Meet Cullen Taniguchi, M.D., Ph.D.
Cullen M. Taniguchi, M.D., Ph.D.
Department of GI Radiation Oncology, Division of Radiation Oncology
About Dr. Taniguchi
Dr. Taniguchi is an Associate Professor at UT MD Anderson Cancer Center, with a joint appointment in Gastrointestinal Radiation Oncology and Experimental Radiation Oncology. He is a physician scientist specializing in gastrointestinal malignancies, with a clinical and research focus on pancreatic cancer. The NIH and CPRIT-funded Taniguchi Lab studies the biology of hypoxia (low oxygen) and how it can be used to improve cancer responses by both reducing normal tissue toxicity and enhancing killing of cancer cells chiefly through a molecule called hypoxia inducible factor-2 (HIF2). His scientific work has garnered national recognition as a V Foundation Scholar, Kimmel Scholar, ASCI Young Investigator, J.W. Osborne Award from the RRS and a AAAS Fellowship. Dr. Taniguchi has leveraged his translational work as the PI of three investigator-initiated trials at MD Anderson. He is also a co-PI on NASA-funded studies with Baylor and a U54 Grant between the University of Puerto Rico and MDACC to enhance the basic and clinical oncology efforts in Puerto Rico, with an emphasis on understanding the reasons behind the significant cancer disparities that impact minority populations. He will use these experiences to help to build and lead the already strong Translational Science Program in the Division of Radiation Oncology at MD Anderson.
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of GI Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Associate Professor, Department of Experimental Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2008 | Harvard Medical School, Boston, MA, USA, MD, Medicine |
| 2005 | Harvard Medical School, Boston, MA, USA, PHD, Cell and Developmental Biology |
| 2000 | University of Oxford, Linacre College, Oxford, GBR, M Phil, Economic and Social History |
| 1998 | Occidental College, Los Angeles, CA, USA, AB, Chemistry |
Postgraduate Training
| 2013-2014 | Research Fellowship, Radiation Oncology, Stanford University, Stanford, CA |
| 2009-2013 | Clinical Residency, Radiation Oncology, Stanford University, Stanford, CA |
| 2008-2009 | Transitional Internship, Santa Clara Valley Medical Center, San Jose, CA |
Board Certifications
| 2014 | American Board of Radiology |
Experience & Service
Academic Appointments
Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2014 - 2020
Honors & Awards
| 2020 | Cancer Research Early Career investigator Award, AACR |
| 2020 | Faculty Scholar Award |
| 2020 | J.W. Osborne Award, Radiation Research Society |
| 2019 | MERIT Award, ASCO Breakthrough |
| 2019 | Early Career Investigator Award, Radiation Research Society |
| 2017 | ASCI Young Clinical Investigator Award |
| 2016 | Sabin Family Fellow, Andrew Sabin Family Fellowship Foundation |
| 2014 | McNair Scholar, The Robert and Janice McNair Foundation |
| 2014 | CPRIT Scholar, Cancer Prevention Research Institute of Texas |
| 2012 | MERIT Award, American Society of Clinical Oncology |
| 2011 | Resident Clinical Poster Award (2nd Place), American Society of Radiation Oncology |
| 2005 | Basic Science Student Award, Endocrine Society |
| 2004 | Medical Scholar, American Diabetes Association |
| 1998 | Scholarship, Glaxo Welcome |
| 1998 | Rhodes Scholarship, The Rhodes Trust |
| 1997 | Scholar, Howard Hughes Medical Institute |
| 1996 | Barry M Goldwater Scholarship, Barry M. Goldwater Scholarship and Excellence in Education Foundation |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Dodoo GN, De B, Lee SS, Abi Jaoude J, Vauthey JN, Tzeng CD, Tran Cao HS, Katlowitz KA, Mandel JJ, Beckham TH, Minsky BD, Smith GL, Holliday EB, Koong AC, Das P, Taniguchi CM, Javle M, Koay EJ, Ludmir EB. Brain Metastases from Biliary Tract Cancer: Case Series and Clinicogenomic Analysis. Oncologist. e-Pub 2023. PMID: 36715178.
- Hsieh RC, Krishnan S, Wu RC, Boda AR, Liu A, Winkler M, Hsu WH, Lin SH, Hung MC, Chan LC, Bhanu KR, Srinivasamani A, De Azevedo RA, Chou YC, DePinho RA, Gubin M, Vilar E, Chen CH, Slay R, Jayaprakash P, Hegde SM, Hartley G, Lea ST, Prasad R, Morrow B, Couillault CA, Steiner M, Wang CC, Venkatesulu BP, Taniguchi C, Kim YSB, Chen J, Rudqvist NP, Curran MA. ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer. Sci Immunol 7(72):eabl9330, 2022. e-Pub 2022. PMID: 35687697.
- Kouzy R, Abi Jaoude J, Minsky BD, Das P, Koong AC, Subbiah IM, Ludmir EB, Taniguchi CM*. Gastrointestinal malignancies and supportive care trials: a snapshot of the last two decades. BMJ Support Palliat Care 12(1):42-45, 2022. e-Pub 2020. PMID: 32943466.
- Vichaya EG, Ford BG, Moltenkine JM, Taniguchi CM, Phillip West A, Dantzer R. Sex differences in the behavioral and immune responses of mice to tumor growth and cancer therapy. Brain Behav Immun 98:161-172, 2021. e-Pub 2021. PMID: 34418499.
- Lee JJ, Bernard V, Semaan A, Monberg ME, Huang J, Stephens BM, Lin D, Rajapakshe KI, Weston BR, Bhutani MS, Haymaker CL, Bernatchez C, Taniguchi CM, Maitra A, Guerrero PA. Elucidation of tumor-stromal heterogeneity and the ligand-receptor interactome by single cell transcriptomics in real-world pancreatic cancer biopsies. Clin Cancer Res 27(21):5912-5921, 2021. e-Pub 2021. PMID: 34426439.
- Christopherson KM, Das P, Berlind C, Lindsay WD, Ahern C, Smith BD, Subbiah I, Koay EJ, Koong AC, Holliday EB, Ludmir EB, Minsky B, Taniguchi CM, Smith GL. A Machine Learning Model Approach to Risk-Stratify Gastrointestinal (GI) Cancer Patients for Hospitalization and Mortality Outcomes. Int J Radiat Oncol Biol Phys 111(1):135-142, 2021. e-Pub 2021. PMID: 33933480.
- Niedzielski JS, Liu Y, Ng SSW, Martin RM, Perles LA, Beddar S, Rebueno N, Koay EJ, Taniguchi CM, Holliday EB, Das P, Smith GL, Minsky BD, Ludmir EB, Herman JM, Koong A, Sawakuchi GO. Dosimetric uncertainties resulting from interfractional anatomic variations for patients receiving pancreas stereotactic body radiation therapy and cone-beam CT image guidance. Int J Radiat Oncol Biol Phys. e-Pub 2021. PMID: 34400267.
- Abi Jaoude J, Kouzy R, Rooney M, Thompson P, Patel R, Turner MC, Ghabach M, Fuller CD, Minsky BD, Taniguchi CM, Ludmir EB. Impact factor and citation metrics in phase III cancer trials. Oncotarget 12(18):1780-1786, 2021. e-Pub 2021. PMID: 34504650.
- Abi Jaoude J, Kouzy R, Ghabach M, Patel R, Pasalic D, Ghossain E, Miller AB, Lin TA, Verma V, Fuller CD, Subbiah V, Minsky BD, Ludmir EB, Taniguchi CM*. Food and Drug Administration approvals in phase 3 Cancer clinical trials. BMC Cancer 21(1):695, 2021. e-Pub 2021. PMID: 34118915.
- Garcia Garcia CJ, Abi Jaoude J, Taniguchi CM*. ADAM10 Evens Out the Double-Edged Sword of Radiotherapy in Pancreatic Cancer. Cancer Res 81(12):3158-3159, 2021. PMID: 34224375.
- Hester R, Advani S, Rashid A, Holliday E, Messick C, Das P, You YN, Taniguchi CM, Koay EJ, Bednarski B, Rodriguez-Bigas M, Skibber J, Wolff R, Chang GJ, Minsky BD, Foo WC, Rothschild N, Morris VK, Eng C. CEA as a blood-based biomarker in anal cancer. Oncotarget 12(11):1037-1045, 2021. e-Pub 2021. PMID: 34084278.
- Lin D, Moningi S, Abi Jaoude J, Singh BS, Cazacu IM, Kouzy R, Nogueras Gonzalez GM, Angsuwatcharakon P, Herman JM, Bhutani MS, Taniguchi CM*. Development of an Objective Scoring System for Endoscopic Assessment of Radiation-Induced Upper Gastrointestinal Toxicity. Cancers (Basel) 13(9):2136, 2021. e-Pub 2021. PMID: 33946696.
- De B, Ng SP, Liu AY, Avila S, Tao R, Holliday EB, Brownlee Z, Kaseb A, Lee S, Raghav K, Vauthey JN, Minsky BD, Herman JM, Das P, Smith GL, Taniguchi CM, Krishnan S, Crane CH, Grassberger C, Hong TS, Lin SH, Koong AC, Mohan R, Koay EJ. Radiation-Associated Lymphopenia and Outcomes of Patients with Unresectable Hepatocellular Carcinoma Treated with Radiotherapy. J Hepatocell Carcinoma 8:57-69, 2021. e-Pub 2021. PMID: 33688489.
- Abi Jaoude J, Kouzy R, Nguyen ND, Lin D, Noticewala SS, Ludmir EB, Taniguchi CM*. Radiation therapy for patients with locally advanced pancreatic cancer: Evolving techniques and treatment strategies. Curr Probl Cancer 44(6):100607, 2020. e-Pub 2020. PMID: 32471736.
- Kouzy R, Abi Jaoude J, Lin D, El Alam MB, Minsky BD, Koay EJ, Das P, Holliday EB, Klopp AH, Colbert LE, Taniguchi CM*. Patient-Reported GI Outcomes in Patients With Anal Cancer Receiving Modern Chemoradiation. JCO Oncol Pract 16(12):OP2000122, 2020. e-Pub 2020. PMID: 32609585.
- Abi Jaoude J, Kouzy R, Minsky BD, Fuller CD, Yuan Y, Do KA, Taniguchi CM, Ludmir EB. Sponsor-involved statistical analyses in Phase III cancer clinical trials. Int J Cancer 147(12):3579-3581, 2020. e-Pub 2020. PMID: 32621758.
- Hoffe S, Frakes JM, Aguilera TA, Czito B, Palta M, Brookes M, Schweizer C, Colbert L, Moningi S, Bhutani MS, Pant S, Tzeng CW, Tidwell RS, Thall P, Yuan Y, Moser EC, Holmlund J, Herman J, Taniguchi CM*. Randomized, Double-Blinded, Placebo-controlled Multicenter Adaptive Phase 1-2 Trial of GC 4419, a Dismutase Mimetic, in Combination with High Dose Stereotactic Body Radiation Therapy (SBRT) in Locally Advanced Pancreatic Cancer (PC). Int J Radiat Oncol Biol Phys 108(5):1399-1400, 2020. e-Pub 2020. PMID: 33427657.
- Slagowski JM, Colbert LE, Cazacu IM, Singh BS, Martin R, Koay EJ, Taniguchi CM, Koong AC, Bhutani MS, Herman JM, Beddar S. Evaluation of the Visibility and Artifacts of 11 Common Fiducial Markers for Image Guided Stereotactic Body Radiation Therapy in the Abdomen. Pract Radiat Oncol 10(6):434-442, 2020. e-Pub 2020. PMID: 31988039.
- Koay EJ, Hanania AN, Hall WA, Taniguchi CM, Rebueno N, Myrehaug S, Aitken KL, Dawson LA, Crane CH, Herman JM, Erickson B. Dose-Escalated Radiation Therapy for Pancreatic Cancer: A Simultaneous Integrated Boost Approach. Pract Radiat Oncol 10(6):e495-e507, 2020. e-Pub 2020. PMID: 32061993.
- Kouzy R, Abi Jaoude J, Mainwaring W, Lin TA, Miller AB, Jethanandani A, Espinoza AF, Verma V, Fuller CD, Minsky BD, Rödel C, Taniguchi CM, Ludmir EB. Professional Medical Writer Assistance in Oncology Clinical Trials. Oncologist 25(11):e1812-e1815, 2020. e-Pub 2020. PMID: 32885898.
- Fuentes NR, Phan J, Huang Y, Lin D, Taniguchi CM*. Resolving the HIF paradox in pancreatic cancer. Cancer Lett 489:50-55, 2020. e-Pub 2020. PMID: 32512024.
- Abi Jaoude J, Kouzy R, El Alam MB, Subbiah V, Taniguchi CM, Ludmir EB, Lin TA. Exclusion of Older Adults in COVID-19 Clinical Trials. Mayo Clin Proc 95(10):2293-2294, 2020. e-Pub 2020. PMID: 33012364.
- Abi Jaoude J, Kouzy R, Mainwaring W, Lin TA, Miller AB, Jethanandani A, Espinoza AF, Pasalic D, Verma V, VanderWalde NA, Smith BD, Smith GL, Fuller CD, Das P, Minsky BD, Rödel C, Fokas E, Jagsi R, Thomas CR, Subbiah IM, Taniguchi CM, Ludmir EB. Performance Status Restriction in Phase III Cancer Clinical Trials. J Natl Compr Canc Netw 18(10):1322-1326, 2020. e-Pub 2020. PMID: 33022640.
- Lukovic J, Kim JJ, Krzyzanowska M, Chadi SA, Taniguchi CM, Hosni A. Anal Adenocarcinoma: A Rare Malignancy in Need of Multidisciplinary Management. JCO Oncol Pract 16(10):635-640, 2020. PMID: 33049179.
- Stecklein SR, Taniguchi CM, Melancon AD, Lombe D, Lishimpi K, Banda L, Mwaba C, Pupwe G, Mwale M, Munkupa H, Kanduza M, Mule B, Mwale A, Court L, Ohrt JD, Kupferman ME, Jhingran A, Msadabwe-Chikuni SC. Radiation Sciences Education in Africa: An Assessment of Current Training Practices and Evaluation of a High-Yield Course in Radiation Biology and Radiation Physics. JCO Glob Oncol 6:1631-1638, 2020. PMID: 33108232.
- Kouzy R, Abi Jaoude J, Lin D, Nguyen ND, El Alam MB, Ludmir EB, Taniguchi CM*. Patient-Reported Outcome Measures in Pancreatic Cancer Receiving Radiotherapy. Cancers (Basel) 12(9), 2020. e-Pub 2020. PMID: 32887363.
- Kouzy R, Abi Jaoude J, Garcia Garcia CJ, El Alam MB, Taniguchi CM, Ludmir EB. Characteristics of the Multiplicity of Randomized Clinical Trials for Coronavirus Disease 2019 Launched During the Pandemic. JAMA Netw Open 3(7):e2015100, 2020. e-Pub 2020. PMID: 32658285.
- Kouzy R, Abi Jaoude J, Yue J, Maldonado JA, Taniguchi CM, Ludmir EB, Colbert LE. Applying to Radiation Oncology Amid a Pandemic. Adv Radiat Oncol 5(4):777-779, 2020. e-Pub 2020. PMID: 32775792.
- Lin D, Kouzy R, Abi Jaoude J, Noticewala SS, Delgado Medrano AY, Klopp AH, Taniguchi CM, Colbert LE. Microbiome Factors in HPV-driven Carcinogenesis and Cancers,. PLoS Pathog 16(6):e1008524, 2020. e-Pub 2020. PMID: 32497113.
- Gronberg MP, Tailor RC, Smith SA, Kry SF, Followill DS, Stojadinovic S, Niedzielski JS, Lindsay PE, Krishnan S, Aguirre F, Fujimoto TN, Taniguchi CM, Howell RM. A Mail Audit Independent Peer Review System for Dosimetry Verification of a Small Animal Irradiator. Radiat Res 193(4):341-350, 2020. e-Pub 2020. PMID: 32068498.
- de la Cruz Bonilla M, Stemler KM, Jeter-Jones S, Fujimoto TN, Molkentine J, Asencio Torres GM, Zhang X, Broaddus RR, Taniguchi CM, Piwnica-Worms H. Fasting reduces intestinal radiotoxicity enabling dose-escalated radiotherapy for pancreatic cancer. Int J Radiat Oncol Biol Phys 105(3):537-547, 2019. e-Pub 2019. PMID: 31271824.
- Choi GW, Suh Y, Das P, Herman J, Holliday E, Koay E, Koong AC, Krishnan S, Minsky BD, Smith GL, Taniguchi CM, Beddar S. Assessment of setup uncertainty in hypofractionated liver radiation therapy with a breath-hold technique using automatic image registration-based image guidance. Radiat Oncol 14(1):154, 2019. e-Pub 2019. PMID: 31470860.
- Moningi S, Ludmir EB, Praveen P, Williamson T, Melkun MM, Herman JD, Krishnan S, Koay EJ, Koong AC, Minsky BD, Smith GL, Taniguchi CM, Das Praj, Holliday EB. Definitive hyperfractionated, accelerated proton reirradiation for patients with pelvic malignancies. Science Direct 19:59-65, 2019. e-Pub 2019. PMID: 31517071.
- Yu M, Nguyen ND, Huang Y, Lin D, Fujimoto TN, Molkentine JM, Deorukhkar A, Kang Y, San Lucas FA, Fernandes CJ, Koay EJ, Gupta S, Ying H, Koong AC, Herman JM, Fleming JB, Maitra A, Taniguchi CM*. Mitochondrial fusion exploits a therapeutic vulnerability of pancreatic cancer. JCI Insight 5, 2019. e-Pub 2019. PMID: 31335325.
- Fujimoto TN, Colbert LE, Huang Y, Molkentine JM, Deorukhkar A, Baseler L, de la Cruz Bonilla , Yu M, Lin D, Gupta S, Cabeceiras PK, Kingsley CV, Tailor RC, Sawakuchi GO, Koay EJ, Piwnica-Worms H, Maitra A, Taniguchi CM*. Selective EGLN Inhibition Enables Ablative Radiotherapy and Improves Survival in Unresectable Pancreatic Cancer. Cancer Res 79(9):2327-2338, 2019. PMID: 31043430.
- Bhutani MS, Cazacu IM, Luzuriaga Chavez AA, Singh BS, Wong FCL, Erwin WD, Tamm EP, Mathew GG, Le DB, Koay EJ, Taniguchi CM, Minsky BD, Pant S, Tzeng CD, Koong AC, Varadhachary GR, Katz MHG, Wolff RA, Fogelman DR, Herman JM. Novel EUS-guided brachytherapy treatment of pancreatic cancer with phosphorus-32 microparticles: first United States experience. VideoGIE 4(5):223-225, 2019. e-Pub 2019. PMID: 31065616.
- Bernard V, Semaan A, Huang J, San Lucas FA, Mulu FC, Stephens BM, Guerrero PA, Huang Y, Zhao J, Kamyabi N, Sen S, Scheet PA, Taniguchi CM, Kim MP, Tzeng CW, Katz MH, Singhi AD, Maitra A, Alvarez HA. Single Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression. Clin Cancer Res 25(7):2194-2205, 2019. e-Pub 2018. PMID: 30385653.
- Coronel E, Cazacu IM, Sakuraba A, Luzuriaga Chavez AA, Uberoi A, Geng Y, Tomizawa Y, Saftoiu A, Shin EJ, Taniguchi CM, Koong AC, Herman JM, Bhutani MS. EUS-guided fiducial placement for GI malignancies: a systematic review and meta-analysis. Gastrointest Endosc 89(4):659-670.e18, 2019. e-Pub 2018. PMID: 30445001.
- Chadha AS, Gunther JR, Hsieh CE, Aliru M, Mahadevan LS, Venkatesulu BP, Crane CH, Das P, Herman JM, Koay EJ, Taniguchi CM, Holliday EB, Minsky BD, Suh Y, Park P, Sawakuchi G, Beddar S, Odisio BC, Gupta S, Loyer E, Kaur H, Raghav K, Javle MM, Kaseb AO, Krishnan S. Proton beam therapy outcomes for localized unresectable hepatocellular carcinoma. Radiother Oncol 133:54-61, 2019. e-Pub 2019. PMID: 30935582.
- Molkentine JM, Fujimoto TN, Horvath TD, Grossberg AJ, Garcia CJG, Deorukhkar A, de la Cruz Bonilla M, Lin D, Samuel ELG, Chan WK, Lorenzi PL, Piwnica-Worms H, Dantzer R, Tour JM, Mason KA, Taniguchi CM*. Enteral Activation of WR-2721 Mediates Radioprotection and Improved Survival from Lethal Fractionated Radiation. Sci Rep 9(1):1949, 2019. e-Pub 2019. PMID: 30760738.
- Bernard V, Kim DU, San Lucas FA, Castillo J, Allenson K, Mulu FC, Stephens BM, Huang J, Semaan A, Guerrero PA, Kamyabi N, Zhao J, Hurd MW, Koay EJ, Taniguchi CM, Herman JM, Javle M, Wolff R, Katz M, Varadhachary G, Maitra A, Alvarez HA. Circulating Nucleic Acids Are Associated With Outcomes Of Patients With Pancreatic Cancer. Gastroenterology 156(1):108-118.e4, 2019. e-Pub 2018. PMID: 30240661.
- Koay EJ, Lee Y, Cristini V, Lowengrub JS, Kang Y, Lucas FAS, Hobbs BP, Ye R, Elganainy D, Almahariq M, Amer AM, Chatterjee D, Yan H, Park PC, Rios Perez MV, Li D, Garg N, Reiss KA, Yu S, Chauhan A, Zaid M, Nikzad N, Wolff RA, Javle M, Varadhachary GR, Shroff RT, Das P, Lee JE, Ferrari M, Maitra A, Taniguchi CM, Kim MP, Crane CH, Katz MH, Wang H, Bhosale P, Tamm EP, Fleming JB. A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma. Clin Cancer Res 24(23):5883-5894, 2018. e-Pub 2018. PMID: 30082477.
- Elganainy D, Holliday EB, Taniguchi CM, Smith GL, Shroff R, Javle M, Raghav K, Kaseb A, Aloia TA, Vauthey JN, Tzeng CD, Herman JM, Koong AC, Krishnan SX, Minsky BD, Crane CH, Das P, Koay EJ. Dose escalation of radiotherapy in unresectable extrahepatic cholangiocarcinoma. Cancer Med 7(10):4880-4892, 2018. e-Pub 2018. PMID: 30152073.
- Jensen G, Tao R, Eng C, Skibber JM, Rodriguez-Bigas M, Chang GJ, You YN, Bednarski BK, Minsky BD, Koay E, Taniguchi CM, Krishnan S, Das P. Treatment of primary rectal adenocarcinoma after prior pelvic radiation: The role of hyperfractionated accelerated reirradiation. Adv Radiat Oncol 3(4):595-600, 2018. e-Pub 2018. PMID: 30370360.
- Colbert LE, Rebueno N, Moningi S, Beddar S, Sawakuchi GO, Herman JM, Koong AC, Das P, Holliday EB, Koay EJ, Taniguchi CM*. Dose escalation for locally advanced pancreatic cancer: How high can we go?. Adv Radiat Oncol 3(4):693-700, 2018. e-Pub 2018. PMID: 30370371.
- de la Cruz Bonilla M, Stemler KM, Taniguchi CM, Piwnica-Worms H. Stem cell enriched-epithelial spheroid cultures for rapidly assaying small intestinal radioprotectors and radiosensitizers in vitro. Sci Rep 8(1):15410, 2018. e-Pub 2018. PMID: 30337664.
- Hunt A, Das P, Minsky BD, Koay EJ, Krishnan S, Herman JM, Taniguchi CM, Koong A, Smith GL, Holliday EB. Hyperfractionated abdominal reirradiation for gastrointestinal malignancies. Radiat Oncol 13(1):143, 2018. e-Pub 2018. PMID: 30086784.
- Amer AM, Zaid M, Chaudhury B, Elganainy D, Lee Y, Wilke CT, Cloyd J, Wang H, Maitra A, Wolff RA, Varadhachary G, Overman MJ, Lee JE, Fleming JB, Tzeng CW, Katz MH, Holliday EB, Krishnan S, Minsky BD, Herman JM, Taniguchi CM, Das P, Crane CH, Le O, Bhosale P, Tamm EP, Koay EJ. Imaging-Based biomarkers: Changes in the Tumor Interface of Pancreatic Ductal Adenocarcinoma on Computed Tomography Scans Indicate Response to Cytotoxic Therapy. Cancer 15(124):1701-1709, 2018. e-Pub 2018. PMID: 29370450.
- Holliday EB, Hunt A, You YN, Chang GJ, Skibber JM, Rodriguez-Bigas MA, Bednarski BK, Eng C, Koay EJ, Minsky BD, Taniguchi CM, Krishnan S, Herman JM, Das P. Short Course Radiation as a Component of Definitive Multidisciplinary Treatment for Select Patients with Metastatic Rectal Adenocarcinoma. J Gastrointest Oncol 8(6):990-997, 2017. PMID: 29299359.
- Huang Y, Lin D, Taniguchi CM*. Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe?. Sci China Life Sci 60(10):1114-1124, 2017. e-Pub 2017. PMID: 29039125.
- Colbert LE, Moningi S, Chadha A, Amer A, Lee Y, Wolff RA, Varadhachary G, Fleming J, Katz M, Das P, Krishnan S, Koay EJ, Park P, Crane CH, Taniguchi CM*. Dose escalation with an IMRT technique in 15 to 28 fractions is better tolerated than standard doses of 3DCRT for LAPC. Adv Radiat Oncol 2(3):403-415, 2017. e-Pub 2017. PMID: 29114609.
- Holliday EB, Tao R, Brownlee Z, Das P, Krishnan S, Taniguchi CM , Minsky BD, Herman JM, Kaseb A, Raghav K, Conrad C, Vauthey JN, Aloia TA, Chun YS, Crane CH, Koay EJ. Definitive radiation therapy for hepatocellular carcinoma with portal vein tumor thrombus. Clin Transl Radiat Oncol 7(4):39-45, 2017. e-Pub 2017. PMID: 29594206.
- Suh HN, Jun S, Oh AY, Srivastava M, Lee S, Taniguchi CM, Zhang S, Lee WS, Chen J, Park BJ, Park JI. Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia. Sci Rep 6:38273, 2016. e-Pub 2016. PMID: 27922049.
- LaGory EL, Wu C, Taniguchi CM, Ding CK, Chi JT, von Eyben R, Scott DA, Richardson AD, Giaccia AJ. Suppression of PGC-1α is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma. Cell Rep 12(1):116-127, 2015. e-Pub 2015. PMID: 26119730.
- Taniguchi CM, Miao YR, Diep AN, Wu C, Rankin EB, Atwood TF, Xing L, Giaccia AJ. PHD Inhibition Mitigates and Protects Against Radiation-Induced Gastrointestinal Toxicity via HIF2. Sci Transl Med 6(236):236ra64, 2014. PMID: 24828078.
- Taniguchi CM, Finger EC, Krieg AJ, Wu C, Diep AN, LaGory EL, Wei K, McGinnis LM, Yuan J, Kuo CJ, Giaccia AJ. Cross-Talk Between Hypoxia and Insulin Signaling through phd3 Regulates Hepatic Glucose and Lipid Metabolism and Ameliorates Diabetes. Nat Med 19(10):1325-1330, 2013. e-Pub 2013. PMID: 24037093.
- Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, Vallon M, Morton LC, Lefai E, Simon MC, Maher JJ, Mithieux G, Rajas F, Annes JP, McGuinness OP, Thurston G, Giaccia AJ, Kuo CJ. A Liver Hif-2α-Irs2 Pathway Sensitizes Hepatic Insulin Signaling and is Modulated by Vegf Inhibition. Nat Med 19(10):1331-1337, 2013. e-Pub 2013. PMID: 24037094.
- Taniguchi CM, Murphy JD, Eclov N, Atwood TF, Kielar KN, Christman-Skieller C, Mok E, Xing L, Koong AC, Chang DT. Dosimetric Analysis of Organs at Risk During Expiratory Gating in Stereotactic Body Radiation Therapy for Pancreatic Cancer. Int J Radiat Oncol Biol Phys 85(4):1090-1095, 2013. e-Pub 2012. PMID: 23273994.
- Townsend KL, Suzuki R, Huang TL, Jing E, Schulz TJ, Lee K, Taniguchi CM, Espinoza DO, McDougall LE, Zhang H, He TC, Kokkotou E, Tseng YH. Bone Morphogenetic Protein 7 (BMP7) Reverses Obesity and Regulates Appetite Through a Central mTOR Pathway. FASEB J 26(5):2187-2196, 2012. e-Pub 2012. PMID: 22331196.
- Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Alemán JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR. The Phosphoinositide 3-Kinase Regulatory Subunit p85alpha can Exert Tumor Suppressor Properties Through Negative Regulation of Growth Factor Signaling. Cancer Res 70(13):5305-5315, 2010. e-Pub 2010. PMID: 20530665.
- Sajan MP, Standaert ML, Rivas J, Miura A, Kanoh Y, Soto J, Taniguchi CM, Kahn CR, Farese RV. Role of Atypical Protein Kinase C in Activation of Sterol Regulatory Element Binding Protein-1c and Nuclear Factor Kappa B (NFkappaB) In Liver of Rodents use as A Rodel of Diabetes, and Relationships to Hyperlipidaemia and Insulin Resistance. Diabetologia 52(6):1197-1207, 2009. e-Pub 2009. PMID: 19357831.
- Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR. New Role of Bone Morphogenetic Protein 7 in Brown Adipogenesis and Energy Expenditure. Nature 454(7207):1000-1004, 2008. PMID: 18719589.
- Taniguchi CM, Aleman JO, Ueki K, Luo J, Asano T, Kaneto H, Stephanopoulos G, Cantley LC, Kahn CR. The p85alpha Regulatory Subunit of Phosphoinositide 3-Kinase Potentiates c-Jun N-Terminal Kinase-Mediated Insulin Resistance. Mol Cell Biol 27(8):2830-2840, 2007. e-Pub 2007. PMID: 17283057.
- Taniguchi CM, Tran TT, Kondo T, Luo J, Ueki K, Cantley LC, Kahn CR. Phosphoinositide 3-Kinase Regulatory Subunit p85alpha Suppresses Insulin Action Via Positive Regulation of PTEN. Proc Natl Acad Sci U S A 103(32):12093-12097, 2006. e-Pub 2006. PMID: 16880400.
- Taniguchi CM, Kondo T, Sajan M, Luo J, Bronson R, Asano T, Farese R, Cantley LC, Kahn CR. Divergent Regulation of Hepatic Glucose and Lipid Metabolism by Phosphoinositide 3-Kinase via Akt and PKClambda/zeta. Cell Metab 3(5):343-353, 2006. PMID: 16679292.
- Taniguchi CM, Emanuelli B, Kahn CR. Critical Nodes in Signaling Pathways: Insights into Insulin Action. Nat Rev Mol Cell Biol 7(2):85-96, 2006. PMID: 16493415.
Editorials
- Taniguchi CM, Maitra A. It's a SMAD/SMAD World. Cell 161(6):1245-6, 2015. PMID: 26046433.
Book Chapters
- Taniguchi CM, Kahn CR. Insulin/IGF-1 Signaling Nodes and their Role in Carcinogenesis. In: Insulin Resistance and Cancer. Springer: Toronto, 2011.
- Taniguchi CM, Guengerich FP. Drug Metabolism. In: Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. 3rd. Lippincott Williams and Wilkins: Baltimore, 49-61, 2010.
- Taniguchi CM, Guengerich FP. Drug Metabolism. In: Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. 2nd. Lippincott Williams and Wilkins: Baltimore, 49-61, 2007.
- Taniguchi CM, Armstrong SR, Green LC, Golan DE, Tashjian AH. Drug Toxicity. In: Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. 2nd. Lippincott Williams and Wilkins: Baltimore, 63-73, 2007.
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