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Zihua Gong

Present Title & Affiliation

N/A

Bio Statement

Zihua Gong is a Research Faculty Assistant Professor (effective 09/01/2010) in the Department of Experimental Radiation Oncology who works in the Dr. Junjie Chens Lab. He is currently study DNA damage proteins in replication checkpoint control

Research Interests

1. Identification of new protein complexes involved in DNA damage response using a proteomic approach. This work will expand our understanding of the complexity of the signal transduction network in DNA damage pathways. 2. Increased understanding of the DNA damage protein TopBP1 in the replication checkpoint pathway. We will work to define the signaling pathway that controls the recruitment and function of TopBP1 following replication stress. 3. Study the role of tyrosine kinases in the cancer development. We hope to reveal new tyrosine kinases complex for developing or inhibiting cancer. Publications: 1. Gong Z, Chen J. E3 ligase RFWD3 participates in replication checkpoint control. The Journal of biological chemistry, 2011 April 18 [Epub ahead of print] 2. Wang J*, Gong Z*, Chen J. MDC1 collaborates with TopBP1 in DNA replication checkpoint control. The Journal of Cell Biology , 2011, 193: 267-273. (* these authors contributed equally to this work) 3. Leung CC, Gong Z, Chen J, Glover JN. Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control. The Journal of biological chemistry, 2011, 286:4292-301 4. Geunyeong P, Gong Z, Chen J, Kim JE. Characterization of the DOT1L network: Implications of diverse roles for DOT1L. Protein Journal, 2010, 29:213-223. 5. Gong Z, Kim, JE, Leung, CC, Glover, JM, Chen J. BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Molecular Cell, 2010, 37:438-446. 6. Huang J*, Gong Z*, Ghosal G, Chen J. SOSS cooperates with RPA to maintain genomic stability. Molecular Cell, 2009, 35:384-393. (* these authors contributed equally to this work) 7. Gong Z, Cho YW, Kim JE, Ge K, Chen J. Accumulation of Pax2 Transactivation Domain Interaction Protein (PTIP) at Sites of DNA Breaks via RNF8-dependent Pathway Is Required for Cell Survival after DNA Damage. The Journal of biological chemistry, 2009, 284: 7284-93. 8. Gong Z, Brackertz M, Renkawitz R. SUMO modification enhances p66 mediated transcriptional repression of the Mi-2/NuRD complex. Molecular and Cellular Biology, 2006, 26: 4519-28. 9. Brackertz M, Gong Z, Leers J, Renkawitz R. p66 alpha and p66 beta of the Mi-2/NuRD complex mediated MBD2 and histone interaction. Nucleic Acids Research, 2006, 34: 397-406.) 10. Wang X, Gong Z, Wu K, Xu M, Wang P, Yuan Y, Xu B. Gastrointestinal dysmotility in patients with acute pancreatitis. Journal of Gastroenterology and Hepatology, 2003, 18: 57-62. 11. Gong Z, Yuan Y, Lou K, Tu S, Di Z, Xu J. Mechanism of chinese herb emodin and somatostatin analogues on pancreatic regeneration in acute pancreatitis in rats. Pancreas, 2002, 25: 154-60. 12. Wang X, Wang B, Wu K, Xu M, Gong Z. Growth hormone downregulated the excessive apoptosis of ileal intestinal epithelial cells in rats during the early course of acute necrotizing pancreatitis. Pancreas, 2002, 25:205-9. 13. Yuan Y, Gong Z, Lou K, Tu S, Di Z, Xu J. Effects and mechanisms of somatostatin analogues on apoptosis of pancreatic acinar cells in acute pancreatitis in mice. Journal of Gastroenterology and Hepatology, 2001, 16: 683-88. (impact factor:2.317) 14. Yuan YZ, Gong Z, Lou KX, Tu SP, Di ZK, Xu JY. Involvement of apoptosis of alveolar cells in pancreatitis-associate lung injury. World Journal of Gastroenterology, 2000, 6: 920-24.

Education & Training

N/A

Selected Publications

Peer-Reviewed Original Research Articles

1. Wang J, Leung JW, Gong Z, Feng L, Shi X, Chen J. PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis. J Biol Chem 288(5). e-Pub 12/2012. PMID: 23229552.
2. Gong Z, Chen J. E3 ligase RFWD3 participates in replication checkpoint control. J Biol Chem 286(25):22308-13, 6/2011. e-Pub 4/2011. PMCID: PMC3121377.
3. Wang J, Gong Z, Chen J. MDC1 collaborates with TopBP1 in DNA replication checkpoint control. J Cell Biol 193(2):267-73, 4/2011. e-Pub 4/2011. PMCID: PMC3080258.
4. Geunyeong P, Gonz Z, Chen J, Kim JE. Characterization of the DOT1L network: Implications of diverse roles for DOT1L. Protein Journal 29:213-223, 2010.
5. Wang X, Gong Z, Wu K, Xu M, Wang P, yuan Y, Xu B. Gastrointestinal dysmotility in patients with acute pancreatitis. Journal of Gastroenterology and Hepatology 18:57-62, 2003.

Last updated: 4/28/2014