Filippo Giancotti, M.D., Ph.D.
Department of Cancer Biology, Division of Basic Sciences
Present Title & Affiliation
Primary Appointment
Professor, Department of Cancer Biology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Scientific Director, Department of David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX
Co-Leader, Department of Prostate Cancer Moon Shots Program, The University of Texas MD Anderson Cancer Center, Houston, TX
Olla S. Stribling Distinguished Chair in Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Division of Cancer Biology Program, Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1988 | University of Torino, School of Medicine, Torino, ITA, PHD, Cell Biology |
| 1981 | University of Torino, School of Medicine, Torino, ITA, MD, Medicine |
Postgraduate Training
| 1989-1991 | Senior Research Fellow, Sanford-Burnham Biomedical Research Institute, La Jolla, CA |
| 1988-1989 | Postdoctoral Scientist, Sanford-Burnham Biomedical Research Institute, La Jolla, CA |
| 1983-1987 | Research Fellowship, University of Torino, School of Medicine, Torino |
| 1981-1983 | Clinical Residency, University of Torino, School of Medicine, Torino |
Board Certifications
| 1985 | Hematology/Oncology |
Experience & Service
Academic Appointments
Professor, Gerstner Sloan-Kettering Graduate School of Biomedical Sciences, New York, NY, 2004 - 2016
Professor, Cornell University Graduate School of Medical Sciences, New York, NY, 2004 - 2016
Professor, Cornell University Graduate School of Medical Sciences, New York, NY, 2000 - 2004
Associate Professor, Cornell University Graduate School of Medicine, New York, NY, 1996 - 2000
Associate Professor, Department of Pathology, New York University School of Medicine, New York, NY, 1996 - 1996
Assistant Professor, Department of Pathology, New York University School of Medicine, New York, NY, 1991 - 1995
Other Appointments/Responsibilities
Co-Leader, Genitourinary Oncology Program, Cancer Center Support Grant, Houston, TX, 2017 - Present
Adjunct Member, Cell Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Institute, New York, NY, 2016 - 2016
Member, Center for Metastasis Research, Memorial Sloan-Kettering Cancer Center, New York, NY, 2010 - 2016
Member (with tenure), Cell Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY, 2004 - 2016
Member (with Tenure) Cellular Biochemistry and Biophysics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY, 2000 - 2004
Associate Member, Sloan-Kettering Institute; Memorial Sloan Kettering Cancer Center, New York, NY, 1996 - 2000
Institutional Committee Activities
IAB Member, SPORE in Gastrointestinal Cancer, Internal Advisory Board, UTMDACC, 2017 - Present
Member, Program Project Grant, Steering Committee, University of Wisconsin-Madison, 2017 - Present
Co-Leader, Prostate Cancer Moon Shot Steering Committee, UTMDACC, 2016 - Present
Member, Intellectual Property Task Force, UTMDACC, 2016 - Present
Co-Chair, Genitourinary Medical Oncology Faculty Search Committee, MDACC, 2016 - Present
Endowed Positions
Laura and Christopher Pucillo Chair in Metastasis Research, Memorial Sloan-Kettering Cancer Center, New York, NY, 2016 - 2016
Honors & Awards
| 2016 | NCI Oustanding Investigator Award "Mechanisms gooverning metastatic dormancy and reactivation", National Cancer Institute |
| 2016 | Scholar Award, Cancer Prevention and Research Institute of Texas (CPRIT) |
| 2015 | Founding Director, Cancer Metastasis Research Institute, East Hospital and School of Medicine of Tongji University |
| 2014 | Distinguished Visiting Professor, East Hospital and School of Medicine of Tongji University |
| 2007 | Member, ChildrenTumor Foundation Preclinical Consortium Oversight Committee, Children Tumor Foundation |
| 2007 | Member, Children Tumor Foundation Research Advisory Board, Children Tumor Foundation |
| 2003 | Member, Faculty of 1000, Cell Biology Section, Cell Biology |
| 2001 | Member, Scientific Committee, Telethon Italia |
| 2000 | Chair, 1st Gordon Research Conference on Signaling by Adhesion Receptors, Salve Regina College |
| 1998 | Member, Pathobiochemistry Study Section, National Institutes of Health |
| 1996 | Charitable Trust Career Scientist Award, Irma T. Hirschl-Monique Weill-Caulier |
| 1996 | Established Investigator Award, American Heart Association |
| 1992 | Whitehead Presidential Fellowship, Rockefeller University |
| 1991 | Charitable Trust Award, Lucille P. Markey |
| 1990 | Postdoctoral Fellowship, Arthritis Foundation |
| 1989 | Senior Postdoctoral Fellowship, American Cancer Society |
| 1987 | Long Term Postdoctoral Fellowship, European Molecular Biology Organization |
| 1987 | Exchange Program Fellowship, European Organisation for Research and Treatment of Cancer |
| 1983 | Scholarship, Italian Ministry of Education |
Selected Publications
Peer-Reviewed Articles
- Chen G, Zhou H, Liu B, Wang Y, Zhao J, Giancotti FG, Long J. A heterotrimeric SMARCB1-SMARCC2 subcomplex is required for the assembly and tumor suppression function of the BAF chromatin-remodeling complex. Cell Discov 6:66, 2020. e-Pub 2020. PMID: 33024572.
- Su W, Han HH, Wang Y, Zhang B, Zhou B, Cheng Y, Rumandla A, Gurrapu S, Chakraborty G, Su J, Yang G, Liang X, Wang G, Rosen N, Scher HI, Ouerfelli O, Giancotti FG. The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression. Cancer Cell 36(2):139-155.e10, 2019. e-Pub 2019. PMID: 31327655.
- Laudato S, Aparicio A, Giancotti FG. Clonal Evolution and Epithelial Plasticity in the Emergence of AR-Independent Prostate Carcinoma. Trends Cancer 5(7):440-455, 2019. e-Pub 2019. PMID: 31311658.
- Jain N, Hartert K, Tadros S, Fiskus W, Havranek O, Ma MCJ, Bouska A, Heavican T, Kumar D, Deng Q, Moore D, Pak C, Liu CL, Gentles AJ, Hartmann E, Kridel R, Smedby KE, Juliusson G, Rosenquist R, Gascoyne RD, Rosenwald A, Giancotti F, Neelapu SS, Westin J, Vose JM, Lunning MA, Greiner T, Rodig S, Iqbal J, Alizadeh AA, Davis RE, Bhalla K, Green MR. Targetable genetic alterations of TCF4 (E2-2) drive immunoglobulin expression in diffuse large B cell lymphoma. Sci Transl Med 11(497), 2019. PMID: 31217338.
- Cooper J, Giancotti FG. Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance. Cancer Cell 35(3):347-367, 2019. PMID: 30889378.
- Er EE, Valiente M, Ganesh K, Zou Y, Agrawal S, Hu J, Griscom B, Rosenblum M, Boire A, Brogi E, Giancotti FG, Schachner M, Malladi S, Massagué J. Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. Nat Cell Biol 20(8):966-978, 2018. e-Pub 2018. PMID: 30038252.
- Thompson BJ, Giancotti FG. Editorial overview: Cell signalling: Signal transduction to the nucleus, cytoskeleton, and organelles. Curr Opin Cell Biol 51:iv-vii, 2018. PMID: 29753428.
- Cooper J, Xu Q, Zhou L, Pavlovic M, Ojeda V, Moulick K, de Stanchina E, Poirier JT, Zauderer M, Rudin CM, Karajannis MA, Hanemann CO, Giancotti FG. Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss-Driven Tumorigenesis. Mol Cancer Ther 16(8):1693-1704, 2017. e-Pub 2017. PMID: 28468780.
- Cooper J, Giancotti FG. Cancer: a new role for non-canonical Hippo signaling. Cell Res 27(4):459-460, 2017. e-Pub 2017. PMID: 28244491.
- Chen YB, Xu J, Skanderup AJ, Dong Y, Brannon AR, Wang L, Won HH, Wang PI, Nanjangud GJ, Jungbluth AA, Li W, Ojeda V, Hakimi AA, Voss MH, Schultz N, Motzer RJ, Russo P, Cheng EH, Giancotti FG, Lee W, Berger MF, Tickoo SK, Reuter VE, Hsieh JJ. Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets. Nat Commun 7:13131, 2016. e-Pub 2016. PMID: 27713405.
- Gao H, Chakraborty G, Zhang Z, Akalay I, Gadiya M, Gao Y, Sinha S, Hu J, Jiang C, Akram M, Brogi E, Leitinger B, Giancotti FG. Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling. Cell 166(1):47-62, 2016. PMID: 27368100.
- Garcia-Rendueles ME, Ricarte-Filho JC, Untch BR, Landa I, Knauf JA, Voza F, Smith VE, Ganly I, Taylor BS, Persaud Y, Oler G, Fang Y, Jhanwar SC, Viale A, Heguy A, Huberman KH, Giancotti F, Ghossein R, Fagin JA. NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition. Cancer Discov 5(11):1178-93, 2015. e-Pub 2015. PMID: 26359368.
- Giancotti FG, Fässler R. Guido Tarone, Ph.D. (1951-2015). J Cell Sci 128(16):2955-6, 2015. PMID: 26495456.
- Giancotti FG, Haynes CM, Machesky LM, Olson MF, Overholtzer M. Alan Hall 1952-2015. Nat Cell Biol 17(7):839-40, 2015. e-Pub 2015. PMID: 26005836.
- Okada T, Sinha S, Esposito I, Schiavon G, López-Lago MA, Su W, Pratilas CA, Abele C, Hernandez JM, Ohara M, Okada M, Viale A, Heguy A, Socci ND, Sapino A, Seshan VE, Long S, Inghirami G, Rosen N, Giancotti FG. The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling. Nat Cell Biol 17(1):81-94, 2015. e-Pub 2014. PMID: 25531777.
- Gao H, Chakraborty G, Lee-Lim AP, Mavrakis KJ, Wendel HG, Giancotti FG. Forward genetic screens in mice uncover mediators and suppressors of metastatic reactivation. Proc Natl Acad Sci U S A 111(46):16532-7, 2014. e-Pub 2014. PMID: 25378704.
- Giancotti FG. Deregulation of cell signaling in cancer. FEBS Lett 588(16):2558-70, 2014. e-Pub 2014. PMID: 24561200.
- Cooper J, Giancotti FG. Molecular insights into NF2/Merlin tumor suppressor function. FEBS Lett 588(16):2743-52, 2014. e-Pub 2014. PMID: 24726726.
- Li W, Cooper J, Zhou L, Yang C, Erdjument-Bromage H, Zagzag D, Snuderl M, Ladanyi M, Hanemann CO, Zhou P, Karajannis MA, Giancotti FG. Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus. Cancer Cell 26(1):48-60, 2014. PMID: 25026211.
- Heller BA, Ghidinelli M, Voelkl J, Einheber S, Smith R, Grund E, Morahan G, Chandler D, Kalaydjieva L, Giancotti F, King RH, Fejes-Toth AN, Fejes-Toth G, Feltri ML, Lang F, Salzer JL. Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system. J Cell Biol 204(7):1219-36, 2014. PMID: 24687281.
- Karajannis MA, Legault G, Hagiwara M, Giancotti FG, Filatov A, Derman A, Hochman T, Goldberg JD, Vega E, Wisoff JH, Golfinos JG, Merkelson A, Roland JT, Allen JC. Phase II study of everolimus in children and adults with neurofibromatosis type 2 and progressive vestibular schwannomas. Neuro Oncol 16(2):292-7, 2014. e-Pub 2013. PMID: 24311643.
- Giancotti FG. Mechanisms governing metastatic dormancy and reactivation. Cell 155(4):750-64, 2013. PMID: 24209616.
- Yoshioka T, Otero J, Chen Y, Kim YM, Koutcher JA, Satagopan J, Reuter V, Carver B, de Stanchina E, Enomoto K, Greenberg NM, Scardino PT, Scher HI, Sawyers CL, Giancotti FG. β4 Integrin signaling induces expansion of prostate tumor progenitors. J Clin Invest 123(2):682-99, 2013. e-Pub 2013. PMID: 23348745.
- Ladanyi M, Zauderer MG, Krug LM, Ito T, McMillan R, Bott M, Giancotti F. New strategies in pleural mesothelioma: BAP1 and NF2 as novel targets for therapeutic development and risk assessment. Clin Cancer Res 18(17):4485-90, 2012. e-Pub 2012. PMID: 22825583.
- Gao H, Chakraborty G, Lee-Lim AP, Mo Q, Decker M, Vonica A, Shen R, Brogi E, Brivanlou AH, Giancotti FG. The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. Cell 150(4):764-79, 2012. PMID: 22901808.
- Li W, Cooper J, Karajannis MA, Giancotti FG. Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus. EMBO Rep 13(3):204-15, 2012. PMID: 22482125.
- Kalamarides M, Acosta MT, Babovic-Vuksanovic D, Carpen O, Cichowski K, Evans DG, Giancotti F, Hanemann CO, Ingram D, Lloyd AC, Mayes DA, Messiaen L, Morrison H, North K, Packer R, Pan D, Stemmer-Rachamimov A, Upadhyaya M, Viskochil D, Wallace MR, Hunter-Schaedle K, Ratner N. Neurofibromatosis 2011: a report of the Children's Tumor Foundation annual meeting. Acta Neuropathol 123(3):369-80, 2012. e-Pub 2011. PMID: 22083253.
- Baranwal S, Wang Y, Rathinam R, Lee J, Jin L, McGoey R, Pylayeva Y, Giancotti F, Blobe GC, Alahari SK. Molecular characterization of the tumor-suppressive function of nischarin in breast cancer. J Natl Cancer Inst 103(20):1513-28, 2011. e-Pub 2011. PMID: 21917605.
- Fan J, Cai B, Zeng M, Hao Y, Giancotti FG, Fu BM. Integrin β4 signaling promotes mammary tumor cell adhesion to brain microvascular endothelium by inducing ErbB2-mediated secretion of VEGF. Ann Biomed Eng 39(8):2223-41, 2011. e-Pub 2011. PMID: 21556948.
- Cooper J, Li W, You L, Schiavon G, Pepe-Caprio A, Zhou L, Ishii R, Giovannini M, Hanemann CO, Long SB, Erdjument-Bromage H, Zhou P, Tempst P, Giancotti FG. Merlin/NF2 functions upstream of the nuclear E3 ubiquitin ligase CRL4DCAF1 to suppress oncogenic gene expression. Sci Signal 4(188):pt6, 2011. e-Pub 2011. PMID: 21878678.
- Huson SM, Acosta MT, Belzberg AJ, Bernards A, Chernoff J, Cichowski K, Gareth Evans D, Ferner RE, Giovannini M, Korf BR, Listernick R, North KN, Packer RJ, Parada LF, Peltonen J, Ramesh V, Reilly KM, Risner JW, Schorry EK, Upadhyaya M, Viskochil DH, Zhu Y, Hunter-Schaedle K, Giancotti FG. Back to the future: proceedings from the 2010 NF Conference. Am J Med Genet A 155A(2):307-21, 2011. e-Pub 2010. PMID: 21271647.
- Li W, Giancotti FG. Merlin's tumor suppression linked to inhibition of the E3 ubiquitin ligase CRL4 (DCAF1). Cell Cycle 9(22):4433-6, 2010. e-Pub 2010. PMID: 21084862.
- Rossi F, Yozgat Y, de Stanchina E, Veach D, Clarkson B, Manova K, Giancotti FG, Antonescu CR, Besmer P. Imatinib upregulates compensatory integrin signaling in a mouse model of gastrointestinal stromal tumor and is more effective when combined with dasatinib. Mol Cancer Res 8(9):1271-83, 2010. e-Pub 2010. PMID: 20736294.
- Ammoun S, Cunliffe CH, Allen JC, Chiriboga L, Giancotti FG, Zagzag D, Hanemann CO, Karajannis MA. ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma. Neuro Oncol 12(8):834-43, 2010. e-Pub 2010. PMID: 20511180.
- Shen S, Fan J, Cai B, Lv Y, Zeng M, Hao Y, Giancotti FG, Fu BM. Vascular endothelial growth factor enhances cancer cell adhesion to microvascular endothelium in vivo. Exp Physiol 95(2):369-79, 2010. e-Pub 2009. PMID: 19880535.
- Li W, You L, Cooper J, Schiavon G, Pepe-Caprio A, Zhou L, Ishii R, Giovannini M, Hanemann CO, Long SB, Erdjument-Bromage H, Zhou P, Tempst P, Giancotti FG. Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus. Cell 140(4):477-90, 2010. PMID: 20178741.
- López-Lago MA, Okada T, Murillo MM, Socci N, Giancotti FG. Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling. Mol Cell Biol 29(15):4235-49, 2009. e-Pub 2009. PMID: 19451229.
- Roberts JE, Nikolopoulos SN, Oktem O, Giancotti F, Oktay K. Integrin beta-4 signaling plays a key role in mouse embryogenesis. Reprod Sci 16(3):286-93, 2009. e-Pub 2008. PMID: 19087978.
- Pylayeva Y, Gillen KM, Gerald W, Beggs HE, Reichardt LF, Giancotti FG. Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. J Clin Invest 119(2):252-66, 2009. e-Pub 2009. PMID: 19147981.
- Oktay K, Buyuk E, Oktem O, Oktay M, Giancotti FG. The c-Jun N-terminal kinase JNK functions upstream of Aurora B to promote entry into mitosis. Cell Cycle 7(4):533-41, 2008. PMID: 18431843.
- Giancotti FG. Targeting integrin beta4 for cancer and anti-angiogenic therapy. Trends Pharmacol Sci 28(10):506-11, 2007. e-Pub 2007. PMID: 17822782.
- Pylayeva Y, Giancotti FG. Tensin relief facilitates migration. Nat Cell Biol 9(8):877-9, 2007. PMID: 17671456.
- Okada T, You L, Giancotti FG. Shedding light on Merlin's wizardry. Trends Cell Biol 17(5):222-9, 2007. e-Pub 2007. PMID: 17442573.
- Pylayeva Y, Guo W, Giancotti FG. Analysis of integrin signaling in genetically engineered mouse models of mammary tumor progression. Methods Enzymol 426:439-61, 2007. PMID: 17697895.
- Guo W, Pylayeva Y, Pepe A, Yoshioka T, Muller WJ, Inghirami G, Giancotti FG. Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 126(3):489-502, 2006. PMID: 16901783.
- Pylayeva Y, Giancotti FG. Development requires activation but not phosphorylation of beta1 integrins. Genes Dev 20(9):1057-60, 2006. PMID: 16651652.
- Okada T, Lopez-Lago M, Giancotti FG. Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane. J Cell Biol 171(2):361-71, 2005. PMID: 16247032.
- Nikolopoulos SN, Blaikie P, Yoshioka T, Guo W, Puri C, Tacchetti C, Giancotti FG. Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration. Mol Cell Biol 25(14):6090-102, 2005. PMID: 15988021.
- Vidal A, Zacharoulis S, Guo W, Shaffer D, Giancotti F, Bramley AH, de la Hoz C, Jensen KK, Kato D, MacDonald DD, Knowles J, Yeh N, Frohman LA, Rafii S, Lyden D, Koff A. p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow. Proc Natl Acad Sci U S A 102(19):6890-5, 2005. e-Pub 2005. PMID: 15867156.
- Nikolopoulos SN, Giancotti FG. Netrin-integrin signaling in epithelial morphogenesis, axon guidance and vascular patterning. Cell Cycle 4(3):e131-5, 2005. e-Pub 2005. PMID: 15725728.
- Nikolopoulos SN, Blaikie P, Yoshioka T, Guo W, Giancotti FG. Integrin beta4 signaling promotes tumor angiogenesis. Cancer Cell 6(5):471-83, 2004. PMID: 15542431.
- Guo W, Giancotti FG. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 5(10):816-26, 2004. PMID: 15459662.
- Gagnoux-Palacios L, Dans M, van't Hof W, Mariotti A, Pepe A, Meneguzzi G, Resh MD, Giancotti FG. Compartmentalization of integrin alpha6beta4 signaling in lipid rafts. J Cell Biol 162(7):1189-96, 2003. PMID: 14517202.
- Giancotti FG. A structural view of integrin activation and signaling. Dev Cell 4(2):149-51, 2003. PMID: 12586058.
- Giancotti FG, Tarone G. Positional control of cell fate through joint integrin/receptor protein kinase signaling. Annu Rev Cell Dev Biol 19:173-206, 2003. PMID: 14570568.
- Weaver VM, Lelièvre S, Lakins JN, Chrenek MA, Jones JC, Giancotti F, Werb Z, Bissell MJ. beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell 2(3):205-16, 2002. PMID: 12242153.
- Klein S, de Fougerolles AR, Blaikie P, Khan L, Pepe A, Green CD, Koteliansky V, Giancotti FG. Alpha 5 beta 1 integrin activates an NF-kappa B-dependent program of gene expression important for angiogenesis and inflammation. Mol Cell Biol 22(16):5912-22, 2002. PMID: 12138201.
- Hirsch E, Barberis L, Brancaccio M, Azzolino O, Xu D, Kyriakis JM, Silengo L, Giancotti FG, Tarone G, Fässler R, Altruda F. Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain. J Cell Biol 157(3):481-92, 2002. e-Pub 2002. PMID: 11980921.
- Dellambra E, Prislei S, Salvati AL, Madeddu ML, Golisano O, Siviero E, Bondanza S, Cicuzza S, Orecchia A, Giancotti FG, Zambruno G, De Luca M. Gene correction of integrin beta4-dependent pyloric atresia-junctional epidermolysis bullosa keratinocytes establishes a role for beta4 tyrosines 1422 and 1440 in hemidesmosome assembly. J Biol Chem 276(44):41336-42, 2001. e-Pub 2001. PMID: 11522777.
- Mariotti A, Kedeshian PA, Dans M, Curatola AM, Gagnoux-Palacios L, Giancotti FG. EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion. J Cell Biol 155(3):447-58, 2001. e-Pub 2001. PMID: 11684709.
- Mettouchi A, Klein S, Guo W, Lopez-Lago M, Lemichez E, Westwick JK, Giancotti FG. Integrin-specific activation of Rac controls progression through the G(1) phase of the cell cycle. Mol Cell 8(1):115-27, 2001. PMID: 11511365.
- Dans M, Giancotti FG. CD104. J Biol Regul Homeost Agents 15(2):193-6, 2001. PMID: 11501983.
- Dans M, Gagnoux-Palacios L, Blaikie P, Klein S, Mariotti A, Giancotti FG. Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes. J Biol Chem 276(2):1494-502, 2001. PMID: 11044453.
- Sumitomo M, Shen R, Walburg M, Dai J, Geng Y, Navarro D, Boileau G, Papandreou CN, Giancotti FG, Knudsen B, Nanus DM. Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signaling. J Clin Invest 106(11):1399-407, 2000. PMID: 11104793.
- Barberis L, Wary KK, Fiucci G, Liu F, Hirsch E, Brancaccio M, Altruda F, Tarone G, Giancotti FG. Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK. J Biol Chem 275(47):36532-40, 2000. PMID: 10976102.
- Bhol KC, Dans MJ, Simmons RK, Foster CS, Giancotti FG, Ahmed AR. The autoantibodies to alpha 6 beta 4 integrin of patients affected by ocular cicatricial pemphigoid recognize predominantly epitopes within the large cytoplasmic domain of human beta 4. J Immunol 165(5):2824-9, 2000. PMID: 10946315.
- Giancotti FG. Complexity and specificity of integrin signalling. Nat Cell Biol 2(1):E13-4, 2000. PMID: 10620816.
- Giancotti FG, Ruoslahti E. Integrin signaling. Science 285(5430):1028-32, 1999. PMID: 10446041.
- Oktay M, Wary KK, Dans M, Birge RB, Giancotti FG. Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle. J Cell Biol 145(7):1461-9, 1999. PMID: 10385525.
- Oktay MH, Mariotti A, Giancotti FG. Assays for kinase activity. Methods Mol Biol 129:51-61, 1999. PMID: 10494557.
- Wary KK, Dans M, Mariotti A, Giancotti FG. Biochemical analysis of integrin-mediated Shc signaling. Methods Mol Biol 129:35-49, 1999. PMID: 10494556.
- Lora JM, Rowader KE, Soares L, Giancotti F, Zaret KS. Alpha3beta1-integrin as a critical mediator of the hepatic differentiation response to the extracellular matrix. Hepatology 28(4):1095-104, 1998. PMID: 9755248.
- Munger JS, Harpel JG, Giancotti FG, Rifkin DB. Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1. Mol Biol Cell 9(9):2627-38, 1998. PMID: 9725916.
- Wary KK, Mariotti A, Zurzolo C, Giancotti FG. A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Cell 94(5):625-34, 1998. PMID: 9741627.
- Pozzi A, Wary KK, Giancotti FG, Gardner HA. Integrin alpha1beta1 mediates a unique collagen-dependent proliferation pathway in vivo. J Cell Biol 142(2):587-94, 1998. PMID: 9679154.
- Murgia C, Blaikie P, Kim N, Dans M, Petrie HT, Giancotti FG. Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain. EMBO J 17(14):3940-51, 1998. PMID: 9670011.
- Sanders RJ, Mainiero F, Giancotti FG. The role of integrins in tumorigenesis and metastasis. Cancer Invest 16(5):329-44, 1998. PMID: 9627681.
- Giancotti FG. Integrin signaling: specificity and control of cell survival and cell cycle progression. Curr Opin Cell Biol 9(5):691-700, 1997. PMID: 9330873.
- Mainiero F, Murgia C, Wary KK, Curatola AM, Pepe A, Blumemberg M, Westwick JK, Der CJ, Giancotti FG. The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation. EMBO J 16(9):2365-75, 1997. PMID: 9171350.
- Wary KK, Mainiero F, Isakoff SJ, Marcantonio EE, Giancotti FG. The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Cell 87(4):733-43, 1996. PMID: 8929541.
- Jones J, Sugiyama M, Giancotti F, Speight PM, Watt FM. Transfection of beta 4 integrin subunit into a neoplastic keratinocyte line fails to restore terminal differentiation capacity or influence proliferation. Cell Adhes Commun 4(4-5):307-16, 1996. PMID: 9117349.
- Klein S, Bikfalvi A, Birkenmeier TM, Giancotti FG, Rifkin DB. Integrin regulation by endogenous expression of 18-kDa fibroblast growth factor-2. J Biol Chem 271(37):22583-90, 1996. PMID: 8798427.
- Mainiero F, Pepe A, Yeon M, Ren Y, Giancotti FG. The intracellular functions of alpha6beta4 integrin are regulated by EGF. J Cell Biol 134(1):241-53, 1996. PMID: 8698818.
- Giancotti FG. Signal transduction by the alpha 6 beta 4 integrin: charting the path between laminin binding and nuclear events. J Cell Sci 109 ( Pt 6):1165-72, 1996. PMID: 8799807.
- Mainiero F, Pepe A, Wary KK, Spinardi L, Mohammadi M, Schlessinger J, Giancotti FG. Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. EMBO J 14(18):4470-81, 1995. PMID: 7556090.
- Spinardi L, Einheber S, Cullen T, Milner TA, Giancotti FG. A recombinant tail-less integrin beta 4 subunit disrupts hemidesmosomes, but does not suppress alpha 6 beta 4-mediated cell adhesion to laminins. J Cell Biol 129(2):473-87, 1995. PMID: 7721947.
- Giancotti FG, Mainiero F. Integrin-mediated adhesion and signaling in tumorigenesis. Biochim Biophys Acta 1198(1):47-64, 1994. PMID: 8199195.
- Thompson KA, Wang B, Argraves WS, Giancotti FG, Schranck DP, Ruoslahti E. BR140, a novel zinc-finger protein with homology to the TAF250 subunit of TFIID. Biochem Biophys Res Commun 198(3):1143-52, 1994. PMID: 7906940.
- Giancotti FG, Spinardi L, Mainiero F, Sanders R. Expression of heterologous integrin genes in cultured eukaryotic cells. Methods Enzymol 245:297-316, 1994. PMID: 7760740.
- Einheber S, Milner TA, Giancotti F, Salzer JL. Axonal regulation of Schwann cell integrin expression suggests a role for alpha 6 beta 4 in myelination. J Cell Biol 123(5):1223-36, 1993. PMID: 8245127.
- Klein S, Giancotti FG, Presta M, Albelda SM, Buck CA, Rifkin DB. Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cells. Mol Biol Cell 4(10):973-82, 1993. PMID: 8298194.
- Spinardi L, Ren YL, Sanders R, Giancotti FG. The beta 4 subunit cytoplasmic domain mediates the interaction of alpha 6 beta 4 integrin with the cytoskeleton of hemidesmosomes. Mol Biol Cell 4(9):871-84, 1993. PMID: 8257791.
- Giancotti FG, Stepp MA, Suzuki S, Engvall E, Ruoslahti E. Proteolytic processing of endogenous and recombinant beta 4 integrin subunit. J Cell Biol 118(4):951-9, 1992. PMID: 1500432.
- Bauer JS, Schreiner CL, Giancotti FG, Ruoslahti E, Juliano RL. Motility of fibronectin receptor-deficient cells on fibronectin and vitronectin: collaborative interactions among integrins. J Cell Biol 116(2):477-87, 1992. PMID: 1370495.
- Giancotti FG, Ruoslahti E. A single-chain integrin?. New Biol 3(5):525-6, 1991. PMID: 1883815.
- Vogel BE, Tarone G, Giancotti FG, Gailit J, Ruoslahti E. A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1). J Biol Chem 265(11):5934-7, 1990. PMID: 2138612.
- Giancotti FG, Ruoslahti E. Elevated levels of the alpha 5 beta 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells. Cell 60(5):849-59, 1990. PMID: 2155708.
- Ruoslahti E, Giancotti FG. Integrins and tumor cell dissemination. Cancer Cells 1(4):119-26, 1989. PMID: 2701367.
- Altruda F, Cervella P, Gaeta ML, Daniele A, Giancotti F, Tarone G, Stefanuto G, Silengo L. Cloning of cDNA for a novel mouse membrane glycoprotein (gp42): shared identity to histocompatibility antigens, immunoglobulins and neural-cell adhesion molecules. Gene 85(2):445-51, 1989. PMID: 2697642.
- Marchisio PC, D'Urso N, Comoglio PM, Giancotti FG, Tarone G. Vanadate-treated baby hamster kidney fibroblasts show cytoskeleton and adhesion patterns similar to their Rous sarcoma virus-transformed counterparts. J Cell Biochem 37(2):151-9, 1988. PMID: 2456294.
- Tarone G, Mascarello P, Zibetti M, Giancotti FG. Purification of the beta subunit of the fibronectin receptor. Eur J Biochem 172(3):713-8, 1988. PMID: 2965011.
- Albini A, Allavena G, Melchiori A, Giancotti F, Richter H, Comoglio PM, Parodi S, Martin GR, Tarone G. Chemotaxis of 3T3 and SV3T3 cells to fibronectin is mediated through the cell-attachment site in fibronectin and a fibronectin cell surface receptor. J Cell Biol 105(4):1867-72, 1987. PMID: 2959668.
- Giancotti FG, Languino LR, Zanetti A, Peri G, Tarone G, Dejana E. Platelets express a membrane protein complex immunologically related to the fibroblast fibronectin receptor and distinct from GPIIb/IIIa. Blood 69(5):1535-8, 1987. PMID: 2952186.
- Giancotti FG, Comoglio PM, Tarone G. Interaction of fibroblasts, hemopoietic cells and platelets with extracellular matrix: characterization and role of a common cell surface glycoprotein. Ann N Y Acad Sci 511:65-76, 1987. PMID: 3439719.
- Giancotti FG, Comoglio PM, Tarone G. Fibronectin-plasma membrane interaction in the adhesion of hemopoietic cells. J Cell Biol 103(2):429-37, 1986. PMID: 2942550.
- Giancotti FG, Comoglio PM, Tarone G. A 135,000 molecular weight plasma membrane glycoprotein involved in fibronectin-mediated cell adhesion. Immunofluorescence localization in normal and RSV-transformed fibroblasts. Exp Cell Res 163(1):47-62, 1986. PMID: 3002832.
- Tarone G, Cirillo D, Giancotti FG, Comoglio PM, Marchisio PC. Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes. Exp Cell Res 159(1):141-57, 1985. PMID: 2411576.
- Giancotti FG, Tarone G, Knudsen K, Damsky C, Comoglio PM. Cleavage of a 135 kD cell surface glycoprotein correlates with loss of fibroblast adhesion to fibronectin. Exp Cell Res 156(1):182-90, 1985. PMID: 2981173.
- Comoglio PM, Di Renzo MF, Tarone G, Giancotti FG, Naldini L, Marchisio PC. Detection of phosphotyrosine-containing proteins in the detergent-insoluble fraction of RSV-transformed fibroblasts by azobenzene phosphonate antibodies. EMBO J 3(3):483-9, 1984. PMID: 6201361.
- Tarone G, Giancotti FG, Comoglio PM. Identification and partial characterization of a plasma membrane glycoprotein that mediates cell-substratum adhesion. The Italian Journal of Biochemistry(33):138-139, 1984.
- Matera L, Giancotti FG. Natural killer activity and low-affinity E rosettes in acute leukemias. Acta Haematol 70(3):158-62, 1983. PMID: 6410642.
Book Chapters
- Giancotti FG, Di Renzo MF, Marchisio PC, Tarone G, Naldini L, et al.. Immunological detection of cellular targets for v-onc gene coded tyrosine kinases. In: Genetic and Phenotypic Markers of Tumors. Plenum Press: New York, 297-303, 1984.
Grant & Contract Support
| Title: | Flagship: Development of Mechanism-based Combination Therapies for Castration-Resistant Prostate Cancer |
| Funding Source: | MD Anderson Cancer Center Moon Shot Program |
| Role: | Co-Program Leader |