Kris Michael Mahadeo, MD, MPH
Department of Pediatrics, Division of Pediatrics
Present Title & Affiliation
Primary Appointment
Section Chief and Medical Director, Pediatric Stem Cell Therapy/Cell Therapy, Department of Pediatrics Patient Care, Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX
, Department of Stem Cell Transplantation, CARTOX Program, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2009 | University of Medicine Dentistry, School of Public Health, Newark, NJ, USA, MPH, Public Health |
| 2003 | St. George's University School of Medicine, Grenada, WI, USA, MD, Medicine |
| 1999 | Adelphi University Honors College, Garden City, NY, USA, BS, Biology |
Postgraduate Training
| 2010-2011 | Clinical Fellowship, Pediatric Blood and Marrow Transplantation, Duke University Medical Center, Durham, NC |
| 2007-2010 | Clinical Fellowship, Pediatric Hematology Oncology, Children's Hospital at Montefiore/Albert Einstein College of Medicine, Bronx, NY |
| 2005-2007 | Clinical Residency, Pediatrics, Children's Hospital at St. Peter's University Hospital, New Brunswick, NJ |
Board Certifications
| 2011 | American Board of Pediatrics, Pediatric Hematology Oncology |
| 2007 | American Board of Pediatrics, General Pediatrics |
Experience & Service
Administrative Appointments/Responsibilities
Section Chief and Medical Director, Pediatric Stem Cell Therapy/Cell Therapy, Department of Pediatrics Patient Care, The University of Texas MD Anderson Cancer Center, Houston, TX, 2017 - Present
Director, Marrow and Blood Transplantation, Children's Hospital at Montefiore, Bronx, NY, 2014 - 2017
Other Appointments/Responsibilities
Co-Chair, Pediatric Acute Lung and Sepsis Investigators: HCT-CI Subgroup, Houston, TX, 2017 - Present
Inspector, Foundation for the Accreditation of Cellular Therapy (FACT), Houston, TX, 2012 - Present
Selected Publications
Peer-Reviewed Articles
- Mahadeo KM, McArthur J, Adams RH, Radhi M, Angelo J, Jeyapalan A, Nicol K, Su L, Rabi H, Auletta JJ, Pai V, Duncan CN, Tamburro R, Dvorak CC, Bajwa RPS. Consensus Report by the Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplant Consortium Joint Working Committees on Supportive Care Guidelines for Management of Veno-Occlusive Disease in Children and Adolescents: Part 2-Focus on Ascites, Fluid and Electrolytes, Renal, and Transfusion Issues. Biol Blood Marrow Transplant 23(12):2023-2033, 2017. e-Pub 2017. PMID: 28823876.
- Bajwa RPS, Mahadeo KM, Taragin BH, Dvorak CC, McArthur J, Jeyapalan A, Duncan CN, Tamburro R, Gehred A, Lehmann L, Richardson P, Auletta JJ, Woolfrey AE. Consensus Report by Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplantation Consortium Joint Working Committees: Supportive Care Guidelines for Management of Veno-Occlusive Disease in Children and Adolescents, Part 1: Focus on Investigations, Prophylaxis, and Specific Treatment. Biol Blood Marrow Transplant 23(11):1817 - 1825, 2017. e-Pub 2017. PMID: 28754544.
- Mahadeo KM, Diop-Bove N, Ramirez SI, Cadilla CL, Rivera E, Martin M, Lerner NB, DiAntonio L, Duva S, Santiago-Borrero PJ, Goldman ID. Prevalence of a loss-of-function mutation in the proton-coupled folate transporter gene (PCFT-SLC46A1) causing hereditary folate malabsorption in Puerto Rico. J Pediatr 159(4):623-7.e1, 2011. e-Pub 2011. PMID: 21489556.
- Mahadeo KM, Oyeku S, Taragin B, Rajpathak SN, Moody K, Santizo R, Driscoll MC. Increased prevalence of osteonecrosis of the femoral head in children and adolescents with sickle-cell disease. Am J Hematol 86(9):806-8, 2011. PMID: 21850660.
- Shin DS, Mahadeo KM, Min SH, Diop-Bove N, Clayton P, Zhao R, Goldman ID. Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorption. Mol Genet Metab 103(1):33-7, 2011. e-Pub 2011. PMID: 21333572.
- Mahadeo KM, Santizo R, Baker L, Curry JO, Gorlick R, Levy AS. Ambulatory high-dose methotrexate administration among pediatric osteosarcoma patients in an urban, underserved setting is feasible, safe, and cost-effective. Pediatr Blood Cancer 55(7):1296-9, 2010. e-Pub 2010. PMID: 20949591.
- Mahadeo KM, Diop-Bove N, Shin D, Unal ES, Teo J, Zhao R, Chang MH, Fulterer A, Romero MF, Goldman ID. Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption. Am J Physiol Cell Physiol 299(5):C1153-61, 2010. e-Pub 2010. PMID: 20686069.
- Mahadeo KM, Cole PD. Successful treatment using omacetaxine for a patient with CML and BCR-ABL1 [corrected] 35INS. Blood 115(18):3852, 2010. PMID: 20448119.
- Mahadeo KM, Dhall G, Ettinger LJ, Kurer CC. Exacerbation of anthracycline-induced early chronic cardiomyopathy with ATRA: role of B-type natriuretic peptide as an indicator of cardiac dysfunction. J Pediatr Hematol Oncol 32(2):134-6, 2010. PMID: 20098333.
- Mahadeo KM, Dhall G, Panigrahy A, Lastra C, Ettinger LJ. Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year-old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury. Pediatr Hematol Oncol 27(1):46-52, 2010. PMID: 20121554.
Grant & Contract Support
| Title: | Phase I/II study of CaspaCide T cells from an HLA-partially matched family donor after negative selection of TCR αβ T cells in pediatric patients affected by hematological disorders |
| Funding Source: | Bellicum |
| Role: | Principal Investigator |
| Title: | Multicenter Expanded Access Protocol of Allogeneic Epstein-Barr Virus Cytotoxic T Lymphocytes (EBV-CTLs) for Patients with EBY-Associated Lymphomas and Lymphoproliferative Disorders in lmmunocompromised Patients for Whom There are No Other Comparable Options |
| Funding Source: | Atara 201 Biotherapeutics, Inc |
| Role: | Principal Investigator |
| Title: | Multicenter, Open-Label, Phase 3 Trial of Allogeneic Epstein-Barr Virus Cytotoxic T Lymphocytes (EBV-CTLs) for Allogeneic Hematopoietic Cell Transplant (alloHCT) Patients with EBV-Associated Post-Transplant Lymphoproliferative Disease (EBV-PTLD) after Failure of Rituximab |
| Funding Source: | Atara 301 Biotherapeutics, Inc |
| Role: | Principal Investigator |
| Title: | Multicenter, Double Blind, Placebo-Controlled, Randomized Phase 3 Trial of Allogeneic Epstein-Barr Virus Cytotoxic T Lymphocytes (EBV-CTLs) Compared with Placebo for Solid Organ Transplant (SOT) Patients with EBV-Associated Post Transplant Lymphoproliferative Disease (EBV-PTLD) after Failure of Rituximab or Rituximab and Chemotherapy |
| Funding Source: | Atara 302 Biotherapeutics, Inc |
| Role: | Principal Investigator |
| Title: | MSB-GVHDOO l : A Single-arm, Prospective Study of Remestemcel-L, Ex-vivo Cultured Adult Human Mesenchymal Stem Cells, for the Treatment of Pediatric Patients who Have Failed to Respond to Steroid Treatment for Acute GVHD |
| Funding Source: | Mesoblast |
| Role: | Principal Investigator |
| Title: | Safety Follow-up Through 180 days of Treatment with Remestemcel-L in Study MSBGVHD001 in Pediatric Patients who Have Failed to Respond to Steroid Treatment for Acute GVHD |
| Funding Source: | Mesoblast |
| Role: | Principal Investigator |
| Title: | Phase 3, Open-label, Multicenter Study of the Safety/Tolerability and Efficacy of Brincidofovir (CMXOO l) for the Prevention of Adenovirus (AdV) Disease in Subjects at with Asymptomatic AdV Infection at Risk of Progression and for the Treatment of Subjects with Localized or Disseminated Adenovirus Disease |
| Funding Source: | Chimerix, Inc |
| Role: | Principal Investigator |
| Title: | A Multicenter Non-Interventional Study to Obtain Retrospective Data for Subjects Previously Diagnosed with Adenovirus Infection to serve as Matched Historical Controls for Study CMXOO l -304 |
| Funding Source: | Chimerix, Inc |
| Role: | Principal Investigator |
| Title: | Congenital amegakaryocytic thrombocytopenia and umbilical cord blood transplantation |
| Funding Source: | NIH/NCI |
| Role: | Postdoctoral Fellow |
| Title: | Proton Coupled Folate Transporter and Chemotherapy |
| Funding Source: | St. Baldrick’s Foundation |
| Role: | Postdoctoral Fellow |
| Title: | Allogeneic Stem Cell Transplantation of NiCord®, Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells, in Patients with Hemoglobinopathies |
| Funding Source: | Gamida Cell Ltd |
| Role: | Co-Investigator |