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Yasuhide Furuta, Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Biochemistry and Molecular Biology, Division of Basic Science Research, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Office Address

The University of Texas M. D. Anderson Cancer Center
6767 Bertner St.
Biochemistry & Molecular Biology
Unit Number: 1000
Houston, TX 77030
Room Number: S9.8316
Phone: 713-834-6262
Fax: 713-792-0346
Email: yfuruta@mdanderson.org

Education & Training

Degree-Granting Education

1993 University of Tsukuba, Tsukuba, Japan, PHD, Biological Sciences
1990 University of Tsukuba, Tsukuba, Japan, MS, Biological Sciences
1988 University of Tsukuba, Tsukuba, Japan, BS, Biological Sciences

Postgraduate Training

4/1995-3/1998 Research Fellow, Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University Medical Center, Nashville, TN
4/1993-3/1994 Special Researcher of Basic Science Program, Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN), Tsukuba, Japan, Dr. Shinichi Aizawa

Selected Publications

Peer-Reviewed Original Research Articles
1. Plas DT, Dhande OS, Lopez JE, Murali D, Thaller C, Henkemeyer M, Furuta Y, Overbeek P, Crair MC. Bone morphogenetic proteins eye patterning, and retinocollicular map formation in the mouse. J. Neurosci 28:7057-7067, 2008.
2. Mao CA, Kiyama T, Pan P, Furuta Y, Hajantonakis AK, Klein WH. Eomesodermin, a target gene of Pou4f2, is required for retinal ganglion cell and optic nerve development in the mouse. Development 135:271-280, 2008.
3. Ikeya M, Nosaka T, Furushima K, Kawada M, Furuta Y, Kitamura T, Sasai Y. ITwisted gastrulation mutation suppresses skeletal defect phenotypes in Crossveinless 2 mutant mice. Mech Dev 125:832-842, 2008.
4. Poche RA, Raven MA, Kwan KM, Furuta Y, Behringer RR, Reese BE,. Somal positioning and dendritic growth of horizontal cells are regulated by interactions with homotypic neighbors. Eur J Neurosci 27:1607-1614, 2008.
5. Poche RA, Furuta Y, Chaboissier MC, Schedl A, Behringer RR. Sox9 is expressed in mouse multipotent retinal progenitor cells and functions in Műller glial cell development. J Comp Neurol 520:237-250, 2008.
6. Lin W, Srajer G, Evard YA, Phan HM, Furuta Y, Dent SYR. Developmental potential of Gcn5-/- ES cells in vivo and in vitro. Dev Dyn 236:1547-1557, 2007.
7. Poche RA, Kwan KM, Raven MA, Furuta Y, Reese BE, Behringer RR. Lim1 is essential for the correct laminar positioning of retinal horizontal cells. J. Neurosci. 27:14099-14107, 2007.
8. Rao MK, Pham J, Imam JS, MacLean JA, Murali D, Furuta Y, Sinha-Hikim AP, Wilkinson MF. Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis. Genes Dev 20:147-152, 1/2006. PMID: 16418481.
9. Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y. Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development 133:4463-4473, 2006.
10. Hentges KE, Nakamura H, Furuta Y, Yu Y, Thompson D, O'Brien W, Bradley A, Justice M. Novel lethal mouse mutants produced in balancer chromosome screens. Gene Expr Patterns 6:653-665, 2006.
11. Lim JH, Booker AB, Luo T, Williams T, Furuta Y, Lagutin O, Oliver G, Sargent TD, Fallon JR. AP-2alpha selectively regulates fragile X mental retardation-1 gene transcription during embryonic development. Hum Mol Genet 14:2027-2034, 2005.
12. Murali D, Yoshikawa S, Plas D, Corrigan R, Lyons KM, Crair M, Oliver, G, Mishina Y, Furuta Y. Distinct developmental programs require different levels of Bmp signaling during retinal development. Development 132:913-923, 2005.
13. Vincentz JW, McWhiter JR, Murre C, Baldini A, Furuta Y. Fgf15 is required for proper morphogenesis of the murine cardiac outflow tract. Genesis 41:192-201, 2005.
14. Zhang Z, Cerrato F, Xu H, Vitelli F, Morishima M, Vincentz J, Furuta Y, Ma L, Martin JF, Baldini A, Lindsay E. Tbx1 expression in pharyngeal epithelia is necessary for aortic arch artery development. Development 132:5307-5315, 2005.
15. Liu, W,, Selever J, Murali, D,, Sun X, Brugger S, Ma L, Schwartz R, Maxson R, Furuta Y, Martin JF. Threshold-specific requirements for Bmp4 in mandibular development. Dev. Biol 283:282-293, 2005.
16. Kishigami S, Yoshikawa S, Castranio T, Okazaki K, Furuta Y, Mishina Y. BMP signaling through ACVRI is essential for the establishment of L-R asymmetry in early mouse embryo. Developmental Biology 276:185-193, 2004.
17. Luan J, Furuta Y, Du J, Richmond A. Developmental expression of two cxc chemokines, mip-2 and kc, and their receptors. Cytokine 14:253-263, 2001.
18. Lagutin O, Zhu C, Furuta, YRowitch, D, McMahon A, Oliver G. Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos. Developmental Dynamics 221:342-349, 2001.
19. Furuta, Y,, Lagutin O, Hogan B, Oliver G. Retina- and ventral forebrain-specific expression of Cre recombinase activity in transgenic mice. Genesis 26:130-132, 2000.
20. Furuta Y, Hogan B. Bmp4 is essential for lens induction in the mouse embryo. Genes & Development 12:3764-3775, 1998.
21. Maruoka Y, Ohbayashi N, Hoshikawa M, Itho N, Hogan B, Furuta Y. Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo. Mechanisms of Development 74:175-177, 1998.
22. Takuma N, Sheng H, Furuta Y, Ward J, Sharma K, Hogan B, Pfaff S, Westphal H, Kimura S, Mahon K. Formation of the Rathke’s pouch requires dual induction from the diencephalon. Development 125:4835-4840, 1998.
23. Furuta Y, Piston D, Hogan B. Bone morphogenetic proteins (BMPs) as regulaters of dorsal forebrain development. Development 124:2203-2212, 1997.
24. Bellusci S, Furuta Y, Rush M, Henderson R, Winnier G, Hogan B. Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Development 124:53-63, 1997.
25. Suzuki N, Labosky P, Furuta Y, Hargett L, Dunn, R Fogo, A, Takahara K, Peters D, Greenspan D, Hogan B. Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila talloid. Development 122:3587-3595, 1996.
26. Ilic D, Kanazawa S, Furuta Y, Yamamoto T, Aizawa S. Impairment of mobility in endodermal cells by FAK deficiency. Experimental Cell Res 222:298-303, 1996.
27. Yoshida M, Yagi T, Furuta Y, Takayanagi K, Kominami R, Takeda N, Tokunaga T, Chiba J, Ikawa Y, Aizawa S. A new strategy of gene trapping in ES cells using 3’RACE. Transgenic research 4:277-287, 1995.
28. Ilic D, Furuta Y, Suda T, Atsumi T, Fujimoto J, Ikawa Y, Yamamoto T, Aizawa S. Focal adhesion kinase is not essential for in vitro and in vivo differentiation of ES cells. Biochem. Biophys. Res. Comm 209:300-309, 1995.
29. Furuta Y, Ilic D, Kanazawa S, Takeda, N,, Yamamoto T, Aizawa S. Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase. FAK. Oncogene 11, 1995.
30. Furuta Y, Shigetani Y, Takeda N, Iwasaki K, Ikawa Y, Aizawa S. Ovarian teratomas in mice lacking the protooncogene c-mos. Japanese J. Cancer Res 86:540-545, 1995.
31. llic D, Furuta Y, Kanazawa S, Takeda N, Sobue K, Nakatsuji N, Nomura S, Fujimoto J, Okada M, Yamamoto T, Aizawa S. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377:539-544, 1995.
32. Inoue T, Hirabayashi Y, Mitsui H, Furuta Y, Suda Y, Aizawa SI, Ikawa Y. Experimental model for MDS-like myelodysplasia in transgenic mice harboring the SV40 large-T antigen under an immunoglobulin enhancer. Leukemia 8(SUPPL.1), 1994.
33. Yagi T, Shigetani Y, Furuta Y, Nada S, Okado N, Ikawa Y, Aizawa S. Fyn expression during early neurogenesis in mouse embryos. Oncogene 9(9):2433-2440, 1994.
34. Tamemoto H, Kadowaki T, Tobe K, Yagi T, Sakura H, Hayakawa T, Terauchi Y, Ueki K, Kaburagi Y, Satoh S, Sekihara H, Yoshioka S, Horikoshi H, Furuta Y, Ikawa Y, Kasuga M, Yazaki Y, Aizawa S. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372(6502):182-186, 1994.
35. Hashimoto N, Watanabe N, Furuta Y, Tamemoto H, Sagata N, Yokoyama M, Okazaki K, Nagayoshi M, Takeda N, Ikawa Y, Aizawa S. Parthenogenetic activation of oocytes in c-mos-deficient mice. Nature 370:68-71, 1994.
36. Yagi T, Tokunaga T, Furuta Y, Nada S, Yoshida M, Tsukada T, Saga Y, Takeda N, Ikawa Y, Aizawa S. A novel ES cell line, TT2, with high germline-differentiating potency. Analytical Biochemistry 214(1):70-76, 1993.
37. Furuta Y, Aizawa S, Suda Y, Ikawa Y, Nakasgoshi H, Nishina Y, Ishii S. Degeneration of skeletal and cardiac muscles in c-myb transgenic mice. Transgenic research 2:199-207, 1993.
38. Furuta Y, Aizawa S, Suda Y, Ikawa Y, Nishikawa SI, Hayashi SI, Hirabayashi Y, Inoue T. MDS-like experimental myelodysplasia: Multilineage abnormal hematopoiesis in transgenic mice harboring the SV40 large T antigen under an immunoglobulin enhancer. Experimental Hematology 21:806-815, 1993.
39. Hino O, Kitagawa T, Nomura K, Ohtake K, Cui L, Furuta Y, Aizawa S. Hepatocarcinogenesis in transgenic mice carrying albumin-promoted SV40 T antigen gene. Jap J Cancer Ree 82:1226-1233, 1991.
40. Lee GH, Li H, Ohtake K, Nomura K, Hino O, Furuta Y, Aizawa S, Kitagawa T. Detection of activated c-H-ras oncogene in hepatocellular carcinomas developed in transgenic mice harboring albumin promoter-regulated simian virus 40 gene. Carcinogenesis 11:1145-1148, 1990.
41. Aizawa S, Suda Y, Furuta Y, Yagi T, Takeda N, Watanabe N, Nagayoshi M, Ikawa Y. Env-derived gp55 gene of Friend spleen focus-forming virus specifically induces neoplastic proliferation of erythoid progenitor cells. EMBO Journal 9(7):2107-2116, 1990.
42. Suda Y, Aizawa S, Furuta Y, Yagi T, Ikawa Y, Saitoh K, Yamada Y, Toyoshima K, Yamamoto T. Induction of a variety of tumors by c-erbB2 and clonal nature of lymphomas even with the mutated gene. (Val659 ? Glu659). EMBO Journal 9(1):181-190, 1990.
43. Furuta Y, Aizawa S, Suda Y, Ikawa Y, Kishimoto H, Asano Y, Tada T, Hikikoshi A, Yoshida M, Seiki M. Thymic atrophy characteristic in transgenic mice that harbor pX genes of human T-cell leukemia virus type I. Journal of Virology 63:3185-3189, 1989.
44. Suda Y, Aizawa S, Hirai S, Inoue T, Furuta Y, Suzuki M, Hirohashi S, Ikawa Y. Driven by the same Ig enhancer and SV40 T promoter ras induced lung adenomatous tumors, myc induced pre-B cell lymphomas and SV40 large T gene a variety of tumors in transgenic mice. EMBO Journal 6(13):4055-4065, 1987.

Invited Articles
1. Furuta Y, Behringer RR. Recent Innovations in Tissue-Specific Gene Modifications in the Mouse. Birth Defects Research 75, (Part C):43-57, 2005.
2. Aizawa S, Yagi T, Furuta Y, Ikawa Y, Nada S, Nakagawa H, Okada M. Non-receptor tyrosine kinases in mammalian neurogenesis. Proc Princess Takamatsu Symp 24:323-337, 1994.
3. Kitagawa T, Hino O, Lee GH, Li H, Liu J, Nomura K, Ohtake K, Furuta Y, Aizawa S. Multistep hepatocarcinogenesis in transgenic mice harboring SV40 T-antigen gene. Proc Princess Takamatsu Symp 22:349-360, 1991.

Last updated: 6/30/2009