jonathan Silver|
|American Association for Cancer Research |
|American Association for the Advancement of Science |
|Society of Chinese Bioscientists in America |
Life member, 2010-present
Peer-Reviewed Original Research Articles
|1.||Rao W, Wang H, Han J, Zhao S, Dumbleton J, Agarwal P, Zhang W, Zhao G, Yu J, Zynger DL, Lu X, He X. Chitosan-Decorated Doxorubicin-Encapsulated Nanoparticle Targets and Eliminates Tumor Reinitiating Cancer Stem-like Cells. ACS Nano 9(6):5725-40, 6/23/2015. e-Pub 5/29/2015. PMID: 26004286.|
|2.||Liu Y, Zhang X, Han C, Wan G, Huang X, Ivan C, Jiang D, Rodriguez-Aguayo C, Lopez-Berestein G, Rao PH, Maru DM, Pahl A, He X, Sood AK, Ellis LM, Anderl J, Lu X. TP53 loss creates therapeutic vulnerability in colorectal cancer. Nature 520(7549):697-701, 4/30/2015. e-Pub 4/22/2015. PMCID: PMC4417759.|
|3.||Han C, Liu Y, Wan G, Choi HJ, Zhao L, Ivan C, He X, Sood AK, Zhang X, Lu X. The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression. Cell Rep 8(5):1447-60, 9/2014. e-Pub 8/2014. PMCID: PMC4163106.|
|4.||Wan G, Hu X, Liu Y, Han C, Sood AK, Calin GA, Zhang X, Lu X. A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation. EMBO J 32(21):2833-47, 10/2013. e-Pub 10/2013. PMCID: PMC3817469.|
|5.||Wan G, Zhang X, Langley RR, Liu Y, Hu X, Han C, Peng G, Ellis LM, Jones SN, Lu X. DNA-Damage-Induced Nuclear Export of Precursor MicroRNAs Is Regulated by the ATM-AKT Pathway. Cell Rep 3(6):2100-12, 6/2013. e-Pub 6/2013. PMID: 23791529.|
|6.||Wan G, Mathur R, Hu X, Zhang X, Lu X. miRNA response to DNA damage. Trends Biochem Sci 36(9):478-84, 9/2011. e-Pub 7/2011. PMID: 21741842.|
|7.||Zhang X, Berger FG, Yang J, Lu X. USP4 Inhibits p53 through Deubiquitinating and Stabilizing ARF-BP1. EMBO J 30(11):2177-89, 6/1/2011. e-Pub 4/26/2011. PMID: 21522127.|
|8.||Zhang X, Wan G, Berger FG, He X, Lu X. The ATM kinase induces microRNA biogenesis in the DNA damage response. Mol Cell 41(4):371-383, 2/18/2011. PMID: 21329876.|
|9.||Zhang W, Gilstrap K, Wu L, K C RB, Moss MA, Wang Q, Lu X, He X. Synthesis and characterization of thermally responsive Pluronic F127-chitosan nanocapsules for controlled release and intracellular delivery of small molecules. ACS Nano 4(11):6747-59, 11/23/2010. e-Pub 11/1/2010. PMID: 21038924.|
|10.||Zhang X, Wan G, Mlotshwa S, Vance V, Berger FG, Chen H, Lu X. Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway. Cancer Res 70(18):7176-86, 9/2010. e-Pub 7/2010. PMCID: PMC2940956.|
|11.||Zhang X, Lin L, Guo H, Yang J, Jones SN, Jochemsen A, Lu X. Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response. Cancer Res 69(20):7960-8, 10/15/2009. e-Pub 10/6/2009. PMCID: PMC2763051.|
|12.||Lu X, Ma O, Nguyen TA, Jones SN, Oren M, Donehower LA. The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell 12(4):342-54, 10/2007. PMID: 17936559.|
|13.||Lu X, Nannenga B, Donehower LA. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev 19(10):1162-74, 5/2005. e-Pub 5/2005. PMCID: PMC1132003.|
|14.||Lu X, Bocangel D, Nannenga B, Yamaguchi H, Appella E, Donehower LA. The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair. Mol Cell 15(4):621-34, 8/2004. PMID: 15327777.|
|15.||Lu X, Xiong Y, Silver J. Asymmetric requirement for cholesterol in receptor-bearing but not envelope-bearing membranes for fusion mediated by ecotropic murine leukemia virus. J Virol 76(13):6701-9, 7/2002. PMCID: PMC136268.|
|16.||Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, Lu X, Soron G, Cooper B, Brayton C, Hee Park S, Thompson T, Karsenty G, Bradley A, Donehower LA. p53 mutant mice that display early ageing-associated phenotypes. Nature 415(6867):45-53, 1/2002. PMID: 11780111.|
|17.||Lu X, Silver J. Ecotropic murine leukemia virus receptor is physically associated with caveolin and membrane rafts. Virology 276(2):251-258, 10/2000. PMID: 11040117.|
Last updated: 4/22/2015