Bingbing Dai, Ph.D.

Peer-Reviewed Articles

1. Li X, Lee Y, Kang Y, Dai B, Perez MR, Pratt M, Koay EJ, Kim M, Brekken RA, Fleming JB. Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma. Cell Death Differ 26(2):382-393, 2019. e-Pub 2018. PMID: 30283082.
2. Cao X, Zhao Y, Wang J, Dai B, Gentile E, Lin J, Pu X, Ji L, Wu S, Meraz I, Majidi M, Roth JA. TUSC2 downregulates PD-L1 expression in non-small cell lung cancer (NSCLC). Oncotarget 8(64):107621-107629, 2017. e-Pub 2017. PMID: 29296193.
3. Li X, Kang Y, Roife D, Lee Y, Pratt M, Perez MR, Dai B, Koay EJ, Fleming JB. Prolonged exposure to extracellular lumican restrains pancreatic adenocarcinoma growth. Oncogene 36(38):5432-5438, 2017. e-Pub 2017. PMID: 28534517.
4. Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Matés JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell 32(1):71-87.e7, 2017. PMID: 28697344.
5. Dai B, Roife D, Kang Y, Gumin J, Rios Perez MV, Li X, Pratt M, Brekken RA, Fueyo-Margareto J, Lang FF, Fleming JB. Preclinical Evaluation of Sequential Combination of Oncolytic Adenovirus Delta-24-RGD and Phosphatidylserine-Targeting Antibody in Pancreatic Ductal Adenocarcinoma. Mol Cancer Ther 16(4):662-670, 2017. e-Pub 2017. PMID: 28138026.
6. Roife D, Dai B, Kang Y, Perez MVR, Pratt M, Li X, Fleming JB. Ex Vivo Testing of Patient-Derived Xenografts Mirrors the Clinical Outcome of Patients with Pancreatic Ductal Adenocarcinoma. Clin Cancer Res 22(24):6021-6030, 2016. e-Pub 2016. PMID: 27259561.
7. Kang Y, Roife D, Lee Y, Lv H, Suzuki R, Ling J, Rios Perez MV, Li X, Dai B, Pratt M, Truty MJ, Chatterjee D, Wang H, Thomas RM, Wang Y, Koay EJ, Chiao PJ, Katz MH, Fleming JB. Transforming Growth Factor-β Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors. Clin Cancer Res 22(19):4934-4946, 2016. e-Pub 2016. PMID: 27126993.
8. Li X, Roife D, Kang Y, Dai B, Pratt M, Fleming JB. Extracellular lumican augments cytotoxicity of chemotherapy in pancreatic ductal adenocarcinoma cells via autophagy inhibition. Oncogene 35(37):4881-90, 2016. e-Pub 2016. PMID: 26876211.
9. Li H, Hu J, Wu S, Wang L, Cao X, Zhang X, Dai B, Cao M, Shao R, Zhang R, Majidi M, Ji L, Heymach JV, Wang M, Pan S, Minna J, Mehran RJ, Swisher SG, Roth JA, Fang B. Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells. Oncotarget 7(3):3548-58, 2016. PMID: 26657290.
10. Rios Perez MV, Dai B, Koay EJ, Wolff RA, Fleming JB. Regression of Stage IV Pancreatic Cancer to Curative Surgery and Introduction of a Novel Ex-Vivo Chemosensitivity Assay. Cureus 7(12):e423, 2015. e-Pub 2015. PMID: 26848412.
11. Dai B, Yan S, Lara-Guerra H, Kawashima H, Sakai R, Jayachandran G, Majidi M, Mehran R, Wang J, Bekele BN, Baladandayuthapani V, Yoo SY, Wang Y, Ying J, Meng F, Ji L, Roth JA. Exogenous Restoration of TUSC2 Expression Induces Responsiveness to Erlotinib in Wildtype Epidermal Growth Factor Receptor (EGFR) Lung Cancer Cells through Context Specific Pathways Resulting in Enhanced Therapeutic Efficacy. PLoS One 10(6):e0123967, 2015. e-Pub 2015. PMID: 26053020.
12. Gao W, Wang M, Wang L, Lu H, Wu S, Dai B, Ou Z, Zhang L, Heymach JV, Gold KA, Minna J, Roth JA, Hofstetter WL, Swisher SG, Fang B. Selective antitumor activity of ibrutinib in EGFR-mutant non-small cell lung cancer cells. J Natl Cancer Inst 106(9), 2014. e-Pub 2014. PMID: 25214559.
13. Lu H, Wang L, Gao W, Meng J, Dai B, Wu S, Minna J, Roth JA, Hofstetter WL, Swisher SG, Fang B. IGFBP2/FAK Pathway Is Causally Associated with Dasatinib Resistance in Non-Small Cell Lung Cancer Cells. Mol Cancer Ther 12(12):2864-73, 2013. e-Pub 2013. PMID: 24130049.
14. Dai B, Yoo SY, Bartholomeusz G, Graham RA, Majidi M, Yan S, Meng J, Ji L, Coombes K, Minna JD, Fang B, Roth JA. KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancer. Cancer Res 73(17):5532-43, 2013. e-Pub 2013. PMID: 23824739.
15. Dai B, Gong A, Jing Z, Aldape KD, Kang SH, Sawaya R, Huang S. Forkhead box M1 is regulated by heat shock factor 1 and promotes glioma cells survival under heat shock stress. J Biol Chem 288(3):1634-42, 2013. e-Pub 2012. PMID: 23192351.
16. Liu X, Guo W, Wu S, Wang L, Wang J, Dai B, Kim ES, Heymach JV, Wang M, Girard L, Minna J, Roth JA, Swisher SG, Fang B. Antitumor activity of a novel STAT3 inhibitor and redox modulator in non-small cell lung cancer cells. Biochem Pharmacol 83(10):1456-64, 2012. e-Pub 2012. PMID: 22387047.
17. Dai B, Meng J, Peyton M, Girard L, Bornmann WG, Ji L, Minna JD, Fang B, Roth JA. STAT3 mediates resistance to MEK inhibitor through microRNA miR-17. Cancer Res 71(10):3658-68, 2011. e-Pub 2011. PMID: 21444672.
18. Dai B, Pieper RO, Li D, Wei P, Liu M, Woo SY, Aldape KD, Sawaya R, Xie K, Huang S. FoxM1B Regulates NEDD4-1 Expression, Leading to Cellular Transformation and Full Malignant Phenotype in Immortalized Human Astrocytes. Cancer Res 70(7):2951-61, 2010. e-Pub 2010. PMID: 20332230.
19. Zhang P, Ying L, Xu R, Ge S, Mei W, Li F, Dai B, Lu J, Qian G. Tumor-specific, hypoxia-regulated WWOX expression adenovirus inhibits human non-small cell lung cancer growth in vivo. Hum Gene Ther 21(1):27-39, 2010. e-Pub 2009. PMID: 19737107.
20. Meng J, Dai B, Fang B, Bekele BN, Bornmann WG, Sun D, Peng Z, Herbst RS, Papadimitrakopoulou V, Minna JD, Peyton M, Roth JA. Combination treatment with MEK and AKT inhibitors is more effective than each drug alone in human non-small cell lung cancer in vitro and in vivo. PLoS One 5(11):e14124, 2010. e-Pub 2010. PMID: 21124782.
21. Meng J, Peng H, Dai B, Guo W, Wang L, Ji L, Minna JD, Chresta CM, Smith PD, Fang B, Roth JA. High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886). Cancer Biol Ther 8(21):2073-80, 2009. e-Pub 2009. PMID: 19783898.
22. Cai R, Xu W, Dai B, Cai X, Xu R, Lu J. SATB1 binds an intronic MAR sequence in human P13kgamma in vitro. Mol Biol Rep, 2009. e-Pub 2009. PMID: 19430959.
23. Li Q, Zhang N, Jia Z, Le X, Dai B, Wei D, Huang S, Tan D, Xie K. Critical role and regulation of transcription factor FoxM1 in human gastric cancer angiogenesis and progression. Cancer Res 69(8):3501-3509, 2009. e-Pub 2009. PMID: 19351851.
24. Zhang Y, Zhang N, Dai B, Liu M, Xie K, Sawaya R, Huang S. FoxM1B transcriptionally regulates vascular endothelial growth factor expression and promotes the angiogenesis and growth of glioma cells. Cancer Res 68(21):8733-8742, 2008. PMID: 18974115.
25. Dai B, Kang SH, Gong W, Liu M, Aldape KD, Sawaya R, Huang S. Aberrant FoxM1B expression increases matrix metalloproteinase-2 transcription and enhances the invasion of glioma cells. Oncogene 26(42):6212-6219, 2007. e-Pub 2007. PMID: 17404569.
26. Li K, Cai R, Dai B, Zhang XQ, Wang HJ, Ge SF, Xu WR, Lu J.. SATB1 regulates SPARC expression in K562 cell line through binding to a specific sequence in the third intron. Biochem Biophys Res Commun 356(1):6-12, 2007. e-Pub 2007. PMID: 17343824.
27. Liu M, Dai B, Kang SH, Ban K, Huang FJ, Lang FF, Aldape KD, Xie TX, Pelloski CE, Xie K, Sawaya R, Huang S. FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells. Cancer Res 66(7):3593-3602, 2006. PMID: 16585184.
28. Dai B, Ying L, Cai R, Li Y, Zhang X, Lu J, Qian G. Identification of a nuclear matrix attachment region like sequence in the last intron of PI3Kgamma. Biochem Biophys Res Commun 341(2):583-90, 2006. e-Pub 2006. PMID: 16430866.
29. Zhao Q, Chen N, Wang WM, Lu J, Dai B. Effect of transforming growth factor-beta on activity of connective tissue growth factor gene promoter in mouse NIH/3T3 fibroblasts. Acta Pharmacol Sin 25(4):485-489, 2004. PMID: 15066218.
30. Chen S, Dai B. Progress and perspective of gene therapy. Chin J Oncol 24:313-315, 2002.

Invited Articles

1. Dai B, Fang B, Roth JA. RNAi-Induced Synthetic Lethality in Cancer Therapy. Cancer Biol Ther 8(23), 2009. e-Pub 2009. PMID: 19949302.

Abstracts

1. Dai B, Free D, Sorrentino J, Augustine J, Hughes T, Kang Y, Roberts P, Fleming J, Kim P.. CDK4/6 inhibition with lerociclib (G1T38) enhances response to PI3K or ERK inhibitors in high-throughput, ex vivo pancreatic PDX screens. AACR Annual Meeting 2019 in Atlanta, Georgia, 2019.
2. Dai B, Liu W, Heymach JV, Byers LA, Wang J, Coombes KR, Fang B, Roth JA.. Identify signaling responses to MEK inhibitor AZD6244 in lung cancer cells with proteomics reverse phase protein array. 102th AACR Annual Meeting, 2012.
3. Dai B, Meng J, Peyton M, Girard L, Bornmann WG, Ji L, Minna JD, Fang B, Roth JA.. STAT3 mediates resistance to MEK inhibitor through microRNA miR-17. 101th AACR Annual Meeting, 2011.
4. Dai B, Jing Z, Kang SH, Li D, Xie K and Huang S.. FOXM1 is regulated by HSF1 and protects glioma cells from heat shock stress-induced cell death. 15th Annual Meeting of the Society for Neuro-Oncology, 2010.
5. Dai B, Pieper R, Gu H, Aldape K, Xie K, Sawaya R, Huang S.. FoxM1B overexpression critically contributes to human astrocyte transformation and glioblastoma multiforme formation. The Thirteenth Annual Meeting of the Society for Neuro-Oncology, 2008.
6. Dai B, Kang SH, Gong W, Aldape K, Sawaya R and Huang S.. Aberrant FoxM1B expression increases matrix metalloproteinase-2 transcription andenhances the invasion of glioma cells. 98th AACR Annual Meeting, 2007.
7. Dai B, Kang SH, Lang FF, Pelloski CE, Aldape KD, Sawaya R, Huang S.. FoxM1B Is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells. Eleventh Annual Meeting of the Society for Neuro-Oncology, 2006.

Book Chapters

1. Dai B, Chen S. Molecular basis of gastric-colorectal cancer. In: Shanghai International Books Publishing Company. Shanghai International Books Publishing Company: Shanghai, China, 2004.
2. Dai B, Chen S.. Oncogene and tumor suppressor gene. In: Med Mol Cell Biol. 2nd. Shanghai Science and Technology Publishing Company: Shanghai, China, 2003.