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Zhiyong Ding, Ph.D.

Present Title & Affiliation

Primary Appointment

Instructor, Department of Systems Biology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
South Campus Research Building II
Unit Number: 950
Houston, TX 77054
Room Number: Room 2SCR3.2010
Phone: (713) 834-6156
Email: zding@mdanderson.org

Education & Training

Degree-Granting Education

2000 Peking University, Beijing, Beiing, China, PHD, Cell Biology
1992 Shandong University, Jinan, Shandong, China, BS, Microbiology

Postgraduate Training

8/2003-8/2006 Postdoctoral Fellowship, Molecular Therapeutics and Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, Dr. Gordon Mills
9/2000-7/2003 Postdoctoral Fellowship, Microbiology and Molecular Genetics, The University of Texas Medical School, Houston, TX, Dr. Peter Christie

Selected Publications

Peer-Reviewed Original Research Articles
1. Ding Z, German P, Bai S, Feng Z, Gao M, Si W, Sobieski MM, Stephan CC, Mills GB, Jonasch E. Agents That Stabilize Mutated von Hippel-Lindau (VHL) Protein: Results of a High-Throughput Screen to Identify Compounds That Modulate VHL Proteostasis. J Biomol Screen 17(5):572-80, 6/2012. e-Pub 2/21/2012. PMID: 22357874.
2. Ji H, Ding Z, Hawke D, Xing D, Jiang BH, Mills GB, Lu Z. AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis. EMBO Rep 13(6):554-60, 6/2012. e-Pub 6/1/2012. PMCID: PMC3367238.
3. Li J, Ding Z, Wang Z, Lu JF, Maity SN, Navone NM, Logothetis CJ, Mills GB, Kim J. Androgen regulation of 5α-reductase isoenzymes in prostate cancer: implications for prostate cancer prevention. PLoS One 6(12):e28840, 2011. e-Pub 12/2011. PMCID: PMC3237548.
4. Zhu QS, Rosenblatt K, Huang KL, Lahat G, Brobey R, Bolshakov S, Nguyen T, Ding Z, Belousov R, Bill K, Luo X, Lazar A, Dicker A, Mills GB, Hung MC, Lev D. Vimentin is a novel AKT1 target mediating motility and invasion. Oncogene. e-Pub 9/2010. PMID: 20856200.
5. Ding Z, Liang J, Li J, Lu Y, Ariyaratna V, Lu Z, Davies MA, Westwick JK, Mills GB. Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase. PLoS One 5(3):e9910, 2010. e-Pub 3/2010. PMCID: PMC2845649.
6. Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M, Kondo S, Dumont DJ, Gutterman JU, Walker CL, Slingerland JM, Mills GB. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 9(2):218-24, 2/2007. e-Pub 1/21/2007. PMID: 17237771.
7. Ding Z, Liang J, Lu Y, Yu Q, Songyang Z, Lin SY, Mills GB. A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners. Proc Natl Acad Sci U S A 103(41):15014-9, 10/2006. e-Pub 10/2006. PMCID: PMC1636760.
8. Atmakuri K, Ding Z, Christie PJ. VirE2, a type IV secretion substrate, interacts with the VirD4 transfer protein at cell poles of Agrobacterium tumefaciens. Mol Microbiol 49(6):1699-713, 9/2003. PMID: 12950931.
9. Ding Z, Christie PJ. Agrobacterium tumefaciens twin-arginine-dependent translocation is important for virulence, flagellation, and chemotaxis but not type IV secretion. J Bacteriol 185(3):760-71, 2/2003. PMCID: PMC142831.
10. Ding Z, Zhao Z, Jakubowski SJ, Krishnamohan A, Margolin W, Christie PJ. A novel cytology-based, two-hybrid screen for bacteria applied to protein-protein interaction studies of a type IV secretion system. J Bacteriol 184(20):5572-82, 10/2002. PMCID: PMC139600.
11. Zhao Z, Sagulenko E, Ding Z, Christie PJ. Activities of virE1 and the VirE1 secretion chaperone in export of the multifunctional VirE2 effector via an Agrobacterium type IV secretion pathway. J Bacteriol 183(13):3855-65, 7/2001. PMID: 11395448.

Invited Articles
1. Ding Z, Atmakuri K, Christie PJ. The outs and ins of bacterial type IV secretion substrates. Trends Microbiol 11(11):527-35, 11/2003. PMID: 14607070.

Last updated: 2/28/2013