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Zhuang Zuo, MD, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Hematopathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1998 The University of South Alabama College of Medicine, Mobile, AL, PHD, Biochemistry and Molecular Biology
1990 Beijing Medical University (currently Peking University Health Science Center), Beijing, China, MD, Medicine

Postgraduate Training

7/2008-6/2009 Clinical Fellowship, Molecular Genetic Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX
7/2005-6/2008 Clinical Residency, Anatomic and Clinical Pathology, The University of South Alabama Medical Center, Mobile, AL
9/1996-6/1997 Graduate Program in Computer and Information Sciences, University of South Alabama, Mobile, AL

Board Certifications

10/2014 Clinical Informatics by American Board of Pathology
9/2012 Molecular Genetic Pathology by American Board of Pathology and American Board of Medical Genetics
7/2011 Clinical Pathology by American Board of Pathology

Experience/Service

Other Appointments/Responsibilities

Senior Bioinformatics Scientist, Physiome Sciences, Inc, Princeton, NJ, 1999-2005

Selected Publications

Peer-Reviewed Original Research Articles

1. Sevcikova K, Zuo Z, Garcia-Manero G, Alvarez R, Kantarjian HM, Mego M, Albarracin C, Tang G, Strom SS, Medeiros LJ, Hortobagyi GN, Reuben JM, Khoury JD. Comprehensive analysis of factors impacting risks and outcomes of therapy-related myeloid neoplasms following breast cancer treatment. Leukemia. In Press.
2. Mehrotra M, Patel KP, Chen T, Miranda RN, Wang Y, Zuo Z, Muddasani R, Mishra BM, Abraham R, Luthra R, Lu R. Genomic and clinicopathologic features of primary myelofibrosis with isolated 13q deletion. Clinical Lymphoma, Myeloma & Leukemia. In Press.
3. Loghavi S, Al-Ibrahimi A, Zuo Z, Garcia-Manero G, Yabe M, Wang SA, Kantarjian HM, Yin CC, Miranda RN, Luthra R, Medeiros LJ, Bueso-Ramos CE, Khoury JD. p53 overexpression is an adverse prognostic factor in myelodysplastic syndromes with fibrosis independent of cytognenetics and bone marrow blast count. British Journal of Haematology. In Press.
4. Loghavi S, Aladily TN, Alayed K, Zuo Z, Ng SB, Tang G, Hu S, Yin CC, Mirande RN, Medeiros LJ, Khoury JD. Plasmablastic lymphoma: Clinicopathologic features and outcome analysis of 61 patients. Journal of Hematology & Oncology. In Press.
5. Zenali M, deKay J, Liu Z, Hamilton S, Zuo Z, Lu X, Bakkar R, Mills G, Broaddus R. Retrospective Review of MET Gene Mutations. Oncoscience. In Press.
6. Li Y, Hu S, Zuo Z, Li S, Lin P, Konoplev S, Wang Z, Young K, Medeiros LJ, Yin CC. CD5-positive follicular lymphoma: a clinicopathologic study of 88 cases. Mod Pathol. e-Pub 3/2015. PMID: 25743023.
7. Peng J, Zuo Z, Fu B, Oki Y, Tang G, Goswami M, Priyanka P, Muzzafar T, Medeiros LJ, Luthra R, Wang SA. Chronic myelomonocytic leukemia with nucleophosmin (NPM1) mutation. European Journal of Haematology. e-Pub 3/2015. PMID: 25809997.
8. Mego M, Zuo Z, Gao H, Cohen EN, Giordano A, Tin S, Anfossi S, Jackson S, Woodward W, Ueno NT, Valero V, Alvarez RH, Hortobagyi GN, Khoury JD, Cristofanilli M, ReubenJM. Circulating tumor cells are linked to plasma D-dimer levels in patients with metastatic breast cancer. Thrombosis and Haemostasis 113(3):593-8, 3/2015. e-Pub 11/2014. PMID: 25373787.
9. Yin CC, Jain N, Mehrotra M, Zhang J, Protopopov A, Zuo Z, Pemmaraju N, DiNardo C, Hirsch-Ginsberg C, Wang SA, Medeiros LJ, Chin L, Patel KP, Ranvandi F, Futreal A, Bueso-Ramos CE. Identification of a novel fusion gene, IRF2BP2-RARA, in acute promyelocytic leukemia. Journal of the National Comprehensive Cancer Network 13(1):19-22, 1/2015. PMID: 25583766.
10. Loghavi S, Zuo Z, Patel KP, Singh R, Zhang L, Medeiros LJ, Stingo F, Routbort M, Cortes J, Ravandi F, Kantarjian HM, Bueso-Ramos C, Luthra R, Khoury JD. Clinical features of De Novo acute myeloid leukemia with concurrent DNMT3A , FLT3 and NPM1 mutations. Journal of Hematology and Oncology 7(1):74, 10/2014. PMID: 25281355.
11. Zuo Z, Maiti S, Hu S, Loghavi S, Calin GA, Garcia-Manero G, Kantarjian HM, Medeiros LJ, Cooper LJN, Bueso-Ramos C,. Plasma Circulating microRNA Profiling for Prognostic Biomarkers in Cytogenetically Normal Myelodysplastic Syndromes. Mod Pathol 28(3). e-Pub 9/2014. PMID: 25216221.
12. Wang S, Medeiros LJ, Xu-Monette ZY, Zhang S, O'Malley DP, Orazi A, Zuo Z, Bueso-Ramos CE, Yin CC, Liu Z, Miranda RN, Young KH. Epstein-Barr virus-positive nodular lymphocyte predominant Hodgkin lymphoma. Ann Diagn Pathol. 18(4):203–209, 8/2014. e-Pub 4/2014. PMID: 24852241.
13. Portier BP, Luthra R, Singh R, Routbort M, Handal B, Reddy N, Barkoh BA, Zuo Z, Medeiros LJ, Aldape K, Patel KP. Quantitative Assessment of Mutant Allele Burden in Solid Tumors by Semiconductor Based Next Generation Sequencing. Am J Clin Pathol 141(4):559-572, 4/2014. PMID: 24619758.
14. Ok CY, Hasserjian RP, Fox PS, Stingo F, Zuo Z, Young KH, Patel K, Medeiros LJ, Garcia-Manero G, Wang SA. Application of the International Prognostic Scoring System-Revised in therapy-related myelodysplastic syndromes and oligoblastic acute myeloid leukemia. Leukemia 28(1):185-9, 1/2014. e-Pub 6/2013.
15. Hoehn D, Lu G, Konoplev S, Zhou Y, Bueso-Ramos CE, Zuo Z, Hsu B, Medeiros LJ, Yin CC. t(15;17)(q24.1;q21.2)/PML-RARA in blast phase of chronic myelogenous leukemia: a unique clonal evolution. J Hematopathol 6(4):187-193, 12/2013. e-Pub 12/2012.
16. Chakhachiro ZI, Zuo Z, Aladily TN, Kantarjian HM, Cortes JE, Alayed K, Nguyen MH, Medeiros LJ, Bueso-Ramos C. CD105 (Endoglin) Is Highly Overexpressed in a Subset of Cases of Acute Myeloid Leukemias. Am J Clin Pathol 140(3):370-378, 9/2013.
17. Fu B, Wang Z, Li X, Wang SA, Zuo Z. Detection of BRAF V600E mutation in langerhans cell histiocytosis using high-resolution melting analysis in decalcified, paraffin-embedded tissue. J Leuk 1:101, http://esciencecentral.org/journals/detection-of-braf-v600e-mutation-in-langerhans-cell-histiocytosis-using-high-resolution-melting-analysis-in-decalcified,-paraffin-embedded%20tissue-2329-6917.1000101.php?aid=14264, 7/2013.
18. Li S, Feng X, Li T, Zhang S, Zuo Z, Lin P, Konoplev S, Bueso-Ramos CE, Vega-Vazquez F, Medeiros LJ, Yin CC. Extranodal NK/T-Cell lymphoma, nasal type: A report of 73 cases at MD Anderson Cancer Center. Am J Surg Pathol 37(1):14-23, 1/2013. PMID: 23232851.
19. Konoplev S, Yin CC, Kornblau SM, Kantarjian HM, Konopleva M, Andreeff M, Lu G, Zuo Z, Luthra R, Medeiros LJ, Bueso-Ramos CE. Molecular characterization of de novo Ph+ Acute Myeloid Leukemia. Leuk Lymphoma 54(1):138-44, 1/2013.
20. Warren M, LUthra R, Yin CC, Ravandi F, Cortes JE, Kantarjian HM, Medeiros LJ, Zuo Z. Clinical impact of change of FLT3 mutation status in acute myeloid leukemia patients. Mod Pathol 25(10):1405-12, 10/2012. e-Pub 6/2012.
21. Zuo Z, Medeiros LJ, Chen Z, Liu D, Bueso-Ramos CE, Luthra R, Wang SA. Acute myeloid leukemia (AML) with erythroid predominance exhibits clinical and molecular characteristics that differ from other types of AML. PLoS ONE 7(7):e41485, 7/2012. e-Pub 7/2012.
22. Tang G, Zuo Z, Thomas DA, Lin P, Liu D, Hu Y, Kantarjian HM, Bueso-Ramos C, Medeiros LJ, Wang SA. B-Acute lymphoblastic Leukemia Occurring in Patients with a History of Prior Malignancies: Is it Therapy-related? Haematologica 97(6):919-25, 6/2012. e-Pub 12/2011. PMID: 22207681.
23. Li C, Thompson MA, Tamayo AT, Zuo Z, Lee J, Vega F, Ford RJ, Pham LV.. Over-expression of Thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma. Oncotarget 3(3):314-26, 3/2012. e-Pub 3/2012.
24. Bai B, Zuo Z, Cheong SH, Vo B, Harper E, Lovshe D, Yang S, Yin CC. Novel chromosomal aberration as evidence of clonal evolution in a case of relapsed acute myeloid leukemia. N Am J Med Sci 5(1):48-50, 1/2012.
25. Zuo Z, Goel S, Carter E. Association of cervical cytology and HPV DNA status during pregnancy with placental abnormalities and preterm birth. Am J Clin Pathol 136(2):260-5, 8/2011. PMID: 21757599.
26. Barakat FH, Luthra R, Barkoh BA, Hai S, Jamil W, Herrman S, Bhakta Y, Chen S, Medeiros LJ, Zuo Z. Detection of nucleophosmin 1 mutations by quantitative real-time polymerase chain reaction versus capillary electrophoresis: a comparative study. Arch Pathol Lab Med 135(8):994-1000, 8/2011. PMID: 21809990.
27. Zuo Z, Calin GA, de Paula HM, Medeiros LJ, Fernandez MH, Shimizu M, Garcia-Manero G, Bueso-Ramos CE. Circulating microRNAs Let-7a and miR-16 predict progression-free survival and overall survival in patients with myelodysplastic syndrome. Blood 118(2):413-5, 7/2011. e-Pub 5/2011. PMID: 21602527.
28. Alseraye FM, Zuo Z, Bueso-Ramos CE, Wang S, Medeiros LJ, Lu G.. Trisomy 11 as an isolated abnormality in acute myeloid leukemia is associated with unfavorable prognosis but not with an NPM1 or KIT mutation. Int J Clin Exp Pathol 4(4):371-7, 4/2011.
29. Bains A, Luthra R, Medeiros LJ, Zuo Z. FLT3 and NPM1 mutations in myelodysplastic syndromes: frequency and potential value for predicting progression to acute myeloid leukemia. Am J Clin Pathol 135(1):62-69, 1/2011.
30. Zuo Z, Jones D, Yao H, Thomas DA, O'Brien S, Ravandi F, Kantarjian HM, Abruzzo LV, Medeiros LJ, Chen SS, Luthra R. A pathway-based gene signature correlates with therapeutic response in patients with adult philadelphia-chromosome positive acute lymphoblastic leukemia. Mod Pathol 23(11):1524-34, 11/2010. e-Pub 8/2010.
31. Zuo Z, Polski JM, Kasyan A, Medeiros LJ. Acute erythroid leukemia. Arch Pathol Lab Med 134(9):1261-1270, 9/2010. PMID: 20807044.
32. Kasyan A, Medeiros LJ, Zuo Z, Santos FP, Ravandi-Kashani F, Miranda R, Vadhan-Raj S, Koeppen H, Bueso-Ramos CE. Acute erythroid leukemia as defined in the World Health Organization classification is a rare and pathogenetically heterogeneous disease. Mod Pathol 23(8). e-Pub 5/2010. PMID: 20473273.
33. Chandra P, Luthra R, Zuo Z, Yao H, Ravandi F, Reddy N, Garcia-Manero G, Kantarjian H, Jones D. Acute myeloid leukemia with t(9;11)(p21-22;q23): common properties of dysregulated ras pathway signaling and genomic progression characterize de novo and therapy-related cases. Am J Clin Pathol 133(5):686-93, 5/2010. PMID: 20395514.
34. Zuo Z*, Hasserjian RP* (*equal contributors), Garcia C, Tang G, Kasyan A, Luthra R, Abruzzo LV, Kantarjian HM, Medeiros LJ, Wang SA. Acute erythroid leukemia: a reassessment using criteria refined in the 2008 WHO classification. Blood 115(10):1985-92, 3/2010. e-Pub 12/2009. PMID: 20040759.
35. Luthra R, Zuo Z. COLD-PCR finds hot application in mutation analysis. Clin Chem 55(12):2077-8, 12/2009. e-Pub 10/2009. PMID: 19833831.
36. Zuo Z, Chen SS, Chandra PK, Galbincea JM, Soape M, Doan S, Barkoh BA, Koeppen H, Medeiros LJ, Luthra R. Application of COLD-PCR for improved detection of KRAS mutations in clinical samples. Mod Pathol 22(8):1023-31, 8/2009. e-Pub 5/2009. PMID: 19430420.
37. Chandra P, Plaza JA, Zuo Z, Diwan AH, Koeppen H, Duvic M, Medeiros LJ, Prieto VG. Clusterin expression correlates with stage and presence of large cells in mycosis fungoides. Am J Clin Pathol 131(4):511-5, 4/2009. PMID: 19289586.
38. Zuo Z, Chandra P, Wen YH, Koeppen H. Molecular diagnostics of acute myeloid leukemia. Diagn Histopathol 15(11):531-9, 2009.
39. Zuo Z, Jimenez X, Witte L, Zhu Z. An efficient route to the production of an IgG-like bispecific antibody. Protein Eng 13(5):361-7, 5/2000. PMID: 10835110.
40. Zuo Z, Urban G, Scammell JG, Dean NM, McLean TK, Aragon I, Honkanen RE. Ser/Thr protein phosphatase type 5 (PP5) is a negative regulator of glucocorticoid receptor-mediated growth arrest. Biochemistry 38(28):8849-57, 7/1999. PMID: 10413457.
41. Wang L, Bhattacharjee A, Zuo Z, Hu F, Honkanen RE, Berggren PO, Li M. A low voltage-activated Ca2+ current mediates cytokine-induced pancreatic beta-cell death. Endocrinology 140(3):1200-4, 3/1999. PMID: 10067844.
42. Cheng A, Balczon R, Zuo Z, Koons JS, Walsh AH, Honkanen RE. Fostriecin-mediated G2-M-phase growth arrest correlates with abnormal centrosome replication, the formation of aberrant mitotic spindles, and the inhibition of serine/threonine protein phosphatase activity. Cancer Res 58(16):3611-9, 8/1998. PMID: 9721869.
43. Zuo Z, Dean NM, Honkanen RE. Serine/threonine protein phosphatase type 5 acts upstream of p53 to regulate the induction of p21(WAF1/Cip1) and mediate growth arrest. J Biol Chem 273(20):12250-8, 5/1998. PMID: 9575175.
44. Zuo Z, Mahesh VB, Zamorano PL, Brann DW. Decreased gonadotropin-releasing hormone neurosecretory response to glutamate agonists in middle-aged female rats on proestrus afternoon: a possible role in reproductive aging? Endocrinology 137(6):2334-8, 6/1996. PMID: 8641183.
45. Shi SQ, Zuo Z, Zuo XC. [Ripening effect of mylis and tiluoan on the uterine cervix in pregnant rats]. Zhonghua Fu Chan Ke Za Zhi 29(4):224-6, 253-4, 4/1994. PMID: 8082446.
46. Zuo XC, Shi SQ, Zuo Z. Ripening effects of mylis and dehydroepiandrosterone on uterine cervix of pregnant rats. Acta Academiae Medicinae Sinicae 14(2):136, 1992.
47. Zuo Z, Li SC. A review of Chinese and Western medical research on free radical related diseases and aging. Beijing Journal of Traditional Chinese Medicine 1:58-60, 1991.

Abstracts

1. Barkoh BA, Patel R, Manekia J, Bartley AN, Zuo Z, Patel K, Luthra R. Comparison of SNaPshot® Fluorescent Capillary Electrophoresis and Sequenom® MassARRAY Based Platforms for Multiplex Solid Tumor Mutation Screening. Journal of Molecular Diagnostics 13(6):775, 11/2011.
2. Zuo Z, Greaves WO, Luthra R, Sargent R, Chen SS, Galbincea J, Medeiros L, Yin C. KIT Mutation Is Rare in Acute Myeloid Leukemias, Almost Always Involves Exon 17, and Occurs Predominantly in AML with t(8;21)(q22;q22). Journal of Molecular Diagnostics 13(6):729, 11/2011.
3. Ma D, Luthra R, Chen SS, Yin CC, Sargent RL, Patel KP, Medeiros J, Zuo Z. RAS Mutational Analysis in 9334 Solid and Hematopoietic Malignancies. Modern Pathology 24(Suppl 1):394A (#1677), 2/2011.
4. Zuo Z, Jones D, Yao H, Thomas DA, O'Brien S, Ravandi F, Kantarjian HM, Abruzzo LV, Medeiros LJ, Chen SS, Luthra R. A nine-gene predictor of therapy response in adult Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL). Journal of Clinical Oncology 27(15), 5/2009.
5. Zuo Z, Goel S, Carter JE. Prepartum Cervical Cytologic Changes Correlated with Abnormal Placental Changes and Preterm Delivery. Modern Pathology 22(Suppl. 1):243A, 1/2009.

Book Chapters

1. Zuo Z, Jabbar KJ. COLD-PCR: Applications and Advantages. In: Methods in Molecular Biology: Clinical Applications of PCR. Humana Press, 2014.
2. Jones D, Zuo Z and Chen S. Molecular diagnostics and cytogenetic testing. In: Experimental and Clinical Hematopathology. Ed(s) D Jones. The Humana Press Inc., 2009.

Last updated: 3/6/2015