Gary V. Martinez, Ph.D.
Department of Imaging Physics, Division of Diagnostic Imaging
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Imaging Physics - Research, Division of Diagnostic Imaging, MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1997 | University of California, Santa Cruz, CA, USA, PHD, Biophysics |
| 1990 | CSU Long Beach, Long Beach, CA, USA, BS, Physics |
Postgraduate Training
| 1994-2004 | Post Doctoral, Department of Chemistry-University of Arizona, Tucson, AZ |
Experience & Service
Academic Appointments
Assistant Professor, University of South Florida, Tampa, FL, 2011 - Present
Senior Research Scientist and Pre-clinical Imaging Facility manager, Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center & Research Metabolism, Tampa, FL, 2009 - 2018
Scientific Lead, Quantitative Pre-Clinical Imaging Group, Division of Basic Sciences, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, 2009 - Present
Assistant Research Scientist, University of Arizona- Arizona Cancer Center, Tucson, AZ, 2004 - 2008
Institutional Committee Activities
Committee Member, Task Force for Core Technology Development, 2017 - Present
Host, Quantiative Imaging Group, 2010 - Present
Honors & Awards
| 2001 | NIH F32 National Research Service Award (NRSA),, University of Arizona |
| 1997 | Stipend, Swedish National Research Council |
| 1993 | NIH Predoctoral Fellowship (National Research Service Award), University of California Santa Cruz |
Selected Publications
Peer-Reviewed Articles
- Martinez GV . Introduction to MRI Physics. Methods in Molecular Biology 1718:3-19, 2018. PMID: 29340999.
- Juan Sanchez-Ramos, Shijie Song, Xiaoyuan Kong, Parastou Foroutan, Gary V Martinez, William Dominguez-Viqueria, Shyam Mohapatra, Subhra Mohapatra, Reka A Haraszti, Anastasia Khvorova, et al. Chitosan-mangafodipir nanoparticles designed for intranasal delivery of sirna and dna to brain. Journal of Drug Delivery Science and Technology 43:453-460, 2018. e-Pub 2018.
- Bruna Jardim-Perassi, S Huang, W Dominguez-Viqueira, J Poleszczuk, M Budzevich, E Ruiz, M Bui, D Zuccari, R Gillies, and Gary V Martinez .. Assessment of intratumoral heterogeneity using MRI-defined tumor habitats in animal models, through co-registration with histology habitats in animal models, through co-registration with histology. Manuscript in preparation, 2018.
- Suning Huang, William Dominguez-Viqueira, Epifanio Ruiz, Mikalai Budzevich, Bruna Jardim-Perassi, Robert Gillies, and Gary V Martinez.. Unraveling sarcoma tumor heterogeneity using mri-defined tumor habitats. Manuscript in preparation, 2018.
- Gary V Martinez and Epifanio Ruiz.. Rapid MRSI: a method of reconstruction for improved spectroscopic bandwidth. Manuscript in preparation, 2018. e-Pub 2018.
- Bruna V Jardim-Perassi, William Dominguez-Viqueira, Dominique F Abrahams, Mikalai Budzevich, Epifanio Ruiz, Suning Huang, Marilyn Bui, Asmaa El-Kenawi, Shonagh Russell, Gary V Martinez, Debora APC Zuccari, and Robert Gillies.. Detection of mri-defined tumor habitats in breast cancer model under melatonin treatment. Manuscript in preparation, 2018.
- Suzanne J Bakewell, Adam Carie, Tara L Costich, Jyothi Sethuraman, J Edward Semple, Bradford Sullivan, Gary V Martinez,William Dominguez-Viqueira, and Kevin N Sill.. Imaging the delivery of drug-loaded, iron-stabilized micelles. Nanomedicine: Nanotechnology, Biology and Medicine 13(4):1353-1362, 2017.
- Trivikram R Molugu, Xiaolin Xu, Avigdor Leftin, Silvia Lope-Piedrafita, Gary V Martinez , Horia I Petrache, and Michael F Brown.. Solid-state deuterium nmr spectroscopy of membranes. Modern Magnetic Resonance, 2017.
- Huang Q, Schneeberger VE, Luetteke N, Jin C, Afzal R, Budzevich MM, Makanji RJ, Martinez GV, Shen T, Zhao L, Fung KM, Haura EB, Coppola D, Wu J. Preclinical Modeling of KIF5B-RET Fusion Lung Adenocarcinoma. Mol Cancer Ther 15(10):2521-2529, 2016. e-Pub 2016. PMID: 27496134.
- Qingling Huang, Valentina E Schneeberger, Noreen Luetteke, Roha Afzal, Mikalai M Budzevich, Rikesh Makanji, Gary Martinez , Domenico Coppola, and Jie Wu.. Characteristics, oncogene dependency, and response to ponatinib of a novel transgenic mouse model of kif5bret- induced lung adenocarcinoma. Journal of Thoracic Oncology 11(2:S54), 2016.
- PedroMEnriquez-Navas, Yoonseok Kam, Tuhin Das, Sabrina Hassan, Ariosto Silva, Parastou Foroutan, Epifanio Ruiz, Gary V Martinez, Susan Minton, Robert J Gillies, et alb.. Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer. Science translational medicine 8(327):327ra24-327ra24, 2016.
- Hong Zheng, Weipeng Zhao, Cihui Yan, Crystina C Watson, Michael Massengill, Mengyu Xie, Chris Massengill, David R Noyes, Gary V Martinez, Roha Afzal, et al.. Hdac inhibitors enhance t-cell chemokine expression and augment response to pd-1 immunotherapy in lung adenocarcinoma. Clinical Cancer Research 22(16):4119-4132, 2016.
- Xiaomeng Zhang, JonathanWWojtkowiak, Gray V Martinez, Heather H Cornnell, Charles P Hart, Amanda F Baker, and Robert Gillies. Mr imaging biomarkers to monitor early response to hypoxia-activated prodrug th-302 in pancreatic cancer xenografts. PloS one 11(5):e0155289, 2016.
- N V Rajeshkumar, Prasanta Dutta, Shinichi Yabuuchi, Roeland F deWilde, Gary V Martinez , Anne Le, Jurre J Kamphorst, Joshua D Rabinowitz, Sanjay K Jain, Manuel Hidalgo, Chi V Dang, Robert J Gillies, and Anirban Maitra. Therapeutic targeting of the warburg effect in pancreatic cancer relies on an absence of p53 function. Cancer Res 75(16):3355-3364, 2015.
- Yoonseok Kam, Tuhin Das, Haibin Tian, Parastou Foroutan, Epifanio Ruiz, Gary V Martinez, Susan Minton, Robert J Gillies, and Robert A Gatenby.. Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges. Int J Cancer, 136(4):E188-196, 2015.
- Wojtkowiak JW, Cornnell HC, Matsumoto S, Saito K, Takakusagi Y, Dutta P, Kim M, Zhang X, Leos R, Bailey KM, Martinez G, Lloyd MC, Weber C, Mitchell JB, Lynch RM, Baker AF, Gatenby RA, Rejniak KA, Hart C, Krishna MC, Gillies RJ. Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302. Cancer Metab 3(1):2, 2015. e-Pub 2015. PMID: 25635223.
- Luhach I, Idiyatullin D, Lynch CC, Corum C, Martinez GV, Garwood M, Gillies RJ. Rapid ex vivo imaging of PAIII prostate to bone tumor with SWIFT-MRI. Magn Reson Med 72(3):858-63, 2014. e-Pub 2013. PMID: 24155275.
- Schneeberger VE, Luetteke N, Ren Y, Berns H, Chen L, Foroutan P, Marinez GV, Haura EB, Chen J, Coppola D, Wu J. SHP2E76K mutant promotes lung tumorigenesis in transgenic mice. Carcinogenesis 35(8):1717-25, 2014. e-Pub 2014. PMID: 24480804.
- Mignion L, Dutta P, Martinez GV, Foroutan P, Gillies RJ, Jordan BF. Monitoring chemotherapeutic response by hyperpolarized 13C-fumarate MRS and diffusion MRI. Cancer Res 74(3):686-94, 2014. e-Pub 2013. PMID: 24285723.
- Kate M Bailey, Heather H Cornnell, Arig Ibrahim-Hashim, Jonathan W Wojtkowiak, Charles P Hart, Xiaomeng Zhang, Rafael Leos, Gary V Martinez , Amanda F Baker, and Robert J Gillies.. Evaluation of the "steal" phenomenon on the efficacy of hypoxia activated prodrug TH-302 in pancreatic cancer. PLoS One 9(12):e113586, 2014.
- Dutta P, Gary V Martinez, and Gillies RJ.. Nanodiamond as a new hyperpolarizing agent and its 13C MRS. Journal of Physical Chemistry Letters 5(3):597-600, 2014.
- Martinez GV, Navath S, Sewda K, Rao V, Foroutan P, Alleti R, Moberg VE, Ahad AM, Coppola D, Lloyd MC, Gillies RJ, Morse DL, Mash EA. Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract. Bioorg Med Chem Lett 23(7):2061-4, 2013. e-Pub 2013. PMID: 23481651.
- Natalie M Barkey, Christian Preihs, Heather H Cornnell, <b> Gary V Martinez</b>, Adam Carie, Josef Vagner, Liping Xu, Mark C Lloyd, Vincent M Lynch, Victor J Hruby, et al.. Development and in vivo quantitative magnetic resonance imaging of polymer micelles targeted to the melanocortin 1 receptor. Journal of medicinal chemistry 56(16):6330-6338, 2013.
- Cubitt CL, Menth J, Dawson J, Martinez GV, Foroutan P, Morse DL, Bui MM, Letson GD, Sullivan DM, Reed DR. Rapid screening of novel agents for combination therapy in sarcomas. Sarcoma 2013:365723, 2013. e-Pub 2013. PMID: 24282374.
- Prasanta Dutta, Gary Martinez , and Robert J. Gillies. A new horizon of DNP technology: application to in-vivo 13C magnetic resonance spectroscopy and imaging. Biophysical Reviews 5(3):271-281, 2013.
- Prasanta Dutta, Anne Le, David L Vander Jagt, Takashi Tsukamoto, Gary V Martinez, Chi V Dang, and Robert J Gillies.. Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors. Cancer Res 73(14):4190-4195, 2013.
- Parastou Foroutan, Jenny M Kreahling, David L Morse, Olya Grove, Mark C Lloyd, Damon Reed, Meera Raghavan, Soner Altiok, Gary V Martinez, and Robert J Gillies.. Diffusion MRI and novel texture analysis in osteosarcoma xenotransplants predicts response to anti-checkpoint therapy. PLoS One 8(12):e82875, 2013.
- Jenny M Kreahling, Parastou Foroutan, Damon Reed, Gary V Martinez, Tiffany Razabdouski, Marilyn M Bui, Meera Raghavan, Douglas Letson, Robert J Gillies, and Soner Altiok. Wee1 inhibition by MK-1775 leads to tumor inhibition and enhances efficacy of gemcitabine in human sarcomas. PLoS One 8(2):e57523, 2013.
- Wang C, Ravi S, Martinez GV, Chinnasamy V, Raulji P, Howell M, Davis Y, Mallela J, Seehra MS, Mohapatra S. Dual-purpose magnetic micelles for MRI and gene delivery. J Control Release 163(1):82-92, 2012. e-Pub 2012. PMID: 22561339.
- D'Silva L, Pola A, Dutta P, Martinez FV, Sprenger P, Gillies RJ, Kuchel PW, Sendhil Velan S. Slow relaxation of longitudinal multispin orders in weakly and strongly coupled two-spin systems. Magn Reson Chem 50(6):443-8, 2012. e-Pub 2012. PMID: 22552892.
- Ibrahim Hashim A, Cornnell HH, Coelho Ribeiro Mde L, Abrahams D, Cunningham J, Lloyd M, Martinez GV, Gatenby RA, Gillies RJ. Reduction of metastasis using a non-volatile buffer. Clin Exp Metastasis 28(8):841-9, 2011. e-Pub 2011. PMID: 21861189.
- Hashim AI, Zhang X, Wojtkowiak JW, Martinez GV, Gillies RJ. Imaging pH and metastasis. NMR Biomed 24(6):582-91, 2011. e-Pub 2011. PMID: 21387439.
- Gary V Martinez, Xiaomeng Zhang, María L García-Martín, David L Morse, Mark Woods, A Dean Sherry, and Robert J Gillies.. Imaging the extracellular pH of tumors by MRI after injection of a single cocktail of T1 and T2 contrast agents. NMR in Biomedicine 24(10):1380-1390, 2011.
- De Leon-Rodriguez LM, Lubag AJ, Malloy CR, Martinez GV , Gillies RJ, Sherry AD. Responsive MRI agents for sensing metabolism in vivo. Acc Chem Res 42(7):948-57, 2009. PMID: 19265438.
- Borden MA, Martinez GV, Ricker J, Tsvetkova N, Longo M, Gillies RJ, Dayton PA, Ferrara KW. Lateral phase separation in lipid-coated microbubbles. Langmuir 22(9):4291-7, 2006. PMID: 16618177.
- Maria L Garcia-Martin, <b>Gary V Martinez</b>, Natarajan Raghunand, A Dean Sherry, Shanrong Zhang, and Robert J Gillies.. High resolution pHe imaging of rat glioma using pH-dependent relaxivity. Magnetic resonance in medicine 55(2):309-315, 2006.
- Henzler-Wildman KA, Martinez GV, Brown MF, Ramamoorthy A. Perturbation of the hydrophobic core of lipid bilayers by the human antimicrobial peptide LL-37. Biochemistry 43(26):8459-69, 2004. PMID: 15222757.
- Martinez GV, Dykstra EM, Lope-Piedrafita S, Brown MF. Lanosterol and cholesterol-induced variations in bilayer elasticity probed by 2H NMR relaxation. Langmuir 20(4):1043-6, 2004. PMID: 15803674.
- Larsson G, Martinez G, Schleucher J, Wijmenga SS. Detection of nano-second internal motion and determination of overall tumbling times independent of the time scale of internal motion in proteins from NMR relaxation data. J Biomol NMR 27(4):291-312, 2003. PMID: 14512728.
- Janusz Zdunek, Gary V Martinez, Jurgen Schleucher, PO Lycksell, Y Yin, S Nilsson, Y Shen, Gunilla Olivecrona, and S Wijmenga.. Global structure and dynamics of human apolipoprotein CII in complex with micelles: evidence for increased mobility of the helix involved in the activation of lipoprotein lipase. Biochemistry 42(7):1872-1889, 2003.
- Martinez GV, Dykstra EM, Lope-Piedrafita S, Job C, Brown MF. NMR elastometry of fluid membranes in the mesoscopic regime. Phys Rev E Stat Nonlin Soft Matter Phys 66(5 Pt 1):050902, 2002. e-Pub 2002. PMID: 12513460.
- Yin Wang, Ana Vitória Botelho, Gary V Martinez, and Michael F Brown.. Electrostatic properties of membrane lipids coupled to metarhodopsin II formation in visual transduction. Journal of the American Chemical Society 124(26):7690-7701, 2002.
- M Bennati, GJ Gerfen, GV Martinez, RG Griffin, DJ Singel, and GL Millhauser.. Nitroxide side-chain dynamics in a spin-labeled helix-forming peptide revealed by high-frequency (139.5- ghz) EPR spectroscopy. Journal of Magnetic Resonance 139(2):281-286, 1999.
- Paul Hanson, D JOE Anderson, Gary V Martinez , Glenn Millhauser, Fernando Formaggio, Marco Crisma, Claudio Toniolo, and Claudio Vita.. Electron spin resonance and structural analysis of water soluble, alanine-rich peptides incorporating to ac. Molecular Physics 95(5):957-966, 1998.
- Gary V Martinez and Glenn L Millhauser.. A neural network approach to the rapid computation of rotational correlation times from slow motional ESR spectra. Journal of Magnetic Resonance 134(1):124-130, 1998.
- Gary V Martinez and Glenn Millhauser. Ftir spectroscopy of alanine-based peptides: assignment of the amide I0 modes for random coil and helix. Journal of structural biology 114(1):23-27, 1995.
- Claudio Toniolo, Ezio Valente, Fernando Formaggio, Marco Crisma, Giuseppe Pilloni, Carlo Corvaja, Antonio Toffoletti, Gary V Martinez,MPaul Hanson, Glenn L Millhauser, et al. Synthesis and conformational studies of peptides containing toac, a spin-labelled Ca;a-disubstituted glycine. Journal of Peptide Science 1(1):45-57, 1995.
- Paul Hanson, GV Martinez, Glenn Millhauser, Fernando Formaggio, Marco Crisma, Claudio Toniolo, and Claudio Vita.. Distinguishing helix conformations in alanine-rich peptides using the unnatural amino acid toac and electron spin resonance. Journal of the American Chemical Society 118(1):271-272, 1993.
- Siobhan M Miick, Gary V Martinez, Wayne R Fiori, A Paul Todd, and Glenn L Millhauser. Short alanine-based peptides may form 310-helices and not alpha-helices in aqueous solution. Nature 359(6396):653-655, 1992.
Abstracts
- T. Mehnert, R. Bittman, Gary V. Martinez, M. F. Brown, F. Kamp, and K. Beyer. Biophysical Journal 88(1):70A-71A, 2005.
- Silvia Lope-Piedrafita, Gary V. Martinez, M. F. Brown, F. Kamp, and K. Beyer. Dynamical membrane stiffening by cholesterol on the mesoscale probed by deuterium NMR relaxation. Biophysical Journal 86(1):31A, 2004.
- Gary V. Martinez, Emily M. Dykstra, Silvia Lope-Piedrafita, Horia I. Petrache, and Michael F. Brown. Lanosterol and cholesterolinduced variations in bilayer elasticity studied by deuterium NMR and x-ray diffraction. Biophysical Journal 86(1):200A-200A, 2004.
- Gary V. Martinez, Martinez, Emily M. Dykstra, Silvia Lope-Piedrafita, and Michael F. Brown. Bilayer elasticity and its implications for the evolution of sterols as determined by 2H solid state NMR. Biophysical Journal 84(2):379A-379A, 2003.
- Emily M. Dykstra, |Gary V. Martinez, Silvia Lope-Piedrafita, and Michael F. Brown. Solid-state deuterium NMR study of the effect of cholesterol and lanosterol on membrane elasticity. Papers of the American Chemical Society 223:375-CHED, 2002.
- Katherine A. H. Wildman, Gary V Martinez, Michael F. Brown, and Ayyalusamy Ramamoorthy. Solid state NMR studies of LL37 peptide-lipid interactions in membranes. Biophysical Journal 82(1):468A-468A, 2002.
- Gary V. Martinez, Silvia Lope-Piedrafita, EmilyM. Dykstra, and Michael F. Brown. Membrane elasticity in the presence of cholesterol and detergents studied by solid state deuterium NMR spectroscopy. Biophysical Journal 80(1):533A-533A, 2001.
- Yin Wang, Ana V. Botelho, Gary V Martinez, and Michael F. Brown. Bilayer lipids govern the conformational energetics of rhodopsin in visual excitation. Biophysical Journal 80(1):605A-606A, 2001.
- Gary V. Martinez, Wayne R. Fiori, and Glenn L. Millhauser. Site-Specific Isotopically Labeled 13C Vibrational Difference Spectroscopy Gives Insight Into Amide-I’ Band Frequency Assignments In Helical Peptides. Biophysical Journal 66(2):A65-A65, 1994.
- Wayne R. Fiori, Gary V. Martinez, andGlenn L. Millhauser. Length Dependence in Alanine-Based Peptides the 310 -Helix To Alpha-Helix Transition. Biophysical Journal 64(2):A378-A378, 1993.
- Gary V. Martinez and Glenn L. Millhauser. Alpha-Helices And 310-Helices In Aqueous-Solution May Readily Be Distinguished Using FTIR Spectroscopy. Biophysical Journal 64(A378-A378), 1993.
Book Chapters
- Gary V Martinez. Introduction to MRI Physics. In: Preclinical MRI, 3-19, 2018.