Federica Pisaneschi, Ph.D.
Department of Cancer Systems Imaging, Division of Diagnostic Imaging Division
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2003 | University of Florence, Firenze, ITA, PHD, Chemical Sciences, Organic Chemistry |
| 1998 | University of Florence, Firenze, ITA, MSc+BSc, Chemistry |
Postgraduate Training
| 2003-2006 | Research Fellowship, Project title: Synthesis of modified peptides for novel therapies for the immune and antiviral response, University of Florence, Firenze |
Experience & Service
Academic Appointments
Instructor, Department of Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2017 - 2018
Research Scientist, Department of Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2015 - 2016
Senior Postdoctoral Researcher, Comprehensive Cancer Imaging Centre, Imperial College, London, 2006 - 2013
Other Appointments/Responsibilities
Radiochemist, Imanova, Centre of Imaging Sciences, London, 2012 - 2013
Visiting Scientist, Technische Universitat, Dresden, 2004 - 2004
Research Associate, University of Florence, Firenze, 1999 - 2000
Socrates-Erasmus Exchange Term, University of Florence, Prof. Jacques Salaun, Firenze, 1998 - 1998
Honors & Awards
| 2005 | Assegno di Ricerca (Research Fellowship), University of Florence, Italy |
| 2004 | Assegno di Ricerca (Research Fellowship), University of Florence, Italy |
| 2000 | Ph.D. Scholarship, University of Florence, Italy |
| 1998 | Socrates-Erasmus Scholarship, University of Paris-Sud XI |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Engel BJ, Gammon ST, Chaudhari R, Lu Z, Pisaneschi F, Yang H, Ornelas A, Yan V, Kelderhouse L, Najjar AM, Tong WP, Zhang S, Piwnica-Worms D, Bast, Jr. RC, and Millward SW. Caspase-3 Substrates for Noninvasive Pharmacodynamic Imaging of Apoptosis by PET/CT. Bioconjugate Chem 29(9):3180-95, 2018. e-Pub 2018. PMID: 30168713.
- Biagiotti G, Fedeli S, Tuci G, Luconi L, Giambastiani G, Brandi A, Pisaneschi F, Cicchi S, Paoli P. Combined therapies with nanostructured carbon materials: there is room still available at the bottom. J Mat Chem B 6(14):2022-2035, 2018.
- Pisaneschi F, Kelderhouse LE, Hardy A, Engel BJ, Mukhopadhyay U, Gonzalez-Lepera C, Gray JP, Ornelas A, Takahashi TT, Roberts RW, Fiacco SV, Piwnica-Worms D, Millward SW. Automated, Resin-Based Method to Enhance the Specific Activity of Fluorine-18 Clicked PET Radiotracers. Bioconjug Chem 28(2):583-589, 2017. e-Pub 2017. PMID: 28150941.
- Leonard PG, Satani N, Maxwell D, Lin YH, Hammoudi N, Peng Z, Pisaneschi F, Link TM, Lee GR, Sun D, Prasad BA, Di Francesco ME, Czako B, Asara JM, Wang YA, Bornmann W, DePinho RA, Muller FL. SF2312 is a natural phosphonate inhibitor of enolase. Nat Chem Biol 12(12):1053-1058, 2016. e-Pub 2016. PMID: 27723749.
- Slade RL, Pisaneschi F, Nguyen QD, Smith G, Carroll L, Beckley A, Kaliszczak MA, Aboagye EO. Identification of ABC Transporter Interaction of a Novel Cyanoquinoline Radiotracer and Implications for Tumour Imaging by Positron Emission Tomography. PLoS One 11(8):e0161427, 2016. e-Pub 2016. PMID: 27552105.
- Witney TH, Pisaneschi F, Alam IS, Trousil S, Kaliszczak M, Twyman F, Brickute D, Nguyen QD, Schug Z, Gottlieb E, Aboagye EO. Preclinical evaluation of 3-18F-fluoro-2,2-dimethylpropionic acid as an imaging agent for tumor detection. J Nucl Med 55(9):1506-12, 2014. e-Pub 2014. PMID: 25012458.
- Pisaneschi F, Slade RL, Iddon L, George GP, Nguyen QD, Spivey AC, Aboagye EO. Synthesis of a new fluorine-18 glycosylated 'click' cyanoquinoline for the imaging of epidermal growth factor receptor. J Labelled Comp Radiopharm 57(2):92-6, 2014. e-Pub 2013. PMID: 24307532.
- George GP, Pisaneschi F, Nguyen QD, Aboagye EO. Positron emission tomographic imaging of CXCR4 in cancer: challenges and promises. Mol Imaging 13, 2014. PMID: 25341373.
- George GP, Stevens E, Åberg O, Nguyen QD, Pisaneschi F, Spivey AC, Aboagye EO. Preclinical evaluation of a CXCR4-specific (68)Ga-labelled TN14003 derivative for cancer PET imaging. Bioorg Med Chem 22(2):796-803, 2014. e-Pub 2013. PMID: 24365390.
- George GP, Pisaneschi F, Stevens E, Nguyen QD, Åberg O, Spivey AC, Aboagye EO. Scavenging strategy for specific activity improvement: application to a new CXCR4-specific cyclopentapeptide positron emission tomography tracer. J Labelled Comp Radiopharm 56(13):679-85, 2013. e-Pub 2013. PMID: 25196030.
- Pisaneschi F, Witney TH, Iddon L, Aboagye EO. Synthesis of 3-[18F] fluoro-2,2-dimethylpropionic acid: an improved PET imaging probe for the fatty acid synthesis pathway in tumours. Med Chem Comm 4:1350-1353, 2013.
- Srikaran R, Kontorgiorgis CA, Warren SA, Pisaneschi F, Spivey AC. Synthesis of a 4-aryl-2-anilinopyrimidine using a germanium-functionalised non cross-linked polystyrene (NCPS) support. Synlett 4:1663-1666, 2013.
- Åberg O, Pisaneschi F , Smith G, Stevens E, Nguyen QD, Aboagye EO. 18F-Labelling of a cyclic pentapeptide inhibitor of the chemokine receptor CXCR4. J Fluorine Chem 135:200-206, 2012.
- Pisaneschi F, Sejberg JJP, Blain C, Ng WH, Aboagye EO, Spivey AC. 2-Substituted-2,3-dihydro-1H-quinolin-4-ones via acid catalyzed tandem Rupe rearrangement/Donnelly-Farrell ring-closure of 2-(3’-hydroxypropynyl)anilines. Synlett 2:241-244, 2011.
- Pisaneschi F, Nguyen QD, Shamsaei E, Glaser M, Robins E, Kaliszczak M, Smith G, Spivey AC, Aboagye EO. Development of a new epidermal growth factor receptor positron emission tomography imaging agent based on the 3-cyanoquinoline core: synthesis and biological evaluation. Bioorg Med Chem 18(18):6634-45, 2010. e-Pub 2010. PMID: 20797871.
- Salvati M, Cordero FM, Pisaneschi F, Melani F, Gratteri P, Cini N, Bottoncetti A, Brandi A. Synthesis, SAR and in vitro evaluation of new cyclic Arg-Gly-Asp pseudopentapeptides containing a s-cis peptide bond as integrin alphavbeta3 and alphavbeta5 ligands. Bioorg Med Chem 16(8):4262-71, 2008. e-Pub 2008. PMID: 18343671.
- Lumini M, Cordero FM, Pisaneschi F, Brandi A. Straightforward synthesis of α-substituted prolines by cross-metathesis. Eur J Org Chem 2008(16):2817-2824, 2008.
- Pisaneschi F, Cordero FM, Lumini M, Brandi A. Click chemistry: a straightforward route to decorated prolines. Synlett 18:2882-2884, 2007.
- Salvati M, Cordero FM, Pisaneschi F, Cini N, Bottoncetti A, Brandi A. New cyclic Arg-Gly-Asp pseudopentapeptide containing the -turn mimetic GPTM. Synlett 13:2067-2070, 2006.
- Pisaneschi F, Piacenti M, Cordero FM, Brandi A. Stereoselective synthesis of a new trihydroxyindolizidine lactone. Tetrahedron: Asymmetry 17:292-296, 2006.
- Cordero FM, Pisaneschi F, Salvati M, Valenza S, Faggi C, Brandi A. Application of Mosher's method for absolute configuration assignment and resolution of 2-hydroxypyrrolizidinones. Chirality 17(3):149-53, 2005. PMID: 15704198.
- Cordero FM, Pisaneschi F, Meschini Batista K, Valenza S, Machetti F, Brandi A. A new bicyclic dipeptide isostere with pyrrolizidinone skeleton. J Org Chem 70(3):856-67, 2005. PMID: 15675843.
- Pisaneschi F, Gensini M, Salvati M, Cordero FM, Brandi A. 1,3-Dipolar cycloadditions of 2-(tert-butoxycarbonyl)-1-pyrroline N-oxide with chiral acrylates and acrylamides. Heterocycles 67:413-420, 2005.
- Salvati M, Cordero FM, Pisaneschi F, Bucelli F, Brandi A. New developments in the synthesis of pyrrolizidinone-based dipeptide isosteres. Tetrahedron 61:8835-8847, 2005.
- Cordero FM, Salvati M, Pisaneschi F, Brandi A. Novel prospects of the acidic thermal rearrangement of spirocyclopropane isoxazolidines to β-lactams. Eur J Org Chem:2205-2213, 2004.
- Cordero FM, Pisaneschi F, Salvati M, Paschetta V, Ollivier J, Salaün J, Brandi A. Selective ring contraction of 5-spirocyclopropane isoxazolidines mediated by acids. J Org Chem 68(8):3271-80, 2003. PMID: 12688801.
- Pisaneschi F, Cordero FM, Brandi A. A concise total synthesis of (+)-heliotridine. Eur J Org Chem:4373-4375, 2003.
- Pisaneschi F, Cordero FM, Brandi A. Resin linked dipolarophiles to mask nitrones. Synlett:1889-1891, 2003.
- Cordero FM, Pisaneschi F, Salvati M, Ollivier J, Salaün J, Brandi A. Selective ring contraction of 5-spirocyclopropane isoxazolidines mediated by acids. J Org Chem 68:3271-3280, 2003.
- Cordero FM, Pisaneschi F, Gensini M, Goti A, Brandi A. Stereodivergent approach to enantiopure hydroxyindolizidines through 1,3-dipolar cycloaddition of 3-hydroxypyrroline N-oxide derivatives. Eur J Org Chem:1941-1951, 2002.
- Cordero FM, Pisaneschi F, Goti A, Ollivier J, Salaün J, Brandi A. New synthesis of beta-lactams by ethylene extrusion from spirocyclopropane isoxazolidines. J Am Chem Soc 122(33):8078-8076, 2000.
- Pisaneschi F, Cordero FM, Goti A, Paugam R, Ollivier J, Brandi A, Salaün J. Palladium(0)-catalysed nucleophilic substitution of asymmetric 1-alkenylcyclopropyl esters by amino acid. Tetrahedron: Asymmetry 11:897-909, 2000.
Abstracts
- Gammon ST, Pisaneschi F, Bandi M, Smith M, Rao Y, Yennu Nanda VG, Sun Y, Davies M, Di Francesco E, Marszalek J, Piwnica-Worms D. [18F]FAZA PET imaging reveals precise pharmacodynamics in vivo of the novel chemotherapeutic IACS-010759. Proceedings of the AACR Annual Meeting 2018, 2018.
- Pisaneschi F, Gammon ST, Piwnica-Worms D. Imaging of MPO in deep tissues with PET: Novel radiotracers to monitor innate immunity activity. Proceedings of the World Molecular Imaging Congress 2017 60:S189, 2017.
- Pisaneschi F, Gammon ST, Piwnica-Worms D. Imaging of MPO in deep tissues with PET: Novel radiotracers to monitor innate immunity activity. Proceedings of the 22nd International Symposium of Radiopharmaceutical Sciences, J. Label. Comp. Radiopharm 60:S189, 2017.
- Pisaneschi F, Gammon ST, Bandi ML, Smith MG, Davies MA, Yennu Nanda VG, Di Francesco ME, Marszalek J, Piwnica-Worms D. Mitochondrial OxPhos Inhibitor IACS-010759 and [18F]FAZA PET Imaging: Non-invasive Monitoring of Target Engagement. Proceedings of the World Molecular Imaging Congress 2016, 2016.
- Kelderhouse L, Hardy A, Pisaneschi F, Peleg Y, Hu B, Engel B, Grey JP, Ornelas A, Yang P, Gammon S, Howell SM, Piwnica-Worms D, Wang P, Takahashi TT, Roberts RW, Fiacco S, Millward SW. Directed evolution of PET imaging agents by scanning unnatural protease resistance (SUPR) mRNA display. Proceedings of the 252nd American Chemical Society National Meeting & Exposition, 2016.
- Kelderhouse LE, Hardy A, Pisaneschi F, Gray JP, Gammon S, Roberts RW, Takahashi TT, Fiacco S, Millward SW. SUPR-PET: Nuclear imaging of Her2-positive breast cancer with SUPR peptides. Proceedings of the AACR Annual Meeting 2016, 2016.
- Witney T, Pisaneschi F, Alam IS, Iddon L, Twyman F, Aboagye EO. [18F]Fluoro-pivalic acid: A novel acetate analog for cancer detection by positron emission tomography. Proceedings of the World Molecular Imaging Congress, 2013.
- Pisaneschi F, Witney T, Iddon L, Chandrashekran A, Aboagye EO. Synthesis and evaluation of ICL-CCIC-37, a new probe for the PET imaging of the fatty acid synthesis pathway in tumors. J Label Comp Radiopharm 56:S408, 2013.
- George G, Stevens E, Pisaneschi F, Åberg O, Nguyen QD, Spivey AC, Aboagye EO. Synthesis, radiolabeling and biological evaluation of new PET probes for CXCR4-specific imaging. J Label Comp Radiopharm 56:S409, 2013.
- Slade R, Pisaneschi F, Kaliszczak M, Smith G, Nguyen QD, Aboagye EO. Cyanoquinoline-based tracers and their interaction with the ABC transporters for the imaging of EGFR in cancer. J Nucl Med 54(S1):23, 2013.
- Åberg O, Stevens E, Pisaneschi F, Smith G, Aboagye EO. Cyclic pentapeptide conjugates as potential CXCR4 imaging agents. Proceedings of the 19th International Symposium of Radiopharmaceutical Sciences, J Label Comp Radiopharm(54):S170, 2011.
- Pisaneschi F, Nguyen QD, Shamsaei E, Glaser M, Robins E, Kaliszczak M, Smith G, Spivey AC, Aboagye EO. A novel [18F] PET imaging agent for the Epidermal Growth Factor Receptor. Proceedings of the 5th European Molecular Imaging Meeting, 2010.
- Pisaneschi F, Nguyen QD, Shamsaei E, Glaser M, Robins E, Kaliszczak M, Smith G, Spivey AC, Aboagye EO. Design, Synthesis and Biological Evaluation of a new EGFR selective PET imaging agent. Proceedings of the 3rd Imperial Imaging Event, 2010.
- Pisaneschi F, Nguyen QD, Shamsaei E, Glaser M, Robins E, Kaliszczak M, Smith G, Spivey AC, Aboagye EO. Design, synthesis and biological evaluation of a new EGFR selective PET imaging agent. Proceedings of the Imaging Centre Conference, 2010.
Book Chapters
- Brandi A, Gensini M, Pisaneschi F. Chapter 14 Molecular Rearrangements: Part 2. In: Organic Reaction Mechanisms 2004. WILEY Publication: London, 2008.
- Brandi A, Gensini M, Pisaneschi F. Chapter 14 Molecular Rearrangements: Part 2. In: Organic Reaction Mechanisms 2002. WILEY Publication: London, 2002.