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Yan Xia, Ph.D.

Present Title & Affiliation

Primary Appointment

Instructor, Department of Neuro-Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2000 Umeň University, Umeň, Sweden, PHD, Medical Microbiology
1991 Nanjing University, Nanjing, China, MBA, Molecular Biology
1988 Nanjing University, Nanjing, China, BS, Biochemistry

Postgraduate Training

4/2004-9/2007 Research Fellowship, Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, Zhimin Lu, Ph.D.
2001-2004 Research Fellowship, Molecular and Cellular Biology, The Salk Institute for Biological Studies, La Jolla, CA, Tony Hunter, Ph.D.

Experience/Service

Academic Appointments

Post Doctoral Fellow, Department of Neuro-Oncology - Research, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 4/2004-9/2007
Research Associate, Umeň University, Umea, Sweden, 1994-2000
Teaching Assistant, Umeň University, Umea, Sweden, 1994-1999
Lecturer, Department of Biochemistry, Nanjing University, Nanjing, China, 1991-1993

Honors and Awards

2007 Nycomed GmbH Outstanding Research Publication Award, The University of Texas M. D. Anderson Cancer Center
2007 The A. Lavoy Moore Endowed Fund Award, The University of Texas M. D. Anderson Cancer Center
2002-2004 California Breast Cancer Research Program Postdoctoral Fellowship, The Salk Institute for Biological Studies
1996-2000 Ph.D. Fellowship "Doktorandtjanst", Umeň University, Sweden

Selected Publications

Peer-Reviewed Original Research Articles

1. Chen H, Xia Y, Fang D, Hawke D, Lu Z. Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis. Mol Cell Biol 29(13). e-Pub 4/2009. PMCID: PMC2698753.
2. Zheng Y, Xia Y, Hawke D, Halle M, Tremblay M, Gao X, Xie K, He J, and Lu Z.. FAK phosphorylation by ERK primes Ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol Cell 35(1):11-25, 2009. PMCID: PMC2715139.
3. Fang D, Hawke D, Zheng Y, Xia Y, Meisenhelder J, Nika H, Mills GB, Kobayashi R, Hunter T, Lu Z. Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem 282(15):11221-9, 4/2007. e-Pub 2/2007. PMCID: PMC1850976.
4. Xia Y, Wang J, Xu S, Johnson GL, Hunter T, Lu Z. MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress. Mol Cell Biol 27(2):510-7, 1/2007. e-Pub 11/2006. PMCID: PMC1800814.
5. Xia Y, Wang J, Liu TJ, Yung WKA, Hunter T, and Lu Z.. c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis. Mol Cell 25(2):219-232, 2007. e-Pub 2007. PMCID: PMC1829326.
6. Lindberg S, Xia Y, Sonden B, Goransson M, Hacker J, and Eric B. Regulatory interactions among adhesin gene systems of uropathogenic Escherichia coli. Infection and Immunity 76(2):771-80, 2007.
7. Xia Y, Suzuki H, Borevitz J, Blount J, Guo Z, Patel K, Dixon RA, Lamb C. An extracellular aspartic protease functions in Arabidopsis disease resistance signaling. EMBO J 23(4):980-8, 2/2004. e-Pub 2/2004. PMCID: PMC380998.
8. Xia Y, Pao GM, Verma IM, and Hung T. Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J Biol Chem 278(7):5255-63, 2003. e-Pub 2003. PMID: 12431996.
9. Xia Y, Gally D, Forsman-Semb K, and Uhlin DE.. Regulatory cross-talk between adhesin operons in Escherichia coli: inhibition of type 1 fimbriae expression by the PapB protein. EMBO J 19(7):1450-1457, 2000. e-Pub 2000. PMCID: PMC310214.
10. Xia Y, Uhlin BE. Mutational analysis of the PapB transcriptional regulator in Escherichia coli. Regions important for DNA binding and oligomerization. J Biol Chem 274(28):19723-30, 7/1999. PMID: 10391913.
11. Xia Y, Forsman K, Jass J, Uhlin BE. Oligomeric interaction of the PapB transcriptional regulator with the upstream activating region of pili adhesin gene promoters in Escherichia coli. Mol Microbiol 30(3):513-23, 11/1998. PMID: 9822817.
12. Xia Y, Ma Z, Dong C, Hua ZC, and Zhu DX. Expression and characterization of ProUrokinase in E.Coli. J Biochem & Biophysics (Chinese) 27(1):17-22, 1995.

Book Chapters

1. Uhlin BE, Balsalobre C, Forsman-Semb K, G÷ransson M, Jass J, Johansson J, Naureckiene S, SondÚn B, Urbonaviciene J, and Xia Y. Control mechanisms in the Pap-pili system. In: Genes and Proteins Underlying Microbial Urinary Tract Virulence, Part of Series: Advances in Experimental Medicine and Biology. 485. Ed(s) L Emődy, T Pßl, J Hacker, G Blum-Oehler. Kluwer Academic Publishers: New York, 113-118, e-Book 2000. PMCID: PMC11109094.
2. Xia Y, Forsman-Semb K, Jass J, and Uhlin BE.. Structural and functional studies of the fimbrial adhesin gene regulator PapB from uropathogenic Escherichia coli. In: Genes and Proteins Underlying Microbial Urinary Tract Virulence, Part of Series: Advances in Experimental Medicine and Biology. 485. Ed(s) L Emődy, T Pßl, J Hacker, G Blum-Oehler. Kluwer Academic/Plenum Publishers: New York, 123-6, e-Book 2000. PMCID: PMC11109096.

Grant & Contract Support

Title: The Role of BRCA1 as an E3 ubiquitin ligase.
Funding Source: The Salk Institute for Biological Studies
Role: Program Leader
Principal Investigator: Zhimin Lu, M.D., Ph.D.
Duration: 2002 - 2004

Last updated: 10/31/2012