Amjad H. Talukder, PhD
Department of Melanoma Medical Oncology, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Instructor, Department of Melanoma Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1998 | Nagoya University, Nagoya, JPN, PHD, Biochemistry |
| 1989 | Dhaka University, Dhaka, BGD, MS, Biochemistry |
| 1987 | Dhaka University, Dhaka, BGD, BS, Biochemistry |
Postgraduate Training
| 1998-2001 | Research Fellowship, Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX |
Experience & Service
Academic Appointments
Instructor, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2008 - 2011
Other Appointments/Responsibilities
Research Scientist, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2008 - 2008
Research Scientist, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2003 - 2008
Research Associate, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2001 - 2002
Research Officer, Laboratory Science Division, International Center for Diarrheal Disease Research in Bangladesh, Dhaka, 1992 - 1993
Research Assistant, Department of Biochemistry, Dhaka University, Dhaka, 1990 - 1992
Honors & Awards
| 1993 | Scholarship, Nagoya University, Japan |
| 1987 | Scholarship, Dhaka University, Bangladesh |
Selected Publications
Peer-Reviewed Articles
- Bradley SD, Chen Z, Melendez B, Talukder A, Khalili JS, Rodriguez-Cruz T, Liu S, Whittington M, Deng W, Li F, Bernatchez C, Radvanyi LG, Davies MA, Hwu P, Lizée G. BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma. Cancer Immunol Res 3(6):602-9, 2015. e-Pub 2015. PMID: 25795007.
- Talukder AH, Bao M, Kim TW, Facchinetti V, Hanabuchi S, Bover L, Zal T, Liu YJ. Phospholipid scramblase 1 regulates Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. Cell Res 22(7):1129-39, 2012. e-Pub 2012. PMID: 22453241.
- Akinmade D, Talukder AH, Zhang Y, Luo WM, Kumar R, Hamburger AW. Phosphorylation of the ErbB3 binding protein Ebp1 by p21-activated kinase 1 in breast cancer cells. Br J Cancer 98(6):1132-40, 2008. e-Pub 2008. PMID: 18283314.
- Bagheri-Yarmand R, Balasenthil S, Gururaj AE, Talukder AH, Wang YH, Lee JH, Kim YS, Zhang X, Jones DM, Medeiros LJ, Stephens LC, Liu YJ, Lee N, Kim I, Kumar R. Metastasis-associated protein 1 transgenic mice: a new model of spontaneous B-cell lymphomas. Cancer Res 67(15):7062-7, 2007. PMID: 17671172.
- Balasenthil S, Gururaj AE, Talukder AH, Bagheri-Yarmand R, Arrington T, Haas BJ, Braisted JC, Kim I, Lee NH, Kumar R. Identification of Pax5 as a target of MTA1 in B-cell lymphomas. Cancer Res 67(15):7132-8, 2007. PMID: 17671180.
- Manavathi B, Peng S, Rayala SK, Talukder AH, Wang MH, Wang RA, Balasenthil S, Agarwal N, Frishman LJ, Kumar R. Repression of Six3 by a corepressor regulates rhodopsin expression. Proc Natl Acad Sci U S A 104(32):13128-33, 2007. e-Pub 2007. PMID: 17666527.
- Meng Q, Rayala SK, Gururaj AE, Talukder AH, O'Malley BW, Kumar R. Signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, PCBP1. Proc Natl Acad Sci U S A 104(14):5866-71, 2007. e-Pub 2007. PMID: 17389360.
- Acconcia F, Barnes CJ, Singh RR, Talukder AH, Kumar R. Phosphorylation-dependent regulation of nuclear localization and functions of integrin-linked kinase. Proc Natl Acad Sci U S A 104(16):6782-7, 2007. e-Pub 2007. PMID: 17420447.
- Zhang H, Singh RR, Talukder AH, Kumar R. Metastatic tumor antigen 3 is a direct corepressor of the Wnt4 pathway. Genes Dev 20(21):2943-8, 2006. e-Pub 2006. PMID: 17050676.
- Acconcia F, Manavathi B, Mascarenhas J, Talukder AH, Mills G, Kumar R. An inherent role of integrin-linked kinase-estrogen receptor alpha interaction in cell migration. Cancer Res 66(22):11030-8, 2006. PMID: 17108142.
- Rayala SK, den Hollander P, Manavathi B, Talukder AH, Song C, Peng S, Barnekow A, Kremerskothen J, Kumar R. Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells. J Biol Chem 281(28):19092-9, 2006. e-Pub 2006. PMID: 16684779.
- Gururaj AE, Singh RR, Rayala SK, Holm C, den Hollander P, Zhang H, Balasenthil S, Talukder AH, Landberg G, Kumar R. MTA1, a transcriptional activator of breast cancer amplified sequence 3. Proc Natl Acad Sci U S A 103(17):6670-5, 2006. e-Pub 2006. PMID: 16617102.
- Talukder AH, Meng Q, Kumar R. CRIPak, a novel endogenous Pak1 inhibitor. Oncogene 25(9):1311-9, 2006. PMID: 16278681.
- Rayala SK, Talukder AH, Balasenthil S, Tharakan R, Barnes CJ, Wang RA, Aldaz CM, Khan S, Kumar R. P21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation. Cancer Res 66(3):1694-701, 2006. PMID: 16452229.
- Singh RR, Barnes CJ, Talukder AH, Fuqua SA, Kumar R. Negative regulation of estrogen receptor alpha transactivation functions by LIM domain only 4 protein. Cancer Res 65(22):10594-601, 2005. PMID: 16288053.
- Barnes CJ, Li F, Talukder AH, Kumar R. Growth factor regulation of a 26S proteasomal subunit in breast cancer. Clin Cancer Res 11(8):2868-74, 2005. PMID: 15837734.
- Talukder AH, Gururaj A, Mishra SK, Vadlamudi RK, Kumar R. Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator. Mol Cell Biol 24(15):6581-91, 2004. PMID: 15254226.
- Mishra SK, Talukder AH, Gururaj AE, Yang Z, Singh RR, Mahoney MG, Francí C, Vadlamudi RK, Kumar R. Upstream determinants of estrogen receptor-alpha regulation of metastatic tumor antigen 3 pathway. J Biol Chem 279(31):32709-15, 2004. e-Pub 2004. PMID: 15169784.
- Mishra SK, Yang Z, Mazumdar A, Talukder AH, Larose L, Kumar R. Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. Oncogene 23(25):4422-9, 2004. PMID: 15077195.
- Talukder AH, Mishra SK, Mandal M, Balasenthil S, Mehta S, Sahin AA, Barnes CJ, Kumar R. MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions. J Biol Chem 278(13):11676-85, 2003. e-Pub 2003. PMID: 12527756.
- Talukder AH, Bagheri-Yarmand R, Williams RR, Ragoussis J, Kumar R, Raz A. Antihuman epidermal growth factor receptor 2 antibody herceptin inhibits autocrine motility factor (AMF) expression and potentiates antitumor effects of AMF inhibitors. Clin Cancer Res 8(10):3285-9, 2002. PMID: 12374700.
- Kumar R, Wang RA, Mazumdar A, Talukder AH, Mandal M, Yang Z, Bagheri-Yarmand R, Sahin A, Hortobagyi G, Adam L, Barnes CJ, Vadlamudi RK. A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm. Nature 418(6898):654-7, 2002. PMID: 12167865.
- Talukder AH, Wang RA, Kumar R. Expression and transactivating functions of the bZIP transcription factor GADD153 in mammary epithelial cells. Oncogene 21(27):4289-300, 2002. PMID: 12082616.
- Bagheri-Yarmand R, Mandal M, Taludker AH, Wang RA, Vadlamudi RK, Kung HJ, Kumar R. Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells. J Biol Chem 276(31):29403-9, 2001. e-Pub 2001. PMID: 11382770.
- Talukder AH, Jorgensen HF, Mandal M, Mishra SK, Vadlamudi RK, Clark BF, Mendelsohn J, Kumar R. Regulation of elongation factor-1alpha expression by growth factors and anti-receptor blocking antibodies. J Biol Chem 276(8):5636-42, 2001. e-Pub 2000. PMID: 11104760.
- Vadlamudi RK, Wang RA, Talukder AH, Adam L, Johnson R, Kumar R. Evidence of Rab3A expression, regulation of vesicle trafficking, and cellular secretion in response to heregulin in mammary epithelial cells. Mol Cell Biol 20(23):9092-101, 2000. PMID: 11074007.
- Talukder AH, Vadlamudi R, Mandal M, Kumar R. Heregulin induces expression, DNA binding activity, and transactivating functions of basic leucine zipper activating transcription factor 4. Cancer Res 60(2):276-81, 2000. PMID: 10667576.
- Talukder AH, Adam L, Raz A, Kumar R. Heregulin regulation of autocrine motility factor expression in human tumor cells. Cancer Res 60(2):474-80, 2000. PMID: 10667603.
- Kim TW, Hong S, Talukder AH, Pascual V, Liu YJ. Grancalcin (GCA) modulates Toll-like receptor 9 (TLR9)-mediated signaling through its direct interaction with TLR9. Eur J Immunol. e-Pub 2015. PMID: 26648480.
- Talukder AH, Li DQ, Manavathi B, Kumar R. Serine 28 phosphorylation of NRIF3 confers its co-activator function for estrogen receptor-alpha transactivation. Oncogene 27(39):5233-42. e-Pub 2008. PMID: 18521086.
Grant & Contract Support
| Title: | Identification of novel immunotherapy targets for AML using computational Genomics and mass spectrometry |
| Funding Source: | Ladies Leukemia League |
| Role: | Collaborator |
| Title: | Pancreatic Moonshot Program |
| Funding Source: | MDACC Moonshot |
| Role: | Co-Principal Investigator |
| Title: | CRC Moon Shot Program |
| Funding Source: | MDACC Moonshot |
| Role: | Co-Principal Investigator |
| Title: | MD Anderson Cancer Center SPORE in Gastrointestinal Cancer (Project 1) |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |