Meet Behrouz Zand, M.D.
Behrouz Zand, M.D., M.S.
Department of Gynecologic Oncology and Reproductive Medicine, Division of Surgery
About Dr. Zand
Dr. Behrouz Zand is a gynecologic oncologist at MD Anderson Cancer Center. He is an assistant professor in the Department of Gynecologic Oncology and Reproductive Medicine.
Dr. Zand’s primary clinic is in the MD Anderson in the Bay Area Center.
Dr. Zand graduated in 2015 from the MD Anderson Cancer Center Gynecologic Oncology fellowship program, where he was selected as the administrative chief fellow in his final year. He completed his residency in obstetrics and gynecology at Baylor College of Medicine in 2011. Dr. Zand received a Master of Science degree with a focus in Clinical and Translational Science from The University of Texas Graduate School of Biomedical Sciences in 2013.
Dr. Zand has outstanding clinical, interpersonal and leadership skills. His clinical interests are in minimally invasive surgery skilled in standard laparoscopy, robotic surgery, and sentinel lymph node mapping of gynecologic cancers. In addition to surgery, Dr. Zand also has expertise in chemotherapy for gynecologic cancers.
He has authored and co-authored several articles in high impact peer-reviewed journals such as Cancer Cell, Journal of National Cancer Institute, Clinical Cancer Research and Gynecologic Oncology.
Dr. Zand is contributing writer for the Houston Chronicle’s Gray Matters where he writes about the health care system, patient experience, and population health.
Dr. Zand i s a member of the Society of Gynecologic Oncologists, American Medical Association, American Society of Clinical Oncology, and the American College of Obstetricians and Gynecologists. In addition, he serves as a reviewer for the journal of Gynecologic Oncology.
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Gynecologic Oncology and Reproductive Medicine, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Clinical Interests
Minimally invasive surgery in gynecologic cancers, chemotherapy in gynecologic cancers, health systems science, patient experience, population health, and health care quality improvement
Education & Training
Degree-Granting Education
| 2013 | The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA, MS, Masters of Science |
| 2007 | University of Nebraska College of Medicine, Lincoln, NE, USA, MD, Doctor of Medicine |
| 2003 | University of Nebraska, Lincoln, NE, USA, BS, Bachelor of Chemistry |
| 2003 | University of Nebraska, Lincoln, NE, USA, BS, Bachelor of Psychology |
Postgraduate Training
| 2011-2015 | Clinical Fellowship, The University of Texas M.D. Anderson Cancer Center, Houston, TX |
| 2010-2010 | Felix Rutledge Fellowship, The University of Texas M.D. Anderson Cancer Center, Houston, TX |
| 2007-2011 | Clinical Residency, Baylor College of Medicine, Houston, TX |
Board Certifications
| 2018 | American Board of Obstectrics & Gynecology, Gynecologic Oncology |
| 2017 | American Board of Obstetrics and Gynecology |
Experience & Service
Academic Appointments
Administrative Chief Fellow, Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2014 - 2015
Clinical Specialist, Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2013 - 2015
Institutional Committee Activities
Member, Fellowship Admissions Subcommittee, 2013 - 2015
Member, Fellowship Planning Committee, 2012 - 2015
Member, Fellowship Didactic Curriculum Subcommittee, 2011 - 2012
Honors & Awards
| 2012 | Selected researcher, Informatics and Statistics for Metabolomics Workshop, Canadian Bioinformatics Workshops;Ontario, Canada |
| 2009 | Baylor College of Medicine Arthur Faris Sr. M.D. Resident Research Abstract Winner - 2nd place |
| 2007 | Baylor OB/GYN Outstanding Medical Student Educator |
| 2003 | Medical Humanities Program, The University of Nebraska-Lincoln |
| 2003 | University of Nebraska Honor's Program |
| 2003 | Who's Who Among Students |
| 2003 | Golden Key International Honor Society |
| 2003 | National Dean's List |
| 2002 | University of Nebraska Chancellor's Leadership Award |
| 2000 | UCARE Research Scholarship Recipient |
| 1999 | University of Nebraska Dean's List |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Miyake T, Pradeep S, Wu SY, Rupaimoole R, Zand B, Wen Y, Gharpure KM, Nagaraja AS, Hu W, Cho MS, Dalton HJ, Previs RA, Taylor ML, Hisamatsu T, Kang Y, Liu T, Shacham S, McCauley D, Hawke DH, Wiktorowicz JE, Coleman RL, Sood AK. XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A. Clin Cancer Res 21(14):3286-97, 2015. e-Pub 2015. PMID: 25878333.
- Bottsford-Miller J, Choi HJ, Dalton HJ, Stone RL, Cho MS, Haemmerle M, Nick AM, Pradeep S, Zand B, Previs RA, Pecot CV, Crane EK, Hu W, Lutgendorf SK, Afshar-Kharghan V, Sood AK. Differential platelet levels affect response to taxane-based therapy in ovarian cancer. Clin Cancer Res 21(3):602-10, 2015. e-Pub 2014. PMID: 25473001.
- Wen Y, Graybill WS, Previs RA, Hu W, Ivan C, Mangala LS, Zand B, Nick AM, Jennings NB, Dalton HJ, Sehgal V, Ram P, Lee JS, Vivas-Mejia PE, Coleman RL, Sood AK. Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer. Clin Cancer Res 21(2):448-59, 2015. e-Pub 2014. PMID: 25416196.
- Pecot CV, Wu SY, Bellister S, Filant J, Rupaimoole R, Hisamatsu T, Bhattacharya R, Maharaj A, Azam S, Rodriguez-Aguayo C, Nagaraja AS, Morelli MP, Gharpure KM, Waugh TA, Gonzalez-Villasana V, Zand B, Dalton HJ, Kopetz S, Lopez-Berestein G, Ellis LM, Sood AK. Therapeutic silencing of KRAS using systemically delivered siRNAs. Mol Cancer Ther 13(12):2876-85, 2014. e-Pub 2014. PMID: 25281617.
- Rupaimoole R, Wu SY, Pradeep S, Ivan C, Pecot CV, Gharpure KM, Nagaraja AS, Armaiz-Pena GN, McGuire M, Zand B, Dalton HJ, Filant J, Miller JB, Lu C, Sadaoui NC, Mangala LS, Taylor M, van den Beucken T, Koch E, Rodriguez-Aguayo C, Huang L, Bar-Eli M, Wouters BG, Radovich M, Ivan M, Calin GA, Zhang W, Lopez-Berestein G, Sood AK. Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression. Nat Commun 5:5202, 2014. e-Pub 2014. PMID: 25351346.
- Stone RL, Baggerly KA, Armaiz-Pena GN, Kang Y, Sanguino AM, Thanapprapasr D, Dalton HJ, Bottsford-Miller J, Zand B, Akbani R, Diao L, Nick AM, DeGeest K, Lopez-Berestein G, Coleman RL, Lutgendorf S, Sood AK. Focal adhesion kinase: an alternative focus for anti-angiogenesis therapy in ovarian cancer. Cancer Biol Ther 15(7):919-29, 2014. e-Pub 2014. PMID: 24755674.
- Pradeep S, Kim SW, Wu SY, Nishimura M, Chaluvally-Raghavan P, Miyake T, Pecot CV, Kim SJ, Choi HJ, Bischoff FZ, Mayer JA, Huang L, Nick AM, Hall CS, Rodriguez-Aguayo C, Zand B, Dalton HJ, Arumugam T, Lee HJ, Han HD, Cho MS, Rupaimoole R, Mangala LS, Sehgal V, Oh SC, Liu J, Lee JS, Coleman RL, Ram P, Lopez-Berestein G, Fidler IJ, Sood AK. Hematogenous metastasis of ovarian cancer: rethinking mode of spread. Cancer Cell 26(1):77-91, 2014. PMID: 25026212.
- Hu W, Liu T, Ivan C, Sun Y, Huang J, Mangala LS, Miyake T, Dalton HJ, Pradeep S, Rupaimoole R, Previs RA, Han HD, Bottsford-Miller J, Zand B, Kang Y, Pecot CV, Nick AM, Wu SY, Lee JS, Sehgal V, Ram P, Liu J, Tucker SL, Lopez-Berestein G, Baggerly KA, Coleman RL, Sood AK. Notch3 pathway alterations in ovarian cancer. Cancer Res 74(12):3282-93, 2014. e-Pub 2014. PMID: 24743243.
- Roh JW, Huang J, Hu W, Yang X, Jennings NB, Sehgal V, Sohn BH, Han HD, Lee SJ, Thanapprapasr D, Bottsford-Miller J, Zand B, Dalton HJ, Previs RA, Davis AN, Matsuo K, Lee JS, Ram P, Coleman RL, Sood AK. Biologic effects of platelet-derived growth factor receptor α blockade in uterine cancer. Clin Cancer Res 20(10):2740-50, 2014. e-Pub 2014. PMID: 24634380.
- Huang J, Hu W, Bottsford-Miller J, Liu T, Han HD, Zand B, Pradeep S, Roh JW, Thanapprapasr D, Dalton HJ, Pecot CV, Rupaimoole R, Lu C, Fellman B, Urbauer D, Kang Y, Jennings NB, Huang L, Deavers MT, Broaddus R, Coleman RL, Sood AK. Cross-talk between EphA2 and BRaf/CRaf is a key determinant of response to Dasatinib. Clin Cancer Res 20(7):1846-55, 2014. e-Pub 2014. PMID: 24486585.
- Wen Y, Zand B, Ozpolat B, Szczepanski MJ, Lu C, Yuca E, Carroll AR, Alpay N, Bartholomeusz C, Tekedereli I, Kang Y, Rupaimoole R, Pecot CV, Dalton HJ, Hernandez A, Lokshin A, Lutgendorf SK, Liu J, Hittelman WN, Chen WY, Lopez-Berestein G, Szajnik M, Ueno NT, Coleman RL, Sood AK. Antagonism of tumoral prolactin receptor promotes autophagy-related cell death. Cell Rep 7(2):488-500, 2014. e-Pub 2014. PMID: 24703838.
- Cho MS, Vasquez HG, Rupaimoole R, Pradeep S, Wu S, Zand B, Han HD, Rodriguez-Aguayo C, Bottsford-Miller J, Huang J, Miyake T, Choi HJ, Dalton HJ, Ivan C, Baggerly K, Lopez-Berestein G, Sood AK, Afshar-Kharghan V. Autocrine effects of tumor-derived complement. Cell Rep 6(6):1085-95, 2014. e-Pub 2014. PMID: 24613353.
- Liu T, Hu W, Dalton HJ, Choi HJ, Huang J, Kang Y, Pradeep S, Miyake T, Song JH, Wen Y, Lu C, Pecot CV, Bottsford-Miller J, Zand B, Jennings NB, Ivan C, Gallick GE, Baggerly KA, Hangauer DG, Coleman RL, Frumovitz M, Sood AK. Targeting SRC and tubulin in mucinous ovarian carcinoma. Clin Cancer Res 19(23):6532-43, 2013. e-Pub 2013. PMID: 24100628.
- Nishimura M, Jung EJ, Shah MY, Lu C, Spizzo R, Shimizu M, Han HD, Ivan C, Rossi S, Zhang X, Nicoloso MS, Wu SY, Almeida MI, Bottsford-Miller J, Pecot CV, Zand B, Matsuo K, Shahzad MM, Jennings NB, Rodriguez-Aguayo C, Lopez-Berestein G, Sood AK, Calin GA. Therapeutic synergy between microRNA and siRNA in ovarian cancer treatment. Cancer Discov 3(11):1302-15, 2013. e-Pub 2013. PMID: 24002999.
- Kang Y, Hu W, Ivan C, Dalton HJ, Miyake T, Pecot CV, Zand B, Liu T, Huang J, Jennings NB, Rupaimoole R, Taylor M, Pradeep S, Wu SY, Lu C, Wen Y, Huang J, Liu J, Sood AK. Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer. J Natl Cancer Inst 105(19):1485-95, 2013. e-Pub 2013. PMID: 24062525.
- Moreno-Smith M, Halder JB, Meltzer PS, Gonda TA, Mangala LS, Rupaimoole R, Lu C, Nagaraja AS, Gharpure KM, Kang Y, Rodriguez-Aguayo C, Vivas-Mejia PE, Zand B, Schmandt R, Wang H, Langley RR, Jennings NB, Ivan C, Coffin JE, Armaiz GN, Bottsford-Miller J, Kim SB, Halleck MS, Hendrix MJ, Bornman W, Bar-Eli M, Lee JS, Siddik ZH, Lopez-Berestein G, Sood AK. ATP11B mediates platinum resistance in ovarian cancer. J Clin Invest 123(5):2119-30, 2013. e-Pub 2013. PMID: 23585472.
- Ivan C, Hu W, Bottsford-Miller J, Zand B, Dalton HJ, Liu T, Huang J, Nick AM, Lopez-Berestein G, Coleman RL, Baggerly KA, Sood AK. Epigenetic analysis of the Notch superfamily in high-grade serous ovarian cancer. Gynecol Oncol 128(3):506-11, 2013. e-Pub 2012. PMID: 23200915.
- Pecot CV, Rupaimoole R, Yang D, Akbani R, Ivan C, Lu C, Wu S, Han HD, Shah MY, Rodriguez-Aguayo C, Bottsford-Miller J, Liu Y, Kim SB, Unruh A, Gonzalez-Villasana V, Huang L, Zand B, Moreno-Smith M, Mangala LS, Taylor M, Dalton HJ, Sehgal V, Wen Y, Kang Y, Baggerly KA, Lee JS, Ram PT, Ravoori MK, Kundra V, Zhang X, Ali-Fehmi R, Gonzalez-Angulo AM, Massion PP, Calin GA, Lopez-Berestein G, Zhang W, Sood AK. Tumour angiogenesis regulation by the miR-200 family. Nat Commun 4:2427, 2013. PMID: 24018975.
- Cho MS, Bottsford-Miller J, Vasquez HG, Stone R, Zand B, Kroll MH, Sood AK, Afshar-Kharghan V. Platelets increase the proliferation of ovarian cancer cells. Blood 120(24):4869-72, 2012. e-Pub 2012. PMID: 22966171.
- Zand B, Frumovitz M, Jofre MF, Nick AM, Dos Reis R, Munsell MF, Sangi-Haghpeykar H, Levenback C, Soliman PT, Schmeler KM, Ramirez PT. Risk factors for prolonged hospitalization after gynecologic laparoscopic surgery. Gynecol Oncol 126(3):428-31, 2012. e-Pub 2012. PMID: 22668880.
- Lee SJ, Ghosh SC, Han HD, Stone RL, Bottsford-Miller J, Shen DY, Auzenne EJ, Lopez-Araujo A, Lu C, Nishimura M, Pecot CV, Zand B, Thanapprapasr D, Jennings NB, Kang Y, Huang J, Hu W, Klostergaard J, Sood AK. Metronomic activity of CD44-targeted hyaluronic acid-paclitaxel in ovarian carcinoma. Clin Cancer Res 18(15):4114-21, 2012. e-Pub 2012. PMID: 22693353.
- Zand B, Coleman RL, Sood AK. Targeting angiogenesis in gynecologic cancers. Hematol Oncol Clin North Am 26(3):543-63, viii, 2012. PMID: 22520979.
- Zand B, Euscher ED, Soliman PT, Schmeler KM, Coleman RL, Frumovitz M, Jhingran A, Ramondetta LM, Ramirez PT. Rate of para-aortic lymph node micrometastasis in patients with locally advanced cervical cancer. Gynecol Oncol 119(3):422-5, 2010. e-Pub 2010. PMID: 20837355.
- Nagaraja AS, Dorniak PL, Sadaoui NC, Kang Y, Lin T, Armaiz-Pena G, Wu SY, Rupaimoole R, Allen JK, Gharpure KM, Pradeep S, Zand B, Previs RA, Hansen JM, Ivan C, Rodriguez-Aguayo C, Yang P, Lopez-Berestein G, Lutgendorf SK, Cole SW, Sood AK. Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis. Oncogene. e-Pub 2015. PMID: 26257064.
Book Chapters
- Zand B, Freedman R. Early-Stage Ovarian Cancer. In: Encyclopedia of Cancer. 3rd. Springer Berlin Heidelberg, 1196-1200, 2012.
- Kulkarni H, Guntupalli K, Zand B. Pregnancy, Infectious Complications. In: Encyclopedia of Intensive Care Medicine. Springer Berlin Heidelberg, 1803-1815, 2012.
- Zand B, Ramirez PT. Robotic Surgery in Gynecologic Oncology. In: Advanced Gynecologic Endoscopy. InTech, 2011.