About Dr. Schluns
Dr. Kimberly Schluns is an Associate Professor in the Department Immunology at MD Anderson Cancer Center. Through her research, she seeks to better understand the mechanisms that regulate antigen-specific CD8 T cell responses and their subsequent differentiation into long-lived, functional memory T cells. Her lab has published numerous findings on the role of cytokines, particularly Interleukin-15, in the generation and maintenance of memory CD8 T cells. IL-15 also enhances responses by cytotoxic cells and has potent anti-tumor properties. Currently, the lab is attempting to identify mechanisms that regulate IL-15 responses in the tumor microenvironment and by IL-15 agonists used in cancer immunotherapy. Ultimately, the insights Dr. Schluns gains by unraveling these mechanisms could be used to guide development of new cancer vaccines and tumor immunotherapies.
Associate Professor, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX
Member, Division of Graduate Faculty, The University of Texas Graduate School of Biomedical Sciences (GSBS), Houston, TX
|1998||Loyola University, Maywood, IL, USA, PHD, Cell Biology|
|1989||University of Illinois, Urbana-Champaign, IL, USA, BS, Physiology|
|1997-2004||Postdoctoral Fellowship, University of Connecticut Health Center, Farmington, CT|
Member, Immunology Graduate Program, The University of Texas Graduate School of Biomedical Sciences (GSBS), Houston, TX, 2004 - Present
Director, Immunology Graduate Program, The University of Texas Graduate School of Biomedical Sciences (GSBS), Houston, TX, 2010 - 2013
Institutional Committee Activities
Member, 2015 Faculty Achievement Award Committee, 2015 - Present
Member, The University of Texas Graduate School of Biomedical Sciences (GSBS) Admissions Committee, 2014 - 2015
Member, 2014 Faculty Achievement Award Committee, 2014 - Present
Representative, Faculty Senate, 2013 - 2016
Member, The University of Texas Graduate School of Biomedical Sciences (GSBS) Immunology Program Steering Committee, 2013 - 2016
Member, Odyssey Program Advisory Committee, 2009 - 2012
Representative, Faculty Senate, 2006 - 2009
|2017||MD Anderson Faculty Educator of the Month, The University of Texas MD Anderson Cancer Center|
|2004||George and Barbara Bush Trust Fellowship, The University of Texas MD Anderson Cancer Center|
|1998||American Association of Anatomist (AAA) Outstanding Dissertation Award, American Association of Anatomist (AAA)|
- Santana Carrero RM, Beceren-Braun F, Rivas SC, Hegde SM, Gangadharan A, Plote D, Pham G, Anthony SM, Schluns KS. IL-15 is a component of the inflammatory milieu in the tumor microenvironment promoting antitumor responses. Proc Natl Acad Sci U S A, 2019. e-Pub 2018.
- Plote D, Choi W, Mokkapati S, Sundi D, Ferguson JE, Duplisea J, Parker NR, Yla-Herttuala S, Committee SCB, McConkey D, Schluns KS, Dinney CP. Inhibition of urothelial carcinoma through targeted type I interferon-mediated immune activation. Oncoimmunology 8(5):e1577125, 2019. e-Pub 2019. PMID: 31069136.
- Haymaker C, Yang Y, Wang J, Zou Q, Sahoo A, Alekseev A, Singh D, Ritthipichai K, Hailemichael Y, Hoang ON, Qin H, Schluns KS, Wang T, Overwijk WW, Sun SC, Bernatchez C, Kwak LW, Neelapu SS, Nurieva R. Absence of Grail promotes CD8(+) T cell anti-tumour activity. Nat Commun 8(1):239, 2017. e-Pub 2017. PMID: 28798332.
- Anthony SM, Rivas SC, Colpitts SL, Howard ME, Stonier SW, Schluns KS. Inflammatory Signals Regulate IL-15 in Response to Lymphodepletion. J Immunol 196(11):4544-52, 2016. e-Pub 2016. PMID: 27183627.
- Singh S, Schluns KS, Yang G, Anthony SM, Barry MA, Sastry KJ. Intranasal Vaccination Affords Localization and Persistence of Antigen-Specific CD8? T Lymphocytes in the Female Reproductive Tract. Vaccines (Basel) 4(1), 2016. e-Pub 2016. PMID: 26999228.
- Huang X, Li J, Dorta-Estremera S, Di Domizio J, Anthony SM, Watowich SS, Popkin D, Liu Z, Brohawn P, Yao Y, Schluns KS, Lanier LL, Cao W. Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species. Cell Rep 12(7):1120-32, 2015. e-Pub 2015. PMID: 26257170.
- Anthony SM, Howard ME, Hailemichael Y, Overwijk WW, Schluns KS. Soluble interleukin-15 complexes are generated in vivo by type I interferon dependent and independent pathways. PLoS One 10(3):e0120274, 2015. e-Pub 2015. PMID: 25756182.
- Puebla-Osorio N, Kim J, Ojeda S, Zhang H, Tavana O, Li S, Wang Y, Ma Q, Schluns KS, Zhu C. A novel Ku70 function in colorectal homeostasis separate from nonhomologous end joining. Oncogene 33(21):2748-57, 2014. e-Pub 2013. PMID: 23752193.
- Lee PH, Puppi M, Schluns KS, Yu-Lee LY, Dong C, Lacorazza HD. The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage. J Immunol 192(1):178-88, 2014. e-Pub 2013. PMID: 24259505.
- Singh S, Yang G, Schluns KS, Anthony SM, Sastry KJ. Sublingual vaccination induces mucosal and systemic adaptive immunity for protection against lung tumor challenge. PLoS One 9(3):e90001, 2014. e-Pub 2014. PMID: 24599269.
- Firth MA, Madera S, Beaulieu AM, Gasteiger G, Castillo EF, Schluns KS, Kubo M, Rothman PB, Vivier E, Sun JC. Nfil3-independent lineage maintenance and antiviral response of natural killer cells. J Exp Med 210(13):2981-90, 2013. e-Pub 2013. PMID: 24277151.
- Colpitts SL, Stonier SW, Stoklasek TA, Root SH, Aguila HL, Schluns KS, Lefrançois L. Transcriptional regulation of IL-15 expression during hematopoiesis. J Immunol 191(6):3017-24, 2013. e-Pub 2013. PMID: 23966624.
- Hailemichael Y, Dai Z, Jaffarzad N, Ye Y, Medina MA, Huang XF, Dorta-Estremera SM, Greeley NR, Nitti G, Peng W, Liu C, Lou Y, Wang Z, Ma W, Rabinovich B, Sowell RT, Schluns KS, Davis RE, Hwu P, Overwijk WW. Persistent antigen at vaccination sites induces tumor-specific CD8? T cell sequestration, dysfunction and deletion. Nat Med 19(4):465-72, 2013. e-Pub 2013. PMID: 23455713.
- Robinson TO, Schluns KS. The potential and promise of IL-15 in immuno-oncogenic therapies. Immunol Lett 190:159-168, 2017. e-Pub 2017. PMID: 28823521.
- Castillo EF, Schluns KS. Regulating the immune system via IL-15 transpresentation. Cytokine 59(3):479-90, 2012. e-Pub 2012. PMID: 22795955.
- Stonier SW, Schluns KS. Trans-presentation: a novel mechanism regulating IL-15 delivery and responses. Immunol Lett 127(2):85-92, 2010. e-Pub 2009. PMID: 19818367.
- Overwijk WW, Schluns KS. Functions of gammaC cytokines in immune homeostasis: current and potential clinical applications. Clin Immunol 132(2):153-65, 2009. e-Pub 2009. PMID: 19428306.
- Schluns KS, Stoklasek T, Lefrançois L. The roles of interleukin-15 receptor alpha: trans-presentation, receptor component, or both?. Int J Biochem Cell Biol 37(8):1567-71, 2005. e-Pub 2005. PMID: 15896666.
- Schluns KS, Lefrançois L. Cytokine control of memory T-cell development and survival. Nat Rev Immunol 3(4):269-79, 2003. PMID: 12669018.
- Anthony SM, Schluns KS. Emerging roles for IL-15 in the activation and function of T cells during immune stimulation. Res Rep Biol. e-Pub 2015.
|Title:||STING stimulation of IL-15: bridging inflammatory signals to enhanced adaptive immunity|
|Funding Source:||The University of Texas MD Anderson Cancer Center CIC Seed Funding|
|Title:||Regulation of infiltration and function of tumor-resident CD8 T cells by IL-15|
|Funding Source:||Cancer Prevention & Research Institute of Texas (CPRIT)|
|Title:||Generating a model system to elucidate in vivo functions of soluble IL-15 complexes|
|Title:||Regulation of memory CD8 T cell homeostasis by IL-15 Ra+|