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Zhiyong Ding, Ph.D.

Present Title & Affiliation


Office Address

The University of Texas MD Anderson Cancer Center
South Campus Research Building II
Unit Number: 950
Houston, TX 77054
Room Number: Room 2SCR3.2010
Phone: (713) 834-6156

Education & Training

Degree-Granting Education

2000 Peking University, Beijing, Beiing, China, PHD, Cell Biology
1992 Shandong University, Jinan, Shandong, China, BS, Microbiology

Postgraduate Training

9/2003-9/2006 Postdoctoral Fellowship, Molecular Therapeutics and Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, Dr. Gordon Mills
9/2000-9/2003 Postdoctoral Fellowship, Microbiology and Molecular Genetics, The University of Texas Medical School, Houston, TX, Dr. Peter Christie

Selected Publications

Peer-Reviewed Original Research Articles

1. Ding Z, Xu C. Detection of Genetically Engineered Microorganisms in Soil by PCR and Molecular Hybridization. Acta Microbiologica Sinica 39:381-384, 1999.
2. Ding Z, Xu C, Wang R. Comparison of Several Isoenzymes between Bt Cotton and Regular Cotton. Acta Ecologica Sinica 21:332-336, 2000.
3. Zhao Z, Sagulenko E, Ding Z, Christie PJ. Activities of virE1 and the VirE1 secretion chaperone in export of the multifunctional VirE2 effector via an Agrobacterium type IV secretion pathway. J Bacteriol 183(13):3855-65, 7/2001. PMID: 11395448.
4. Ding Z, Zhao Z, Jakubowski SJ, Krishnamohan A, Margolin W, Christie PJ. A novel cytology-based, two-hybrid screen for bacteria applied to protein-protein interaction studies of a type IV secretion system. J Bacteriol 184(20):5572-82, 10/2002. PMCID: PMC139600.
5. Ding Z, Christie PJ. Agrobacterium tumefaciens twin-arginine-dependent translocation is important for virulence, flagellation, and chemotaxis but not type IV secretion. J Bacteriol 185(3):760-71, 2/2003. PMCID: PMC142831.
6. Atmakuri K, Ding Z, Christie PJ. VirE2, a type IV secretion substrate, interacts with the VirD4 transfer protein at cell poles of Agrobacterium tumefaciens. Mol Microbiol 49(6):1699-713, 9/2003. PMID: 12950931.
7. Ding Z, Liang J, Lu Y, Yu Q, Songyang Z, Lin SY, Mills GB. A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners. Proc Natl Acad Sci U S A 103(41):15014-9, 10/2006. PMCID: PMC1636760.
8. Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M, Kondo S, Dumont DJ, Gutterman JU, Walker CL, Slingerland JM, Mills GB. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 9(2):218-24, 2/2007. PMID: 17237771.
9. Zhu QS, Rosenblatt K, Huang KL, Lahat G, Brobey R, Bolshakov S, Nguyen T, Ding Z, Belousov R, Bill K, Luo X, Lazar A, Dicker A, Mills GB, Hung MC, Lev D. Vimentin is a novel AKT1 target mediating motility and invasion. Oncogene. e-Pub 9/2010. PMID: 20856200.
10. Ding Z, Liang J, Li J, Lu Y, Ariyaratna V, Lu Z, Davies MA, Westwick JK, Mills GB. Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase. PLoS One 5(3):e9910, 2010. PMCID: PMC2845649.
11. Li J, Ding Z, Wang Z, Lu JF, Maity SN, Navone NM, Logothetis CJ, Mills GB, Kim J. Androgen regulation of 5α-reductase isoenzymes in prostate cancer: implications for prostate cancer prevention. PLoS One 6(12):e28840, 2011. PMCID: PMC3237548.
12. Ding Z, German P, Bai S, Feng Z, Gao M, Si W, Sobieski MM, Stephan CC, Mills GB, Jonasch E. Agents That Stabilize Mutated von Hippel-Lindau (VHL) Protein: Results of a High-Throughput Screen to Identify Compounds That Modulate VHL Proteostasis. J Biomol Screen 17(5):572-80, 6/2012. e-Pub 2/21/2012. PMID: 22357874.
13. Ji H, Ding Z, Hawke D, Xing D, Jiang BH, Mills GB, Lu Z. AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis. EMBO Rep 13(6):554-60, 6/2012. PMCID: PMC3367238.
14. Cancer Genome Atlas Research Network. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature 499(7456):43-9, 7/4/2013. e-Pub 6/23/2013. PMID: 23792563.
15. Guo H, Gao M, Lu Y, Liang J, Lorenzi PL, Bai S, Hawke DH, Li J, Dogruluk T, Scott KL, Jonasch E, Mills GB, Ding Z. Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules. Oncogene, 2013. PMID: 23912456.
16. Gao M, Liang J, Lu Y, Guo H, German P, Bai S, Jonasch E, Yang X, Mills GB, Ding Z. Site-specific activation of AKT protects cells from death induced by glucose deprivation. Oncogene, 2013. PMID: 23396361.

Invited Articles

1. Ding Z, Atmakuri K, Christie PJ. The outs and ins of bacterial type IV secretion substrates. Trends Microbiol 11(11):527-35, 11/2003. PMID: 14607070.

Book Chapters

1. Ding Z. Experiments in Microbiology. In: General Microbiology. Ed(s) B Du. Beijing Agricultural University Press: Beijing, China, 1994.

Last updated: 9/16/2013