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Xiongbin Lu, PhD

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Member of the Graduate Faculty, The University of Texas Graduate School of Biomedical Sciences, Houston, TX

Research Interests

Genomic DNA of human cells is under the constant attack of chemicals, free radicals, and UV or ionizing radiation from environmental exposure, by-products of intracellular metabolism, or medical therapy. In response to diverse genotoxic stresses, cells activate DNA damage checkpoint pathways to protect genomic integrity and promote survival of the organism. DNA damage response are a cascade of phosphorylation events initiated by the activation of phosphoinositide 3-kinase (PI3K)-related protein kinases including ATM, ATR and DNA-PK. A vast network of over 700 ATM/ATR targets have been identified and shown to play pivotal roles in the complex cellular response to DNA damage.

In my labortory, we are interested to identify and investigate regulators that modulate the activity of the DNA damage response. Current areas of emphasis include:

(1) Regulation of the ATM-p53 signaling pathway.

(2) Therapeutic intervention of p53 deficiency in human cancers.

(3) Regulation of miRNA and other non-coding RNAs in the DNA damage response.

A combined approach of proteomics, genomics and mouse cancer models will be used in our studies.

Office Address

The University of Texas MD Anderson Cancer Center
7777 Knight Road
Unit Number: 173
Houston, TX 77054
Room Number: Smith Research Building, SRB1.705
Phone: 713-745-6247
Email: XLu2@mdanderson.org

Education & Training

Degree-Granting Education

1998 Shanghai Institute of Biochemistry, Chinese Academy of Sciences, Shanghai, China, PHD, Biochemistry
1993 Zhejiang University, Hangzhou, Zhejiang, China, BS, Biological Sciences

Postgraduate Training

2000-2003 Postdoctoral Fellow, Cancer Biology, Baylor College of Medicine, Houston, TX, Lawrence Donehower
1998-2000 Postdoctoral Fellow, Retrovirology, National Institutes of Health, Bethesda, MD, Jonathan Silver

Experience/Service

Academic Appointments

Assistant Professor, Department of Cancer Biology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 12/2010-8/2012
Assistant Professor, University of South Carolina, Columbia, SC, 8/2007-11/2010
Research Assistant Professor, Baylor College of Medicine, Houston, TX, 2003-2007

Institutional Committee Activities

Member, American Cancer Society RNA Mechanisms Study Section, 2014
Review Editor, In Frontiers in Pharmacotherapy of Inflammation, 2010-present
Member, Society of Chinese Bioscientists in America, 2010-present
Editorial Board, In American Journal of Cancer Research, 2010-present
Member, The Metastasis Research Center, MD Anderson Cancer Center, 2010-present
Member, Graduate School of Biomedical Sciences, University of Texas, 2010-present
Invited reviewer, The James & Esther King Biomedical Research Program and the Bankhead-Coley Cancer Research Program, Florida Department of Health, 2010-2011
Member, In the review panel for DOD Breast Cancer Idea Award, 2010
Ad Hoc reviewer, NIH RC1 grant, 2009
Member, American Association for Cancer Research, 2008-present
Member and Target PI, South Carolina Colon Cancer Center, Columbia, South Carolina, 2007-2010
Invited reviewer, A*STAR Biomedical Research Council in Singapore, 2007
Member, American Association for the Advancement of Science, 2005-present
Member, Dan L. Duncan Cancer Center, Houston, Texas, 2003-2007

Honors and Awards

2014 Dr. Guohui Wan’s NIH K99/R00 Award
2012 Supervisor for the Odyssey Fellowship Award
2011 Zhang et al. Mol Cell paper was commented in Mol Cell and highly recommended by the Faculty of 1000
2010-2012 Stars Plus Award, University of Texas System
2009-2010 Target PI, Center for Colon Cancer Research at the University of South Carolina
2008 Lu et al. Genes & Dev. paper was profiled in Nature Reviews Cancer and recommended by the Faculty of 1000
2008 Research Award, American Federation for Aging Research
2007 Lu et al. Cancer Cell paper was profiled in Nature Reviews Cancer
2000 Lu et al. paper selected as cover story in Virology
1997 Amersham Research Award, Amersham Life Science
1996 Di Ao Research Award, Chinese Academy of Sciences
1996 Director's Award, Shanghai Institute of Biochemistry
1991 Zhejiang University Scholarship

Professional Memberships

American Association for Cancer Research
Member, 2007-present
American Association for the Advancement of Science
Member, 2006-present
Society of Chinese Bioscientists in America
Life member, 2010-present

Selected Publications

Peer-Reviewed Original Research Articles

1. 1. Liu Y, Zhang X, Han C, Wan G, Huang X, Ivan C, Jiang D, Rodriguez-Aguayo C, Lopez-Berestein G, Rao PH, Maru DM, Pahl A, He X, Sood AK, Ellis LM, Anderl J, Lu X. TP53 loss creates therapeutic vulnerability in colorectal cancer. Nature. In Press.
2. Han C, Liu Y, Wan G, Choi HJ, Zhao L, Ivan C, He X, Sood AK, Zhang X, Lu X. The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression. Cell Rep 8(5):1447-60, 9/2014. e-Pub 8/2014. PMCID: PMC4163106.
3. Wan G, Hu X, Liu Y, Han C, Sood AK, Calin GA, Zhang X, Lu X. A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation. EMBO J 32(21):2833-47, 10/2013. e-Pub 10/2013. PMCID: PMC3817469.
4. Wan G, Zhang X, Langley RR, Liu Y, Hu X, Han C, Peng G, Ellis LM, Jones SN, Lu X. DNA-Damage-Induced Nuclear Export of Precursor MicroRNAs Is Regulated by the ATM-AKT Pathway. Cell Rep 3(6):2100-12, 6/2013. e-Pub 6/2013. PMID: 23791529.
5. Wan G, Mathur R, Hu X, Zhang X, Lu X. miRNA response to DNA damage. Trends Biochem Sci 36(9):478-84, 9/2011. e-Pub 7/2011. PMID: 21741842.
6. Zhang X, Berger FG, Yang J, Lu X. USP4 Inhibits p53 through Deubiquitinating and Stabilizing ARF-BP1. EMBO J 30(11):2177-89, 6/1/2011. e-Pub 4/26/2011. PMID: 21522127.
7. Zhang X, Wan G, Berger FG, He X, Lu X. The ATM kinase induces microRNA biogenesis in the DNA damage response. Mol Cell 41(4):371-383, 2/18/2011. PMID: 21329876.
8. Zhang W, Gilstrap K, Wu L, K C RB, Moss MA, Wang Q, Lu X, He X. Synthesis and characterization of thermally responsive Pluronic F127-chitosan nanocapsules for controlled release and intracellular delivery of small molecules. ACS Nano 4(11):6747-59, 11/23/2010. e-Pub 11/1/2010. PMID: 21038924.
9. Zhang X, Wan G, Mlotshwa S, Vance V, Berger FG, Chen H, Lu X. Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway. Cancer Res 70(18):7176-86, 9/2010. e-Pub 7/2010. PMCID: PMC2940956.
10. Zhang X, Lin L, Guo H, Yang J, Jones SN, Jochemsen A, Lu X. Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response. Cancer Res 69(20):7960-8, 10/15/2009. e-Pub 10/6/2009. PMCID: PMC2763051.
11. Lu X, Ma O, Nguyen TA, Jones SN, Oren M, Donehower LA. The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell 12(4):342-54, 10/2007. PMID: 17936559.
12. Lu X, Nannenga B, Donehower LA. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev 19(10):1162-74, 5/2005. e-Pub 5/2005. PMCID: PMC1132003.
13. Lu X, Bocangel D, Nannenga B, Yamaguchi H, Appella E, Donehower LA. The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair. Mol Cell 15(4):621-34, 8/2004. PMID: 15327777.
14. Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, Lu X, Soron G, Cooper B, Brayton C, Hee Park S, Thompson T, Karsenty G, Bradley A, Donehower LA. p53 mutant mice that display early ageing-associated phenotypes. Nature 415(6867):45-53, 1/2002. PMID: 11780111.
15. Lu X, Silver J. Ecotropic murine leukemia virus receptor is physically associated with caveolin and membrane rafts. Virology 276(2):251-258, 10/2000. PMID: 11040117.

Last updated: 4/16/2015