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Yuanqing Ye, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Epidemiology, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX
Instructor, Department of Epidemiology, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2002 North Carolina State University, Raleigh, NC, PHD, Mathematics
1998 Nanjing University, Nanjing, Jiangsu, China, BS, Mathematics

Postgraduate Training

7/2006-2/2008 Postdoctoral Fellowship, Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, Xifeng Wu
9/2002-6/2006 Postdoctoral Associate, Biostatistics, Yale University, New Haven, CT, Heping Zhang

Honors and Awards

2007 AACR-Aflac, Incorporated Scholar-in-Training Award, AACR
2007 Berlex Oncology Award in Patient-Oriented Research Poster Winner, UT MD Anderson Cancer Center
2007 Janice David Gordon Memorial Fellowship Award
2001-present Pi Mu Epsilon Honorary Mathematics Society

Selected Publications

Peer-Reviewed Original Research Articles

1. Hildebrandt MA, Tan W, Tamboli P, Huang M, Ye Y, Lin J, Lee JS, Wood CG, Wu X. Kinome expression profiling identifies IKBKE as a predictor of overall survival in clear cell renal cell carcinoma patients. Carcinogenesis 33(4):799-803, 4/2012. e-Pub 1/2012. PMCID: PMC3324439.
2. Wagner KW, Ye Y, Lin J, Vaporciyan AA, Roth JA, Wu X. Genetic Variations in Epigenetic Genes Are Predictors of Recurrence in Stage I or II Non-Small Cell Lung Cancer Patients. Clin Cancer Res 18(2):585-92, 1/2012. PMCID: PMC3373176.
3. Wu X, Scelo G, Purdue MP, Rothman N, Johansson M, Ye Y, Wang Z, Zelenika D, Moore LE, Wood CG, Prokhortchouk E, Gaborieau V, Jacobs KB, Chow WH, Toro JR, Zaridze D, Lin J, Lubinski J, Trubicka J, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Jinga V, Bencko V, Slamova A, Holcatova I, Navratilova M, Janout V, Boffetta P, Colt JS, Davis FG, Schwartz KL, Banks RE, Selby PJ, Harnden P, Berg CD, Hsing AW, Grubb RL, Boeing H, Vineis P, Clavel-Chapelon F, Palli D, Tumino R, Krogh V, Panico S, Duell EJ, Quirós JR, Sanchez MJ, Navarro C, Ardanaz E, Dorronsoro M, Khaw KT, Allen NE, Bueno-de-Mesquita HB, Peeters PH, Trichopoulos D, Linseisen J, Ljungberg B, Overvad K, Tjønneland A, Romieu I, Riboli E, Stevens VL, Thun MJ, Diver WR, Gapstur SM, Pharoah PD, Easton DF, Albanes D, Virtamo J, Vatten L, Hveem K, Fletcher T, Koppova K, Cussenot O, Cancel-Tassin G, Benhamou S, Hildebrandt MA, Pu X, Foglio M, Lechner D, Hutchinson A, Yeager M, Fraumeni JF, Lathrop M, Skryabin KG, McKay JD, Gu J, Brennan P, Chanock SJ. A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23. Hum Mol Genet. e-Pub 11/2011. PMID: 22010048.
4. Garcia-Closas M, Ye Y*, Rothman N, Figueroa JD, Malats N, Dinney CP, Chatterjee N, Prokunina-Olsson L, Wang Z, Lin J, Real FX, Jacobs KB, Baris D, Thun M, De Vivo I, Albanes D, Purdue MP, Kogevinas M, Kamat AM, Lerner SP, Grossman HB, Gu J, Pu X, Hutchinson A, Fu YP, Burdett L, Yeager M, Tang W, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Johnson A, Schwenn M, Karagas MR, Schned A, Andriole G, Grubb R, Black A, Jacobs EJ, Diver WR, Gapstur SM, Weinstein SJ, Virtamo J, Hunter DJ, Caporaso N, Landi MT, Fraumeni JF, Silverman DT, Chanock SJ, Wu X. A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3. Hum Mol Genet 20(21):4282-9, 11/2011. e-Pub 8/2011. PMCID: PMC3188994. *co-first author.
5. Wu X, Ye Y, Rosell R, Amos CI, Stewart DJ, Hildebrandt MA, Roth JA, Minna JD, Gu J, Lin J, Buch SC, Nukui T, Ramirez Serrano JL, Taron M, Cassidy A, Lu C, Chang JY, Lippman SM, Hong WK, Spitz MR, Romkes M, Yang P. Genome-Wide Association Study of Survival in Non-Small Cell Lung Cancer Patients Receiving Platinum-Based Chemotherapy. J Natl Cancer Inst 103(10):817-25, 5/2011. e-Pub 4/2011. PMCID: PMC3096796.
6. Gu J, Chen M, Shete S, Amos CI, Kamat A, Ye Y, Lin J, Dinney CP, Wu X. A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer. Cancer Prev Res (Phila) 4(4):514-21, 4/2011. e-Pub 4/2011. PMCID: PMC3076128.
7. Gu J, Ye Y*, Spitz MR, Lin J, Kiemeney LA, Xing J, Hildebrandt MA, Ki Hong W, Amos CI, Wu X. A genetic variant near the PMAIP1/Noxa gene is associated with increased bleomycin sensitivity. Hum Mol Genet 20(4):820-6, 2/2011. e-Pub 11/2010. PMCID: PMC3024041. *co-first author.
8. Lee JJ, Wu X, Hildebrandt MA, Yang H, Khuri FR, Kim E, Gu J, Ye Y, Lotan R, Spitz MR, Hong WK. Global assessment of genetic variation influencing response to retinoid chemoprevention in head and neck cancer patients. Cancer Prev Res (Phila) 4(2):185-93, 2/2011. PMID: 21292633.
9. Purdue MP, Johansson M, Zelenika D, Toro JR, Scelo G, Moore LE, Prokhortchouk E, Wu X, Kiemeney LA, Gaborieau V, Jacobs KB, Chow WH, Zaridze D, Matveev V, Lubinski J, Trubicka J, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Bucur A, Bencko V, Foretova L, Janout V, Boffetta P, Colt JS, Davis FG, Schwartz KL, Banks RE, Selby PJ, Harnden P, Berg CD, Hsing AW, Grubb RL, Boeing H, Vineis P, Clavel-Chapelon F, Palli D, Tumino R, Krogh V, Panico S, Duell EJ, Quirós JR, Sanchez MJ, Navarro C, Ardanaz E, Dorronsoro M, Khaw KT, Allen NE, Bueno-de-Mesquita HB, Peeters PH, Trichopoulos D, Linseisen J, Ljungberg B, Overvad K, Tjønneland A, Romieu I, Riboli E, Mukeria A, Shangina O, Stevens VL, Thun MJ, Diver WR, Gapstur SM, Pharoah PD, Easton DF, Albanes D, Weinstein SJ, Virtamo J, Vatten L, Hveem K, Njølstad I, Tell GS, Stoltenberg C, Kumar R, Koppova K, Cussenot O, Benhamou S, Oosterwijk E, Vermeulen SH, Aben KK, van der Marel SL, Ye Y, Wood CG, Pu X, Mazur AM, Boulygina ES, Chekanov NN, Foglio M, Lechner D, Gut I, Heath S, Blanche H, Hutchinson A, Thomas G, Wang Z, Yeager M, Fraumeni JF, Skryabin KG, McKay JD, Rothman N, Chanock SJ, Lathrop M, Brennan P. Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3. Nat Genet 43(1):60-5, 1/2011. e-Pub 12/2010. PMCID: PMC3049257.
10. Pu X, Hildebrandt MA, Lu C, Lin J, Stewart DJ, Ye Y, Gu J, Spitz MR, Wu X. PI3K/PTEN/AKT/mTOR pathway genetic variation predicts toxicity and distant progression in lung cancer patients receiving platinum-based chemotherapy. Lung Cancer 71(1):82-8, 1/2011. e-Pub 5/2010. PMCID: PMC2952281.
11. Liang D, Meyer L, Chang DW, Lin J, Pu X, Ye Y, Gu J, Wu X, Lu K. Genetic Variants in MicroRNA Biosynthesis Pathways and Binding Sites Modify Ovarian Cancer Risk, Survival, and Treatment Response. Cancer Res 70(23):9765-76, 12/2010. e-Pub 11/2010. PMID: 21118967.
12. Gu J, Ajani JA, Hawk ET, Ye Y, Lee JH, Bhutani MS, Hofstetter WL, Swisher SG, Wang KK, Wu X. Genome-wide catalogue of chromosomal aberrations in barrett's esophagus and esophageal adenocarcinoma: a high-density single nucleotide polymorphism array analysis. Cancer Prev Res (Phila) 3(9):1176-86, 9/2010. e-Pub 7/2010. PMID: 20651033.
13. Li Y, Sheu CC, Ye Y*, de Andrade M, Wang L, Chang SC, Aubry MC, Aakre JA, Allen MS, Chen F, Cunningham JM, Deschamps C, Jiang R, Lin J, Marks RS, Pankratz VS, Su L, Li Y, Sun Z, Tang H, Vasmatzis G, Harris CC, Spitz MR, Jen J, Wang R, Zhang ZF, Christiani DC, Wu X, Yang P. Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol 11(4):321-30, 4/2010. e-Pub 3/2010. PMCID: PMC2945218. *co-first author.
14. Clague J, Lippman SM, Yang H, Hildebrandt MA, Ye Y, Lee JJ, Wu X. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. Mol Carcinog 49(2):183-9, 2/2010. PMID: 19851984.
15. Hildebrandt MA, Komaki R, Liao Z, Gu J, Chang JY, Ye Y, Lu C, Stewart DJ, Minna JD, Roth JA, Lippman SM, Cox JD, Hong WK, Spitz MR, Wu X. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. PLoS One 5(8), 2010. PMCID: PMC2928273.
16. Chen M, Ye Y*, Yang H, Tamboli P, Matin S, Tannir NM, Wood CG, Gu J, Wu X. Genome-wide profiling of chromosomal alterations in renal cell carcinoma using high-density single nucleotide polymorphism arrays. Int J Cancer 125(10):2342-8, 11/2009. e-Pub 6/2009. PMCID: PMC2768265. *co-first author.
17. Wu X, Ye Y, Kiemeney LA, Sulem P, Rafnar T, Matullo G, Seminara D, Yoshida T, Saeki N, Andrew AS, Dinney CP, Czerniak B, Zhang ZF, Kiltie AE, Bishop DT, Vineis P, Porru S, Buntinx F, Kellen E, Zeegers MP, Kumar R, Rudnai P, Gurzau E, Koppova K, Mayordomo JI, Sanchez M, Saez B, Lindblom A, de Verdier P, Steineck G, Mills GB, Schned A, Guarrera S, Polidoro S, Chang SC, Lin J, Chang DW, Hale KS, Majewski T, Grossman HB, Thorlacius S, Thorsteinsdottir U, Aben KK, Witjes JA, Stefansson K, Amos CI, Karagas MR, Gu J. Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer. Nat Genet 41(9):991-5, 9/2009. e-Pub 8/2009. PMID: 19648920.
18. Wu X, Spitz MR, Lee JJ, Lippman SM, Ye Y, Yang H, Khuri FR, Kim E, Gu J, Lotan R, Hong WK. Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants. Cancer Prev Res (Phila Pa) 2(7):617-24, 7/2009. PMCID: PMC2964280.
19. Chen M, Cassidy A, Gu J, Delclos GL, Zhen F, Yang H, Hildebrandt MA, Lin J, Ye Y, Chamberlain RM, Dinney CP, Wu X. Genetic variations in PI3K-AKT-mTOR pathway and bladder cancer risk. Carcinogenesis 30(12):2047-52, 2009. PMCID: PMC2792319.
20. Horikawa Y, Wood CG, Yang H, Zhao H, Ye Y, Gu J, Lin J, Habuchi T, Wu X. Single Nucleotide Polymorphisms of microRNA Machinery Genes Modify the Risk of Renal Cell Carcinoma. Clin Cancer Res 14(23):7956-62, 12/2008. PMCID: PMC2650498.
21. Ye Y, Lippman SM, Lee JJ, Chen M, Frazier ML, Spitz MR, Wu X. Genetic variations in cell-cycle pathway and the risk of oral premalignant lesions. Cancer 113(9):2488-95, 11/2008. PMCID: PMC2577230.
22. Ye Y, Wang KK, Gu J, Yang H, Lin J, Ajani JA, Wu X. Genetic Variations in MicroRNA-Related Genes Are Novel Susceptibility Loci for Esophageal Cancer Risk. Cancer Prev Res (Phila Pa) 1(6):460-9, 11/2008. PMCID: PMC2768267.
23. Wu X, Lu C, Ye Y, Chang J, Yang H, Lin J, Gu J, Hong WK, Stewart D, Spitz MR. Germline Genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy. Pharmacogenet Genomics 18(11):955-65, 11/2008. PMCID: PMC2665725.
24. Ye Y, Yang H, Grossman HB, Dinney C, Wu X, Gu J. Genetic variants in cell cycle control pathway confer susceptibility to bladder cancer. Cancer 112(11):2467-74, 6/2008. PMID: 18361427.
25. Yang H, Dinney CP, Ye Y, Zhu Y, Grossman HB, Wu X. Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer. Cancer Res 68(7):2530-7, 4/2008. PMID: 18381463.
26. Yang H, Gu J, Lin X, Grossman HB, Ye Y, Dinney CP, Wu X. Profiling of genetic variations in inflammation pathway genes in relation to bladder cancer predisposition. Clin Cancer Res 14(7):2236-44, 4/2008. PMID: 18381966.
27. Zhang H, Ye Y. A Tree-Based Method for Modeling a Multivariate Ordinal Response. Stat Interface 1(1):169-178, 2008. PMCID: PMC2566541.
28. Zhang H, Ye Y, Diggle P, Shi J. Joint Modeling of Time Series Measures and Recurrent Events and Analysis of the Effects of Air Quality on Respiratory Symptoms. Journal of the American Statistical Association 103:48-60, 2008.
29. Zhang H, Ye Y, Wang X, Gelernter J, Ma JZ, Li MD. DOPA decarboxylase gene is associated with nicotine dependence. Pharmacogenomics 7(8):1159-66, 12/2006. PMID: 17184203.
30. Wang X*, Ye Y*, Zhang H. Family-based association tests for ordinal traits adjusting for covariates. Genet Epidemiol 30(8):728-36, 12/2006. PMCID: PMC17086513. *co-first author.
31. Zhang H, Wang X, Ye Y. Detection of genes for ordinal traits in nuclear families and a unified approach for association studies. Genetics 172(1):693-9, 1/2006. e-Pub 10/2005. PMCID: PMC1456175.
32. Ye Y, Zhong X, Zhang H. A genome-wide tree- and forest-based association analysis of comorbidity of alcoholism and smoking. BMC Genet 6 Suppl 1:S135, 2005. PMCID: PMC1866801.
33. Cupples LA, Bailey J, Cartier KC, Falk CT, Liu KY, Ye Y, Yu R, Zhang H, Zhao H. Data mining. Genet Epidemiol 29 Suppl 1:S103-9, 2005. PMID: 16342179.
34. Zhang H, Zhong X, Ye Y . Multivariate linkage analysis using the electrophysiological phenotypes in the COGA alcoholism data. BMC Genet 6 Suppl 1:S118, 2005. PMCID: PMC1866820.
35. Ye Y. Semiclean Rings. Communications in Algebra 31(11):5609-5625, 2003.

Grant & Contract Support

Title: Molecular pathways linking obesity and RCC tumorigenesis (PQ1)
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Xifeng Wu
Duration: 9/1/2012 - 6/30/2016
 
Title: A pilot study of global serum metabolomic profiling and lung cancer risk
Funding Source: UT SPORE in Lung Cancer Development Award
Role: Principal Investigator
Duration: 11/1/2011 - 4/30/2012
 
Title: Predicting the risk of developing lung cancer: A multigenic statistical approach to microRNA
Funding Source: Duncan Family Institute for Cancer Prevention and Risk Assessment
Role: Principal Investigator
Duration: 3/1/2010 - 2/28/2012
 
Title: Genome-wide association analysis of bladder cancer (Supplement)
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Xifeng Wu
Duration: 9/1/2009 - 8/31/2011
 
Title: Telomere length, telomere maintenance gene polymorphisms, and bladder cancer risk
Funding Source: NIH/NCI
Role: Co-Investigator
Duration: 7/1/2008 - 6/30/2013
 
Title: Genome-wide association analysis of bladder cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Xifeng Wu
Duration: 4/1/2008 - 3/31/2013
 
Title: Genetic instability and risk for esophageal carcinoma
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Xifeng Wu
Duration: 3/10/2008 - 1/31/2013
 
Title: MD Anderson Cancer Center SPORE in GU Cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Colin Dinney/Xifeng Wu
Duration: 9/25/2001 - 8/31/2016
 
Title: MD Anderson Cancer Center SPORE in GU Cancer, Project 2: Markers of susceptibility as predictors of bladder cancer recurrence
Funding Source: NIH/NCI
Role: Co-Investigator: Project 2
Principal Investigator: Xifeng Wu
Duration: 9/25/2001 - 8/31/2012
 
Title: Mechanisms & Prevention of Environmental Disease
Funding Source: NIH/NIEHS
Role: Co-Investigator
Principal Investigator: Shen
Duration: 4/1/1997 - 3/31/2012
 
Title: University of Texas SPORE in Lung Cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Minna
Duration: 9/30/1996 - 4/30/2013

Last updated: 2/5/2013